25,191 results match your criteria infarct volume

Relation of Pre-stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.

Ann Neurol 2021 Sep 18. Epub 2021 Sep 18.

Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Korea.

Objective: We investigated a) the associations between pre-stroke aspirin use and thrombus burden, infarct volume, hemorrhagic transformation, early neurological deterioration (END), and functional outcome, and b) whether stroke subtypes modify these associations in first-ever ischemic stroke.

Methods: This multicenter MRI-based study included 5,700 consecutive patients with acute first-ever ischemic stroke, who did not undergo intravenous thrombolysis or endovascular thrombectomy, from May-2011 through February-2014. Propensity score-based augmented inverse probability weighting was performed to estimate adjusted effects of pre-stroke aspirin use. Read More

View Article and Full-Text PDF
September 2021

Traditional Chinese Medicine Intervenes Ventricular Remodeling Following Acute Myocardial Infarction: Evidence From 40 Random Controlled Trials With 3,659 Subjects.

Front Pharmacol 2021 31;12:707394. Epub 2021 Aug 31.

Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China.

We intend to conduct a meta-analysis on the systematic evaluation of traditional Chinese medicine (TCM) in the treatment of ventricular remodeling following acute myocardial infarction (AMI). Our findings may provide certain references for the clinical treatment of ventricular remodeling. A systematic literature search was conducted in PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wanfang Data, CQVIP, and CBM before 20 July 2020. Read More

View Article and Full-Text PDF

Dose-Dependent Variation of Synchronous Metabolites and Modules in a Yin/Yang Transformation Model of Appointed Ischemia Metabolic Networks.

Front Neurosci 2021 20;15:645185. Epub 2021 Aug 20.

Center for Statistics and Data Science, Beijing Normal University at Zhuhai, Zhuhai, China.

Aim: Chinese medicine Danhong injection (DHI) is an effective pharmaceutical preparation for treating cerebral infarction. Our previous study shows that DHI can remarkably reduce the ischemic stroke-induced infarct volume in a dose-dependent manner, but the pharmacological mechanism of the DHI dose-dependent relationship is not clear. Therefore, the dose-dependent efficacy of DHI on cerebral ischemia and the underlying mechanisms were further investigated in this study. Read More

View Article and Full-Text PDF

[Effect of neuregulin-1 on cardiac glucose metabolism in rats with experimental myocardial infarction].

Zhonghua Xin Xue Guan Bing Za Zhi 2021 Sep;49(9):912-919

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

To investigate the effect of neuregulin-1(NRG-1) on cardiac glucose metabolism in Sprague Dawley (SD) rats with experimental myocardial infarction (MI). Adult male SD rats were randomly divided into three groups: the sham-operated group, MI group, and MI+NRG1 group. The rat MI model was established via ligation of the left anterior descending coronary artery. Read More

View Article and Full-Text PDF
September 2021

[Preoperative stress testing in patients prior to vascular surgery].

Angiol Sosud Khir 2021 ;27(3):159-164

Department of Faculty Surgery, Samara State Medical University of the RF Ministry of Public Health, Samara, Russia.

Myocardial infarction is the leading cause of mortality during peripheral artery surgery. The review summarizes the data on cardiac event risk stratification in angiosurgical patients by preoperative stress testing. The prognostic value of positive and negative results is described. Read More

View Article and Full-Text PDF
September 2021

Application of Artificial Intelligence in Acute Coronary Syndrome: A Brief Literature Review.

Adv Ther 2021 Sep 15. Epub 2021 Sep 15.

Department of Cardiology, Peking University People's Hospital, Beijing, People's Republic of China.

Artificial intelligence (AI) is defined as a set of algorithms and intelligence to try to imitate human intelligence. Machine learning is one of them, and deep learning is one of those machine learning techniques. The application of AI in healthcare systems including hospitals and clinics has many possible advantages and future prospects. Read More

View Article and Full-Text PDF
September 2021

Left Ventricular Global Function Index and the Impact of its Companion Metric.

Front Cardiovasc Med 2021 30;8:695883. Epub 2021 Aug 30.

Department of Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands.

Left ventricular (LV) global function index (LVGFI) has been introduced as a volume-based composite metric for evaluation of ventricular function. The definition formula combines stroke volume (SV), end-systolic volume (ESV), end-diastolic volume (EDV) and LV mass/density. Being a dimensionless ratio, this new metric has serious limitations which require evaluation at a mathematical and clinical level. Read More

View Article and Full-Text PDF

Remote Ischemic Conditioning May Improve Disability and Cognition After Acute Ischemic Stroke: A Pilot Randomized Clinical Trial.

Front Neurol 2021 30;12:663400. Epub 2021 Aug 30.

Department of Clinical Neurosciences, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Remote ischemic conditioning is a procedure purported to reduce the ischemic injury of an organ. This study aimed to explore the efficiency and safety of remote ischemic conditioning in patients with acute ischemic stroke. We hypothesized that remote ischemic conditioning administered from the first day of hospital admission would improve the infarct volume and clinical outcome at 180 days. Read More

View Article and Full-Text PDF

Dengzhanxixin Injection Ameliorates Cognitive Impairment Through a Neuroprotective Mechanism Based on Mitochondrial Preservation in Patients With Acute Ischemic Stroke.

Front Pharmacol 2021 30;12:712436. Epub 2021 Aug 30.

State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

Acute ischemic stroke (AIS) is a global health burden and cognitive impairment is one of its most serious complication. Adequate interventions for AIS may have the potential to improve cognitive outcomes. In the present study, we selected (Vaniot) Hand. Read More

View Article and Full-Text PDF

An Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury.

Drug Des Devel Ther 2021 7;15:3783-3808. Epub 2021 Sep 7.

Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.

Background: Cerebral ischemia-reperfusion injury (CIRI) is a crucial factor leading to a poor prognosis for ischemic stroke patients. As a novel Chinese medicine formula, Naotaifang (NTF) was proven to exhibit a neuroprotective effect against ischemic stroke, clinically, and to alleviate CIRI in animals. However, the mechanisms underlying the beneficial effect have not been fully elucidated. Read More

View Article and Full-Text PDF
September 2021

Ceftriaxone therapy attenuates brain trauma in rats by affecting glutamate transporters and neuroinflammation and not by its antibacterial effects.

BMC Neurosci 2021 Sep 14;22(1):54. Epub 2021 Sep 14.

Departments of Neurosurgery, Chi-Mei Medical Center, 901 Chung Hwa Road, Yung Kang City, Tainan, Taiwan.

Background: Ceftriaxone is a β-lactam antibiotic used to treat central nervous system infections. Whether the neuroprotective effects of ceftriaxone after TBI are mediated by attenuating neuroinflammation but not its antibacterial actions is not well established.

Methods: Anesthetized male Sprague-Dawley rats were divided into sham-operated, TBI + vehicle, and TBI + ceftriaxone groups. Read More

View Article and Full-Text PDF
September 2021

Ephrin-B2 PB-mononuclear cells reduce early post-stroke deficit in diabetic mice but not long-term memory impairment.

Exp Neurol 2021 Sep 11;346:113864. Epub 2021 Sep 11.

Université de Paris, INSERM U1148, Laboratory for Vascular Translational Science, F-75018 Paris, France; Service de Physiologie Clinique, AP-HP, Hôpital Lariboisière, 75475 Paris, France. Electronic address:

Background And Purpose: Post-stroke cognitive impairment (PSCI) has become a major public health issue, as a leading cause of dementia. The inflammation that develops soon after cerebral artery occlusion and may persist for weeks or months after stroke is a key component of PSCI. Our aim was to take advantage of the immunomodulatory properties of peripheral blood mononuclear cells (PB-MNC) stimulated with ephrin-B2/fc (PB-MNC) for preventing PSCI. Read More

View Article and Full-Text PDF
September 2021

Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats.

Brain Behav 2021 Sep 14:e32366. Epub 2021 Sep 14.

Department of Neurobiology, Institute for Basic Research on Aging and Medicine, School of Basic Medical Science, Fudan University, Shanghai, China.

Background: Sleep disorders are highly prevalent among stroke survivors and impede stroke recovery. It is well established that melatonin has neuroprotective effects in animal models of ischemic stroke. However, as a modulator of endogenous physiological circadian rhythms, the effects of melatonin on poststroke sleep disorders remain unclear. Read More

View Article and Full-Text PDF
September 2021

Neuroprotective effect of herniarin following transient focal cerebral ischemia in rats.

Metab Brain Dis 2021 Sep 14. Epub 2021 Sep 14.

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Ischemic stroke is a devastating central nervous disease. Despite extensive research in to this area, few innovative neuroprotective treatments have been presented. 7-methoxycoumarin, also known as herniarin, is a common natural coumarin in several plant species. Read More

View Article and Full-Text PDF
September 2021

Heat-related cardiovascular morbidity and mortality in Switzerland: a clinical perspective.

Swiss Med Wkly 2021 Sep 13;151:w30013. Epub 2021 Sep 13.

Swiss Tropical and Public Health Institute, University of Basel, Switzerland.

Aims: Previous studies found increased cardiovascular mortality during hot days, while emergency hospital admissions were decreasing. We explored potential underlying reasons by analysing clinically similar cardiovascular disease groups taking into account primary, underlying and immediate causes of death.

Methods And Results: We assessed associations of daytime maximum temperature in relation to cardiovascular deaths and emergency hospital admissions between 1998 and 2016 in Switzerland. Read More

View Article and Full-Text PDF
September 2021

Effect of changes in perfusion defect size during serial stress myocardial perfusion imaging on cardiovascular outcomes in patients treated with primary percutaneous coronary intervention after myocardial infarction.

J Nucl Cardiol 2021 Sep 13. Epub 2021 Sep 13.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, 80131, Naples, Italy.

Background: We evaluated the prognostic value of changes in perfusion defect size (PDS) on serial MPS in patients treated with primary percutaneous coronary intervention (PCI) after acute myocardial infarction (AMI).

Methods: We enrolled 112 patients treated with primary PCI after AMI who underwent two stress MPS within 1 month and after 6 months. Improvement in PDS was defined as a reduction ≥5%. Read More

View Article and Full-Text PDF
September 2021

Impact of red blood cell distribution width and mean platelet volume in patients with ST-segment elevation myocardial infarction.

Heart Vessels 2021 Sep 13. Epub 2021 Sep 13.

Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan.

The complete blood cell count is one of the most frequently ordered laboratory tests, and many parameters, including red blood cell distribution width (RDW) and mean platelet volume (MPV), are available. The purpose of this study was to investigate the usefulness of the combination of RDW and MPV in patients with ST-segment elevation myocardial infarction (STEMI). Patients with STEMI who underwent primary percutaneous coronary intervention were retrospectively enrolled (n = 229). Read More

View Article and Full-Text PDF
September 2021

Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.

J Cell Mol Med 2021 Sep 12. Epub 2021 Sep 12.

Neuroprotective Drug Discovery Key Laboratory, Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, China.

Oridonin, a natural diterpenoid compound extracted from a Chinese herb, has been proved to exert anti-oxidative stress effects in various disease models. The aim of the present study was to investigate the protective effects of oridonin on oxidative stress-induced endothelial injury in ischaemic stroke. We found oridonin repaired blood-brain barrier (BBB) integrity presented with upregulation of tight junction proteins (TJ proteins) expression, inhibited the infiltration of periphery inflammatory cells and neuroinflammation and thereby reduced infarct volume in ischaemic stroke mice. Read More

View Article and Full-Text PDF
September 2021

Dexmedetomidine and Phosphocreatine Post-treatment Provides Protection against Focal Cerebral Ischemia-reperfusion Injury in Rats.

Acta Histochem Cytochem 2021 Aug 7;54(4):105-113. Epub 2021 Jul 7.

Department of Anesthesiology, First Affiliated Hospital of the University of Science and Technology of China, No. 1 Swan Lake Road, Hefei 230036, Anhui, China.

In this study we investigated the neuroprotective efficacy of dexmedetomidine (Dex) and phosphocreatine (PCr) alone or in combination in a rat model of focal cerebral ischemia-reperfusion injury (I/R). I/R was induced by intraluminal middle cerebral artery occlusion (MCAO) and reperfusion. Male Sprague-Dawley rats were randomly allocated to the Sham group and I/R group, and the I/R group was further divided into three subgroups: Dex (9 μg. Read More

View Article and Full-Text PDF

Peripheral microvascular dysfunction is associated with plaque progression and adverse long-term outcomes in heart transplant patients.

ESC Heart Fail 2021 Sep 12. Epub 2021 Sep 12.

Department of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55902, USA.

Aims: Cardiac allograft vasculopathy (CAV) is the major cause of increased morbidity and mortality after heart transplantation. Peripheral endothelial dysfunction (PED) is associated with early atherosclerosis and future risk of major adverse cardiovascular events (MACE) in non-heart transplant population. We aimed to investigate the association of PED with future MACE, and plaque progression assessed by intravascular ultrasound (IVUS) after heart transplantation. Read More

View Article and Full-Text PDF
September 2021

Serum neopterin levels and their role in the prognosis of patients with ischemic stroke: A systematic review and meta-analysis.

Lin-Lie Meng Li Cao

J Clin Neurosci 2021 Oct 3;92:55-60. Epub 2021 Aug 3.

Department of Neurology, Nangang Branch, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, China. Electronic address:

Background: Neopterin is an inflammatory marker that is found to have prognostic value in cardiovascular diseases but its prognostic role in cerebrovascular diseases is not as clear. This study evaluates the prognostic role of neopterin in patients with ischemic stroke.

Method: Studies were identified after a literature search in electronic databases (Ovid, PubMed, Science Direct, and Wiley) and were selected based on precise eligibility criteria. Read More

View Article and Full-Text PDF
October 2021

Vagus nerve stimulation mediates microglia M1/2 polarization via inhibition of TLR4 pathway after ischemic stroke.

Biochem Biophys Res Commun 2021 Sep 3;577:71-79. Epub 2021 Sep 3.

Department of Rehabilitation, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. Electronic address:

Ischemic stroke is the leading cause of death and disability. Microglia are polarized toward the proinflammatory M1 phenotype and neuroprotective M2 phenotype after stroke and play an important role in the pathological process of ischemic stroke. Emerging research suggests that vagus nerve stimulation (VNS) can mediate microglia polarization after ischemic stroke and may serve as a potential treatment for ischemic stroke. Read More

View Article and Full-Text PDF
September 2021

Accelerating whole-heart 3D T2 mapping: Impact of undersampling strategies and reconstruction techniques.

PLoS One 2021 10;16(9):e0252777. Epub 2021 Sep 10.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

Purpose: We aim to determine an advantageous approach for the acceleration of high spatial resolution 3D cardiac T2 relaxometry data by comparing the performance of different undersampling patterns and reconstruction methods over a range of acceleration rates.

Methods: Multi-volume 3D high-resolution cardiac images were acquired fully and undersampled retrospectively using 1) optimal CAIPIRINHA and 2) a variable density random (VDR) sampling. Data were reconstructed using 1) multi-volume sensitivity encoding (SENSE), 2) joint-sparsity SENSE and 3) model-based SENSE. Read More

View Article and Full-Text PDF
September 2021

Risk factors associated with intra-stent restenosis after percutaneous coronary intervention.

Exp Ther Med 2021 Oct 9;22(4):1141. Epub 2021 Aug 9.

1 Medical Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.

The present study aimed to explore the correlations between clinical, biological, imagistic and procedural factors with the risk of intra-stent restenosis (ISR) in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). An observational cross-sectional study was conducted in a high-volume PCI center over a period of 2 years. A total of 235 consecutive patients diagnosed with angina or acute coronary syndrome treated by PCI were included in the study. Read More

View Article and Full-Text PDF
October 2021

Effect of the combination of astragaloside IV and saponins on pyroptosis and necroptosis in rat models of cerebral ischemia-reperfusion.

Exp Ther Med 2021 Oct 4;22(4):1123. Epub 2021 Aug 4.

Department of Physiology, Medical School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China.

Pyroptosis and necroptosis are closely associated with the mechanism underlying cerebral ischemia-reperfusion (I/R) injury. The combination of astragaloside IV (AST IV) and saponins (PNS) has remarkable effects on the alleviation of cerebral I/R damage. However, whether inhibition of pyroptosis and necroptosis is the mechanism underlying the beneficial effects of this drug combination on cerebral I/R injury remains unclear. Read More

View Article and Full-Text PDF
October 2021

Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.

Molecules 2021 Aug 26;26(17). Epub 2021 Aug 26.

Laboratory of Peptide Chemistry, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya Street, 16/10, 117997 Moscow, Russia.

: Mutual effect of the preliminary and therapeutic intranasal treatment of SD rats with DSIP (8 days) on the outcome of focal stroke, induced with intraluminal middle cerebral occlusion (MCAO), was investigated. : The groups were the following: MCAO + vehicle, MCAO + DSIP, and SHAM-operated. DSIP or vehicle was applied nasally 60 (±15) minutes prior to the occlusion and for 7 days after reperfusion at dose 120 µg/kg. Read More

View Article and Full-Text PDF

Neferine Protects Against Brain Damage in Permanent Cerebral Ischemic Rat Associated with Autophagy Suppression and AMPK/mTOR Regulation.

Mol Neurobiol 2021 Sep 8. Epub 2021 Sep 8.

Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Neferine is the major alkaloid compound isolated from the seed embryos of lotus. Neferine has many pharmacological effects, such as anti-inflammatory, antioxidative stress, and antiapoptotic effects, and it maintains autophagic balance. The purpose of this study was to explore the mechanism by which neferine attenuates autophagy after permanent cerebral ischemia in rats. Read More

View Article and Full-Text PDF
September 2021

Caspofungin Suppresses Brain Cell Necroptosis in Ischemic Stroke Rats via Up-Regulation of Pellino3.

Cardiovasc Drugs Ther 2021 Sep 8. Epub 2021 Sep 8.

Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China.

Purpose: Pellino3, an ubiquitin E3 ligase, prevents the formation of the death-induced signaling complex in response to TNF-α by targeting receptor-interacting protein kinase 1 (RIPK1), and bioinformatics analysis predicted an interaction between Pellino3 and caspofungin, a common antifungal drug used in clinics. This study aimed to explore the effect of caspofungin on brain injury in ischemic stroke and the underlying mechanisms.

Methods: Ischemic stroke injury was induced in Sprague Dawley rats by occlusion of the middle cerebral artery (MCA) for 2 h, followed by 24 h reperfusion. Read More

View Article and Full-Text PDF
September 2021

Predictors and clinical impact of infarct progression rate in the ESCAPE-NA1 trial.

J Neurointerv Surg 2021 Sep 7. Epub 2021 Sep 7.

Department of Diagnostic Imaging, University of Calgary, Calgary, Alberta, Canada

Background: Determining infarct progression rate in acute ischemic stroke (AIS) is important for patient triage, treatment decision-making, and outcome prognostication.

Objective: To estimate infarct progression rate in patients with AIS with large vessel occlusion (LVO) and determine its predictors and impact on clinical outcome.

Methods: Data are from the ESCAPE-NA1 Trial. Read More

View Article and Full-Text PDF
September 2021

CMR predictors of secondary moderate to severe mitral regurgitation and its additive prognostic role in previous myocardial infarction.

J Cardiol 2021 Sep 4. Epub 2021 Sep 4.

C.N.R. Clinical Physiology Institute, Pisa, Italy.

Background: We aimed to determine predictors and the additive prognostic role of moderate to severe (MS) ischemic mitral regurgitation (MR) in myocardial infarction (MI).

Methods: Four hundred twenty-two patients with previous MI underwent cardiac magnetic resonance (CMR) imaging for the assessment of left ventricular (LV) ejection fraction (EF), end-diastolic (EDV) and end-systolic volume (ESV), sphericity index, wall motion score index (WMSI), and late gadolinium enhancement (LGE). Echocardiography was performed to assess MR. Read More

View Article and Full-Text PDF
September 2021