127,099 results match your criteria infant mortality]

The Unrecognized Mortality Burden of Genetic Disorders in Infancy.

Am J Public Health 2021 Jul;111(S2):S156-S162

Monica H. Wojcik and Pankaj B. Agrawal are with the Division of Newborn Medicine and Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School, Boston, MA. Rachel Stadelmaier is with the Department of Pediatrics, Boston Children's Hospital and Harvard Medical School. Dominique Heinke is with the Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health and Harvard T. H. Chan School of Public Health, Harvard University, Boston. Ingrid A. Holm and Wen-Hann Tan are with the Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital and Harvard Medical School.

To determine how deaths of infants with genetic diagnoses are described in national mortality statistics. We present a retrospective cohort study of mortality data, obtained from the National Death Index (NDI), and clinical data for 517 infants born from 2011 to 2017 who died before 1 year of age in the United States. Although 115 of 517 deceased infants (22%) had a confirmed diagnosis of a genetic disorder, only 61 of 115 deaths (53%) were attributed to , codes representing congenital anomalies or genetic disorders (Q00-Q99) as the underlying cause of death because of inconsistencies in death reporting. Read More

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Individualized precision dosing approaches to optimize antimicrobial therapy in pediatric populations.

Expert Rev Clin Pharmacol 2021 Jul 27. Epub 2021 Jul 27.

University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.

Introduction: : Severe infections continue to impose a major burden on critically ill children and mortality rates remain stagnant. Outcomes rely on accurate and timely delivery of antimicrobials achieving target concentrations in infected tissue. Yet, developmental aspects, disease-related variables, and host factors may severely alter antimicrobial pharmacokinetics in pediatrics. Read More

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COViD-19: We're All in This Together - Some More Than Others.

Chris Alderman

Sr Care Pharm 2021 Aug;36(8):358-360

It has long been apparent that gross disparities exist in health care in the United States, and, indeed, other nations with fully developed economies. All kinds of markers point to these inequities, with measures such as overall life expectancy, hospitalization rates, premature mortality, adverse outcomes associated with medical and surgical treatment, infant mortality, and the impact of many significant disease types higher and more impactful among minority groups and those of the most modest economic means. This is not new. Read More

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Challenges parents encounter when implementing infant safe sleep advice.

Acta Paediatr 2021 Jul 23. Epub 2021 Jul 23.

School of Nursing, Midwifery and Paramedicine, University of the Sunshine Coast, Sippy Downs, Australia.

Aim: To understand which safe sleep recommendations parents find most challenging to implement, identifying common barriers encountered; and, investigate if challenges are associated with practices employed.

Methods: A cross-sectional survey of 3341 Australian families with young infants who birthed a live baby during April-May 2017. Caregivers were asked about infant care practices and family characteristics. Read More

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The effects of malaria in pregnancy on neurocognitive development in children at one and six years of age in Benin: a prospective mother-child cohort.

Clin Infect Dis 2021 Jul 23. Epub 2021 Jul 23.

Ecole des Hautes Etudes en Santé Publique (EHESP), Rennes, France.

Background: Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in Sub-Saharan Africa and has consequences on survivors, such as pre-term birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown.

Methods: Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. Read More

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Uterine dehiscence in pregnant with previous caesarean delivery.

Ann Med 2021 Dec;53(1):1265-1269

Medical Administrative Department, Zhengzhou University Third Hospital and Henan Province Women and Children's Hospital, Zhengzhou, China.

Background: The main risk factor for uterine scar dehiscence is a previous caesarean section. Better characterisation of the ultrasonographic features of uterine scar dehiscence may improve preoperative diagnostic accuracy in pregnant women with a caesarean scar. This study aimed to evaluate the ultrasonographic features of uterine scar dehiscence in pregnant women and maternal and neonatal outcomes. Read More

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December 2021

The health management status of medical and health service institutions and its correlation with residents' health risk.

Yansheng Zhang

Work 2021 Jul 18. Epub 2021 Jul 18.

Background: The rapid progression of a moderately prosperous society leads to people's higher requirements for health status.

Objective: The study aims to explore the health management status of medical and health institutions and its correlation with health risk level.

Methods: The differences in health management level and health risk level within a certain region and between regions are analyzed, with Entropy method, Min-Max standardization method, Theil index, coefficient of variation, and spatial analysis methods involved. Read More

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Neonatal mortality rates, characteristics, and risk factors for neonatal deaths in Ghana: analyses of data from two health and demographic surveillance systems.

Glob Health Action 2021 Jan;14(1):1938871

Mother and Infant Research Unit, School of Health Sciences, University of Dundee, Dundee, UK.

Background: Reducing neonatal mortality rates (NMR) in developing countries is a key global health goal, but weak registration systems in the region stifle public health efforts.

Objective: To calculate NMRs, investigate modifiable risk factors, and explore neonatal deaths by place of birth and death, and cause of death in two administrative areas in Ghana.

Methods: Data on livebirths were extracted from the health and demographic surveillance systems in Navrongo (2004-2012) and Kintampo (2005-2010). Read More

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January 2021

The Pattern and Level of Knowledge on Obstetric and Newborn Danger Signs and Birth Preparedness among Pregnant Women in Dodoma Municipal: a Cross Sectional Study.

East Afr Health Res J 2020 26;4(1):73-80. Epub 2020 Jun 26.

Department of Clinical Medicine, the University of Dodoma, Tanzania.

Background: Unacceptable high maternal mortality rates remain a major challenge in many low-income countries. Early detection and management of antenatal risk factors and good preparation for birth and emergencies are critical for improved maternal and infant outcomes. The aim of this study was to understand the pattern and level of knowledge on obstetric and newborn danger signs, Individual Birth Preparedness and Complication Readiness (IBPACR) among pregnant women in Dodoma Municipal. Read More

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Challenges in the Surgical Treatment of Atrioventricular Septal Defect in Children With and Without Down Syndrome in Romania-A Developing Country.

Front Pediatr 2021 7;9:612644. Epub 2021 Jul 7.

Department of Pediatrics, "Victor Babeş" University of Medicine and Pharmacy, Timisoara, Romania.

Atrioventricular septal defect (AVSD) is a cardiac malformation that accounts for up to 5% of total congenital heart disease, occurring with high frequency in people with Down Syndrome (DS). We aimed to establish the surgical challenges and outcome of medical care in different types of AVSD in children with DS compared to those without DS (WDS). The study included 62 children (31 with DS) with AVSD, evaluated over a 5 year period. Read More

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necrotizing bronchopneumonia.

Ranjit I Kylat

Autops Case Rep 2021 6;11:e2021271. Epub 2021 May 6.

University of Arizona, College of Medicine, Department of Pediatrics, Tucson, Arizona, USA.

Extremely low birth weight (ELBW) infants are at particularly high risk for infection due to an immature immune system, invasive procedures such as endotracheal intubation, intravascular catheterization, and other factors. Neonatal infections in this population are associated with a high mortality, poor growth, and neurodevelopmental outcomes. () infection is an uncommon but potentially devastating cause of pneumonia and sepsis in the ELBW population. Read More

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Retropharyngeal abscess due to complicated by bilateral neck and intraabdominal abscesses in an immunocompetent infant.

IDCases 2021 28;25:e01209. Epub 2021 Jun 28.

Division of Infectious Diseases and Immunology, Saitama Children's Medical Center, 1-2 Shintoshin, Chuou-ku, Saitama-shi, Saitama, 330-8777, Japan.

Retropharyngeal abscess is a serious condition, with potentially high morbidity and mortality if not detected early. The patient, a previously healthy 10-month-old girl, was admitted due to retropharyngeal and bilateral cervical lymph node abscesses. The neck abscesses recurred, despite surgical drainage and treatment with intravenous ampicillin-sulbactam. Read More

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Postpartum care indications and methodological quality:a systematic review of guidelines.

Z Gesundh Wiss 2021 Jul 19:1-15. Epub 2021 Jul 19.

School of Nursing, Guangzhou University of Chinese Medicine, No. 232, Waihuan East Road, Guangzhou University City, Panyu District, Guangzhou, Guangdong China.

Background: The coverage of postpartum care is not ideal, and has not been used very well due to not enough attention being paid to the puerperal women and newborns, especially in developing countries. Practice guidelines on postpartum care provide beneficial practice guidance and help to reduce maternal mortality. However, little is known about the credibility and consistency of those guidelines. Read More

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De Novo Mutation of the ADAMTS13 Gene with Mesenteric Ischemia in an Infant with Congenital Thrombotic Thrombocytopenic Purpura.

Case Rep Hematol 2021 6;2021:5516863. Epub 2021 Jul 6.

Umm Al-Qura University, Makkah, Saudi Arabia.

Introduction: Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare autosomal recessive disease characterized by ADAMTS13 deficiency or a severe decrease in its activity that is caused by homozygous or combined heterozygous mutations in its encoding gene. Here, we describe a de novo genetic mutation of the ADAMTS13 gene and a rare complication of cTTP in a neonate. . Read More

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Experiences of Fetal or Infant Loss among Tanzanian Women in HIV Care.

J Loss Trauma 2019 29;24(7):625-635. Epub 2019 Apr 29.

Duke Global Health Institute, Duke University, Durham, NC, USA.

This study examined the impact of fetal or infant loss on HIV care engagement. We conducted semi-structured interviews with 15 HIV-infected women who experienced fetal or infant loss while enrolled in prevention of mother-to-child transmission (PMTCT) services in Tanzania. Women attributed the loss to delays in receiving healthcare. Read More

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Translation and validation of Training Needs Analysis Questionnaire among reproductive, maternal and newborn health workers in Tanzania.

BMC Health Serv Res 2021 Jul 24;21(1):735. Epub 2021 Jul 24.

Department of Population Health, the Aga Khan University, Nairobi, Kenya.

Background: Continuous professional development (CPD) has been reported to enhance healthcare workers' knowledge and skills, improve retention and recruitment, improve the quality of patient care, and reduce patient mortality. Therefore, validated training needs assessment tools are important to facilitate the design of effective CPD programs.

Methods: A cross-sectional survey was conducted using self-administered questionnaires. Read More

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The Urinary Uric Acid / Cr ratio as a marker of morbidity and mortality of preterm infants: a case-control study.

BMC Pediatr 2021 Jul 24;21(1):325. Epub 2021 Jul 24.

Department of Pediatrics, School of Medicine, Ayatollah Moussavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.

Background: Perinatal asphyxia is one of the main causes of preterm infant mortality. Some studies have shown that The Urinary Uric Acid / Cr (UUA/Cr) ratio may be used as an additional marker for perinatal asphyxia.This study intend to investigate the relationship of this ratio with outcomes of preterm infants admitted to NICU. Read More

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Association of the p.P479L Metabolic Gene Variant With Childhood Respiratory and Other Infectious Illness in Nunavut.

Front Pediatr 2021 6;9:678553. Epub 2021 Jul 6.

Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

Infectious illness, including lower respiratory tract infection (LRTI), is a leading cause of childhood morbidity and infant mortality in Inuit children in Nunavut Canada. The carnitine palmitoyltransferase 1A (CPT1A) p.P479L variant is common in arctic Indigenous populations of Alaska, Canada, and Greenland. Read More

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Early neonatal mortality trend in adolescent pregnant women in the State of São Paulo, Brazil, from 1996 to 2017.

Transl Pediatr 2021 Jun;10(6):1573-1585

Laboratório de Delineamento de Estudos e Escrita Científica, Centro Universitário Saúde ABC, Santo André, SP, Brasil.

Background: The Infant mortality rate indicates the quality of life of a population. Infant mortality has two important components: neonatal mortality, divided into early and late and post-neonatal mortality. The more developed a country is and the greater its population's well-being, the greater the weight of the neonatal component on infant mortality. Read More

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Male involvement in promotion of safe motherhood in low- and middle-income countries: A scoping review.

Midwifery 2021 Jul 14;103:103089. Epub 2021 Jul 14.

Centre for Midwifery, Maternal & Perinatal Health, Faculty of Health and Social Sciences, Bournemouth University, 10 St Paul's Ln, Boscombe BH8 8AJ, United Kingdom. Electronic address:

Background: Maternal health programmes that focus on the woman alone are limiting in LMICs as pregnant women often relate to maternity services through a complex social web that reflects power struggles within the kinship and the community.

Methods: A scoping review was conducted to explore the rationale for male involvement in maternal health in LMICs. This review was guided by the question: What is the current state of knowledge regarding the inclusion of men in maternal health services in LMICs? The literature search was conducted using mySearch, Bournemouth University`s iteration of the EBSCO Discovery Service (EDS) tool. Read More

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Differential in infant, childhood and under-five death clustering among the empowered and non-empowered action group regions in India.

BMC Public Health 2021 Jul 21;21(1):1436. Epub 2021 Jul 21.

International Institute for Population Sciences, Mumbai, 400088, India.

Background: With 8,82,000 deaths in the under-five period, India observed varied intra-state and inter-regional differences across infant and child mortality in 2018. However, scarce literature is present to capture this unusual concentration of mortality in certain families by examining the association of the mortality risks among the siblings of those families along with various unobserved characteristics of the mother. Looking towards the regional and age differential in mortality, this paper attempts to provide evidence for the differential in mortality clustering among infants (aged 0-11 months), children (12-59 months) and under-five (0-59 months) period among mothers from the Empowered Action Group (EAG) and non-EAG regions of India. Read More

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Early Interventions for Infants at Risk for Developmental Impairment: The South Asian Perspective.

Indian J Pediatr 2021 Jul 21. Epub 2021 Jul 21.

Department of Disability Studies, Faculty of Medicine, University of Kelaniya, Sri Lanka Ayati National Centre for Children With Disabilities, North Colombo, Teaching Hospital, P O Box 6, Thalagolla Road, Ragama, 11010, Sri Lanka.

Majority of under-five children with developmental disabilities live in low- and middle-income countries (LMIC). A considerable proportion of disabilities results from perinatal adversities. The neonatal and infant mortality rates in India, Bangladesh, and Sri Lanka have improved over the last two decades, implying survival of infants at risk for developmental impairments. Read More

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Child mortality for avoidable causes in Rondônia: temporal series study, 2008-2018.

Rev Gaucha Enferm 2021 16;42:e20200297. Epub 2021 Jul 16.

Fundação Universidade Federal de Rondônia (UNIR), Centro de Ensino e Pesquisa em Saúde Coletiva. Porto Velho, Rondônia, Brasil.

Objective: To investigate the trend of infant mortality from preventable causes in children under one year of age in Rondônia from 2008 to 2018.

Method: Epidemiological study of time series with data from the Mortality and Live Birth Information Systems, driven by STATA® version 11.0, trend measured by Prais-Winsten linear regression and autocorrelation with Durbin and Watson test. Read More

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Spinal Muscular Atrophy: Diagnosis, Incidence, and Newborn Screening in Japan.

Int J Neonatal Screen 2021 Jul 20;7(3). Epub 2021 Jul 20.

Department of Community Medicine and Social Healthcare Science, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Kobe 650-0017, Japan.

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder that causes degeneration of anterior horn cells in the human spinal cord and subsequent loss of motor neurons. The severe form of SMA is among the genetic diseases with the highest infant mortality. Although SMA has been considered incurable, newly developed drugs-nusinersen and onasemnogene abeparvovec-improve the life prognoses and motor functions of affected infants. Read More

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Schedules for home visits in the early postpartum period.

Cochrane Database Syst Rev 2021 Jul 21;7:CD009326. Epub 2021 Jul 21.

Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Maternal complications, including psychological/mental health problems and neonatal morbidity, have commonly been observed in the postpartum period. Home visits by health professionals or lay supporters in the weeks following birth may prevent health problems from becoming chronic, with long-term effects. This is an update of a review last published in 2017. Read More

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Infant mortality and causes of infant deaths in 2018, in Adana, Turkey.

Turk Arch Pediatr 2021 Mar 6;56(2):127-130. Epub 2021 Jan 6.

Department of Pediatrics, Division of Neonatology, Çukurova University Faculty of Medicine, Adana, Turkey.

Objective: Understanding the etiologies of infant deaths and predicting risk begins with defining cases correctly. The collection and analysis of reliable statistical data are an essential part of comprehensive investigations on local and national levels.

Material And Methods: This was a descriptive study. Read More

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Determinants of fertility differentials in Burundi: evidence from the 2016-17 Burundi demographic and health survey.

Pan Afr Med J 2021 30;38:316. Epub 2021 Mar 30.

Cadi Ayyad University of Marrakech, Semlalia Faculty of Science, Department of Biology, Marrakech, Morocco.

Introduction: although fertility control remains a major priority for the Burundian government and most of its partners, few studies on Burundi´s fertility determinants are available to guide interventions. To address this gap, our study aims to examine the most factors influencing fertility differentials in Burundi by using the latest Burundi demographic and health survey data.

Methods: using data from the 2016-17 Burundi demographic and health survey, one-way analysis of variance was performed to describe variations in mean number of children ever born across categories of correlate variables. Read More

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Characteristics and predictors of mortality in-hospital mortality following burn injury in infants in a resource-limited setting.

Burns 2021 Jul 13. Epub 2021 Jul 13.

Department of Surgery, University of North Carolina at Chapel Hill, United States; Kamuzu Central Hospital, Lilongwe, Malawi. Electronic address:

Purpose: Burn outcome data in infants is lacking from sub-Saharan Africa. We, therefore, sought to assess the characteristics and predictors of in-hospital burn mortality in a resource-limited setting.

Methods: We performed a retrospective study of the prospectively collected Burn Injury Surveillance database from June 2011 to December 2019. Read More

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Maternal nativity and risk of adverse perinatal outcomes among Black women residing in California, 2011-2017.

J Perinatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, USA.

Objective: Examine the risk of adverse perinatal outcomes among the United States (US)-born and foreign-born Black women in California.

Study Design: The study comprised all singleton live births to Black women in California between 2011 and 2017. We defined maternal nativity as US-born or foreign-born. Read More

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Changes in prevalence of nosocomial infection pre- and post-COVID-19 pandemic from a tertiary Hospital in China.

BMC Infect Dis 2021 Jul 20;21(1):693. Epub 2021 Jul 20.

Intensive Care Unit, Children Hospital of Soochow University, Suzhou, Jiangsu, China.

Background: Nosocomial infections (NIs) are an important cause of mortality, and increasing evidence reveals that the prevalence of NIs can be reduced through effective prevention and control measures. The aim of this study was to investigate the impact of the prevention and control measures for the COVID-19 pandemic on NIs.

Methods: A retrospective study was conducted to analyze the prevalence of NIs before and after COVID-19 pandemic for 6 months in the Children's Hospital of Soochow University. Read More

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