57,721 results match your criteria infant presented


Graves disease in infancy: a patient presentation and literature review.

Endocrinol Diabetes Metab Case Rep 2021 Jun 1;2021. Epub 2021 Jun 1.

Icahn School of Medicine, Mount Sinai Department of Pediatric Endocrinology, Kravis Children's Hospital, New York, NY, USA.

Summary: We describe a case of an infant who presented with clinical features of hyperthyroidism. The child was found to be tachycardic, hypertensive and diaphoretic, she was noted to have poor weight gain and difficulty in sleeping. The child was admitted to the pediatric intensive care unit for care. Read More

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Gastroschisis and late-onset neonatal sepsis in a tertiary referral center in Southeastern Brazil.

J Pediatr (Rio J) 2021 Jun 18. Epub 2021 Jun 18.

Universidade de São Paulo, Faculdade de Medicina, Instituto da Criança, Unidade de Terapia Intensiva Neonatal, São Paulo, SP, Brazil.

Objectives: To analyze late-onset sepsis and to describe the etiological agents in newborns with gastroschisis.

Methods: A retrospective cohort, including newborns with gastroschisis whose admissions occurred in the period between January 2012 to December 2018 in a tertiary referral center. Maternal and newborn characteristics, surgical procedures and evolution in hospitalization were verified. Read More

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Videofluoroscopic Swallow Study Findings and Correlations in Infancy of Children with Cerebral Palsy.

Ann Otol Rhinol Laryngol 2021 Jun 21:34894211026741. Epub 2021 Jun 21.

Department of Otolaryngology Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.

Objectives: Cerebral palsy (CP) in infants can affect global motor function and lead to swallowing difficulties. This study aims to characterize oral and pharyngeal swallowing dynamics in infancy of patients later diagnosed with CP and to determine if swallow study performance in early infancy is associated with later CP severity and characteristics.

Methods: This is a retrospective chart review of infants who underwent videofluoroscopic swallow studies (VFSS) between 6/2008 and 10/2018 at a tertiary children's hospital, and were later diagnosed with CP. Read More

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When novelty prevails on familiarity: Visual biases for child versus infant faces in 3.5- to 12-month-olds.

J Exp Child Psychol 2021 Jun 15;210:105174. Epub 2021 Jun 15.

University of Grenoble Alpes, Laboratoire de Psychologie et Neurocognition, F-38000 Grenoble, France; Laboratoire de Psychologie et Neurocognition, CNRS, F-38000 Grenoble, France.

The current study examined the influence of everyday perceptual experience with infant and child faces on the shaping of visual biases for faces in 3.5-, 6-, 9-, and 12-month-old infants. In Experiment 1, infants were presented with pairs of photographs of unfamiliar child and infant faces. Read More

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Multilevel Airway Stenosis Being Bypassed by a Customized Tracheostomy Tube in an Infant with Myhre Syndrome.

Pediatr Allergy Immunol Pulmonol 2021 Jun;34(2):83-87

Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Myhre syndrome is a rare connective tissue disorder caused by heterozygous pathogenic variants in the gene. Although recognizing Myhre syndrome in early childhood is challenging, it is important to manage airway stenosis in patients with Myhre syndrome. We report the case of a 2-month-old boy who initially presented with severe multilevel airway stenosis, dysmorphic face, and multiple abnormalities. Read More

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Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect.

Mol Genet Metab 2021 Jun 10. Epub 2021 Jun 10.

Department of Pediatrics, Section of Clinical Genetics and Metabolism, University of Colorado, Aurora, CO, USA; Department of Pathology and Laboratory Services, Children's Hospital Colorado, Aurora, CO, USA. Electronic address:

Cardiac dysfunction is a common phenotypic manifestation of primary mitochondrial disease with multiple nuclear and mitochondrial DNA pathogenic variants as a cause, including disorders of mitochondrial translation. To date, five patients have been described with pathogenic variants in MRPL44, encoding the ml44 protein which is part of the large subunit of the mitochondrial ribosome (mitoribosome). Three presented as infants with hypertrophic cardiomyopathy, mild lactic acidosis, and easy fatigue and muscle weakness, whereas two presented in adolescence with myopathy and neurological symptoms. Read More

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Emotional Closeness Among NICU Fathers: A Qualitative Descriptive Study.

Adv Neonatal Care 2021 Jun 16. Epub 2021 Jun 16.

Department of Nursing Science, University of Turku, Turku, Finland (Drs Lebel and Axelin); Université du Québec en Outaouais, St-Jérôme, Canada (Dr Lebel); Ingram School of Nursing, McGill University, Montreal, Canada (Dr Feeley); and Université de Sherbrooke, École des sciences infirmières, Sherbrooke, Canada (Dr Gosselin).

Background: The unique perspective of fathers with an infant in the neonatal unit on the development of emotional closeness toward their infant is not well understood. The purpose of this study is to explore experiences and instances of emotional closeness from the perspective of fathers as well as factors influencing emotional closeness during an infant's hospitalization in the neonatal unit.

Methods: This qualitative descriptive study employed one-on-one interviews with fathers recruited in a level 3 neonatal unit. Read More

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A tale of orbital cellulitis and retinopathy of prematurity in an infant: First case report.

Eur J Ophthalmol 2021 Jun 17:11206721211026098. Epub 2021 Jun 17.

Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Pondicherry, Tamil Nadu, India.

Purpose: Orbital cellulitis is an infectious pathology affecting fat and muscles behind the orbital septum. Retinopathy of prematurity (ROP) is an abnormal retinal blood vessel proliferation affective preterm low birth weight infants. Here we report the first case report of a 4-month-old infant who presented to our outpatient setting with orbital cellulitis and bilateral ROP sequelae. Read More

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Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2.

Cell Rep Med 2021 Jun 9:100327. Epub 2021 Jun 9.

School of Cellular and Molecular Medicine, University of Bristol, UK.

Severe COVID-19 appears rare in children. This is unexpected, especially in young infants, who are vulnerable to severe disease caused by other respiratory viruses. We evaluate convalescent immune responses in four infants under 3 months old with confirmed COVID-19 who presented with mild febrile illness, alongside their parents, and adult controls recovered from confirmed COVID-19. Read More

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Case Report of Novel Genetic Variant in KCNT1 Channel and Pharmacological Treatment With Quinidine. Precision Medicine in Refractory Epilepsy.

Front Pharmacol 2021 28;12:648519. Epub 2021 May 28.

Department of Neurology, Garrahan Hospital, Buenos Aires City, Argentina.

In this work we present a female infant patient with epilepsy of infancy with migrating focal seizures (EIMFS). Although many pharmacological schemes were attempted, she developed an encephalopathy with poor response to antiepileptic drugs and progressive cerebral dysfunction. To present the pharmacological response and therapeutic drug monitoring of a paediatric patient with a severe encephalopathy carrying a genetic variant in KCNT1 gene, whose identification led to include quinidine (QND) in the treatment regimen as an antiepileptic drug. Read More

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Hirschsprung disease with Edward syndrome: A rare association: A case report.

Int J Surg Case Rep 2021 Jun 9;84:106084. Epub 2021 Jun 9.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal. Electronic address:

Introduction And Importance: Edward's syndrome (ES) occurs as a result of trisomy of chromosome 18 and is associated with multisystem congenital anomalies. The association of ES with various gastrointestinal malformations but Hirschsprung disease (HD) is well documented.

Case Presentation: A female infant on her 5th day of life presented with episodes of bilious vomiting along with abdominal distension and no passage of stool. Read More

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Fluid-structure interaction modeling of lactating breast: Newtonian vs. non-Newtonian milk.

J Biomech 2021 May 13;124:110500. Epub 2021 May 13.

Department of Mechanical Engineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA. Electronic address:

Breastfeeding is a highly dynamic and complex mechanism. The suckling process by the infant involves compression and intra-oral vacuum pressure, leading to milk expression from breast. The accumulated milk from the nipple varies depending on the milk properties and transient flow rate during the suckling cycle. Read More

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Role of multiparametric ultrasound in testicular focal lesions and diffuse pathology evaluation, with particular regard to elastography: Review of literature.

Andrology 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiological Sciences, Oncology and Pathology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Background: Ultrasound is the main requested technique for the assessment of traumatic, vascular, neoplastic, and inflammatory testicular pathology. Moreover, the role of ultrasound has broadened over the years along with the introduction of new techniques, such as contrast enhanced ultrasound and ultrasound elastography.

Objective: An updated representation of the pre-existing Literature evidence for multiparametric ultrasound imaging with particular regard to elastography, in the evaluation of focal and diffuse testicular pathologies, has been presented. Read More

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Mapping Hospital-Based Lactation Care Provided to Bereaved Mothers: A Basis for Quality Improvement.

Breastfeed Med 2021 Jun 9. Epub 2021 Jun 9.

Research School of Social Sciences, Australian National University, Acton, Australia.

The study aimed to identify and map the factors that shape the delivery of hospital-based lactation care for bereaved mothers to inform quality improvement initiatives targeting hospital-based lactation care. Focus groups and interviews were conducted at three large hospitals in Australia with 113 health professionals including obstetricians, neonatologists, midwives, neonatal nurses, lactation consultants, social workers or pastoral care workers, Human Milk Bank (HMB) staff, and perinatal bereavement nurses. Thematic and interactional data analysis identified the nature, scope, and pattern of bereavement lactation care. Read More

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Newborn bath: construction and validation of the instrument content.

Rev Bras Enferm 2021 4;74Suppl 4(Suppl 4):e20200102. Epub 2021 Jun 4.

Universidade Federal Triângulo Mineira. Uberaba, Minas Gerais, Brazil.

Objective: To build and validate the content of a good practice tool in the newborn bath.

Method: Methodological study, developed from December 2018 to January 2019, in a Joint Neonatal Housing Unit of a teaching hospital, in three stages: bibliographic survey, construction of the instrument and content validation by nine judges. The content validity index was used above 80% and general analysis with ten requirements. Read More

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Naturally occurring anti-Kp in an infant with recurrent bacterial infection: A case report and review of the literature.

Vox Sang 2021 Jun 8. Epub 2021 Jun 8.

Department of Immunohematology & Blood Transfusion, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Naturally occurring anti-Kp antibody is extremely rare and was first reported in 1957, named after the first producer 'Penney'. However, the subsequent anti-Kp reports presented were all anti-Kp due to isoimmunization. Individuals with severe bacterial infections particularly Gram-negative bacteria are known to be capable of producing cross-reactive antibodies against Kell blood group system. Read More

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Hair loss in an infant presenting with failure to thrive.

SAGE Open Med Case Rep 2021 30;9:2050313X211020220. Epub 2021 May 30.

Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.

An 11-month-old male child with a complex past medical history presented for admission due to failure to thrive. He had hair loss throughout his scalp, and his abdomen was distended. There was parental report of hair pulling and hair in his stool. Read More

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Determinants of pre-lacteal feeding practices among mothers having children aged less than 36 months in Ethiopia: Evidence from 2016 Ethiopian demographic and health survey.

SAGE Open Med 2021 25;9:20503121211019235. Epub 2021 May 25.

Department of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia.

Background: Pre-lacteal feeding is associated with infant morbidity and mortality especially during the neonatal period. About 96% infant deaths in developing countries are attributable to inappropriate feeding practice during the first 6 months of life. This study assessed determinants of pre-lacteal feeding practices in Ethiopia using the data from nationally representative survey. Read More

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[Clinical features of epilepsy in children with IRF2BPL gene variation].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):506-510

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To summarize the genotype and phenotype of epilepsy in patients with interferon regulatory factor 2 binding protein-like (IRF2BPL) gene variants. Data of 6 epilepsy patients with IRF2BPL gene variants seen from May 2017 to September 2020 in the Department of Pediatrics of Peking University First Hospital were retrospectively collected. The clinical characteristics and genetic test results were analyzed. Read More

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Sildenafil Citrate Overdose in a 3-Month Postterm Premature Infant With Pulmonary Artery Hypertension.

Pediatr Emerg Care 2021 Jun 7. Epub 2021 Jun 7.

From the Department of Paediatrics, Máxima Medical Centre, Veldhoven, the Netherlands.

Objective: We aimed to describe a case of prematurely born infant with accidental sildenafil overdose.

Methods: This was a retrospective case report followed with chart and literature review.

Main Findings: A prematurely born infant with moderate bronchopulmonary dysplasia, corrected congenital heart disease, and pulmonary hypertension presented with an accidental sildenafil overdose. Read More

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Early postnatal discharge from hospital for healthy mothers and term infants.

Cochrane Database Syst Rev 2021 Jun 8;6:CD002958. Epub 2021 Jun 8.

Murdoch Children's Research Institute, Parkville, Australia.

Background: Length of postnatal hospital stay has declined dramatically in the past 50 years. There is ongoing controversy about whether staying less time in hospital is harmful or beneficial. This is an update of a Cochrane Review first published in 2002, and previously updated in 2009. Read More

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Technical Features of Biventricular Repair for Unbalanced Transitional AVSD With LVOTO.

World J Pediatr Congenit Heart Surg 2021 Jun 7:2150135120988633. Epub 2021 Jun 7.

Pediatric Cardiology, Cardiac Sciences, 37532Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.

Surgical management of left ventricle outflow tract obstruction in infants with right-dominant unbalanced transitional atrioventricular septal defect poses difficulties. A two-month-old infant with transitional atrioventricular septal defect and complex left ventricle outflow tract obstruction presented in cardiogenic shock. The patient underwent successful biventricular repair. Read More

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Spontaneous intraperitoneal renal rupture with urinoma formation in the fetus.

Urol Case Rep 2021 Jul 5;37:101697. Epub 2021 May 5.

Department of Urology and Renal Transplantation, Nagasaki University Hospital, Nagasaki, Japan.

Spontaneous intraperitoneal renal rupture with urinoma formation in fetuses is an unusual condition that is caused by upper or lower urinary tract obstruction. We report the case of a neonatal male infant who presented with a spontaneous intraperitoneal right renal rupture accompanying ipsilateral ureterovesical junction obstruction (UVJO). Fetuses with UVJO accompanying contralateral multicystic dysplastic kidney should be observed carefully because of the risk of spontaneous renal rupture. Read More

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Xiang Study: an association of breastmilk composition with maternal body mass index and infant growth during the first 3 month of life.

Nutr Res Pract 2021 Jun 6;15(3):367-381. Epub 2020 Oct 6.

H&H Group, Global Research and Technology Center, Guangzhou 510700, China.

Background/objectives: This study aimed to establish a mother and child cohort in the Chinese population, and investigate human breastmilk (HBM) composition and its relationship with maternal body mass index (BMI) and infant growth during the first 3 mon of life.

Subjects/methods: A total of 101 Chinese mother and infant pairs were included in this prospective cohort. Alterations in the milk macronutrients of Chinese mothers at 1 mon (T1), 2 mon (T2), and 3 mon (T3) lactation were analyzed. Read More

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ALG3-CDG: a patient with novel variants and review of the genetic and ophthalmic findings.

BMC Ophthalmol 2021 Jun 5;21(1):249. Epub 2021 Jun 5.

Department of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 2, 128 08, Prague, Czech Republic.

Background: ALG3-CDG is a rare autosomal recessive disease. It is characterized by deficiency of alpha-1,3-mannosyltransferase caused by pathogenic variants in the ALG3 gene. Patients manifest with severe neurologic, cardiac, musculoskeletal and ophthalmic phenotype in combination with dysmorphic features, and almost half of them die before or during the neonatal period. Read More

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Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down Syndrome.

J Clin Immunol 2021 Jun 5. Epub 2021 Jun 5.

Center for Inborn Errors of Immunity, Icahn School of Medicine At Mount Sinai, New York, NY, USA.

While adults with Down syndrome (DS) are at increased risk of severe COVID-19 pneumonia, little is known about COVID-19 in children with DS. In children without DS, SARS-CoV-2 can rarely cause severe COVID-19 pneumonia, or an even rarer and more typically pediatric condition, multisystem inflammatory syndrome in children (MIS-C). Although the underlying mechanisms are still unknown, MIS-C is thought to be primarily immune-mediated. Read More

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Intradural Extramedullary Primary Central Nervous System Melanoma of the Craniovertebral Junction during Pregnancy: Observations and Outcomes.

Surg Neurol Int 2021 3;12:198. Epub 2021 May 3.

Department of Surgery, University of Texas Rio Grande Valley, Edinburg, Texas, United States.

Background: Primary central nervous system (CNS) melanoma is a rare lesion derived from neural crest precursors. While its management is analogous to metastatic spinal melanoma, the literature does not describe this entity clearly in pregnant patients and the unique implications it presents. Here, we describe the case of a pregnant patient who presented with primary CNS melanoma of the cervical spine. Read More

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Perinatal outcomes of high-dose vitamin D administration in the last trimester

Turk J Obstet Gynecol 2021 06;18(2):159-162

University of Health Sciences Turkey, Dr. Sami Ulus Maternity and Children's Research and Training Hospital, Clinic of Pediatric Endocrinology, Ankara, Turkey

In recent years, interest in the evaluation of vitamin D levels and the possible outcomes of their deficiency during pregnancy has increased. However, there is no consensus on when to start vitamin D supplementation, its duration, dosage, and the optimum level during pregnancy. The toxicity of vitamin D is as important as its deficiency. Read More

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Learning to learn from video? 30-month-olds benefit from continued use of supportive scaffolding.

Infant Behav Dev 2021 Jun 1;64:101574. Epub 2021 Jun 1.

Department of Applied Psychology and Human Development, Ontario Institute for Studies in Education, University of Toronto, United States.

Young children struggle to learn new words presented on video, but adult co-viewers can support them by providing scaffolds that explicitly connect the video and real world. In this study, we asked whether scaffolding facilitates children's symbolic understanding of the video, such that they will subsequently transfer labels from video to real referents. Sixty-three 30-month-olds and 61 36-month-olds participated in a series of three word learning trials in one of three conditions. Read More

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Heat stroke: knowledge and practices of medical professionals in pediatric emergency medicine departments - a survey study.

Isr J Health Policy Res 2021 Jun 2;10(1):35. Epub 2021 Jun 2.

Pediatric Emergency Medicine, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center Sackler Faculty of Medicine, Tel Aviv University, Weizman Street, 64239, Tel Aviv, Israel.

Background And Importance: Heat stroke is a life-threatening condition affecting children worldwide. Rapid cooling remains the most important feature of emergency management. The accepted preferred method of evaporative cooling in the ED as listed by the reference text book endorsed by the Israeli Society of Pediatric Emergency Medicine (PEMI), is actively cooling the patient by spraying him with water and positioning fans to blow air across the body. Read More

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