50,651 results match your criteria individuals diabetes


European Guidelines for Obesity Management in Adults with a Very Low-Calorie Ketogenic Diet: A Systematic Review and Meta-Analysis.

Obes Facts 2021 Apr 21:1-24. Epub 2021 Apr 21.

Dipartimento di Medicina, Università degli Studi di Padova, Padova, Italy.

Background: The very low-calorie ketogenic diet (VLCKD) has been recently proposed as an appealing nutritional strategy for obesity management. The VLCKD is characterized by a low carbohydrate content (<50 g/day), 1-1.5 g of protein/kg of ideal body weight, 15-30 g of fat/day, and a daily intake of about 500-800 calories. Read More

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Insulin glargine 300 units/mL for the treatment of individuals with type 2 diabetes in the real world: a review of the DELIVER programme.

Diabetes Obes Metab 2021 Apr 21. Epub 2021 Apr 21.

University College London, London, UK.

Evidence from randomised controlled trials (RCTs) has shown that second-generation basal insulin (BI) analogues, insulin glargine 300 U/mL (Gla-300) and insulin degludec (IDeg), provide similar glycaemic control with lower risk of hypoglycaemia compared with the first-generation BI analogue insulin glargine 100 U/mL (Gla-100) in people with type 2 diabetes (T2D). However, the highly selected participants and frequent follow-up of RCTs may not be truly representative of real-life clinical practice. It is important to assess the safety and effectiveness of these second-generation BI analogues in real-life clinical practice settings. Read More

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Urinary dipeptidyl peptidase-4 protein is increased by linagliptin and is a potential predictive marker of urine albumin-to-creatinine ratio reduction in patients with type 2 diabetes.

Diabetes Obes Metab 2021 Apr 21. Epub 2021 Apr 21.

Boehringer Ingelheim International GmbH, Ingelheim, Germany.

Results of a post-hoc analysis of urinary dipeptidyl peptidase-4 (DPP-4) protein as a predictor of urinary albumin-to-creatinine ratio (UACR) response to linagliptin treatment based on MARLINA-T2D trial data are described. MARLINA was a 24-week, phase 3b, multinational, placebo-controlled clinical trial in which patients with type 2 diabetes (T2D), glycated haemoglobin 6.5-10. Read More

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AMBULATORY NON-INSULIN TREATMENT OF TYPE 2 DIABETES MELLITUS IN THE UNITED STATES, 2015-2019.

Diabetes Obes Metab 2021 Apr 21. Epub 2021 Apr 21.

Center for Drug Safety and Effectiveness, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Tens of millions of individuals in the United States have Type 2 diabetes, and most require treatment with glucose-lowering medications to manage the disease.

Objective: To examine trends in non-insulin drug treatment of Type 2 diabetes, including first-line and second-line therapies on top of metformin, from 2015 to 2019.

Design, Setting And Participants: We conducted a descriptive analysis of cross-sectional data using the IQVIA National Disease and Therapeutic Index (NDTI), a nationally representative audit of ambulatory physician practices in the United States. Read More

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Advances in Type 1 Diabetes Prediction using Islet Autoantibodies: Beyond a Simple Count.

Endocr Rev 2021 Apr 21. Epub 2021 Apr 21.

Diabetes Clinical Research Program, and Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA.

Islet autoantibodies are key markers for the diagnosis of type 1 diabetes. Since their discovery, they have also been recognized for their potential to identify at-risk individuals prior to symptoms. To date, risk prediction using autoantibodies has been based on autoantibody number; it has been robustly shown that nearly all multiple-autoantibody-positive individuals will progress to clinical disease. Read More

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SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS AND THE RISK OF GOUT: A DANISH POPULATION BASED COHORT STUDY AND SYMMETRY ANALYSIS.

Pharmacoepidemiol Drug Saf 2021 Apr 21. Epub 2021 Apr 21.

Clinical Pharmacology, Pharmacy and Environmental Medicine, University of Southern Denmark.

Purpose: Sodium-glucose cotransporter-2 inhibitors (SGLT2-I) are frequently used in type 2 diabetes and have recently been associated with lower rates of gout compared to glucagon-like peptide-1 receptor agonists (GLP1-RA). Our objective was to assess the association of SGLT2-I and gout using a cohort study design and a symmetry analysis.

Methods: Using the Danish nationwide health registries, we conducted an active comparator, new user cohort study comparing the 3-year risk of gout among SGLT2-I users with propensity score matched GLP1-RA users. Read More

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Epidemiology of Heart Failure Stages in Middle-Aged Black People in the Community: Prevalence and Prognosis in the Atherosclerosis Risk in Communities Study.

J Am Heart Assoc 2021 Apr 21:e016524. Epub 2021 Apr 21.

Department of Medicine University of Mississippi Medical Center Jackson MS.

Background Black individuals have a higher burden of risk factors for heart failure (HF) and subclinical left ventricular remodeling. Methods and Results We evaluated 1871 Black participants in the Atherosclerosis Risk in Communities Study cohort who attended a routine examination (1993-1996, median age 58 years) when they underwent echocardiography. We estimated the prevalences of 4 HF stages: (1) : no risk factors; (2) : presence of HF risk factors (hypertension, diabetes mellitus, obesity, smoking, dyslipidemia, coronary artery disease without clinical myocardial infarction), no cardiac structural/functional abnormality; (3) : presence of prior myocardial infarction, systolic dysfunction, left ventricular hypertrophy, regional wall motion abnormality, or left ventricular enlargement; and (4) : prevalent HF. Read More

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A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19.

Sci Rep 2021 Apr 20;11(1):8562. Epub 2021 Apr 20.

Division of Biostatistics and Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, El Paso, TX, 79905, USA.

Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior studies. This systematic review and meta-analysis aimed to determine geographical, age, and gender related differences in the prevalence of comorbidities and associated severity and mortality rates among COVID-19 patients. Read More

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Cardiovascular risk factors and autonomic indices in relation to fatal and non-fatal coronary events.

Open Heart 2021 Apr;8(1)

Department of Clinical Sciences, Lund University, Malmö, Sweden.

Objective: Mortality caused by coronary artery disease has markedly decreased in recent years. However, a substantial proportion of patients suffering a coronary event (CE) die within the first day, most of them out of hospital. We aimed to investigate how established cardiovascular (CV) risk factors and CV autonomic indices associate with fatal versus non-fatal CEs in the population. Read More

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Association between cardiovascular risk factors and degenerative disc disease of the thoracolumbar spine in the general population: results from the KORA MRI Study.

Acta Radiol 2021 Apr 20:2841851211010391. Epub 2021 Apr 20.

Department for Diagnostic and Interventional Radiology, Eberhard Karls University Tuebingen, University Hospital Tuebingen, Tübingen, Germany.

Background: Little is known about the associations between cardiovascular risk factors (CRF) and disc degeneration (DD).

Purpose: To evaluate the potential association between CRFs and intervertebral DD in a population-based sample.

Methods: A total of 400 participants from the community-based KORA-study were assessed in terms of CRFs, specifically obesity, hypertension, diabetes, elevated LDL-c, low HDL-c, elevated triglycerides, smoking status, and alcohol consumption. Read More

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Hepatic Steatosis and Fibrosis in Type 2 Diabetes: A Risk-Based Approach to Targeted Screening.

Arch Iran Med 2021 Mar 1;24(3):177-186. Epub 2021 Mar 1.

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Background: Non-alcoholic fatty liver disease (NAFLD) is common in people with type 2 diabetes mellitus (T2DM). We aimed to explore predictive factors of NAFLD in T2DM and identify high risk subgroups.

Methods: This was a cross-sectional study including 100 individuals with T2DM and 100 without diabetes matched for age, sex, and body mass index (BMI). Read More

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Liver-targeting drugs and their effect on blood glucose and hepatic lipids.

Diabetologia 2021 Apr 20. Epub 2021 Apr 20.

Department of Internal Medicine IV, University of Tübingen, Tübingen, Germany.

The global epidemic of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) and the high prevalence among individuals with type 2 diabetes has attracted the attention of clinicians specialising in liver disorders. Many drugs are in the pipeline for the treatment of NAFLD/NASH, and several glucose-lowering drugs are now being tested specifically for the treatment of liver disease. Among these are nuclear hormone receptor agonists (e. Read More

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Mortality Trends in Risk Conditions and Invasive Mycotic Disease in the United States, 1999-2018.

Clin Infect Dis 2021 Apr 20. Epub 2021 Apr 20.

Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, Georgia USA.

Background: Invasive fungal infections (IFIs) in the United States are chronically underdiagnosed and a lack of coordinated surveillance makes the true burden of disease difficult to determine. The purpose of this analysis was to capture mortality-associated burden of risk conditions and fungal infections.

Methods: We analyzed data from the National Vital Statistics System from 1999-2018 to estimate the mortality attributed to risk conditions and related fungal disease. Read More

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Failure of chronic hydroxychloroquine in preventing severe complications of COVID-19 in patients with rheumatic diseases.

Rheumatol Adv Pract 2021 2;5(1):rkab014. Epub 2021 Mar 2.

NewYork-Presbyterian Hospital, Weill Cornell Medical Center.

Objective: To compare baseline characteristics, clinical presentations and outcomes of patients with rheumatic conditions requiring hospitalization for coronavirus disease 2019 (COVID-19) who received chronic HCQ with those who did not receive chronic HCQ.

Methods: We identified all patients with a rheumatologic disease who were admitted with COVID-19 to two hospitals in New York City between 3 March 3 and 30 April 2020. Patients who received chronic HCQ prior to admission were matched 1:2 (±10 years of age) with patients who did not receive chronic HCQ. Read More

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COVID-19 dynamics after a national immunization program in Israel.

Nat Med 2021 Apr 19. Epub 2021 Apr 19.

Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.

Studies on the real-life effect of the BNT162b2 vaccine for Coronavirus Disease 2019 (COVID-19) prevention are urgently needed. In this study, we conducted a retrospective analysis of data from the Israeli Ministry of Health collected between 28 August 2020 and 24 February 2021. We studied the temporal dynamics of the number of new COVID-19 cases and hospitalizations after the vaccination campaign, which was initiated on 20 December 2020. Read More

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Differences in glycated hemoglobin levels and cholesterol levels in individuals with diabetes according to Helicobacter pylori infection.

Sci Rep 2021 Apr 19;11(1):8416. Epub 2021 Apr 19.

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, 6139001, Tel Aviv, Israel.

This study examined differences in glycated hemoglobin (HbA1c), fasting plasma glucose and cholesterol levels between H. pylori infected and uninfected persons with diabetes. Anonymized data of Maccabi Healthcare Services in Israel were analyzed, of 12,207 individuals (50. Read More

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Oral Health Behaviour and Predictors of Oral Health Behaviour Among Patients With Diabetes in the Republic of Mauritius.

Int Dent J 2021 Apr 16. Epub 2021 Apr 16.

International Research Collaborative - Oral Health and Equity, School of Human Sciences, University of Western Australia, Crawley, Australia.

Objectives: To investigate the oral care habits and assess the determinants of oral care behaviour among people with diabetes in the Republic of Mauritius.

Methods: The present study draws on data collected from 589 dentate persons with diabetes by means of a close-ended questionnaire. Multivariate logistic regression analyses were used to estimate the association of different demographic and clinical factors with recommended dental hygiene practices. Read More

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Video-based eye tracking performance for computer-assisted diagnostic support of diabetic neuropathy.

Artif Intell Med 2021 Apr 5;114:102050. Epub 2021 Mar 5.

Group of Applied AI and Data Science, Maersk-McKinney-Moller Institute, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark. Electronic address:

Diabetes is currently one of the major public health threats. The essential components for effective treatment of diabetes include early diagnosis and regular monitoring. However, health-care providers are often short of human resources to closely monitor populations at risk. Read More

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Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload.

Mol Metab 2021 Apr 16:101235. Epub 2021 Apr 16.

Department of Pediatric Hematology, Oncology and Immunology - University of Heidelberg, Heidelberg, Germany; Molecular Medicine Partnership Unit, Heidelberg, Germany. Electronic address:

Objective: The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications, a pro-inflammatory status, oxidative stress and reactive metabolites generated by metabolic processes were postulated to be involved. Individuals with metabolic syndrome (MetS) frequently progress to T2DM, whereby 70% of T2DM patients show non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of MetS, and insulin resistance (IR). Read More

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Effect of type II diabetes-induced osteoarthritis on articular cartilage aging in rats: A study in vivo and in vitro.

Exp Gerontol 2021 Apr 16:111354. Epub 2021 Apr 16.

Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. Electronic address:

Objectives: Some evidence suggests that type II diabetes mellitus (T2DM) and osteoarthritis (OA) usually occur together clinically, and the symptoms are more obvious compared with non-diabetic patients with OA. We aimed to explore the effects in cartilage degradation, damage, and aging after T2DM combined with OA.

Methods: Thirty male Sprague-Dawley (SD) rats were randomly divided into the young-control group (YCG, n = 10), old-control group (OCG, n = 10), and old T2DM-induced OA group (OTOG, n = 10) after the pre-experiment. Read More

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Burden of Kidney Disease, Health-Related Quality of Life, and Employment Among Patients Receiving Peritoneal Dialysis and In-Center Hemodialysis: Findings From the DOPPS Program.

Am J Kidney Dis 2021 Apr 16. Epub 2021 Apr 16.

St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. Electronic address:

Rationale & Objective: Individuals faced with decisions regarding kidney replacement therapy options need information on how dialysis treatments might affect daily activities and quality of life, and what factors might influence the evolution over time of the impact of dialysis on daily activities and quality of life.

Study Design: Observational cohort study.

Setting & Participants: 7,771 HD and PD participants from 6 countries participating in the Peritoneal and Dialysis Outcomes and Practice Patterns Studies (PDOPPS/DOPPS). Read More

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Trends in the prevalence and management of major metabolic risk factors for chronic disease in the Korea National Health and Nutrition Examination Survey, 1998-2018.

Epidemiol Health 2021 Apr 19:e2021028. Epub 2021 Apr 19.

Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Chungcheongbuk-do, Korea.

Purpose: We aimed to explore trends in the prevalence and management of obesity, hypertension, diabetes, and hypercholesterolemia in Korean adults from 1998 to 2018 using data from the Korea National Health and Nutrition Examination Survey (KNHANES).

Methods: The study participants included 79,753 individuals aged ≥30 years who had participated in the health examination and health interview of the first (1998) to the seventh (2016-2018) KNHANES. The prevalence and management as well as Annual percent change (APC) in chronic diseases were analyzed using SAS and the Joinpoint software program. Read More

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Evaluation of the relationship between central serous chorioretinopathy and liver cirrhosis: A nationwide, population-based study.

J Chin Med Assoc 2021 Apr 13. Epub 2021 Apr 13.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC Department of Ophthalmology, Song-Shan Branch of Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan, ROC Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.

Background: Central serous chorioretinopathy (CSCR) and liver cirrhosis share numerous risk factors and may have possible connections. We aimed to investigate whether patients with liver cirrhosis and the severity of cirrhosis have an increased incidence of CSCR.

Methods: This population-based retrospective cohort study was conducted by collecting data from the Taiwan National Health Insurance Research Database from January 1, 2000 to December 31, 2015. Read More

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Use of non-insulin antidiabetic drugs in children and young adults - a Scandinavian drug utilization study from 2010-2019.

Br J Clin Pharmacol 2021 Apr 19. Epub 2021 Apr 19.

Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Denmark.

Knowledge on utilization patterns of non-insulin antidiabetic drugs in childhood and youth is limited. Therefore, we conducted a population-based drug utilization study using publicly available aggregate data on use of non-insulin antidiabetics from 2010-2019 in Scandinavia (Denmark, Norway, and Sweden) in individuals aged up to 24 years. For each non-insulin antidiabetic drug, we calculated the annual prevalence proportion of users, overall and for specific age groups. Read More

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Relationship between Functional Cluster Variants and Susceptibility to Type 2 Diabetes Mellitus: A Preliminary Case-Control Study and Bioinformatics Analyses.

Endocr Res 2021 Apr 17:1-11. Epub 2021 Apr 17.

Diabetes Center, Ali Asghar Hospital, Zahedan University of Medical Sciences, Zahedan, IR Iran.

To investigate the link between two variants (rs4705342 and rs4705343) in the promoter of the cluster with Type 2 diabetes mellitus (T2DM) risk. A total of 1200 subjects were genotyped using the ARMS-PCR method. The rs4705342 variant enhanced the risk of T2DM under codominant CC (OR = 3. Read More

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The association between non-communicable disease and hearing aid adoption in older adults with hearing loss.

Int J Audiol 2021 Apr 18:1-7. Epub 2021 Apr 18.

Mathematics Education Centre, Loughborough University, Loughborough, UK.

To assess whether specific non-communicable diseases are associated with hearing aid adoption in older adults with hearing loss. A cross-sectional, observational study. Data was obtained from one of the largest pharmacy-led health and beauty retailers in the United Kingdom. Read More

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Periodic breathing is associated with blood pressure above the recommended target in patients with type 2 diabetes.

Sleep Med X 2020 Dec 7;2:100013. Epub 2020 May 7.

Department of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

Background: Due to its prognostic importance for patients with type 2 diabetes (DM2), current guidelines recommend a systolic <130 mm Hg and diastolic <80 mm Hg blood pressure target. Periodic breathing, a form of sleep-disordered breathing, acutely causes repetitive hypoxia, sympathetic nervous system activation as well as oscillations of heart rate and blood pressure. However, limited data on the association of periodic breathing and control of blood pressure (BP) in patients with DM2 are available. Read More

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December 2020

Using Polygenic Scores in Social Science Research: Unraveling Childlessness.

Front Sociol 2019 22;4:74. Epub 2019 Nov 22.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Biological, genetic, and socio-demographic factors are all important in explaining reproductive behavior, yet these factors are typically studied in isolation. In this study, we explore an innovative sociogenomic approach, which entails including key socio-demographic (marriage, education, occupation, religion, cohort) and genetic factors related to both behavioral [age at first birth (AFB), number of children ever born (NEB)] and biological fecundity-related outcomes (endometriosis, age at menopause and menarche, polycystic ovary syndrome, azoospermia, testicular dysgenesis syndrome) to explain childlessness. We examine the association of all sets of factors with childlessness as well as the interplay between them. Read More

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November 2019

Classical homocystinuria, is it safe to exercise?

Mol Genet Metab Rep 2021 Jun 26;27:100746. Epub 2021 Mar 26.

Center for Molecular Diseases, Division of Genetic Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Background Cystationine β-synthase (CBS) deficiency is a genetic disorder characterized by severe hyperhomocysteinemia and thrombotic complications. In healthy individuals, physical exercise may result in a transient increase in plasma total homocysteine (tHcy) raising the possibility that exercise might be detrimental in CBS deficiency. Our main objective was to determine plasma tHcy kinetics in response to physical exercise in homocystinuria patients. Read More

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Burden and prevalence of risk factors for severe COVID-19 in the ageing European population - a SHARE-based analysis.

Z Gesundh Wiss 2021 Apr 11:1-10. Epub 2021 Apr 11.

Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, J.B. Winsløws Vej 9B, 5000 Odense, Denmark.

Aim: International health authorities suggest that individuals aged 65 years and above and people with underlying comorbidities such as hypertension, chronic lung disease, cardiovascular disease, cancer, diabetes, and obesity are at increased risk of severe Coronavirus Disease 2019 (COVID-19); however, the prevalence of risk factors is unknown in many countries. Therefore, we aimed to describe the distribution of these risk factors across Europe.

Subject And Methods: Prevalence of risk factors for severe COVID-19 was identified based on interviews from 73,274 Europeans aged 50+ participating in the Survey of Health, Ageing and Retirement in Europe (SHARE) in 2017. Read More

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