1,213,643 results match your criteria infants] article

Use of Vasopressors in Extremely Preterm Infants in First Week of Life.

Am J Perinatol 2021 May 14. Epub 2021 May 14.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.

Objective:  A significant variability exists for diagnosis and treatment of hypotension in extremely preterm infants. Benefits of the use of vasopressors remain unclear. We wanted to identify the risk factors associated with use of vasopressors in the first week of life and their impact on outcomes of extremely preterm infants. Read More

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Cholesterol at ages 6, 12 and 24 months: Tracking and associations with diet and maternal cholesterol in the Infant Cholesterol Study.

Atherosclerosis 2021 May 6;326:11-16. Epub 2021 May 6.

Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, 0317, Oslo, Norway; Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital Aker, PO Box 4959, Nydalen, 0424, Oslo, Norway. Electronic address:

Background And Aims: There are indications for tracking of circulating total cholesterol concentration (TC) from childhood to later in life. An increased lifelong TC exposure increases the risk of developing atherosclerosis, however little is known about the determinants of TC early in life. We aimed to describe TC in Norwegian offspring aged 6, 12 and 24 months, and to explore if maternal TC, breastfeeding and offspring diet are associated with offspring TC. Read More

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Early iron supplementation and iron sufficiency at one month of age in NICU patients at-risk for iron deficiency.

Blood Cells Mol Dis 2021 May 6;90:102575. Epub 2021 May 6.

Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA; Intermountain Healthcare Research, Salt Lake City, UT, USA; Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA; Department of Pediatrics, Division of Hematology/Oncology, University of Utah Health, Salt Lake City, UT, USA.

In order to reduce iron deficiency in neonates at-risk for iron deficiency, we implemented a guideline to increase the consistency of early iron supplementation in infants of diabetic mothers, small for gestational age neonates and very low birthweight premature neonates. Three years following implementation we performed a retrospective analysis in order to assess adherence to the guideline and to compare timing of early iron supplementation and reticulocyte-hemoglobin (RET-He) values at one month of life in at-risk infants. Adherence with early iron supplementation guidelines was 73. Read More

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Selective attention to the mouth of a talker in Japanese-learning infants and toddlers: Its relationship with vocabulary and compensation for noise.

Cortex 2021 Apr 21;140:145-156. Epub 2021 Apr 21.

Department of Psychology, Faculty of Integrated Arts and Social Sciences, Japan Women's University, Kanagawa, Japan.

Infants increasingly gaze at the mouth of talking faces during the latter half of the first postnatal year. This study investigated mouth-looking behavior of 120 full-term infants and toddlers (6 months-3 years) and 12 young adults (21-24 years) from Japanese monolingual families. The purpose of the study included: (1) Is such an attentional shift to the mouth in infancy similarly observed in Japanese environment where contribution of visual speech is known to be relatively weak? (2) Can noisy conditions increase mouth-looking behavior of Japanese young children? (3) Is the mouth-looking behavior related to language acquisition? To this end, movies of a talker speaking short phrases were presented while manipulating signal-to-noise ratio (SNR: Clear, SN+4, and SN-4). Read More

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Spontaneous remission of West syndrome associated with acute infection and fever in five patients.

Epilepsy Res 2021 May 8;174:106663. Epub 2021 May 8.

Department of Neurology, Hospital Materno Infantil Salta, Argentina. Electronic address:

Objective: We analyzed the records of 198 patients with West syndrome (WS) seen at a single pediatric neurology center in Argentina between June 2004 and June 2017. Five patients with infection-related spontaneous remission of the electroclinical manifestations were identified.

Methods: The following parameters were investigated: personal and family history, clinical characteristics of the seizures - mainly spasms - and EEG findings, type of treatment, and outcome. Read More

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What's an early triadic interaction made of? A methodological proposal to study the musical dynamics of interaction.

Infant Behav Dev 2021 May 11;63:101572. Epub 2021 May 11.

Facultad de Psicología, Departamento Interfacultativo de Psicología Evolutiva y de la Educación, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:

Classical theories of intersubjectivity hold that the first interactions in which children participate are dyadic (adult-baby). However, thanks to the material shift that is taking place in the cognitive sciences, an increasing number of authors began to recognise the constitutive role that materiality has for cognition, from the very beginning of life. Interactions do not occur in a vacuum, but within a meaning-loaded material world that adults actively seek to bring to children. Read More

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Increasing muscle activity correlations during spontaneous movements in the first six months of life.

Neurosci Lett 2021 May 11:135957. Epub 2021 May 11.

Laboratory of Neuromotor Physiology, Fondazione Santa Lucia, Rome, Italy.

Spontaneous muscle activity in the first months of life is an important prerequisite to developing voluntary motor skills and to adapting sensorimotor circuits and muscle tone to body and environmental changes. Even though high variability is a characteristic of early development, several studies have reported significant correlations of limb movements. These assessments were typically made based on kinematics, while the analysis of lower and upper limb muscle activity may provide additional information about maturation of the neuromuscular control. Read More

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Mol Cell Endocrinol 2021 May 11:111319. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Division of Reproductive Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Pediatrics, Section of Neonatology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Aims: Infants born to women with Type 2 Diabetes Mellitus (T2DM) are at risk of being born large for gestational age due to excess fetal fat accretion. Placental nutrient transport determines fetal nutrient availability, impacting fetal growth. The aims of the study were to evaluate the effect of T2DM on placental insulin signaling, placental nutrient transporters and neonatal adiposity. Read More

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Early Observation of Red Flags in 12-Month-Old Infant Siblings Later Diagnosed With Autism Spectrum Disorder.

Am J Speech Lang Pathol 2021 May 14:1-10. Epub 2021 May 14.

Department of Clinical Sciences, Florida State University, Tallahassee.

Purpose Valid and reliable screening tools are needed to improve early detection and optimize developmental outcomes for toddlers at risk for autism spectrum disorder (ASD). The current study aimed to evaluate the utility of the Systematic Observation of Red Flags (SORF) for ASD at 12 months of age in a sample of high-risk infant siblings of children with ASD. Method As part of a prospective, longitudinal study, we examined the sensitivity and specificity of the SORF at 12 months for predicting a diagnosis of ASD at 24 months in a sample of 122 infants, 31 of whom were diagnosed with ASD. Read More

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Association of maternal birth weight with the risk of low birth weight and small-for-gestational-age in offspring: A prospective single-center cohort study.

PLoS One 2021 14;16(5):e0251734. Epub 2021 May 14.

Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

Background: Although low birth weight in Japan has slightly increased over the past several decades, the association between maternal birth weight and pregnancy outcomes remains poorly understood.

Methods: In this hospital-based, prospective cohort study conducted at the National Center for Child Health and Development, we obtained information on pregnant women's birth weight via their maternal and child health handbook. We analyzed 944 women born at term after dividing them into five categories according to their birth weight: <2500 g, 2500-2999 g, 3000-3499 g, 3500-3999 g, and ≥4000 g. Read More

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Family-centered music therapy-Empowering premature infants and their primary caregivers through music: Results of a pilot study.

PLoS One 2021 14;16(5):e0250071. Epub 2021 May 14.

Department of Neonatology, University Children's Hospital, Heidelberg, Germany.

Background: In Neonatal Intensive Care Units (NICUs) premature infants are exposed to various acoustic, environmental and emotional stressors which have a negative impact on their development and the mental health of their parents. Family-centred music therapy bears the potential to positively influence these stressors. The few existing studies indicate that interactive live-improvised music therapy interventions both reduce parental stress factors and support preterm infants' development. Read More

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Quantitative magnetic resonance imaging for focal liver lesions: bridging the gap between research and clinical practice.

Br J Radiol 2021 May 14:20210220. Epub 2021 May 14.

Service de Radiologie, Hôpital Beaujon, APHP.Nord, Clichy, France.

Magnetic resonance imaging (MRI) is highly important for the detection, characterization, and follow-up of focal liver lesions. Several quantitative MRI-based methods have been proposed in addition to qualitative imaging interpretation to improve the diagnostic work-up and prognostics in patients with focal liver lesions. This includes DWI with apparent diffusion coefficient measurements, intravoxel incoherent motion, perfusion imaging, MR elastography, and radiomics. Read More

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The Large Uterus Classification System (LUCS): A Prospective Observational Study.

BJOG 2021 May 14. Epub 2021 May 14.

Department of Obstetrics and Gynaecology, University of Insubria, F. Del Ponte Hospital, Varese, Italy.

Objective: To investigate the Large Uterus Classification System (LUCS) ability to predict surgical outcomes and complications in total laparoscopic hysterectomies (TLHs) for large uteri.

Design: Prospective observational study.

Setting: Two referral centres. Read More

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Language familiarity influences own-race face recognition in 9- and 12-month-old infants.

Infancy 2021 May 14. Epub 2021 May 14.

Univ. Grenoble Alpes, LPNC, Grenoble, France.

During their first year, infants attune to the faces and language(s) that are frequent in their environment. The present study investigates the impact of language familiarity on how French-learning 9- and 12-month-olds recognize own-race faces. In Experiment 1, infants were familiarized with the talking face of a Caucasian bilingual German-French speaker reciting a nursery rhyme in French (native condition) or in German (non-native condition). Read More

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Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life: An explorative pilot study.

JPEN J Parenter Enteral Nutr 2021 May 14. Epub 2021 May 14.

Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences.

Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. In a pilot trial whether the supplement type, BC or human donor milk (DM), affects gut colonization in preterm infants during the first week of life was tested. Read More

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Genotypes of rhinovirus detected among children in two communities of South-West Nigeria.

Virus Genes 2021 May 14. Epub 2021 May 14.

Department of Virology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Rhinoviruses (RVs) are the most common etiological agent implicated in respiratory infections among infants and children. There are currently no approved antivirals and vaccine for use against the virus; hence, the need for information on the genotypes of rhinovirus from developing countries of the world with high burden of the infection. This study determined the genotypes of rhinovirus circulating among children in selected cities in Nigeria. Read More

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Assessing standards for prevention of early onset group B streptococcal (GBS) disease in Ireland.

Ir J Med Sci 2021 May 14. Epub 2021 May 14.

Obstetrics and Gynaecology, Rotunda Hospital, Dublin, Ireland.

Background: Early onset group B streptococcal (GBS) disease can cause significant neonatal morbidity and mortality. There is currently no Irish national guideline for GBS screening, and protocols vary across maternity units. Polymerase chain reaction (PCR) testing at induction or labour onset informs triage for antibiotic prophylaxis; however, there are human and infrastructural resource requirements to enable widespread implementation. Read More

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Risk factors for post-nephrectomy hypotension in pediatric patients.

Pediatr Nephrol 2021 May 14. Epub 2021 May 14.

Division of Nephrology and Rheumatology, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan.

Background: Although hypotension is a life-threatening complication of nephrectomy in children, risk factors for its development remain unknown. We evaluated the incidence, clinical course, and associated risk factors of pediatric post-nephrectomy hypotension in an observational study.

Methods: This retrospective observational study included the clinical data of children who underwent nephrectomy in our center between 2002 and 2020. Read More

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An App-Based Parenting Program to Promote Healthy Energy Balance-Related Parenting Practices to Prevent Childhood Obesity: Protocol Using the Intervention Mapping Framework.

JMIR Form Res 2021 May 14;5(5):e24802. Epub 2021 May 14.

Behavioural Science Institute, Radboud University, Nijmegen, Netherlands.

Background: The family environment plays an important role in the development of children's energy balance-related behaviors. As a result, parents' energy balance-related parenting practices are important targets of preventive childhood obesity programs. Families with a lower socioeconomic position (SEP) may benefit from participating in such programs but are generally less well reached than families with a higher SEP. Read More

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Comparison of allergenicity among cow, goat, and horse milks using a murine model of atopy.

Food Funct 2021 May 14. Epub 2021 May 14.

Key Laboratory of Agro-products Processing Technology, Jilin Provincial Department of Education, Changchun University, 6543 Weixing Road, Changchun 130022, Jilin, People's Republic of China.

Due to the prevalence and severity of cow milk (CM) allergy (CMA), an ideal substitute is urgently needed to develop hypoallergenic infant formula for infants who experience anaphylaxis to typical whey-based CM formula. Goat milk (GM) and horse milk (HM) are considered appropriate substitutes; however, whether GM and HM are less allergenic than CM is unclear. In the present study, the difference in allergenicity among CM, GM, and HM was investigated using the Balb/c mouse model. Read More

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Defective Cortisol Secretion in Response to Spontaneous Hypoglycemia but Normal Cortisol Response to ACTH stimulation in neonates with Hyperinsulinemic Hypoglycemia (HH).

Acta Biomed 2021 May 12;92(2):e2021182. Epub 2021 May 12.

Departments of Pharmacology, Hamad General Hospital, Doha, Qatar.

Introduction: Hyperinsulinemic Hypoglycaemia (HH) is the most common cause of recurrent and persistent hypoglycemia in the neonatal period. Cortisol and GH play an important role as a counterregulatory hormone during hypoglycemia. Both antagonize the peripheral effects of insulin and directly influences glucose metabolism Patients and Methods: We studied cortisol and GH secretion in newborn infants with HH during spontaneous hypoglycemia. Read More

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Iron, iodine and vitamin D deficiencies during pregnancy - epidemiology, risk factors and developmental impacts.

Proc Nutr Soc 2021 May 14:1-33. Epub 2021 May 14.

Cork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, College of Science, Engineering and Food Science, University College Cork, Ireland.

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Still-face Effect in Dogs (). A Pilot Study.

J Appl Anim Welf Sci 2021 May 14:1-14. Epub 2021 May 14.

Facultad de Medicina, Instituto de Investigaciones Médicas A. Lanari, Universidad de Buenos Aires, Buenos Aires, Argentina.

The Still-face Paradigm has been widely used for the assessment of emotion regulation in infants, as well as for the study of the mother-child relationship. Given the close bond that dogs have with humans, the purpose of this research was to evaluate, through an exploratory descriptive study, the presence of the Still-face effect in dogs. To this end, a group of Beagle dogs were exposed to three one-minute phases in which first, an unknown experimenter interacted actively and positively with each dog (Interaction). Read More

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Carboplatin-Paclitaxel in triple-negative metastatic breast cancer during pregnancy with neoplastic thrombosis.

Minerva Obstet Gynecol 2021 May 14. Epub 2021 May 14.

Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy -

The treatment of breast cancer diagnosed during pregnancy is a challenging situation for the patient, family and healthcare providers. Here we describe the case of a 35-year-old woman diagnosed with a triple-negative breast cancer relapse during pregnancy. She previously underwent neoadjuvant chemotherapy without any response, subsequent left skin sparing mastectomy plus axillary node dissection and radiation therapy to the chest wall and supraclavicular lymph nodes. Read More

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Sensing of mycobacterial arabinogalactan by galectin-9 exacerbates mycobacterial infection.

EMBO Rep 2021 May 13:e51678. Epub 2021 May 13.

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Mycobacterial arabinogalactan (AG) is an essential cell wall component of mycobacteria and a frequent structural and bio-synthetical target for anti-tuberculosis (TB) drug development. Here, we report that mycobacterial AG is recognized by galectin-9 and exacerbates mycobacterial infection. Administration of AG-specific aptamers inhibits cellular infiltration caused by Mycobacterium tuberculosis (Mtb) or Mycobacterium bovis BCG, and moderately increases survival of Mtb-infected mice or Mycobacterium marinum-infected zebrafish. Read More

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Innate IL-23/Type 17 immune responses mediate the effect of the 17q21 locus on childhood asthma.

Clin Exp Allergy 2021 May 13. Epub 2021 May 13.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.

Background: Several childhood asthma risk loci that relate to immune function have been identified by genome-wide association studies (GWAS), but the underlying mechanisms remain unknown.

Objective: Here, we examined whether perturbed innate immune responses mediate the association between known genetic risk variants and development of childhood asthma.

Methods: Peripheral blood mononuclear cells from 336 six-month-old infants from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC ) cohort were stimulated in vitro with six different innate ligands (LPS, CpG, poly(I:C), R848, HDMAPP, and aluminum hydroxide together with low levels of LPS) followed by quantification of 18 released cytokines and chemokines 40h after the stimulations. Read More

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Measuring the impact of cardiotocograph decision support software on neonatal outcomes: A propensity score-matched observational study.

Aust N Z J Obstet Gynaecol 2021 May 13. Epub 2021 May 13.

Mater Mothers' Hospital, South Brisbane, Queensland, Australia.

Background: This study follows the 2017 UK INFANT Collaborative Group RCT, which compared neonatal outcomes with and without the use of the INFANT cardiotocograph decision support system for over 46 000 patients in labour. The original trial failed to demonstrate a significant improvement to neonatal outcomes; however, the study design was subject to methodological critique.

Aims: This Australian retrospective cohort study aimed to report perinatal outcomes before and after the introduction of INFANT decision support software for cardiotocograph use in labour. Read More

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European Childhood Obesity Risk Evaluation (CORE) index based on perinatal factors and maternal sociodemographic characteristics: the Feel4Diabetes-study.

Eur J Pediatr 2021 May 14. Epub 2021 May 14.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, 70 El Venizelou Ave, 176 71 Kallithea, Athens, Greece.

The aim of this study was to develop and examine the predictive accuracy of an index that estimates obesity risk in childhood based on perinatal factors and maternal sociodemographic characteristics. Analysis was conducted by using cross-sectional and retrospective data collected from a European cohort of 2775 schoolchildren and their families participating in the Feel4Diabetes-study. The cohort was randomly divided by using two-thirds of the sample for the development of the index and the remaining one third for assessing its predictive accuracy. Read More

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Development of Pretreatment Method for Analysis of Vitamin B in Cereal Infant Formula using Immunoaffinity Chromatography and High-Performance Liquid Chromatography.

Food Sci Anim Resour 2021 Mar 1;41(2):335-342. Epub 2021 Mar 1.

Department of Food Marketing and Safety, Konkuk University, Seoul 05029, Korea.

Vitamin B deficiency may lead to serious health issues in both infants and adults. A simple analytical method involving sample pretreatment with enzyme, followed by cyanide addition under acidic conditions; separation on an immunoaffinity column; and high-performance liquid chromatography (HPLC) was developed for the rapid detection and quantitation of vitamin B in powdered milk. Detection limit and powdered milk recovery were determined by quantitative analysis. Read More

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MiR-542-3p Suppresses Neuroblastoma Cell Proliferation and Invasion by Downregulation of KDM1A and ZNF346.

Open Life Sci 2020 10;15:173-184. Epub 2020 Apr 10.

Department II of General Surgery, Xi'an Children's Hospital, Xi'an, Shaanxi, China.

Neuroblastoma is one of the most common malignancies in infants and children. MicroRNAs (miRNAs) have been reported as significant regulators that play important roles in neuroblastoma development. This research aimed to analyze the functional mechanism of miR-542-3p in neuroblastoma. Read More

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