788,525 results match your criteria inflammation

Association between isotretinoin (Roaccutanne) use and changes in periodontal clinical parameters and MMP-8 and MMP-9 salivary levels.

Front Biosci (Landmark Ed) 2021 Jul;26(7):191-197

Department of Periodontics and Community Dentistry, Dental College, King Saud University, 11545 Riyadh, Saudi Arabia.

: to evaluate changes in clinical periodontal parameters, salivary levels of MMP-8 and MMP-9, in individuals taking Isotretinoin (INN), and compare with individuals not taking the medication and to compare findings among different stages of periodontal disease and healthy periodontium. : A case-control study was conducted with a total of 180 human adults divided into six groups. Clinical parameters, including pocket depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were measured at six sites per tooth. Read More

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Mammographic and sonographic findings in the breast and axillary tail following a COVID-19 vaccine.

Clin Imaging 2021 Jul 26;80:202-204. Epub 2021 Jul 26.

Mayo Clinic, Department of Breast Imaging and Intervention, Rochester, MN, United States of America. Electronic address:

Axillary lymphadenopathy on breast imaging after recent coronavirus disease 2019 (COVID-19) vaccination has been reported in the literature as immunization has become more widespread. While muscle edema at the injection site has been observed on MRI secondary to an immune response, ipsilateral breast imaging observations of edema have not been reported to be seen with the COVID-19 vaccinations to date. Mammographic findings such as trabecular and skin thickening, along with increased echogenicity on ultrasound, can be seen with edema secondary to capillary leak or poor lymphatic drainage, and should be considered as a possible etiology for the observed breast edema following a recent COVID-19 vaccine. Read More

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Temporal lobe epilepsy: Evaluation of central and systemic immune-inflammatory features associated with drug resistance.

Seizure 2021 Jul 26;91:447-455. Epub 2021 Jul 26.

Unidad Mixta de Estudio de la Neuroinflamación, Instituto de Investigaciones Biomédicas (IIBO), Universidad Nacional Autónoma de México (UNAM) / Instituto Nacional de Neurología y Neurocirugía (INNN), Ciudad de México, México; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México Ciudad Universitaria. Apartado Postal 70228. México DF 04510. México. Electronic address:

Neuroinflammation is probably one of the factors involved in drug resistance in people with epilepsy. Finding peripheral markers reflecting the intensity of neuroinflammation could be of great help to decide for which patients anti-inflammatory treatment might be an option. In this context, peripheral cytokines levels and lymphocyte phenotypes were assessed by ELISA and flow cytometry in 3 groups of subjects: drug resistant patients with temporal lobe epilepsy (DR-TLE), non DR-TLE patients and healthy controls. Read More

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Targeting immunosuppressor cells with nanoparticles in autoimmunity: How far have we come to?

Cell Immunol 2021 Jul 27;368:104412. Epub 2021 Jul 27.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

Autoimmunity is the assault of immune response towards self-antigens, resulting to inflammation and tissue injury. It is staged into three phases and caused by malfunction of immune tolerance. In our body, immune tolerance is synchronized by several immunosuppressor cells such as regulatory T cells and B cells as well as myeloid-derived suppressor cells, which are prominently dysregulated in autoimmunity. Read More

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Abnormalities of the type I interferon signaling pathway in lupus autoimmunity.

Cytokine 2021 Jul 30;146:155633. Epub 2021 Jul 30.

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States; Fels Cancer Institute for Personalized Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic condition linked to inflammation. Both IFNα and IFNβ trigger a signaling cascade that, through the activation of JAK1, TYK2, STAT1 and STAT2, initiates gene transcription of IFN stimulated genes (ISGs). Noteworthy, other STAT family members and IFN Responsive Factors (IRFs) can also contribute to the activation of the IFN response. Read More

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TSPO deficiency accelerates amyloid pathology and neuroinflammation by impairing microglial phagocytosis.

Neurobiol Aging 2021 Jul 3;106:292-303. Epub 2021 Jul 3.

Department of Immunology, CAMS Key Laboratory for T Cell and Immunotherapy, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, State Key Laboratory of Medical Molecular Biology, Beijing, China. Electronic address:

Increasing evidence has placed inflammation and immune dysfunction at the center of the pathogenesis of Alzheimer's disease (AD). The mitochondrial protein translocator protein (18 kDa) (TSPO) is highly upregulated in microglia and astrocytes in response to inflammatory stimulation. However, the biological action of TSPO in the pathogenesis of AD has not been determined to date. Read More

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Impact of ozone exposure on heart rate variability and stress hormones: A randomized-crossover study.

J Hazard Mater 2021 Jul 26;421:126750. Epub 2021 Jul 26.

Department of Environmental Health, School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, P.O. Box 249,130 Dong-An Road, Shanghai 200032, China; Children's Hospital of Fudan University, National Center for Children's Health, Shanghai, China. Electronic address:

The biological mechanisms underlying the associations between atmospheric ozone exposure and adverse cardiometabolic outcomes are yet to be identified. Imbalanced autonomic nervous system (ANS) as well as activations of the sympatho-adrenomedullary (SAM) and hypothalamic-pituitary-adrenal (HPA) axes are among possible early biological responses triggered by ozone, and may eventually lead to cardiometabolic abnormalities. To determine whether acute ozone exposure causes ANS imbalance and increases the secretion of neuroendocrine stress hormones, we conducted a randomized, double-blind, crossover trial, under controlled 2-hour exposure to either ozone (200 ppb) or clean air with intermittent exercise among 22 healthy young adults. Read More

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Design, synthesis and evaluation of side-chain hydroxylated derivatives of lithocholic acid as potent agonists of the vitamin D receptor (VDR).

Bioorg Chem 2021 Jul 22;115:105202. Epub 2021 Jul 22.

Departamento de Química Orgánica, Laboratorio de Investigación Ignacio Ribas, Universidad de Santiago de Compostela, Avda das Ciencias s/n, 15782 Santiago de Compostela, Spain. Electronic address:

A high number of biologically active and low-calcemic secosteroidal ligands of the vitamin D receptor (VDR) have been developed, some of which are already used clinically although with limited success in the treatment of hyperproliferative diseases because the required pharmaceutical dosages induce toxicity. We describe here the in silico design, synthesis, structural analysis and biological evaluation of two novel active lithocholic acid derivatives hydroxylated at the side chain as highly potent inhibitors of atopic dermatitis-relevant keratinocyte inflammation of potential therapeutic interest. Read More

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Dioscin prevents DSS-induced colitis in mice with enhancing intestinal barrier function and reducing colon inflammation.

Int Immunopharmacol 2021 Jul 31;99:108015. Epub 2021 Jul 31.

Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province, China. Electronic address:

Dioscin is a natural steroid saponin derived from plants of the genus Dioscoreaceae. Previous studies have proved its effects of antibacterial, anti-inflammatory and hypolipidemic. In this study, our aim was to explore the protective effect and preliminary mechanism of Dioscin on dextran sulfate sodium (DSS)-induced colitis in mice. Read More

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miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.

Int Immunopharmacol 2021 Jul 30;99:108022. Epub 2021 Jul 30.

Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address:

Cisplatin is a highly effective and broad-spectrum anticancer drug for the clinical treatment of solid tumors. However, it causes acute kidney injury (AKI) in patients with cancer. Consequently, its clinical application is limited. Read More

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Investigating the medicinal potential, material basis and mechanism of Polygoni Orientalis Fructus based on multi-technology integrated network pharmacology.

Phytomedicine 2021 Jul 25;91:153685. Epub 2021 Jul 25.

Jiangsu Engineering Research Center of Cardiovascular Drugs Targeting Endothelial Cells, College of Health Sciences, School of Life Science, Jiangsu Normal University, Xuzhou, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. Electronic address:

Background: Polygoni Orientalis Fructus (POF) refers to the dried ripe fruit of Polygonum orientale L. which has a long historical application in clinic for treatment of various conditions in China. However, its chemical constituents, pharmacological effects and their coupled correlation have not been intensively investigated. Read More

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Network pharmacology-based identification of significant pathway for protection of Yinhuang granule in a mice model of metabolic-associated fatty liver disease.

Phytomedicine 2021 Jul 16;91:153666. Epub 2021 Jul 16.

The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.

Background: Metabolic-associated fatty liver disease (MAFLD) is a spectrum of liver disorders. Nonalcoholic steatohepatitis (NASH) is defined as a more serious process of MAFLD with liver inflammation.

Purpose: This study aims to observe the alleviation of Yinhuang granule (YHG), a Chinese patent medicine, on methionine and choline-deficient diet (MCD)-induced MAFLD in mice. Read More

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The neuroprotective potential of carotenoids in vitro and in vivo.

Phytomedicine 2021 Jul 21;91:153676. Epub 2021 Jul 21.

School of Bio Sciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India. Electronic address:

Background: Despite advances in research on neurodegenerative diseases, the pathogenesis and treatment response of neurodegenerative diseases remain unclear. Recent studies revealed a significant role of carotenoids to treat neurodegenerative diseases. The aim of this study was to systematically review the neuroprotective potential of carotenoids in vivo and in vitro and the molecular mechanisms and pathological factors contributing to major neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and stroke). Read More

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Current concepts and perspectives on brain arteriovenous malformations: A review of pathogenesis and multidisciplinary treatment.

World Neurosurg 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, 060-8638 Sapporo, Japan. Electronic address:

Brain arteriovenous malformations (bAVMs) are unusual vascular pathologies characterized by the abnormal aggregation of dilated arteries and veins in the brain parenchyma and for which the absence of a normal vascular structure and capillary bed leads to direct connections between arteries and veins. Although bAVMs have long been believed to be congenital anomalies that develop during the prenatal period, current studies show that inflammation is associated with AVM genesis, growth, and rupture. Interventional treatment options include microsurgery, stereotactic radiosurgery, and endovascular embolization, and management often comprises a multidisciplinary combination of these modalities. Read More

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Long-term cognitive deficits after traumatic brain injury associated with microglia activation.

Clin Immunol 2021 Jul 30:108815. Epub 2021 Jul 30.

Department of Experimental Pathology, Immunology, and Microbiology, Faculty of Medicine, American University of Beirut, Lebanon; Nehme and Therese Tohme Multiple Sclerosis Center, Faculty of Medicine, American University of Beirut Medical Center, Lebanon. Electronic address:

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases of the central nervous system. We hypothesize that microglia may play a beneficial or detrimental role in TBI depending on their state of activation and duration. Read More

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Proneurogenic and neuroprotective effect of a multi strain probiotic mixture in a mouse model of acute inflammation: involvement of the gut-brain axis.

Pharmacol Res 2021 Jul 30:105795. Epub 2021 Jul 30.

Institute of Biochemistry and Cell Biology, IBBC, CNR, Monterotondo, Rome, Italy. Electronic address:

Neuroinflammation can severely affect brain homeostasis and adult hippocampal neurogenesis with detrimental effects on cognitive processes. Brain and gut are intimately connected via the "gut-brain axis", a bidirectional communication system, and the administration of live bacteria (probiotics) has been shown to represent an intriguing approach for the prevention or even the cure of several diseases. In the present study we evaluated the putative neuroprotective effect of 15-days consumption of a multi-strain probiotic formulation based on food-associated strains and human gut bacteria at the dose of 10 CFU/mouse/day in a mouse model of acute inflammation, induced by an intraperitoneal single injection of LPS (0. Read More

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The potential role of the adipokine HMGB1 in obesity and insulin resistance. Novel effects on adipose tissue biology.

Mol Cell Endocrinol 2021 Jul 30;536:111417. Epub 2021 Jul 30.

Department of Cell Biology, Physiology, and Immunology, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/University of Córdoba/Reina Sofia University Hospital, 14014, Córdoba, Spain; CIBER Fisiopatología de La Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spain.

Discovery of the adipose tissue as a major source of signaling molecules almost three decades ago set a novel physiological paradigm that paved the way for the identification of metabolic organs as endocrine organs. Adipocytes, the main adipose tissue cell type, do not only represent the principal site of energy storage in form of triglycerides, but also produce a variety of molecules for short and long distance intercellular communication, named adipokines, which coordinate systemic responses. Although the best known adipokines identified and characterized hitherto are leptin and adiponectin, novel adipokines are continuously being described, what have significantly helped to elucidate the role of adipocyte biology in obesity and associated comorbidities. Read More

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Monocyte perturbation modulates the ovarian response to an immune challenge.

Mol Cell Endocrinol 2021 Jul 30:111418. Epub 2021 Jul 30.

School of Health and Biomedical Sciences RMIT University, Melbourne, VIC, Australia; Barwon Health Laboratory, Barwon Health University Hospital, Geelong, VIC, Australia; Institute for Physical and Mental Health and Clinical Transformation, School of Medicine, Faculty of Health, Deakin University, Australia. Electronic address:

Our recent findings indicate that an acute depletion of monocytes has no sustained effects on ovarian follicle health. Here, we utilised a Cx3cr1-Dtr transgenic Wistar rat model to transiently deplete monocytes and investigated the impact of an acute immune challenge by lipopolysaccharide (LPS) on ovarian follicle health and ovulatory capacity relative to wt once the monocytes had repopulated. Monocyte depletion and repopulation exacerbated the effects of LPS in several domains. Read More

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Bariatric surgery and pain outcomes in osteoarthritis.

Osteoarthritis Cartilage 2021 Jul 30. Epub 2021 Jul 30.

Department of Surgery, Boston, MA; Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

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Plasma 25-hydroxyvitamin D levels, quality of life, inflammation and depression in older adults: Are they related?

Exp Gerontol 2021 Jul 30;153:111503. Epub 2021 Jul 30.

University Hospital, Federal University of São Carlos (HU-UFSCar), São Carlos, Brazil; Department of Medicine, Federal University of São Carlos (UFSCar), São Carlos, Brazil. Electronic address:

Background And Objectives: This study aimed to determine whether there is an association between inflammation and depression taking into account the effect of several confounders, but specially plasma 25-hydroxyvitamin D (25[OH]D) levels.

Material And Methods: A cross-sectional study was conducted on adults (n = 346) aged 60 years or older recruited from primary healthcare centres. Depression was assessed by the Geriatric Depression Scale (GDS), while plasma 25(OH)D and inflammatory cytokines were measured following routine biochemical laboratory protocols. Read More

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Psychiatric and neuropsychiatric sequelae of COVID-19 - a systematic review.

Brain Behav Immun 2021 Jul 30. Epub 2021 Jul 30.

Translational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, 8000 Aarhus C, Denmark. Electronic address:

It has become evident that coronavirus disease 2019 (COVID-19) has a multi-organ pathology that includes the brain and nervous system. Several studies have also reported acute psychiatric symptoms in COVID-19 patients. An increasing number of studies are suggesting that psychiatric deficits may persist after recovery from the primary infection. Read More

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Elevated Inflammatory Markers in Women with Remitted Major Depressive Disorder and the Role of Early Life Maltreatment.

Brain Behav Immun 2021 Jul 30. Epub 2021 Jul 30.

Charité, Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Campus Charité Mitte, Department of Psychiatry and Psychotherapy, Berlin, Germany.

Major depressive disorder (MDD) has been linked to elevated inflammation markers. It remains unclear whether the elevation of C-reactive protein (CRP) and interleukin-6 (IL-6) levels are not only observable in acute MDD but also in patients after remission. MDD is a common sequela of early life maltreatment (ELM), which has also been associated with elevated inflammation markers. Read More

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Evaluation of chickens infected with a recombinant virulent NDV clone expressing chicken IL4.

Microb Pathog 2021 Jul 30:105116. Epub 2021 Jul 30.

Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA, 30602-7388, United States.

Background: There is evidence that chicken IL4 (chIL4) functions similarly to its mammalian analogue by enhancing type 2 T helper (Th2) humoral immunity and promoting protection against parasitic infections; however, no studies have been performed to assess the effect of chIL4 on the pathogenesis of Newcastle disease (ND). To assess the role of chIL4 in velogenic NDV pathogenesis we created a vNDV infectious clone expressing chIL4. We hypothesized that co-expression of chIL4 during virus replication would result in decreased inflammation caused by the Th1 response and thereby increasing survival to challenge with vNDV. Read More

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Morus alba L. (Sangzhi) alkaloids (SZ-A) exert anti-inflammatory effects via regulation of MAPK signaling in macrophages.

J Ethnopharmacol 2021 Jul 30:114483. Epub 2021 Jul 30.

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Key Laboratory of Polymorphic Drugs of Beijing, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Ethnopharmacological Relevance: Morus alba L. (Sangzhi) alkaloid (SZ-A) tablets have been approved by the China National Medical Products Administration for T2DM treatment. Our previous study (Liu et al. Read More

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The association of air pollutants exposure with subclinical inflammation and carotid atherosclerosis.

Int J Cardiol 2021 Jul 30. Epub 2021 Jul 30.

1st Cardiology Clinic, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.

Background: Air pollution is a well-described environmental factor with evidence suggesting a firm association with cardiovascular diseases. The purpose of this study was to determine the association of exposure to gaseous air pollutants on atherosclerosis burden.

Methods: 1955 inhabitants of the Corinthia region, aged 40 years or older, underwent clinical and biochemical assessment as well as carotid ultrasonography to evaluate carotid intima-media thickness (cIMT) and plaque burden. Read More

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The inflammatory proteome of hidradenitis suppurativa skin is more expansive than that of psoriasis vulgaris.

J Am Acad Dermatol 2021 Jul 30. Epub 2021 Jul 30.

Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA. Electronic address:

Background: While hidradenitis suppurativa (HS) shares some transcriptomic and cellular infiltrate features with psoriasis, their skin proteome remains unknown.

Objective: To define and compare inflammatory protein biomarkers of HS and psoriasis skin.

Methods: We assessed 92 inflammatory biomarkers in HS (n=13), psoriasis (n=11) and control skin (n=11) using Olink high-throughput proteomics. Read More

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Computation of the conditions for anti-angiogenesis and gene therapy synergistic effects: sensitivity analysis and robustness of target solutions.

J Theor Biol 2021 Jul 30:110850. Epub 2021 Jul 30.

Universite de Lorraine - CNRS UMR 7360 Laboratoire Interdisciplinaire des Environnements Continentaux Campus Bridoux - 8 Rue du General Delestraint, Metz 57070, France. Electronic address:

Both anti-angiogenesis and gene therapy involve complex processes depending on non-point parameters belonging to a space of values. To successfully overcome the challenges involved in their therapeutic approaches, there is a need to analyze the sensitivity of these parameters. In this paper, a new mathematical model that combines immune system stimulations, inflammatory processes associated with tumor development, and gene therapy aimed at enhancing the efficacy of both treatments are explored. Read More

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Myopericarditis following mRNA COVID-19 Vaccination in Adolescents 12 through 18 Years of Age.

J Pediatr 2021 Jul 30. Epub 2021 Jul 30.

Beaumont Children's Hospital, 3601 W 13 Mile Road, Royal Oak, Michigan, 48073 and Oakland University William Beaumont School of Medicine, 586 Pioneer Drive, Rochester, Michigan 48309.

Objectives: To characterize the clinical course and outcomes of children who developed probable myopericarditis after vaccination with the Pfizer- BioNTech (BNT162b2) COVID-19 mRNA vaccine.

Study Design: A cross-sectional study of 32 children, aged 12 through 18 years, diagnosed with probable myopericarditis following COVID-19 mRNA vaccination as per the CDC criteria for myopericarditis at 9 US centers between May 10, 2021 and June 20, 2021. We retrospectively collected the following data: demographics, SARS-CoV-2 virus detection or serologic testing, clinical manifestations, laboratory test results, imaging study results, treatment and time to resolutions of symptoms. Read More

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HDAC3 inhibitor suppresses endothelial-to-mesenchymal transition via modulating inflammatory response in atherosclerosis.

Biochem Pharmacol 2021 Jul 30:114716. Epub 2021 Jul 30.

Department of Medical Laboratory Animal Science, Xi'an Jiaotong University Health Science Center, Xi'an, China; Research Institute of Atherosclerotic Disease, Xi'an Jiaotong University Cardiovascular Research Center, Xi'an, China. Electronic address:

A total number of 18 different isoforms of histone deacetylases (HDACs) which were categorized into 4 classes have been identified in human. HDAC3 is categorized as Class I HDACs and is closely related to the occurrence and development of atherosclerosis. Recent evidence has pointed to endothelial-to-mesenchymal transition (EndMT) as a key process in vascular inflammation in atherosclerosis. Read More

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