Brain Res 2021 Jun 6:147557. Epub 2021 Jun 6.
Laboratory of Pharmacology of Pain, Department of Pharmacology, Federal University of Paraná, 81531-170 Curitiba, PR, Brazil. Electronic address:
Neuropathic pain, depression, and anxiety are common comorbidities in diabetic patients, whose pathophysiology involves hyperglycemia-induced increased oxidative stress. Bixin (BIX), an apocarotenoid extracted from the seeds of Bixa orellana, has been used in traditional medicine to treat diabetes and has been recognized by its antioxidant profile. We aimed to investigate the effect of the BIX over the mechanical allodynia, depressive, and anxious-like behaviors associated with experimental diabetes, along with its involved mechanisms. Read More