316 results match your criteria infiltration pigmented


Systemic dendrimer nanotherapies for targeted suppression of choroidal inflammation and neovascularization in age-related macular degeneration.

J Control Release 2021 May 29;335:527-540. Epub 2021 May 29.

Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, United States of America. Electronic address:

Inflammation and neovascularization are key pathological events in human age-related macular degeneration (AMD). Activated microglia/macrophages (mi/ma) and retinal pigmented epithelium (RPE) play an active role in every stage of disease progression. Systemic therapies that can target these cells and address both inflammation and neovascularization will broaden the impact of existing therapies and potentially open new avenues for early AMD where there are no viable therapies. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

[Correlation study of superantigens and formation of human ear keloid].

Zhonghua Shao Shang Za Zhi 2021 Mar;37(3):257-262

Department of Dermatology, Affiliated Hospital of Nantong University, Nantong 226001, China.

To investigate the correlation of superantigens and human ear keloid formation. The retrospective case-control study method was used. The discarded keloid tissue was collected from 10 patients (9 females and 1 male, aged 19-59 years) with ear keloid after core excision of ear keloid, and the discarded normal skin tissue was collected from 3 female patients (aged 20-24 years) with pigmented nevus after operation, who were admitted to affiliated Hospital of Nantong University from June 2017 to March 2018. Read More

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TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism.

J Immunother Cancer 2021 Feb;9(2)

Ludwig Institute for Cancer Research, De Duve Institute, Brussels, Belgium

Background: Transforming growth factor-β (TGFβ) is emerging as a promising target for cancer therapy, given its ability to promote progression of advanced tumors and to suppress anti-tumor immune responses. However, TGFβ also plays multiple roles in normal tissues, particularly during organogenesis, raising toxicity concerns about TGFβ blockade. Dose-limiting cardiovascular toxicity was observed, possibly due to the blockade of all three TGFβ isoforms. Read More

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February 2021

Dematiaceous fungal invasion of a bandage contact lens.

BMJ Case Rep 2021 Feb 18;14(2). Epub 2021 Feb 18.

Ophthalmic Pathology, LV Prasad Eye Institute Bhubaneswar Campus, Bhubaneswar, India.

A 61-year-old man presented with a 1-month history of reduced vision, redness and pain in the right eye. Examination revealed a bandage contact lens (BCL) in situ with diffuse, pigmented deposits. On removal, the underlying cornea was found to be clear. Read More

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February 2021

Skin tags imaged by reflectance confocal microscopy, optical coherence tomography and multispectral optoacoustic tomography at the bedside.

Skin Res Technol 2021 May 11;27(3):324-331. Epub 2020 Oct 11.

Department of Dermatology, Bispebjerg and Frederiksberg, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Skin tags are common and mostly benign, but occasionally contain skin cancers. This study analysed skin tags by combining three advanced optical imaging technologies: reflectance confocal microscopy (RCM), optical coherence tomography (OCT) and multispectral optoacoustic imaging (MSOT) supplemented by dermoscopy MATERIALS AND METHODS: A prospective clinical study recruiting patients with skin tags from a university hospital clinic over a 2-week period. OCT, RCM and MSOT imaging were performed prior to excisional biopsies. Read More

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Comparison of diagnostic accuracy of 3 diagnostic criteria combined with refined pathological scoring system for drug-induced liver injury.

Medicine (Baltimore) 2020 Oct;99(41):e22259

Tianjin Research Institute of Liver Diseases, Tianjin.

Drug-induced liver injury (DILI) is difficult in diagnose, criteria used now are mostly based on history review. We tried to evaluate the value of these criteria and histopathology features in DILI to perform a method diagnosing DILI more definitely.We enrolled 458 consecutive hospitalized DILI patients from January 1, 2012 to December 31, 2018, using Roussel-Uclaf Causality Assessment Method (RUCAM), Maria & Victorino scale (M&V), and Digestive Disease Week-Japan criterion (DDW-J) combined with refined pathological scoring system respectively to perform the evaluation. Read More

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October 2020

Effectiveness of Home Bleaching Treatment after Resin Infiltrant Application.

Oral Health Prev Dent 2020;18(1):549-554

Purpose: Resin infiltration may be a barrier for bleaching gels. The aim of this study was to compare dental bleaching effectiveness using low-concentration gels on heavily or mildly stained teeth that were or were not treated with resin infiltration agents.

Materials And Methods: Forty bovine enamel surfaces were submitted to demineralisation, after which two staining protocols were performed. Read More

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Retinal microglia are critical for subretinal neovascular formation.

JCI Insight 2020 06 18;5(12). Epub 2020 Jun 18.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California, USA.

Abnormal subretinal neovascularization is a characteristic of vision-threatening retinal diseases, including macular telangiectasia (MacTel) and retinal angiomatous proliferation (RAP). Subretinal neovascular tufts and photoreceptor dysfunction are observed in very-low-density lipoprotein receptor (Vldlr-/-) mutant mice. These changes mirror those observed in patients with MacTel and RAP, but the pathogenesis is largely unknown. Read More

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Identification of a new R3 MYB type repressor and functional characterization of the members of the MBW transcriptional complex involved in anthocyanin biosynthesis in eggplant (S. melongena L.).

PLoS One 2020 14;15(5):e0232986. Epub 2020 May 14.

CREA, Research Centre for Genomics and Bioinformatics, Montanaso Lombardo (LO), Italy.

Here we focus on the highly conserved MYB-bHLH-WD repeat (MBW) transcriptional complex model in eggplant, which is pivotal in the transcriptional regulation of the anthocyanin biosynthetic pathway. Through a genome-wide approach performed on the recently released Eggplant Genome (cv. 67/3) previously identified, and reconfirmed by us, members belonging to the MBW complex (SmelANT1, SmelAN2, SmelJAF13, SmelAN1) were functionally characterized. Read More

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[Pathology of the nipple-areola complex : I. Paget's disease of the nipple, variants, and differential diagnoses].

Pathologe 2020 Jul;41(4):393-399

Pathologisches Institut, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland.

The classical Paget's disease of the nipple is histologically characterized by tumor cell infiltration originating in intraductal or invasive breast carcinoma, immunohistologically by a frequent overexpression of HER2 and clinically by eczema-like changes of the nipple and areola. Variants with different histological, immunohistological, and clinical features are observed in nonclassical forms of Paget's disease, such as isolated Paget's disease of the nipple, anaplastic Paget's disease, Paget's disease with invasion, and pigmented Paget's disease of the nipple. In the differential diagnosis of Paget's disease, benign changes have to be considered, including Toker cell hyperplasia, nipple eczema, and rare dermatoses. Read More

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Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus.

Diagn Pathol 2020 May 11;15(1):51. Epub 2020 May 11.

Department of Pathology, Peking University Cancer Hospital & Institute, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing, 100142, People's Republic of China.

Background/objective: Acral and cutaneous melanomas are usually difficult to accurately diagnose in the early stage, owing to the similarity in clinical manifestations and morphology with those of dysplastic nevus (DN). In this study, we aimed to evaluate the diagnostic value of four-color fluorescence in-situ hybridization (FISH) probes specific to the RREB1,CCND1,and MYB genes, and centromere of chromosome 6, in distinguishing DN and melanoma.

Methods: Fifty one DN and 58 melanoma cases were collected and tested with four-color FISH. Read More

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Multimodal imaging of secondary vitreoretinal lymphoma with optic neuritis and retinal vasculitis.

Am J Ophthalmol Case Rep 2020 Jun 8;18:100696. Epub 2020 Apr 8.

Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Purpose: To report the findings determined by multimodal imaging in an eye with secondary vitreoretinal lymphoma (VRL) with optic neuritis and retinal vasculitis.

Observation: The case was a 71-year-old woman with a secondary VRL exhibiting optic neuritis and retinal vasculitis in her right eye. Color fundus photographs and fluorescein angiograms showed optic neuritis and vasculitis in the posterior pole of the right eye. Read More

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Pigmented epithelioid melanocytoma: a rare lytic bone lesion involving intradural extension and subtotal resection in a 14-month-old girl.

J Neurosurg Pediatr 2020 Mar 13:1-4. Epub 2020 Mar 13.

2Department of Pediatrics, and.

Pigmented epithelioid melanocytomas (PEMs) are low-grade, intermediate-type borderline melanocytic tumors with limited metastatic potential. To date, PEMs have been treated via gross-total resections. Postoperative recurrence and mortality are rare. Read More

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Diabetes-Induced Inflammation and Vascular Alterations in the Goto-Kakizaki Rat Retina.

Curr Eye Res 2020 08 20;45(8):965-974. Epub 2020 Jan 20.

École d'optométrie, Université de Montréal , Montréal, Québec, Canada.

Purpose: Diabetic retinopathy is characterized by multiple microcirculatory dysfunctions and angiogenesis resulting from hyperglycemia, oxidative stress, and inflammation. In this study, the retina and retinal pigmented epithelium of non-insulin-dependent diabetic Goto-Kakizaki (GK) rats were examined to detect microvascular alterations, gliosis, macrophage infiltration, lipid deposits, and fibrosis. Emphasis was given to the distribution of kinin B1 receptor (B1R) and vascular endothelial growth factor (VEGF), two major factors in inflammation and angiogenesis. Read More

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Long-Term Sequelae of Smoking and Cessation in Spontaneously Hypertensive Rats.

Toxicol Pathol 2020 04 24;48(3):422-436. Epub 2019 Dec 24.

Center for Health and the Environment, University of California, Davis, CA, USA.

Smoking is a major risk factor for heart attack, stroke, and lung cancer. Tobacco smoke (TS) causes bronchitis, emphysema, persistent cough, and dyspnea. Smoking cessation minimizes risks of TS-related disease. Read More

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Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects.

An Bras Dermatol 2019 Nov - Dec;94(6):637-657. Epub 2019 Nov 6.

Department of Dermatology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.

Actinic keratoses are dysplastic proliferations of keratinocytes with potential for malignant transformation. Clinically, actinic keratoses present as macules, papules, or hyperkeratotic plaques with an erythematous background that occur on photoexposed areas. At initial stages, they may be better identified by palpation rather than by visual inspection. Read More

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January 2020

Tumour-infiltrating lymphocytes in canine melanocytic tumours: An investigation on the prognostic role of CD3 and CD20 lymphocytic populations.

Vet Comp Oncol 2020 Sep 11;18(3):370-380. Epub 2019 Dec 11.

Department of Veterinary Medicine, Università degli Studi di Perugia, Perugia, Italy.

The study of the immune response in several types of tumours has been rapidly increasing in recent years with the dual aim of understanding the interactions between neoplastic and immune cells and their importance in cancer pathogenesis and progression, as well as identifying targets for cancer immunotherapy. Despite being considered one of the most immunogenic tumour types, melanoma can progress in the presence of abundant lymphocytic infiltration, therefore suggesting that the immune response is not able to efficiently control tumour growth. The purpose of this study was to investigate whether the density, distribution and grade of tumour-infiltrating lymphocytes (TILs) in 97 canine melanocytic tumours is associated with histologic indicators of malignancy and can be considered a prognostic factor in the dog. Read More

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September 2020

[Clinical-pathological analysis of 71 cases of dermatosis papulosa nigra of Han Chinese people].

Zhonghua Yi Xue Za Zhi 2019 Oct;99(37):2903-2906

Department of Dermatology, Third People's Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University, Hangzhou 310002, China.

To analyze and summarize the clinical-pathological features of dermatosis papulosa nigra of Han Chinese people. We collected 71 cases of dermatosis papulosa nigra in the Third people's Hospital of Hangzhou Affiliated to Zhejiang Chinese Medical University of Department of Dermatology from January 2010 to January 2019 which were confirmed clinically and pathologically. The clinical and histopathological data of all patients were analyzed and summarized, and relevant literature were reviewed. Read More

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October 2019

Giant Lumbar Polypoid Tumor with Bullae on its Surface.

Acta Dermatovenerol Croat 2019 Jun;27(2):127-128

Dr. Jorge Ocampo-Candiani, Chair of the Dermatology Department, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Mitras Centro, Avenida Gonzalitos y Madero S/N, 64460 Monterrey, Mexico;

Dear Editor, Acrochordons are common benign neoplasms found in everyday practice. We present a rare case of a giant and single acrochordon on the lumbar region with signs of ischemia. The correlation of clinical, dermatoscopic, and histopathological analyses may help the clinician differentiate this entity from other benign and malignant dermatoses. Read More

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Confocal laser scanning microscopy, a diagnostic alternative for five pigmented lesions on the face: An observational study.

Skin Res Technol 2019 Nov 24;25(6):871-876. Epub 2019 Jul 24.

Department of Dermatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.

Objective: To describe the confocal laser scanning microscopy (CLSM) features of five different facial hyperpigmentation diseases and to highlight the features that can be used to differentiate between the diseases.

Materials And Methods: Confocal laser scanning microscopy features of skin lesions of 406 patients with different facial hyperpigmentation diseases (chloasma, naevus fusco-caeruleus zygomaticus, naevus of Ota, freckles and Riehl melanosis) were retrospectively analysed. All patients were diagnosed clinically. Read More

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November 2019

Giant congenital melanocytic nevus associated with lipoma in an Indian man.

BMJ Case Rep 2019 Jul 3;12(7). Epub 2019 Jul 3.

Pathology, Banaras Hindu University Institute of Medical Sciences, Varanasi, UP, India.

Congenital melanocytic nevus is a inborn melanocytic proliferation either present since birth or soon afterward and shows characteristic histopathological features comprising proliferation of benign melanocytes and extension of nevus cells into the deep reticular dermis and subcutis. We report the case of a 35-year-old male patient who presented with a progressively enlarging soft tissue mass in bilateral flank region. High-resolution ultrasound imaging showed multiple lipomatous masses within the soft tissues on the either flank region. Read More

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Prodigiosins from a marine sponge-associated actinomycete attenuate HCl/ethanol-induced gastric lesion via antioxidant and anti-inflammatory mechanisms.

PLoS One 2019 13;14(6):e0216737. Epub 2019 Jun 13.

Zoology and Entomology Department, Faculty of Science, Helwan University, Ain Helwan, Cairo, Egypt.

Gastric ulcer is sores that form in the stomach mucosal layer because of erosion caused by high acid secretion and excessive use of non-steroidal anti-inflammatory drugs. Prodigiosins (PdGs) are red-pigmented secondary metabolites produced by bacteria, including actinomycetes. Butylcycloheptylprodigiosin (1) and undecylprodigiosin (2) were identified and isolated from a crude extract of the actinomycete RA2 isolated from the Red Sea Sponge Spheciospongia mastoidea. Read More

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February 2020

Towards melanin radicals detection in melanomas by electron paramagnetic resonance (EPR) spectroscopy: a proof-of-concept study.

Free Radic Res 2019 Apr 4;53(4):405-410. Epub 2019 Apr 4.

a Biomedical Magnetic Resonance Research Group, Louvain Drug Research Institute, Université Catholique de Louvain , Brussels , Belgium.

Melanoma is the most aggressive skin tumour type. Although complete cure can be achieved when the whole tumour is resected, prognostic dramatically drops when melanoma cells reach deeper tissues and lymph nodes. Hence, there is an urgent need to develop accurate tools allowing () discriminating benign naevi from malignant tumours and () being able to characterise melanoma infiltration. Read More

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Radioisotope Synoviorthesis in the Control of Refractory Synovitis in Castilla-La Mancha. A 10-year Experience.

Reumatol Clin (Engl Ed) 2020 Nov - Dec;16(6):485-489. Epub 2019 Jan 25.

Servicio de Reumatología, Hospital General Universitario de Ciudad Real, Ciudad Real, España.

Our hospital is the nuclear medicine referral hospital for radioisotopic synoviorthesis for all of Castilla-La Mancha.

Objective: To describe the experience in the performance of radioisotopic synoviorthesis for arthritis refractory to other treatments in our hospital.

Methodology: Observational, descriptive and cross-sectional study protocolised through the review of the database of radioisotopic synoviorthesis performed between 2007 and 2017. Read More

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January 2019

Pigmented skin lesions displaying regression features: Dermoscopy and reflectance confocal microscopy criteria for diagnosis.

Exp Dermatol 2019 02 14;28(2):129-135. Epub 2019 Jan 14.

Centro Oncologico ad Alta Tecnologia Diagnostica, Azienda Unità Sanitaria Locale - IRCCS, Reggio Emilia, Italy.

Melanomas and nevi displaying regression features can be difficult to differentiate. To describe reflectance confocal microscopy features in benign and malignant pigmented skin lesions characterized by regression features in dermoscopy. Observational retrospective study. Read More

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February 2019

UVB-induced depletion of donor-derived dendritic cells prevents allograft rejection of immune-privileged hair follicles in humanized mice.

Am J Transplant 2019 05 28;19(5):1344-1355. Epub 2018 Dec 28.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Dendritic cells (DCs) are key targets for immunity and tolerance induction; they present donor antigens to recipient T cells by donor- and recipient-derived pathways. Donor-derived DCs, which are critical during the acute posttransplant period, can be depleted in graft tissue by forced migration via ultraviolet B light (UVB) irradiation. Here, we investigated the tolerogenic potential of donor-derived DC depletion through in vivo and ex vivo UVB preirradiation (UV) combined with the injection of anti-CD154 antibody (Ab) into recipients in an MHC-mismatched hair follicle (HF) allograft model in humanized mice. Read More

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NFAT1 enhances the effects of tumor-associated macrophages on promoting malignant melanoma growth and metastasis.

Biosci Rep 2018 12 18;38(6). Epub 2018 Dec 18.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, P.R. China

Tumor-associated macrophages (TAMs) play substantial roles in tumor growth, invasion, and metastasis. Nuclear factor of activated T cell (NFAT1) has been shown to promote melanoma growth and metastasis We herein aim to investigate whether NFAT1 is capable to promote melanoma growth and metastasis by influencing TAM properties. Melanoma-conditioned TAMs were obtained from human monocytes after incubation with conditioned medium from A375 cell culture. Read More

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December 2018

Induction of angiogenic and inflammation-associated dermal biomarkers following acute UVB exposure on bio-engineered pigmented dermo-epidermal skin substitutes in vivo.

Pediatr Surg Int 2019 Jan 14;35(1):129-136. Epub 2018 Nov 14.

Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland.

Purpose: Ultraviolet (UV) radiation adversely affects skin health at cellular and molecular levels. Hence, UV radiation can directly induce inflammatory responses in the dermis by inducing erythema, edema, inflammation, dermal fibroblasts alterations, and extracellular matrix modifications.

Methods: Human keratinocytes, melanocytes, and fibroblasts were isolated from skin biopsies, cultured, and expanded in vitro. Read More

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January 2019

A case of radiation-associated angiosarcoma after breast cancer.

Surg Case Rep 2018 Nov 7;4(1):131. Epub 2018 Nov 7.

Department of Breast Oncology, Aichi Cancer Center Hospital, 1-1 Kanokoden, chikusa-ku, Nagoya, Aichi, 〒464-8681, Japan.

Background: Radiation-associated angiosarcoma (RAAS) is a rare subtype of secondary angiosarcoma that is characterized by rapid proliferation and extensive tissue infiltration. Although various treatments for RAAS (such as surgery, chemotherapy, and radiation therapy) have been reported, there is no consensus as to which approach is the best.

Case Presentation: A 76-year-old woman presented with right breast cancer (T1N0M0, stage I) 9 years ago. Read More

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November 2018