553,397 results match your criteria induced rats


Protection of Beta Boswellic Acid against Streptozotocin-induced Alzheimer's Model by Reduction of Tau Phosphorylation Level and Enhancement of Reelin Expression.

Planta Med 2021 Jun 11. Epub 2021 Jun 11.

Laboratory of Neuro-organic Chemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.

Alzheimer's disease is a growing general health concern with huge implications for individuals and society. Beta boswellic acid, a major compound of the plant, has long been used for the treatment of various inflammatory diseases. The exact mechanism of beta boswellic acid action in Alzheimer's disease pathogenesis remains unclear. Read More

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Increased pro-inflammatory cytokines in ovary and effect of γ-linolenic acid on adipose tissue inflammation in a polycystic ovary syndrome model.

J Reprod Immunol 2021 Jun 5;146:103345. Epub 2021 Jun 5.

Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India. Electronic address:

Polycystic Ovary Syndrome (PCOS), a major endocrine disorder, affects the reproductive function of a woman, along with an association with metabolic conditions like insulin resistance and inflammation. The inflammatory nature of PCOS is much debated over, owing to numerous cases of elevation in cytokine levels. Studies have shown the beneficiary effect of Gamma-Linolenic acid (GLA) in reducing inflammation related to many conditions such as atopic dermatitis, rheumatoid arthritis, arterial disease, obesity, and even PCOS. Read More

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Effects of gonadal status and the estrogen milieu on hypothalamic oxytocin gene expression and serum oxytocin levels in female rats.

Horm Behav 2021 Jun 8;133:105005. Epub 2021 Jun 8.

Department of Obstetrics and Gynecology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-Cho, Tokushima 770-8503, Japan. Electronic address:

Oxytocin (OT) and its receptor (OTR) play various roles in the central and peripheral regulation of appetite and body weight. Previously, we have shown that the administration of OT markedly decreased appetite and body weight gain in ovariectomized (OVX) obese rats. In addition, recent studies have shown that the endogenous OT system is also affected by endogenous or exogenous estrogen. Read More

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Toxicologic effect and transcriptome analysis for short-term orally dosed enrofloxacin combined with two veterinary antimicrobials on rat liver.

Ecotoxicol Environ Saf 2021 Jun 8;220:112398. Epub 2021 Jun 8.

College of Veterinary Medicine, China Agricultural University, Beijing 100193, China; Beijing Key Laboratory of Animal-derived Food Safety Testing Technology, Beijing 100193, China; Chinese National Reference Laboratory for Veterinary Drug Residues, Beijing 100193, China. Electronic address:

Presently, toxicological assessment of multiple veterinary antimicrobials has not been performed on mammals. In this study, we assessed the short-term toxicity of enrofloxacin (E) combined with colistin (C) and quinocetone (Q). Young male rats were orally dosed drug mixtures and single drugs in 14 consecutive days, each at the dose of 20, 80, and 400 mg/(kg·BW) for environmental toxicologic study. Read More

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Telmisartan induces a specific gut microbiota signature which may mediate its antiobesity effect Anti-obesity effect of telmisartan and the gut microbiota.

Pharmacol Res 2021 Jun 8:105724. Epub 2021 Jun 8.

Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Germany; DZHK (German Centre for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck, Lübeck, Germany; CBBM (Center of Brain, Behavior and Metabolism). Electronic address:

Telmisartan prevents diet-induced obesity (DIO) in rodents. Given that the precise underlying mechanism is not known, we examined whether a gut-related mechanism might be involved. Sprague-Dawley rats received cafeteria diet (CD) for 3 months to develop DIO and were administered either telmisartan (8mg/kg) or vehicle. Read More

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Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins.

J Ethnopharmacol 2021 Jun 8:114315. Epub 2021 Jun 8.

Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India. Electronic address:

Ethnopharmacological Relevance: Dalbergia sissoo DC. (Indian rosewood or Sheesham) is a traditional medicinal plant, reported since time immemorial for its analgesic, anti-nociceptive, anti-inflammatory, and immuno-modulatory properties. D. Read More

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Subregion-specific effects on striatal neurotransmission and dopamine-signaling by acute and repeated amphetamine exposure.

Neuropharmacology 2021 Jun 8:108638. Epub 2021 Jun 8.

Addiction Biology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden; Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy University of Gothenburg, Sweden. Electronic address:

Repeated administration of psychostimulants, such as amphetamine, is associated with a progressive increased sensitivity to some of the drug's effects, but tolerance towards others. We hypothesized that these adaptations in part could be linked to differential effects by amphetamine on dopaminergic signaling in striatal subregions. To test this theory, acute and long-lasting changes in dopaminergic neurotransmission were assessed in the nucleus accumbens (nAc) and the dorsomedial striatum (DMS) following amphetamine exposure in Wistar rats. Read More

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REVISITING THE ACUTE KIDNEY INJURY IN WISTAR RATS EXPERIMENTALLY ENVENOMATED WITY Bothrops jararacussu VENOM.

Toxicon 2021 Jun 8. Epub 2021 Jun 8.

Programa de Pós-graduação em Farmacologia e Química Medicinal, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil. Electronic address:

There is no consensus on whether serotherapy prevents acute kidney injury (AKI) and there is no pharmacotherapy to impede the disease. We aimed to elaborate an AKI model induced by the administration of Bothrops jararacussu (Bj) venom for preclinical studies. Male Wistar rats were randomly divided into 3 different groups: (1) Bj-IV: intravenous administration of 0. Read More

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Kidney Injury in a Hemodilution Model of Hemorrhagic Shock and Fluid Resuscitation.

Am J Med Sci 2021 Jun 8. Epub 2021 Jun 8.

Department of Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China. Electronic address:

Background: Fluid therapy is indispensable in treating patients with hemorrhagic shock. However, fluid overload correlates with kidney injury in patients with hemorrhagic shock. We hypothesized that hemodilution after fluid treatment contributes to the kidney injury. Read More

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Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis and ERK activation.

FEBS Open Bio 2021 Jun 11. Epub 2021 Jun 11.

Department of Emergency, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

ATP-sensitive potassium channels (KATPs) have protective effects in ischemia-reperfusion-induced injuries and can be activated by levosimendan. This study investigated the effects of levosimendan on renal injury, inflammation, apoptosis and survival in a rat model of acute kidney injury (AKI) following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). Rats underwent a 5-minute asphyxia-based CA and resuscitation. Read More

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Downhill Running Decreases the Acetylation of Tubulins and Impairs Autophagosome Degradation in Rat Skeletal Muscle.

Med Sci Sports Exerc 2021 Jun 11. Epub 2021 Jun 11.

School of Sports Science, Beijing Sport University, Beijing, CHINA College of Rehabilitation, Gannan Medical University, Ganzhou, CHINA.

Purpose: This study was designed to probe the effect of downhill running on microtubule acetylation and autophagic flux in rat skeletal muscle.

Methods: Sprague-Dawley rats were subjected to an exercise protocol of a 90-min downhill run with a slope of -16° and a speed of 16 m/min, and then the soleus was sampled at 0 h, 12 h, 24 h, 48 h, and 72 h after exercise. Protein expression levels of microtubule-associated protein 1 light chain 3 (LC3), p62/sequestosome 1 (p62), α-tubulin and acetylated α-tubulin (AcK40 α-tubulin) were detected by Western blotting. Read More

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MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway.

Bioengineered 2021 Dec;12(1):2639-2648

Department of Radiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi China.

The purpose of this study was to investigate the impact and mechanism of microRNA miR-126 on brain injury induced by blood-brain barrier (BBB) damage in septic rats. We used cecal ligation and perforation (CLP) to create a rat model of sepsis. The experimental rats were randomly divided into Control group, CLP group, CLP + miR-NC group, CLP + miR-126 group and CLP + miR-126 + NF-κB pathway agonist (PMA) group. Read More

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December 2021

Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis.

Bioengineered 2021 Dec;12(1):2676-2687

Department of Cardiovascular Internal Medicine, The Second Affiliated Hospital of Guizhou Medical University, Kaili City, Guizhou Province, China.

Myocardial cell injury caused by myocardial ischemia and reperfusion is one of the main causes of the occurrence and development of heart disease. Recent study has shown that inducing mitophagy of cardiomyocytes is a crucial method to alleviate ischemia-reperfusion injury. While, Polo-like kinase 1 (PLK1) can induce the mitophagy of breast cancer cells. Read More

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December 2021

Olive Leaf Powder Modulate Insulin Production and Circulating Adipokines in Streptozotocin Induced Diabetic Rats.

J Diet Suppl 2021 Jun 11:1-16. Epub 2021 Jun 11.

National Research Center, Cairo, Egypt.

Olives () have natural phytochemical compounds that are of great importance for their potential beneficially health effects. This study aimed to evaluate the effects of olive leaf powder (OLP) on insulin production and circulating adipokines in streptozotocin-induced diabetic rats. Forty Wistar-albino male rats, weighing 200-225 g were divided into four groups ( = 10); group I: Normal healthy rats received balanced diet; group II: Diabetic control rats receiving balanced diet; group III: Diabetic rats receiving balanced diet + standard antidiabetic drugs (metformin, 600 mg/bw) and group four: Diabetic rats received diet supplemented with 2. Read More

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Anti-inflammatory effects of paeoniflorin caused by regulation of the hif1a/miR-210/caspase1/GSDMD signaling pathway in astrocytes: a novel strategy for hypoxia-induced brain injury in rats.

Immunopharmacol Immunotoxicol 2021 Jun 11:1-9. Epub 2021 Jun 11.

The First Clinical Medical College, Lanzhou University, Lanzhou, China.

Hypoxia-induced injury is a classic symptom of obstructive sleep apnea hypopnea syndrome (OSAHS), which is a risk factor of various diseases, such as hypertension, heart failure and stroke. However, there is no effective therapy for hypoxia-induced injury or OSAHS due to the elusive mechanism involved. This study aimed to assess the effects of paeoniflorin on hypoxia-induced injury and explore the underlying mechanism. Read More

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Protection against experimental cisplatin-induced optic nerve toxicity using resveratrol: A mouse model study.

Cutan Ocul Toxicol 2021 Jun 11:1-17. Epub 2021 Jun 11.

Erzincan Binali Yildirim University Faculty of Medicine, Department of Pharmacology, 24100, Erzincan, Turkey.

To investigate the effects of resveratrol on oxidative stress and inflammation parameters and histological alterations in cisplatin-induced optic nerve damage in a mouse model. At the end of the experimental period, the rats were sacrificed with high-dose (50 mg/kg) thiopental sodium, and their optic nerves were dissected. Malondialdehyde (MDA), total glutathione (tGSH), total oxidant status (TOS), total antioxidant status (TAS), tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-KB) levels, and histopathological findings were assessed using the optic nerve tissues. Read More

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Bone healing around titanium implants in a preclinical model of bile duct ligation-induced liver injury.

Clin Oral Implants Res 2021 Jun 11. Epub 2021 Jun 11.

Department of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.

Objectives: Chronic liver disease increases the risk for periodontal disease and osteoporotic fractures, but its impacts on bone regeneration remain unknown. Herein we studied the impact of liver cirrhosis on peri-implant bone formation.

Material And Methods: A total of 20 male Wistar rats were randomly divided into two groups; one with the common bile duct ligated (BDL) and the respective sham-treated control group (SHAM). Read More

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Zhuifeng Tougu capsules improve rheumatoid arthritis symptoms in rats by regulating the toll-like receptor 2/4-nuclear factor kappa-B signaling pathway.

J Tradit Chin Med 2021 Jun;41(3):447-454

Postdoctoral Research Workstation, Hinye Pharmaceutical Co. Ltd., Hinye Pharmaceutical Co., Ltd., Changsha 410331, China.

Objective: To investigate the efficacy of Zhuifeng tougu capsules (, ZFTG) in the treatment of rheumatoid arthritis (RA) in rats and study its mechanism, focusing on the toll-like receptor 2/4-nuclear factor kappa-B (TLR2/4-NF-κB) signaling pathway.

Methods: Type Ⅱ collagen and an artificial climate box were used to construct the rat model of collagen-induced arthritis with wind-cold-dampness arthralgia syndrome. The rats were divided randomly into a control group, wind-cold-dampness syndrome model group, and high-, medium-, and low-dose ZFTG groups. Read More

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Effect of Rongchang capsule on seizure behavior, cognitive impairment, and hippocampal DNA damage and inflammatory factors in epileptic rat.

J Tradit Chin Med 2021 Jun;41(3):438-446

Department of pediatrics, Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.

Objective: To observe the behavioral changes and changes in DNA fragments and related inflammatory factors in the hippocampus of epileptic rats pretreated with Rongchang capsule ().

Methods: Eighty Sprague-Dawley rats were randomly divided into the normal group (NG), model group (MG), sodium valproate group (VG), and Rongchang capsule group (RG) (n = 20 in each group). Pentylentetrazol was administered to the MG, VG, and RG to induce epilepsy. Read More

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Full composition granules of Huanglian (Rhizoma Coptidis) decrease the serum monocyte chemotactic protein-1 and connective tissue growth factor levels and inhibit kidney nuclear factor-κB expression in rats with high-fat diet-induced diabete.

J Tradit Chin Med 2021 Jun;41(3):424-431

Department of Traditional Chinese Medicine, the Mongolian Medical and Traditional Chinese Medicine Hospital of Wuhai, Wuhai 016000, China.

Objective: To investigate the efficacy of the full composition granules of Huanglian (Rhizoma Coptidis) (FGC) on the serum monocyte chemotactic protein-1 (MCP-1) and connective tissue growth factor (CTGF) levels and kidney nuclear factor-κB (NF-κB) expression in rats with high-fat diet-induced diabetes.

Methods: Diabetes was induced in rats by feeding a high-fat chow combined with intravenous streptozotocin injection. Forty diabetic Sprague- Dawley rats were randomly assigned to a normal group (NG), model group (MG), irbesartan group (IG), and low-, middle-, and high-dosage FGC groups (LFGC, MFGC, HFGC), with eight rats per group. Read More

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Effect of compound Sophorae decoction in the treatment of ulcerative colitis by tissue extract metabolomics approach.

J Tradit Chin Med 2021 Jun;41(3):414-423

Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objective: To investigate how compound Sophorae decoction (CSD) works on rats' models of ulcerative colitis (UC) induced by 2,4,6-trinitrobenzenesulfonic acid solution (TNBS) by metabolomics studies of colon, liver, and kidney tissue extracts.

Methods: Rats with UC induced by TNBS enema were used as models in this study. Metabolic profiles of the three tissues were analyzed and pathway analysis of biomarkers was performed after CSD administration and further integration of metabolic networks. Read More

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Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum-mitochondria miscommunication.

Mol Cell Biochem 2021 Jun 10. Epub 2021 Jun 10.

Faculty of Medicine, Department of Biophysics, Ankara University, Ankara, Turkey.

Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated cardiovascular dysfunction and increased platelet P2Y12 receptor activation. Although P2Y12 receptor antagonist ticagrelor (Tica) plays roles in reduction of cardiovascular events, its beneficial mechanism remains poorly understood. Therefore, we aimed to clarify whether Tica can exert a direct protective effect in ventricular cardiomyocytes from high-carbohydrate diet-induced MetS rats, at least, through affecting sarcoplasmic reticulum (SR)-mitochondria (Mit) miscommunication. Read More

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Effects of detraining on preconditioning exercise-induced neuroprotective potential after ischemic stroke in rats.

Brain Struct Funct 2021 Jun 10. Epub 2021 Jun 10.

Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.

Preconditioning exercise prior to stroke exerts neuroprotection, which is an endogenous strategy that leads the brain cells to express several intrinsic factors and inhibits their apoptosis. However, it is unclear how long these benefits last after exercise cessation. The aim of this study was to investigate the effects of detraining on preconditioning exercise-induced neuroprotective potential after stroke. Read More

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modulates the gut microbiota and improves inflammation in type 2 diabetic rats.

Food Funct 2021 Jun 11. Epub 2021 Jun 11.

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.

This study aimed to investigate the effects of probiotic Lactobacillus paracasei NL41 on inflammation and the gut microbiota of type 2 diabetic (T2D) rats induced by high-fat diet (HFD) and low-dose streptozotocin (STZ). A T2D rat model was established by inducing Sprague-Dawley rats with HFD/STZ, followed by 12-weeks L. paracasei NL41 gavage. Read More

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Caffeine and dobutamine challenge induces bidirectional ventricular tachycardia in normal rats.

Heart Rhythm O2 2020 Dec 8;1(5):359-367. Epub 2020 Sep 8.

Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.

Background: Bidirectional ventricular tachycardia (BD-VT) is an intriguing arrhythmia, characterized by a beat-to-beat alternation of the QRS polarity on electrocardiogram. Currently there is no simple BD-VT animal model.

Objective: We report a simple animal model of BD-VT induced by caffeine and dobutamine (C+D) challenge in normal rats in which the arrhythmia can be attenuated by dantrolene (a ryanodine receptor stabilizer) treatment, but not by the pacemaker channel blocker ivabradine treatment. Read More

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December 2020

Chronic dantrolene treatment attenuates cardiac dysfunction and reduces atrial fibrillation inducibility in a rat myocardial infarction heart failure model.

Heart Rhythm O2 2020 Jun 15;1(2):126-135. Epub 2020 Jun 15.

Department of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.

Background: Cardiac ryanodine receptor 2 (RyR2) dysfunction and elevated diastolic Ca leak have been linked to arrhythmogenesis not only in inherited arrhythmia syndromes but also in acquired forms of heart disease including heart failure (HF) and atrial fibrillation (AF). Thus, stabilizing RyR2 may exert therapeutic effects in these conditions.

Objective: The purpose of this study was to investigate the effects of stabilizing RyR2 with chronic dantrolene treatment on HF development and AF inducibility in a myocardial infarction (MI)-induced HF model in rats. Read More

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Novel beta-blocker pretreatment prevents alcohol-induced atrial fibrillation in a rat model.

Heart Rhythm O2 2020 Jun 15;1(2):120-125. Epub 2020 Jun 15.

Department of Clinical Specialties, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York.

Background: A case report published in 2019 described a patient who presented with difficult-to-manage atrial fibrillation (AF) that consistently was associated with alcohol consumption. After the patient did not respond to drug therapy, a novel beta-blocker (BB) pretreatment regimen initiated immediately before alcohol consumption successfully prevented AF occurrence.

Objective: The purpose of this study was to test the hypothesis that a novel prophylactic BB therapy given before alcohol consumption could prevent AF in a rat model. Read More

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Intersectional analysis of chronic mild stress-induced lncRNA-mRNA interaction networks in rat hippocampus reveals potential anti-depression/anxiety drug targets.

Neurobiol Stress 2021 Nov 25;15:100347. Epub 2021 May 25.

Institute of Neuroscience, Chongqing Medical University, Chongqing, 400016, China.

Despite studies providing insight into the neurobiology of chronic stress, depression and anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying the common and distinct pathophysiology of these stress-induced disorders remain nonconclusive. In a previous study, we used the chronic mild stress paradigm to separate depression-susceptible, anxiety-susceptible and insusceptible rat subpopulations. In the current study, lncRNA and messenger RNA (mRNA) expression was comparatively profiled in the hippocampus of the three stress groups using microarray technology. Read More

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November 2021

Cardiac Natriuretic Peptide Profiles in Chronic Hypertension by Single or Sequentially Combined Renovascular and DOCA-Salt Treatments.

Front Physiol 2021 25;12:651246. Epub 2021 May 25.

Facultad de Farmacia y Bioquímica, Cátedras de Fisiopatología y Anatomía e Histología, Universidad de Buenos Aires, Buenos Aires, Argentina.

The involvement of natriuretic peptides was studied during the hypertrophic remodeling transition mediated by sequential exposure to chronic hemodynamic overload. We induced hypertension in rats by pressure (renovascular) or volume overload (DOCA-salt) during 6 and 12 weeks of treatment. We also studied the consecutive combination of both models in inverse sequences: RV 6 weeks/DS 6 weeks and DS 6 weeks/RV 6 weeks. Read More

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Blockade of β-Adrenergic Receptors by Propranolol Disrupts Reconsolidation of Drug Memory and Attenuates Heroin Seeking.

Front Pharmacol 2021 25;12:686845. Epub 2021 May 25.

National Institute on Drug Abuse, Molecular Targets and Medications Discovery Branch, Baltimore, MD, United States.

Persistent traces of drug reward memories contribute to intense craving and often trigger relapse. A number of pharmacological interventions on drug-associated memories have shown significant benefits in relapse prevention at a preclinical level but their translational potential is limited due to deleterious side effects. Propranolol, a non-specific β-adrenergic receptors antagonist, is known for its ability to erase maladaptive memories associated with nicotine or cocaine in rodents and humans. Read More

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