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Biocide-tolerance and antibiotic-resistance in community environments and risk of direct transfers to humans: Unintended consequences of community-wide surface disinfecting during COVID-19?

Environ Pollut 2021 Apr 3;283:117074. Epub 2021 Apr 3.

Department of Environmental Science and Engineering, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, 730000, PR China.

During the current pandemic, chemical disinfectants are ubiquitously and routinely used in community environments, especially on common touch surfaces in public settings, as a means of controlling the virus spread. An underappreciated risk in current regulatory guidelines and scholarly discussions, however, is that the persisting input of chemical disinfectants can exacerbate the growth of biocide-tolerant and antibiotic-resistant bacteria on those surfaces and allow their direct transfers to humans. For COVID-19, the most commonly used disinfecting agents are quaternary ammonium compounds, hydrogen peroxide, sodium hypochlorite, and ethanol, which account for two-thirds of the active ingredients in current EPA-approved disinfectant products for the novel coronavirus. Read More

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Surface engineering induced superstructure TaO mesocrystals for enhanced visible light photocatalytic antibiotic degradation.

J Colloid Interface Sci 2021 Mar 24;596:468-478. Epub 2021 Mar 24.

Henan Engineering Research Center of Resource & Energy Recovery from Waste, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. Electronic address:

Mesocrystals are types of fascinating multifunctional materials in fabricating rapid charge transport pathways, and surface engineering could be considered as a significant influencing factor in boosting charge separation for efficient photocatalytic application. In this work, surface engineered TaO mesocrystals were synthesized by facile alkali treatment strategy for enhanced visible light photocatalytic tetracycline degradation. The highly enhanced photocatalytic activity could be attributed to the highly increased surface areas and surface hydroxyl groups to compare with those of commercial TaO and pristine TaO mesocrystals, which could provide more surface reactive sites and high electron density center for trapping photo-generated holes. Read More

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Gut-specific arylphorin mediates midgut regenerative response against cry-induced damage in Achaea janata.

Comp Biochem Physiol B Biochem Mol Biol 2021 Apr 10:110600. Epub 2021 Apr 10.

Department of Human Genetics and Molecular Medicine, School of Health Sciences, Central University of Punjab, Ghudda, Bathinda 151401, India.

Development of insect resistance to biopesticides is a current and pertinent global issue. Earlier, it was established that lepidopteran larvae can recover from Bt intoxication via a midgut regenerative response and subsequently generate resistance. Molecular aspects of restoration of the midgut integrity following toxin exposure are emerging recently. Read More

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ENTPD1(CD39) expression inhibits ultraviolet radiation-induced DNA damage repair via purinergic signaling and is associated with metastasis in human cutaneous squamous cell carcinoma.

J Invest Dermatol 2021 Apr 10. Epub 2021 Apr 10.

Department of Dermatology, Duke University School of Medicine, Durham, NC, USA; Pinnell Center for Investigative Dermatology and Skin Disease Research Center, Duke University School of Medicine, Durham, NC; Duke Cancer Institute, Duke University Medical Center, Durham, NC; Department of Immunology, Duke University School of Medicine, Durham, NC; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC. Electronic address:

Ultraviolet radiation (UVR) and immunosuppression are major risk factors for cutaneous squamous cell carcinoma (cSCC). Regulatory T cells (Tregs) promote cSCC carcinogenesis and in other solid tumors, infiltrating Tregs and CD8 T cells express ENTPD1 (also known as CD39), an ecto-enzyme that catalyzes the rate-limiting step in converting extracellular ATP to extracellular adenosine. We previously demonstrated that extracellular purine nucleotides influence DNA Damage Repair (DDR). Read More

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The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder.

J Clin Invest 2021 Apr 13. Epub 2021 Apr 13.

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, United States of America.

Opioid use disorder (OUD) has become a leading cause of death in the US, yet current therapeutic strategies remain highly inadequate. To identify novel potential treatments for OUD, we screened a targeted selection of over 100 drugs using a recently developed opioid self-administration assay in zebrafish. This paradigm showed that finasteride, a steroidogenesis inhibitor approved for the treatment of benign prostatic hyperplasia and androgenetic alopecia, reduced self-administration of multiple opioids without affecting locomotion or feeding behavior. Read More

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Investigating the effects of Citrullus colocynthis on cognitive performance and anxiety-like behaviors in STZ-induced diabetic rats.

Int J Neurosci 2021 Apr 13:1-18. Epub 2021 Apr 13.

Student Research Committee, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Diabetes can impair cognitive performance and lead to dementia. Patients with type 1 diabetes mellitus (T1DM) are reported with different levels of cognitive dysfunctions in various cognitive domains ranging from general intellectual testing to specific deficits with visuospatial abilities, motor speed, writing, attention, reading, and psychomotor efficiency. The present study aimed to investigate the effect of cognitive functions. Read More

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Cell-Based Therapies for Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:265-293

Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. The pathogenesis of AMD involves dysfunction and loss of the retinal pigment epithelium (RPE), a monolayer of cells that provide nourishment and functional support for the overlying photoreceptors. RPE cells in mammals are not known to divide, renew or regenerate in vivo, and in advanced AMD, RPE loss leads to degeneration of the photoreceptors and impairment of vision. Read More

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January 2021

LncRNA LOC729178 acts as a sponge of miR-144-3p to mitigate cigarette smoke extract-induced inflammatory injury via regulating PHLPP2 in 16HBE cells.

J Mol Histol 2021 Apr 13. Epub 2021 Apr 13.

First People's Hospital of Jining City Affiliated to Jining Medical College, Jining City, Shandong Province, China.

Chronic obstructive pulmonary disease (COPD) is an inflammatory respiratory disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of COPD. In the present study, we set to investigate the role and mechanism of LOC729178 on cigarette smoke extract (CSE)-induced inflammatory damage in 16HBE cells. Read More

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Intrathecal Injection of GRIP-siRNA Reduces Postoperative Synaptic Abundance of Kainate Receptor GluK2 Subunits in Rat Dorsal Horns and Pain Hypersensitivity.

Neurochem Res 2021 Apr 13. Epub 2021 Apr 13.

Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, No. 8, Gongtinan Road, Beijing, 100020, China.

The mechanisms underlying postoperative pain differ from the inflammatory or neuropathic pain. Previous studies have demonstrated that intrathecal α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) -kainate (KA) receptor antagonist inhibits the guarding pain behavior and mechanical hyperalgesia, indicating a critical role of spinal KA receptors in postoperative pain hypersensitivity. However, how the functional regulations of spinal KA receptor subunits are involved in the postoperative pain hypersensitivity remains elusive. Read More

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GPER mediates estrogen cardioprotection against epinephrine-induced stress.

J Endocrinol 2021 Apr 1. Epub 2021 Apr 1.

H Sun, physiology department, Xuzhou Medical University, Xuzhou, China.

Currently, there are no conventional treatments for stress-induced cardiomyopathy (SCM, also known as Takotsubo syndrome), and the existing therapies are not effective. The recently discovered G protein- coupled estrogen receptor (GPER) executes the rapid effects of estrogen (E2). In this study, we investigated the effects and mechanism of GPER on epinephrine (Epi)-induced cardiac stress. Read More

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Role of Mitochondria-Derived Danger Signals Released after Injury in Systemic Inflammation and Sepsis.

Antioxid Redox Signal 2021 Apr 13. Epub 2021 Apr 13.

Beth Israel Deaconess Medical Center, 1859, Boston, Massachusetts, United States;

Significance: Sepsis is a major public health concern, with high mortality and morbidity, especially among trauma patients. It is characterized by a systemic inflammatory response syndrome (SIRS) occurring in response to infection. Although classically associated with pathogens, many patients with SIRS do not have infection. Read More

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