95,351 results match your criteria industry findings


Organic-inorganic epoxide hydrolase hybrid nanoflowers with enhanced catalytic activity: Hydrolysis of styrene oxide to 1-phenyl-1,2-ethanediol.

J Biotechnol 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemical Engineering, Institute of Chemical Technology, Nathalal Parekh Marg, Mumbai-400019, India. Electronic address:

Epoxide hydrolases are ubiquitous in nature and are utilized to catalyze the cofactor-independent hydrolysis of epoxides to their corresponding diols. These enzymes have tremendous potential and have been applied in the synthesis of bulk and fine chemical industry and utilized as chiral building blocks. Herein, we report a green, facile, and economical method for immobilization of epoxide hydrolase based on biomimetic mineralization. Read More

View Article and Full-Text PDF
September 2021

The United Kingdom Research study into Ethnicity And COVID-19 outcomes in Healthcare workers (UK-REACH): protocol for a prospective longitudinal cohort study of healthcare and ancillary workers in UK healthcare settings.

BMJ Open 2021 Sep 17;11(9):e050647. Epub 2021 Sep 17.

Department of Respiratory Sciences, University of Leicester, Leicester, UK

Introduction: The COVID-19 pandemic has resulted in significant morbidity and mortality and devastated economies globally. Among groups at increased risk are healthcare workers (HCWs) and ethnic minority groups. Emerging evidence suggests that HCWs from ethnic minority groups are at increased risk of adverse COVID-19-related outcomes. Read More

View Article and Full-Text PDF
September 2021

Enhancing public health and safety by diagnosing and treating obstructive sleep apnea in the transportation industry: an American Academy of Sleep Medicine position statement.

J Clin Sleep Med 2021 Sep 17. Epub 2021 Sep 17.

Division of Sleep Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Obstructive sleep apnea (OSA) may lead to serious health, safety, and financial implications - including sleepiness-related crashes and incidents - in workers who perform safety-sensitive functions in the transportation industry. Evidence and expert consensus support its identification and treatment in high-risk commercial operators. An Advanced Notice of Proposed Rulemaking (ANPRM) regarding the diagnosis and treatment of OSA in commercial truck and rail operators was issued by the Federal Motor Carrier Safety Administration (FMCSA) and Federal Railroad Administration (FRA), but it was later withdrawn. Read More

View Article and Full-Text PDF
September 2021

Surgical clinical trials with non-inferiority design: a cross-sectional bibliometric analysis.

Ann Transl Med 2021 Aug;9(16):1302

Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: Wide-spread concerns have been raised about possible bias in published surgical non-inferiority trials. Therefore, we performed a comprehensive bibliometric analysis to identify the existence of bias, and provided recommendations for future non-inferiority trials.

Methods: Databases including MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were systematically searched (last update on 27 April 2020) to include published phase II and phase III non-inferiority surgical trials. Read More

View Article and Full-Text PDF

Glycosaminoglycan from attenuates hyperlipidemia and regulates gut microbiota in high-cholesterol diet-fed zebrafish.

Food Sci Nutr 2021 Sep 26;9(9):5198-5210. Epub 2021 Jul 26.

Qinzhou Key Laboratory of Food Flavor Analysis and Control Beibu Gulf University Qinzhou China.

Hyperlipidemia an immense group of acquired or genetic metabolic disorders that is characterized by an excess of lipids in the bloodstream. Altogether, they have a high prevalence worldwide and constitute a major threat to human health. Glycosaminoglycans (GAG) are natural biomolecules that have hypolipidemic activity. Read More

View Article and Full-Text PDF
September 2021

Unraveling the Genetic Basis of Fertility Restoration for Cytoplasmic Male Sterile Line Originated From in .

Front Plant Sci 2021 31;12:721980. Epub 2021 Aug 31.

College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China.

Crosses that lead to heterosis have been widely used in the rapeseed ( L.) industry. Cytoplasmic male sterility (CMS)/restorer-of-fertility () systems represent one of the most useful tools for rapeseed production. Read More

View Article and Full-Text PDF

Pharmacological Properties of 2,4,6-Trihydroxy-3-Geranyl Acetophenone and the Underlying Signaling Pathways: Progress and Prospects.

Front Pharmacol 2021 31;12:736339. Epub 2021 Aug 31.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

2,4,6-Trihydroxy-3-geranyl acetophenone (tHGA) is a bioactive phloroglucinol compound found in (Champ. ex Benth.) T. Read More

View Article and Full-Text PDF

Tomatidine Improves Pulmonary Inflammation in Mice with Acute Lung Injury.

Mediators Inflamm 2021 7;2021:4544294. Epub 2021 Sep 7.

Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Taoyuan City 33303, Taiwan.

Tomatidine, which is isolated from green tomato, can ameliorate inflammation and oxidative stress in cells and animal experiments and has been shown to improve airway inflammation in a murine model of asthma. Here, we investigated whether tomatidine can ameliorate acute lung injury in mice. Mice were given tomatidine by intraperitoneal injection for 7 consecutive days, and then, lung injury was induced via intratracheal instillation of lipopolysaccharide (LPS). Read More

View Article and Full-Text PDF
September 2021

TFF-1 Functions to Suppress Multiple Phenotypes Associated with Lung Cancer Progression.

Onco Targets Ther 2021 10;14:4761-4777. Epub 2021 Sep 10.

Department of Thoracic Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

Introduction: Trefoil Factor (TFF) is a member of a protein family comprised of three isoforms, of which TFF-1 exhibits antithetical functions; promotion or suppression of cell proliferation, survival and invasion, depending on the cancer type. However, the pathobiological function of TFF-1 in lung carcinoma has been still unclear.

Methods: We examined the expression and secretion of TFF-1 using cultured human lung carcinoma cells by immunoblotting, immunofluorescence, enzyme-linked immunosorbent assay and quantitative real-time PCR analyses. Read More

View Article and Full-Text PDF
September 2021

Turning a threat into an opportunity: British American Tobacco's weakening of the Protocol to Eliminate Illicit Trade in Tobacco Products.

Tob Control 2021 Sep 16. Epub 2021 Sep 16.

Tobacco Control Research Group, Department for Health, University of Bath, Bath, UK.

Background: Previous research has outlined transnational tobacco company (TTC) efforts to undermine implementation of the Protocol to Eliminate Illicit Trade in Tobacco Products (Protocol) and evidence of ongoing TTC complicity in the illicit tobacco trade (ITT). However, the industry's views on the Protocol and role in its development are not well understood.

Methods: Systematic searching and analysis of leaked documents-approximately 15 000 from British American Tobacco (BAT) and 35 from Philip Morris International, triangulated via searches of online resources and interviews with five stakeholders across academia, international organisations, governments, civil society and the private sector. Read More

View Article and Full-Text PDF
September 2021

Interactions of chlorogenic acid and isochlorogenic acid A with model lipid bilayer membranes: Insights from molecular dynamics simulations.

Chem Phys Lipids 2021 Sep 13:105136. Epub 2021 Sep 13.

School of Food Science and Technology · School of Chemical Engineering, Hubei University of Arts and Science, Xiangyang, 441053, China; Food Ingredients Engineering Technology Research Center of Hubei, Xiangyang, 441053, China. Electronic address:

Because of the negative side-effects of synthetic preservatives, the naturally-occurring polyphenols aroused intense interest of researchers. It has been suggested that chlorogenic acid (CA) and isochlorogenic acid A (iso-CAA) were good candidates to replace the synthetic preservatives. Moreover, the bactericidal activity of iso-CAA was stronger than CA, and the anti-bacterial activities of iso-CAA and CA were highly membrane-dependent. Read More

View Article and Full-Text PDF
September 2021

Overconnectivity of the right Heschl's and inferior temporal gyrus correlates with symptom severity in preschoolers with autism spectrum disorder.

Autism Res 2021 Sep 16. Epub 2021 Sep 16.

Department of Electronics and Information Engineering, Korea University, Sejong, Republic of Korea.

Previous studies have reported varying findings regarding the association of brain connectivity in autism spectrum disorder (ASD) with overconnectivity, underconnectivity, or both. Despite the emerging understanding that ASD is a developmental disconnection syndrome, very little is known about structural brain networks in preschool-aged children with low-functioning ASD. We aimed to investigate the structural brain connectivity of low-functioning ASD using diffusion magnetic resonance imaging and graph theory to examine alterations in different brain network topologies and identify any correlations with the clinical severity of ASD in preschool-aged children. Read More

View Article and Full-Text PDF
September 2021

Dietary patterns and cardiometabolic risks in diverse less-developed ethnic minority regions: results from the China Multi-Ethnic Cohort (CMEC) Study.

Lancet Reg Health West Pac 2021 Oct 20;15:100252. Epub 2021 Aug 20.

West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Background In Western developed countries, food-based dietary patterns have been associated with the risk of cardiometabolic diseases, but little is known about such associations in less developed ethnic minority regions (LEMRs), where the cardiometabolic disease burden is growing rapidly and food patterns differ substantially. Methods Between May 2018 and September 2019, we recruited 99556 participants aged 30-79 years from the China Multi-Ethnic Cohort (CMEC) Study. We measured habitual dietary intake with validated food frequency questionnaire (FFQ) and then calculated dietary pattern scores for two of the most studied a priori dietary patterns, i. Read More

View Article and Full-Text PDF
October 2021

Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study.

Lancet Reg Health West Pac 2021 Aug 5;13:100188. Epub 2021 Jul 5.

Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Background: Spirometric lung function impairment is an independent predictor of respiratory and cardiovascular disease, and mortality across a broad range of socioeconomic backgrounds and environmental settings. No contemporary studies have explored these relationships in a predominantly regional/remote First Nations population, whose health outcomes are worse than for non-First Nations populations, and First Nations people living in urban centres.

Methods: This was a retrospective cohort study of 1,734 adults (1,113 First Nations) referred to specialist respiratory outreach clinics in the state of Queensland, Australia from February 2012 to March 2020. Read More

View Article and Full-Text PDF

Effects of the Brazilian tax reform plans on the tobacco market.

Tob Control 2021 Sep 15. Epub 2021 Sep 15.

School of Public Policy and Government, Getulio Vargas Foundation, Brasília, Distrito Federal, Brazil.

Background: There has been an intense debate in the Brazilian National Congress on how to reform the country's tax system on consumption. This paper investigates the effects of the tax reform under the Constitutional Amendment Bill 45/2019 on cigarette prices, consumption and tax collection. The reform will introduce a new goods and services tax (GST) and tobacco excise tax (TET). Read More

View Article and Full-Text PDF
September 2021

Effect of tobacco outlet density on quit attempts in Korea: a multi-level analysis of the 2015 Korean Community Health Survey.

Epidemiol Health 2021 3;43:e2021048. Epub 2021 Aug 3.

Department of Public Health Sciences, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, Korea.

Objectives: This study aimed to examine whether the regional density of tobacco outlets in Korea was associated with the likelihood of attempting to quit among smokers.

Methods: This study was designed as a secondary data analysis of a cross-sectional study. Data from the 2015 Korean Community Health Survey and tobacco outlet registrations in 17 metropolitan cities and provinces with 254 communities in Korea were used for the analysis. Read More

View Article and Full-Text PDF

Stable isotope fractionation of thallium as novel evidence for its geochemical transfer during lead‑zinc smelting activities.

Sci Total Environ 2021 Sep 2;803:150036. Epub 2021 Sep 2.

Department of Civil and Environmental Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.

Thallium (Tl) is a highly toxic trace metal. Lead (Pb)‑zinc (Zn) smelting, which is a pillar industry in various countries, is regarded as one of the dominant anthropogenic sources of Tl contamination in the environment. In this study, thallium isotope data have been evaluated for raw material and a set of industrial wastes produced at different stages of Pb-Zn smelting in a representative large facility located by the North River, South China, in order to capture Tl isotope signatures of such typical anthropogenic origin for laying the foundation of tracking Tl pollution. Read More

View Article and Full-Text PDF
September 2021

A Comprehensive Qualitative Review of Studies Evaluating the Impact of Local US Laws Restricting the Sale of Flavored and Menthol Tobacco Products.

Nicotine Tob Res 2021 Sep 15. Epub 2021 Sep 15.

Truth Initiative Schroeder Institute, Washington, DC USA.

Objectives: To assess the quality of evidence on the effectiveness of local US laws restricting the sale of flavored tobacco products.

Methods: We conducted a systematic search and qualitative scoping review of English-language papers published through May 2020 that evaluated flavored tobacco sales policies implemented by US jurisdictions during 2010-2019. We constructed a conceptual model for flavored and menthol tobacco sales restriction outcomes, assigned GRADE quality of evidence ratings to policy outcomes evaluated through the included studies, and summarized factors that might explain weak or inconsistent findings. Read More

View Article and Full-Text PDF
September 2021

COVID-19 transmission and the safety of air travel during the pandemic: a scoping review.

Curr Opin Infect Dis 2021 Oct;34(5):415-422

Institute of Preventive and Social Medicine, University of Bern, Switzerland.

Purpose Of Review: To examine the literature assessing safety of air travel relating to coronavirus disease 2019 (COVID-19) transmission from January 2020 to May 2021. The COVID-19 pandemic has had an unprecedented impact on air travel and global mobility, and various efforts are being implemented to determine a safe way forward. As the pandemic evolves, so do the challenges that force various stakeholders, including the aviation industry, health authorities, and governments, to reassess and adapt their practices to ensure the safety of travellers. Read More

View Article and Full-Text PDF
October 2021

Grass Carp Reovirus VP56 Allies VP4, Recruits, Blocks, and Degrades RIG-I to More Effectively Attenuate IFN Responses and Facilitate Viral Evasion.

Microbiol Spectr 2021 Sep 15:e0100021. Epub 2021 Sep 15.

Department of Aquatic Animal Medicine, College of Fisheries, Huazhong Agricultural Universitygrid.35155.37, Wuhan, China.

Grass carp reovirus (GCRV), the most virulent aquareovirus, causes epidemic hemorrhagic disease and tremendous economic loss in freshwater aquaculture industry. VP56, a putative fibrin inlaying the outer surface of GCRV-II and GCRV-III, is involved in cell attachment. In the present study, we found that VP56 localizes at the early endosome, lysosome, and endoplasmic reticulum, recruits the cytoplasmic viral RNA sensor retinoic acid-inducible gene I (RIG-I) and binds to it. Read More

View Article and Full-Text PDF
September 2021

The asymmetric effect eco-innovation and tourism towards carbon neutrality target in Turkey.

J Environ Manage 2021 Sep 9;299:113653. Epub 2021 Sep 9.

Transilvania University of Brasov, Brașov, Romania. Electronic address:

After the Paris Climate Conference (Conference of the Paris COP21), emerging countries also start progressing as the world has shown serious concern towards carbon neutrality targets. In doing this, the tourism and hospitality businesses have also emerged as an industry that has shown tremendous economic positive outputs and support to an economy with the lease inputs. However, tourism has also been reported to lead to increased environmental degradation as foreigners came to the host country, whereby ecological innovation emerged as a potential solution for eliminating the level of carbon emissions. Read More

View Article and Full-Text PDF
September 2021

2D/2D FeNi-layered double hydroxide/bimetal-MOFs nanosheets for enhanced photo-Fenton degradation of antibiotics: Performance and synergetic degradation mechanism.

Chemosphere 2021 Sep 1;287(Pt 1):132061. Epub 2021 Sep 1.

College of Environmental Science and Engineering, Hunan University, Changsha, 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, PR China.

The photo-Fenton system exhibits great potential in environmental remediation. However, photo-Fenton process suffers from slow reaction kinetics, which is caused by the low yield of available charge carriers and active radicals. In this work, the 2D/2D FeNi-layered double hydroxide/bimetal-organic frameworks nanosheets (FeNi-LDH/BMNSs) photocatalyst was fabricated via an in-situ semi-sacrificial template strategy. Read More

View Article and Full-Text PDF
September 2021

COVID-19 challenges: from SARS-CoV-2 infection to effective point-of-care diagnosis by electrochemical biosensing platforms.

Biochem Eng J 2021 Sep 9:108200. Epub 2021 Sep 9.

Laboratório de Imunopatologia Keizo Asami - LIKA/ UFPE, Av. Prof. Moraes Rego, s/n, CEP: 506070-901, Recife, PE, Brazil.

In January 2020, the World Health Organization (WHO) identified a new zoonotic virus, SARS-CoV-2, responsible for causing the COVID-19 (coronavirus disease 2019). Since then, there has been a collaborative trend between the scientific community and industry. Multidisciplinary research networks try to understand the whole SARS-CoV-2 pathophysiology and its relationship with the different grades of severity presented by COVID-19. Read More

View Article and Full-Text PDF
September 2021

Difficulties with Workplace Support for a Patient with Frontotemporal Dementia: A Case Report.

Int Med Case Rep J 2021 7;14:621-625. Epub 2021 Sep 7.

Cyclotron Radioisotope Center, Tohoku University, Sendai, Miyagi, Japan.

A 59-year-old, right-handed woman made many mistakes in her job in a pharmacy, despite having considerable experience working in this setting. She had a can-do attitude, but also showed no sign of remorse when she failed. Other staff grew impatient with her and she was diagnosed with frontotemporal dementia based on clinical and brain imaging findings. Read More

View Article and Full-Text PDF
September 2021

Methodological Considerations in the Assessment of Effectiveness of Homeopathic Care: A Critical Review of the EPI3 Study.

Authors:
Yola Moride

Homeopathy 2021 Sep 14. Epub 2021 Sep 14.

Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada.

Background:   EPI3 is an observational study of a representative sample of general practitioners (GPs) and patients in France, demonstrating that patient characteristics differ according to the prescribing preferences of their GPs for homeopathy. For selected conditions (musculoskeletal disorders, sleep disorders, anxiety/depression, upper respiratory tract infections), progression of symptoms and adverse events over follow-up in the homeopathy preference group did not significantly differ from other practice preferences, but there was a two-fold to four-fold lower usage of conventional medicines. The EPI3 study's validity was challenged due to absence of head-to-head comparison of medicines to conclude on a causal association between homeopathy and outcomes. Read More

View Article and Full-Text PDF
September 2021

Water extract of medicinal ink (WEMI) attenuates lipopolysaccharide-induced NO production of Raw264.7 cells via downregulating JAK2/STAT3-mediated iNOS expression.

J Ethnopharmacol 2021 Sep 11;282:114636. Epub 2021 Sep 11.

Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Program in Molecular Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Biomedical Industry Ph.D. Program, National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address:

Ethnopharmacological Relevance: Medicinal ink is used as a traditional topical medicine for treating inflammatory diseases via detoxification, relieving pain, hemostasis, and reducing swelling. However, the effect of medicinal ink on the inhibition of inflammatory responses and the underlying molecular mechanism remain unclear.

Aim Of The Study: The present study aimed to investigate the anti-inflammatory function of water extract of medical ink (WEMI) and elucidate its active mechanisms. Read More

View Article and Full-Text PDF
September 2021

Evaluating the frequency of English language requirements in clinical trial eligibility criteria: A systematic analysis using ClinicalTrials.gov.

PLoS Med 2021 09 14;18(9):e1003758. Epub 2021 Sep 14.

Multi-Regional Clinical Trials Center of Brigham and Women's Hospital and Harvard, Boston, Massachusetts, United States of America.

Background: A number of prior studies have demonstrated that research participants with limited English proficiency in the United States are routinely excluded from clinical trial participation. Systematic exclusion through study eligibility criteria that require trial participants to be able to speak, read, and/or understand English affects access to clinical trials and scientific generalizability. We sought to establish the frequency with which English language proficiency is required and, conversely, when non-English languages are affirmatively accommodated in US interventional clinical trials for adult populations. Read More

View Article and Full-Text PDF
September 2021

Preventive maintenance for the flexible flowshop scheduling under uncertainty: a waste-to-energy system.

Environ Sci Pollut Res Int 2021 Sep 14. Epub 2021 Sep 14.

Department of Civil & Environmental Engineering, Florida A&M University-Florida State University (FAMU-FSU) College of Engineering, 2525 Pottsdamer Street, Building A, Suite A124, Tallahassee, FL, 32310-6046, USA.

Nowadays, an efficient and robust plan for maintenance activities can reduce the total cost significantly in the equipment-driven industry. Maintenance activities are directly associated with the impact on the plant output, production quality, production cost, safety, and the environmental performance. To address this challenge more broadly, this paper presents an optimization model for the problem of flexible flowshop scheduling in a series-parallel waste-to-energy (WTE) system. Read More

View Article and Full-Text PDF
September 2021

Trends in the Concentration and Distribution of Health Care Expenditures in the US, 2001-2018.

JAMA Netw Open 2021 Sep 1;4(9):e2125179. Epub 2021 Sep 1.

Recon Strategy, Cambridge, Massachusetts.

Importance: The concentration of health care expenditures has important implications for managing risk pools, drug benefit design, and care management.

Objective: To examine trends in the concentration of health care spending in different population groups and expenditure categories in the US between 2001 and 2018.

Design, Setting, And Participants: This study is a cross-sectional analysis of Medical Expenditure Panel Surveys (MEPS) collected between 2001 and 2018. Read More

View Article and Full-Text PDF
September 2021