36,498 results match your criteria induction term

Impact of interval training with probiotic (L. plantarum / Bifidobacterium bifidum) on passive avoidance test, ChAT and BDNF in the hippocampus of rats with Alzheimer's disease.

Neurosci Lett 2021 May 8:135949. Epub 2021 May 8.

Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

It has been suggested that gut microbiota dysbiosis can lead to Alzheimer's disease (AD), inducing the production of many AD-related pre-inflammatory cytokines. On the other hand, daily probiotic administration and regular exercise training are assumed to improve clinical AD-related symptoms. To take this line of research further, this study was aimed at investigating the impact of moderate-intensity interval training (MIIT) with a combined administration of Lactobacillus plantarum and Bifidobacterium bifidum (probiotic, BROB) on the passive avoidance test (Shuttle Box), choline acetyltransferase (ChAT) and the brain derived neurotrophic factor (BDNF) in the hippocampus of a rat model of AD. Read More

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Hypertrophic Preconditioning Attenuates Myocardial Ischaemia-Reperfusion Injury by Modulating SIRT3-SOD2-mROS-Dependent Autophagy.

Cell Prolif 2021 May 11:e13051. Epub 2021 May 11.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Ischaemic preconditioning elicited by brief periods of coronary occlusion and reperfusion protects the heart from a subsequent prolonged ischaemic insult. Here, we test the hypothesis that short-term non-ischaemic stimulation of hypertrophy renders the heart resistant to subsequent ischaemic injury.

Methods And Results: Transient transverse aortic constriction (TAC) was performed for 3 days in mice and then withdrawn for 4 days by aortic debanding, followed by subsequent exposure to myocardial ischaemia-reperfusion (I/R) injury. Read More

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Revisiting the classification of squamate adhesive setae: historical, morphological and functional perspectives.

R Soc Open Sci 2021 Feb 17;8(2):202039. Epub 2021 Feb 17.

Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada T2N 1N4.

Research on gecko-based adhesion has become a truly interdisciplinary endeavour, encompassing many disciplines within the natural and physical sciences. Gecko adhesion occurs by the induction of van der Waals intermolecular (and possibly other) forces between substrata and integumentary filaments (setae) terminating in at least one spatulate tip. Gecko setae have increasingly been idealized as structures with uniform dimensions and a particular branching pattern. Read More

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February 2021

Evaluation of mitochondria in mouse oocytes following cisplatin exposure.

J Ovarian Res 2021 May 10;14(1):65. Epub 2021 May 10.

Ovarian Biology Laboratory, Biomedicine Discovery Institute, Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.

Background: Cisplatin is a platinum-based chemotherapeutic that damages genomic DNA leading to cell death. It also damages mitochondrial DNA and induces high levels of mitochondrial reactive oxygen species (mtROS), further sensitising cells to apoptosis. Notably, immature oocytes are particularly vulnerable to cisplatin treatment, a common side effect of which is depletion of the primordial follicle reserve, leading to infertility and early menopause. Read More

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Donor Recipient Chimeric Cells Induce Chimerism and Extend Survival of Vascularized Composite Allografts.

Arch Immunol Ther Exp (Warsz) 2021 May 10;69(1):13. Epub 2021 May 10.

Department of Orthopaedics, University of Illinois At Chicago, Molecular Biology Research Building, 900 S. Ashland Ave. Room# 3356, Chicago, IL, 60607, USA.

This study evaluated the efficacy of donor recipient chimeric cell (DRCC) therapy created by fusion of donor and recipient derived bone marrow cells (BMC) in chimerism and tolerance induction in a rat vascularized composite allograft (VCA) model. Twenty-four VCA (groin flaps) from MHC-mismatched ACI (RT1) donors were transplanted to Lewis (RT1) recipients. Rats were randomly divided into (n = 6/group): Group 1-untreated controls, Groups 2-7-day immunosuppression controls, Group 3-DRCC, and Group 4-DRCC with 7-day anti-αβTCR monoclonal antibody and cyclosporine A protocol. Read More

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Cesarean delivery at term for non-reassuring fetal heart rate tracing: risk factors and predictability.

J Matern Fetal Neonatal Med 2021 May 9:1-7. Epub 2021 May 9.

Department of Obstetrics, Gynecology, and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objective: To delineate risk factors for adverse outcomes among those who underwent cesarean delivery (CD) for non-reassuring fetal heart rate tracing (NRFHT) and ascertain whether neonatal or maternal morbidity can be predicted accurately.

Methods: The Consortium on Safe Labor Database was utilized for this secondary analysis. Inclusion criteria were non-anomalous, singleton gestations between 37. Read More

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Development of Donor Recipient Chimeric Cells of bone marrow origin as a novel approach for tolerance induction in transplantation.

Stem Cell Investig 2021 19;8. Epub 2021 Apr 19.

Department of Orthopaedics, University of Illinois at Chicago, Chicago, IL, USA.

Background: Cell therapies and chimerism-based strategies are currently the most successful approach for tolerance induction in transplantation. This study aimed to establish and characterize novel Donor Recipient Chimeric Ccell (DRCC) therapy of bone marrow (BM) origin presenting donor-recipient phenotype to support tolerance induction.

Methods: fusions of fully MHC-mismatched BM cells from ACI (RT1) and Lewis (RT1) rats were performed using polyethylene-glycol (PEG). Read More

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Persistent DNA Double-Strand Breaks After Repeated Diagnostic CT Scans in Breast Epithelial Cells and Lymphocytes.

Front Oncol 2021 23;11:634389. Epub 2021 Apr 23.

Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.

DNA double-strand break (DSB) induction and repair have been widely studied in radiation therapy (RT); however little is known about the impact of very low exposures from repeated computed tomography (CT) scans for the efficiency of repair. In our current study, DSB repair and kinetics were investigated in side-by-side comparison of RT treatment (2 Gy) with repeated diagnostic CT scans (≤20 mGy) in human breast epithelial cell lines and lymphoblastoid cells harboring different mutations in known DNA damage repair proteins. Immunocytochemical analysis of well known DSB markers H2AX and 53BP1, within 48 h after each treatment, revealed highly correlated numbers of foci and similar appearance/disappearance profiles. Read More

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Dopaminergic Neuromodulation of Spike Timing Dependent Plasticity in Mature Adult Rodent and Human Cortical Neurons.

Front Cell Neurosci 2021 22;15:668980. Epub 2021 Apr 22.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Synapses in the cerebral cortex constantly change and this dynamic property regulated by the action of neuromodulators such as dopamine (DA), is essential for reward learning and memory. DA modulates spike-timing-dependent plasticity (STDP), a cellular model of learning and memory, in juvenile rodent cortical neurons. However, it is unknown whether this neuromodulation also occurs at excitatory synapses of cortical neurons in mature adult mice or in humans. Read More

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Stress-Induced Enhanced Long-Term Potentiation and Reduced Threshold for N-Methyl-D-Aspartate Receptor- and β-Adrenergic Receptor-Mediated Synaptic Plasticity in Rodent Ventral Subiculum.

Front Mol Neurosci 2021 22;14:658465. Epub 2021 Apr 22.

Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Stress is a biologically relevant signal and can modulate hippocampal synaptic plasticity. The subiculum is the major output station of the hippocampus and serves as a critical hub in the stress response network. However, stress-associated synaptic plasticity in the ventral subiculum has not been adequately addressed. Read More

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Regulation of Long-Term Courtship Memory by Ecdysis Triggering Hormone.

Front Neurosci 2021 22;15:670322. Epub 2021 Apr 22.

Neuroscience Graduate Program, University of California, Riverside, Riverside, CA, United States.

Endocrine state is an important determinant of learning and memory in animals. In , rejection of male courtship overtures by mated females leads to an aversive response manifested as courtship memory. Here we report that ecdysis triggering hormone (ETH) is an obligatory enabler of long-term courtship memory (LTM). Read More

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Colligation in modelling practices: From Whewell's tides to the San Francisco Bay Model.

Stud Hist Philos Sci 2021 Feb 30;85:1-15. Epub 2020 Dec 30.

Technical University Berlin, Straße des 17. Juni 135 10623 Berlin, Germany. Electronic address:

"Colligation", a term first introduced in philosophy of science by William Whewell (1840), today sparks a renewed interest beyond Whewell scholarship. In this paper, we argue that adopting the notion of colligation in current debates in philosophy of science can contribute to our understanding of scientific models. Specifically, studying colligation allows us to have a better grasp of how integrating diverse model components (empirical data, theory, useful idealization, visual and other representational resources) in a creative way may produce novel generalizations about the phenomenon investigated. Read More

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February 2021

The degree of cervical length shortening as a predictor of successful or failed labor induction.

Taiwan J Obstet Gynecol 2021 May;60(3):503-508

Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Objective: To evaluate whether the degree of cervical length change was associated with successful cervical dilatation during labor induction.

Materials And Methods: We conducted a secondary analysis of a prospective observational study of term singleton pregnant women who underwent labor inductions. Cases of Cesarean section due to fetal distress or maternal request during the first stage of labor were excluded. Read More

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Early onset senescence and cognitive impairment in a murine model of repeated mTBI.

Acta Neuropathol Commun 2021 May 8;9(1):82. Epub 2021 May 8.

Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Canada.

Mild traumatic brain injury (mTBI) results in broad neurological symptoms and an increased risk of being diagnosed with a neurodegenerative disease later in life. While the immediate oxidative stress response and post-mortem pathology of the injured brain has been well studied, it remains unclear how early pathogenic changes may drive persistent symptoms and confer susceptibility to neurodegeneration. In this study we have used a mouse model of repeated mTBI (rmTBI) to identify early gene expression changes at 24 h or 7 days post-injury (7 dpi). Read More

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Hippocampal subfield-specific Homer1a expression is triggered by learning-facilitated long-term potentiation and long-term depression at medial perforant path synapses.

Hippocampus 2021 May 8. Epub 2021 May 8.

Medical Faculty, Department of Neurophysiology, Ruhr University Bochum, Bochum, Germany.

Learning about general aspects, or content details, of space results in differentiated neuronal information encoding within the proximodistal axis of the hippocampus. These processes are tightly linked to long-term potentiation (LTP) and long-term depression (LTD). Here, we explored the precise sites of encoding of synaptic plasticity in the hippocampus that are mediated by information throughput from the perforant path. Read More

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Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8 T cells.

Biomaterials 2021 Apr 27;274:120844. Epub 2021 Apr 27.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, 48109, USA; Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Identification of tumor-specific mutations, called neoantigens, offers new exciting opportunities for personalized cancer immunotherapy. However, it remains challenging to achieve robust induction of neoantigen-specific T cells and drive their infiltration into the tumor microenvironment (TME). Here, we have developed a novel polyethyleneimine (PEI)-based personalized vaccine platform carrying neoantigen peptides and CpG adjuvants in a compact nanoparticle (NP) for their spatio-temporally concerted delivery. Read More

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Hydrogen sulfide attenuates induction and prevents progress of the 6-hydroxydopamine-induced Parkinsonism in rat through activation of ATP-sensitive potassium channels and suppression of ER stress.

Toxicol Appl Pharmacol 2021 May 4:115558. Epub 2021 May 4.

Cellular and Molecular Research Center, Research Institute for Prevention of Non-Communicable Disease, Qazvin University of Medical Sciences, Qazvin, Iran.

Purpose: Studies argue in favor of hydrogen sulfide (HS) as the next potent therapeutic agent for neurodegenerative diseases. In present study, we investigated the effect of long term treatment with NaHS (as donor of HS) on induction and progress of the 6-hydroxydopamine (6-OHDA) -induced Parkinsonism in rat.

Methods: The 6-OHDA was injected into medial forebrain bundle of right hemisphere by stereotaxic surgery. Read More

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UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder.

Biochem Pharmacol 2021 May 4:114592. Epub 2021 May 4.

Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China. Electronic address:

UGT1A1 is the only enzyme that can metabolize bilirubin, and its encoding gene is frequently mutated. UGT1A1*6 (G71R) is a common mutant in Asia which leads to the decrease of UGT1A1 activity and abnormal bilirubin metabolism. However, it is not clear whether low UGT1A1 activity-induced bilirubin metabolism disorder increases hepatocyte fragility. Read More

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Light Promotes Neural Correlates of Fear Memory via Enhancing Brain-Derived Neurotrophic Factor (BDNF) Expression in the Prelimbic Cortex.

ACS Chem Neurosci 2021 May 7. Epub 2021 May 7.

Behavioral Neuroscience Laboratory, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China.

Exposure to light has been shown to enhance vigilance and improve working memory, possibly due to changes in prefrontal function. Ample evidence supports the critical role of prefrontal cortex (PFC) in fear memory performance. However, the effects of light on memory processing and its potential mechanisms remain unclear. Read More

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An Experimental Liver Metastasis Mouse Model Suitable for Short and Long-Term Intravital Imaging.

Curr Protoc 2021 May;1(5):e116

Department of Cell and Chemical Biology and Oncode Institute, Leiden University Medical Center, 2333ZC Leiden, the Netherlands.

The liver is a frequent site of cancer metastasis, but current treatment options for cancer patients with liver metastasis are limited, resulting in poor prognosis. Colonization of the liver by cancer cells is a multistep and temporally controlled process. Investigating this process in biological relevant settings in a dynamic manner may lead to new therapeutic avenues. Read More

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Short-term Intensive Insulin as Induction and Maintenance Therapy for the Preservation of Beta-cell Function in early Type 2 Diabetes (RESET IT): A 2-year Randomized Controlled Trial.

Diabetes Obes Metab 2021 May 6. Epub 2021 May 6.

Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada.

Aims: When administered in early T2DM, short-term intensive insulin therapy (IIT) can improve reversible beta-cell dysfunction and induce remission of diabetes, but these effects are not permanent. To preserve beta-cell function, we have previously suggested that "induction" IIT should be followed by a "maintenance therapy", such as metformin. Herein, we test the hypothesis that the addition of periodic courses of short-term IIT could enhance the effect of metformin maintenance therapy on preservation of beta-cell function following induction IIT. Read More

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Association of Risk Factors With Patient-Reported Voice and Speech Symptoms Among Long-term Survivors of Oropharyngeal Cancer.

JAMA Otolaryngol Head Neck Surg 2021 May 6. Epub 2021 May 6.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: Voice and speech production are critical physiological functions that affect quality of life and may deteriorate substantially after oropharyngeal cancer (OPC) treatment. There is limited knowledge about risk factors associated with voice and speech outcomes among survivors of OPC.

Objective: To identify the risk factors of voice and speech symptoms among long-term survivors of OPC. Read More

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Dinoprostone pessary for labor induction in Chinese patients with premature rupture of membranes at term: A retrospective cohort.

J Obstet Gynaecol Res 2021 May 5. Epub 2021 May 5.

Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Aim: Whether the use of dinoprostone pessary increased the vaginal delivery rate of labor induction in Chinese nulliparous women with term premature rupture of membranes (PROM) and unfavorable cervices?

Methods: PROM women at term with singleton pregnancies and Bishop scores ≤4 who needed labor induction were enrolled in this retrospective study. They received either the dinoprostone pessary followed by oxytocin infusion if necessary (n = 102, PGE2 group) or oxytocin infusion alone (n = 103, oxytocin group).

Results: Compared with oxytocin infusion alone, vaginal delivery within 12 h and total vaginal delivery were higher in the PGE2 group (28. Read More

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Does steroid-free immunosuppression improve the outcome in kidney transplant recipients compared to conventional protocols?

World J Transplant 2021 Apr;11(4):99-113

Department of Transplantation, Sheffield Teaching Hospitals, Sheffield S5 7AU, United Kingdom.

Steroids continue to be the cornerstone of immune suppression since the early days of organ transplantation. Steroids are key component of induction protocols, maintenance therapy and in the treatment of various forms of rejection. Prolonged steroid use resulted in significant side effects on almost all the body organs owing to the presence of steroid receptors in most of the mammalian cells. Read More

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Role of ILC2 in Viral-Induced Lung Pathogenesis.

Front Immunol 2021 19;12:675169. Epub 2021 Apr 19.

Department of Pathology, University of Michigan, Ann Arbor, MI, United States.

Innate lymphoid type-2 cells (ILC2) are a population of innate cells of lymphoid origin that are known to drive strong Type 2 immunity. ILC2 play a key role in lung homeostasis, repair/remodeling of lung structures following injury, and initiation of inflammation as well as more complex roles during the immune response, including the transition from innate to adaptive immunity. Remarkably, dysregulation of this single population has been linked with chronic lung pathologies, including asthma, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrotic diseases (IPF). Read More

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Vitamin C Enema Advances Induction of Remission in the Dextran Sodium Sulfate-Induced Colitis Model in Rats.

J Nutr Sci Vitaminol (Tokyo) 2021 ;67(2):91-98

Graduate School of Agricultural and Life Science, Kindai University.

The current main treatment for ulcerative colitis (UC) is induction therapy by long-term administration of 5-aminosalicylic acid (5-ASA), but various side effects have been reported. Therefore, a radical cure for UC is desired. A vitamin C (VC) has anti-inflammatory effects. Read More

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January 2021

Association of chorioamnionitis with failed conversion of epidural labor analgesia to cesarean delivery anesthesia: A retrospective cohort study.

PLoS One 2021 5;16(5):e0250596. Epub 2021 May 5.

Department of Anesthesiology, Juntendo University Hospital, Hongo, Bunkyo-ku, Tokyo, Japan.

Aim: This study aimed to examine the association between clinically diagnosed chorioamnionitis and failed conversion of epidural labor analgesia to cesarean delivery anesthesia.

Methods: This retrospective, single-center cohort study, conducted in a university hospital, enrolled term parturients undergoing emergency cesarean section after induction of epidural labor analgesia between September 2015 and May 2019. For the purpose of this study, all cases were re-examined to ensure that they fulfilled the criteria of chorioamnionitis, regardless of the actual indication for cesarean section proposed by obstetricians at the time of application. Read More

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Air-gap embedded triboelectric nanogenerator surface modification of non-contact layer using sandpapers.

Nanoscale 2021 May 5. Epub 2021 May 5.

Department of Electronic Engineering, Institute for Wearable Convergence Electronics, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin 17104, Republic of Korea.

With the increased number of small electronics and demand for their energy source, renewable energy sources have received much attention. Above all, a triboelectric nanogenerator (TENG) based on the combination of contact electrification and electrostatic induction has been researched as a method of converting mechanical energy into electricity. In order to increase the electrical output of TENGs with raising the surface charge density, a lot of researchers have focused on the fabrication methods to employ micro-/nano-structures onto a contact surface of the TENG, but have been facing several issues regarding the degradation of the output performance from the iterative operation process. Read More

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Expression of Therapy-Induced Senescence Markers in Breast Cancer Samples Upon Incomplete Response to Neoadjuvant Chemotherapy.

Biosci Rep 2021 May 5. Epub 2021 May 5.

The University of Jordan, Amman, Jordan.

Senescence is a cell stress response induced by replicative, oxidative, oncogenic, and genotoxic stresses. Tumor cells undergo senescence in response to several cancer therapeutics in vitro (Therapy-Induced Senescence, TIS), including agents utilized as Neoadjuvant Chemotherapy (NAC) in the treatment of invasive breast cancer. TIS has been proposed to contribute to adverse therapy outcomes including relapse. Read More

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Impact of age on the circadian visual system and the sleep-wake cycle in mus musculus.

NPJ Aging Mech Dis 2021 May 4;7(1):10. Epub 2021 May 4.

Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Age plays a critical role in disease development and tolerance to cancer treatment, often leading to an increased risk of developing negative symptoms including sleep disturbances. Circadian rhythms and sleep become disrupted as organisms age. In this study, we explored the behavioral alterations in sleep, circadian rhythms, and masking using a novel video system and interrogate the long-term impact of age-based changes in the non-image forming visual pathway on brain anatomy. Read More

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