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Effects of endplate healing morphology on intervertebral disc degeneration after pedicle screw fixation for thoracolumbar fractures.

Medicine (Baltimore) 2021 Apr;100(17):e25636

Orthopaedic Trauma Service Center, The Third Hospital of Hebei Medical University, Major Laboratory of Orthopaedic Biomechanics in Hebei Province.

Abstract: The cartilage endplate plays an important role in the stress distribution and nutrition metabolism of the intervertebral disc. The healing morphology of the endplate after spinal fracture and its effect on the intervertebral disc degeneration are still unclear.This was a retrospective study. Read More

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Menses, pregnancy, delivery, and menopause in hidradenitis suppurativa: A patient survey.

Int J Womens Dermatol 2020 Dec 10;6(5):368-371. Epub 2020 Jul 10.

Department of Medicine, Division of Dermatology, University of California Los Angeles, Los Angeles, CA, United States.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder that primarily affects women of childbearing age. There is a paucity of data on HS disease activity during menstruation, pregnancy, and menopause and the potential impact of HS on the method of delivery.

Objective: We aimed to characterize the natural history of HS symptoms during menses, pregnancy, and menopause. Read More

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December 2020

Nutritional Risk Screening in Cancer Patients: The First Step Toward Better Clinical Outcome.

Front Nutr 2021 7;8:603936. Epub 2021 Apr 7.

Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.

Disease-related malnutrition is highly prevalent among cancer patients, with 40-80% suffering from it during the course of their disease. Malnutrition is associated with numerous negative outcomes such as: longer hospital stays, increased morbidity and mortality rates, delayed wound healing, as well as decreased muscle function, autonomy and quality of life. In cancer patients, malnutrition negatively affects treatment tolerance (including anti-cancer drugs, surgery, chemo- and radiotherapy), increases side effects, causes adverse reactions, treatment interruptions, postoperative complications and higher readmission rates. Read More

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Prognostic Indicators of Delayed Surgical Recovery in Patients Undergoing Cardiac Surgery.

J Nurs Scholarsh 2021 Apr 22. Epub 2021 Apr 22.

Associate Professor, Undergraduate and Graduate Nursing Programs, Federal Fluminense University, CNPq Researcher, Rio de Janeiro, Brazil.

Purpose: The purpose of this study was to analyze the prognostic capacity of the clinical indicators of a delayed surgical recovery nursing diagnosis throughout the hospital stay of patients having cardiac surgery.

Design: A prospective cohort design was adopted. A sample of inpatients undergoing elective cardiac surgery was followed during the immediate preoperative period and hospitalization. Read More

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Multidisciplinary team meetings for patients with complex extremity defects: a retrospective analysis of treatment recommendations and prognostic factors for non-implementation.

BMC Surg 2021 Mar 29;21(1):168. Epub 2021 Mar 29.

Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center-BG Trauma Center Ludwigshafen, Hand and Plastic Surgery of the University of Heidelberg, Ludwig Guttmann Str. 13, 67071, Ludwigshafen, Germany.

Background: This study aimed to assess a multidisciplinary team (MDT) meeting approach for the management of patients with complex extremity defects, analyze treatment recommendations, and evaluate factors influencing non-implementation.

Methods: All patients introduced to an MDT meeting for complex extremity defects from 2015 to 2017 were included in a retrospective cohort study. Patients' characteristics and defect causes were evaluated. Read More

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Sexual Violence: A Review and Case Study Utilizing Watson's Caring Science.

Nurs Sci Q 2021 04;34(2):132-134

Director Nursing Informatics & Innovation, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.

The care provided to persons who experience sexual violence is complex and needs to be individualized and account for the person's expressed needs. Nurses have the potential to facilitate the recovery from such traumatic events. Utilizing Watson's theory of human caring science, nursing care practices provide an influence through their utilization of artistry with caring-healing processes and attending to the healing environment for people. Read More

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Oleanolic acid inhibits osteosarcoma cell proliferation and invasion by suppressing the SOX9/Wnt1 signaling pathway.

Exp Ther Med 2021 May 28;21(5):443. Epub 2021 Feb 28.

Department of Osteopathic Medicine, Daping Hospital, Army Medical University, Chongqing 400042, P.R. China.

Osteosarcoma is the most common primary bone malignancy in children and adolescents. Inhibition of SOX9/Wnt1-mediated signaling might suppress osteosarcoma metastasis, and oleanolic acid (OA) might decrease the activity of the SOX9/Wnt1 signaling pathway. The aim of the present study was to determine the role of OA in osteosarcoma cell proliferation and invasion. Read More

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Treating the burnt auricle using Biobrane.

ANZ J Surg 2021 03 1;91(3):453-454. Epub 2020 Dec 1.

Department of Burns, Reconstructive and Plastic Surgery, Royal North Shore Hospital, Reserve Rd, Sydney, New South Wales, 2065, Australia.

Auricle burns remain a challenge for surgeons who must navigate the common and morbid complication of chondritis through often complex and painful dressing regimes. Our technique involving the application of Biobrane promotes healing, is individualized, single application and conducive to topical antimicrobial application. We find it is a simple and effective approach to treating the burnt auricle. Read More

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Diverse Treatments for Deep Burn Wounds: A Case Report.

Adv Skin Wound Care 2021 Apr;34(4):1-6

At the State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China, Ling Zhou, MS, is a plastic surgeon; Chunmei Liu, MS, is a nurse; Yimei Luo, MS, is a nurse; Fei Xiang, MD, is a plastic surgeon; and Huapei Song, MD, is a plastic surgeon. Acknowledgments: This work was supported by the Project of Key Laboratory of Medical Protection for Electromagnetic Radiation, Ministry of Education (Grant No. 2017DCKF005) and the Technological Innovation Foundation of Chongqing (cstc2018jscx-msybX0112). The authors have disclosed no other financial relationships related to this article. Submitted May 4, 2020; accepted in revised form June 8, 2020.

Abstract: Patients with extensive deep burns usually experience infections and organ dysfunction. Proactive and effective wound repair is key to treatment. If large wounds remain open, systemic infection and multiple organ dysfunction syndrome can occur, threatening the lives of patients. Read More

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Enkurin domain containing 1 (ENKD1) regulates the proliferation, migration and invasion of non-small cell lung cancer cells.

Asia Pac J Clin Oncol 2021 Mar 15. Epub 2021 Mar 15.

Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, China.

Non-small cell lung cancer (NSCLC) is the most common cause of cancer mortality worldwide. NSCLC has an aggressive phenotype and poor prognosis, and is quite heterogeneous without effective and specific targeted therapies. Therefore, exploring new tumor markers and drug targets for NSCLC is crucial towards individualized treatment. Read More

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Tea eggs-inspired high-strength natural polymer hydrogels.

Bioact Mater 2021 Sep 18;6(9):2820-2828. Epub 2021 Feb 18.

School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin, 300350, China.

Natural polymer (NP) hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety; however, the intrinsic poor mechanical strengths severely limit their applications as structural tissue engineering scaffolds. Inspired by the stiffening albumen gel of tea eggs, a traditional Chinese snack, high-strength NP hydrogels are constructed by simply soaking in aqueous solution of tea polyphenols (TP), an active ingredient extracted from tea. The TP-treated representative NP hydrogels exhibit considerably enhanced multifaceted mechanical properties with maximum 19-/30-, 8. Read More

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September 2021

The Pathogenesis and Clinical Management of Stricturing Crohn Disease.

Inflamm Bowel Dis 2021 Mar 9. Epub 2021 Mar 9.

Virginia Commonwealth University, Division of Gastroenterology and Hepatology, Richmond, Virginia, USA.

Stricturing of the gastrointestinal tract is a common complication in Crohn disease and is a significant cause of morbidity and mortality among this population. The inflammatory process initiates fibrosis, leading to aberrant wound healing and excess deposition of extracellular matrix proteins. Our understanding of this process has grown and encompasses cellular mechanisms, epigenetic modifications, and inherent genetic predisposition toward fibrosis. Read More

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Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs.

Biology (Basel) 2021 Feb 23;10(2). Epub 2021 Feb 23.

Drug Research Program, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland.

Specific proteolytic cleavages turn on, modify, or turn off the activity of vascular endothelial growth factors (VEGFs). Proteolysis is most prominent among the lymph-angiogenic VEGF-C and VEGF-D, which are synthesized as precursors that need to undergo enzymatic removal of their C- and N-terminal propeptides before they can activate their receptors. At least five different proteases mediate the activating cleavage of VEGF-C: plasmin, ADAMTS3, prostate-specific antigen, cathepsin D, and thrombin. Read More

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February 2021

[Effectiveness of open reduction and internal fixation for bipolar fracture-dislocation of forearm].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Feb;35(2):149-153

Department of Upper Extremity Orthopaedics, Zhengzhou Orthopaedic Hospital, Zhengzhou Henan, 450052, P.R.China.

Objective: To explore the effectiveness of open reduction and internal fixation for bipolar fracture-dislocation of the forearm.

Methods: Between June 2014 and March 2019, 14 patients with bipolar fracture-dislocation of the forearm were treated. There were 9 males and 5 females, aged from 19 to 52 years (mean, 34. Read More

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February 2021

Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer.

Cancer Cell Int 2021 Feb 23;21(1):130. Epub 2021 Feb 23.

Department of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, China.

Background: Breast cancer (BC) remains a prevalent and common form of cancer with high heterogeneity. Making efforts to explore novel molecular biomarkers and serve as potential disease indicators, which is essential to effectively enhance the prognosis and individualized treatment of BC. FBXO proteins act as the core component of E3 ubiquitin ligase, which play essential regulators roles in multiple cellular processes. Read More

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February 2021

Bioinformatic Analysis of the Wound Peptidome Reveals Potential Biomarkers and Antimicrobial Peptides.

Front Immunol 2020 3;11:620707. Epub 2021 Feb 3.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, Lund, Sweden.

Wound infection is a common and serious medical condition with an unmet need for improved diagnostic tools. A peptidomic approach, aided by mass spectrometry and bioinformatics, could provide novel means of identifying new peptide biomarkers for wound healing and infection assessment. Wound fluid is suitable for peptidomic analysis since it is both intimately tied to the wound environment and is readily available. Read More

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February 2021

What gets measured gets noticed. Tracking surgical site infection post caesarean section through community surveillance: A post intervention study protocol.

J Adv Nurs 2021 May 19;77(5):2530-2538. Epub 2021 Feb 19.

Nursing and Midwifery Research Centre, Hunter New England Local Health District and University of Newcastle, Newcastle, NSW, Australia.

Aim: This study aims to evaluate the effectiveness of HealthTracker, a surgical site infection surveillance system that aims to improve the notification of surgical site infection for women after giving birth by caesarean section.

Design: This protocol is an intervention study to evaluate the effectiveness of the surveillance system called "HealthTracker" in monitoring surgical site infections post caesarean section.

Methods: This study will use a mobile web application to automatically send a text message inviting all women who give birth to a live baby by caesarean section over six months during 2020-2021, at an Australian tertiary referral hospital. Read More

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The Clinical and Radiological Outcome of Stages 1 and 2 Enneking Benign Bone Lesions with Pathological Fracture.

Injury 2021 Jan 27. Epub 2021 Jan 27.

Department of Orthopedic Surgery, Menoufia University Faculty of Medicine, Shebin El-Kom, Menoufia, Egypt. Electronic address:

Background: Presentation of benign lesions with a pathological fracture may be confusing to general orthopedic surgeons regarding missing a fracture in a pathological bone, the need for special care for these lesions, and the potential for healing of these fractures. The objective of this work was to evaluate the clinical and radiological outcomes of the treatment of patients with stages 1 and 2 Enneking benign bone-tumors presented with pathological fractures.

Methods: This retrospective study included 66 patients who presented with a pathological fracture through stage 1 or 2 Enneking benign bone lesions and were received at the emergency unit of the orthopedic department between 2014 and 2018. Read More

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January 2021

Ultrasound-Mediated Remotely Controlled Nanovaccine Delivery for Tumor Vaccination and Individualized Cancer Immunotherapy.

Nano Lett 2021 02 1;21(3):1228-1237. Epub 2021 Feb 1.

Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, China.

Vaccines are one of utmost important weapons in modern medicine to fight a wide range of diseases. To achieve optimal vaccination effects, repeated injections of vaccines are often required, which would largely decrease patient comfort. Herein, an ultrasound-responsive self-healing hydrogel system loaded with nanovaccines is designed for remotely controlled tumor vaccine release and individualized cancer immunotherapy. Read More

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February 2021

Molecular pathogenesis of rhegmatogenous retinal detachment.

Sci Rep 2021 Jan 13;11(1):966. Epub 2021 Jan 13.

Department of Ophthalmology, Unit of Vitreoretinal Surgery, Helsinki University Hospital, Haartmaninkatu 4 C, 00290, Helsinki, Finland.

Rhegmatogenous retinal detachment (RRD) is an ophthalmic emergency, which usually requires prompt surgery to prevent further detachment and restore sensory function. Although several individual factors have been suggested, a systems level understanding of molecular pathomechanisms underlying this severe eye disorder is lacking. To address this gap in knowledge we performed the molecular level systems pathology analysis of the vitreous from 127 patients with RRD using state-of-the art quantitative mass spectrometry to identify the individual key proteins, as well as the biochemical pathways contributing to the development of the disease. Read More

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January 2021

Efficacy of infliximab treatment on the mucosal healing of different intestinal segments in patients with ileocolonic Crohn's disease.

Therap Adv Gastroenterol 2020 21;13:1756284820976923. Epub 2020 Dec 21.

Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, China.

Background: Mucosal healing (MH) is the key aim of the treat-to-target strategy for patients with Crohn's disease (CD). The efficacy of infliximab (IFX) on MH in different ileocolonic segments is unclear. The aim of this study was to investigate endoscopic MH in different ileocolonic segments in patients with CD who received IFX treatment. Read More

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December 2020

[Incidence and management of cesarean scar pregnancies after in vitro fertilization-embryo transfer].

Zhonghua Yi Xue Za Zhi 2020 Dec;100(47):3759-3763

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

To explore the incidence, clinical characteristics, management strategies and reproductive outcomes of cesarean scar pregnancies (CSP) after in vitro fertilization-embryo transfer (IVF-ET). The patients who were diagnosed with CSP followed IVF/ET in the Center for Reproductive Medicine of Peking University Third Hospital between April 1, 2010 and March 31, 2020 were included. The clinical data of each patient were analyzed retrospectively. Read More

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December 2020

[Retrospective analysis on treatment methods and curative effects of reducing the disability rate of multiple ligament injuries and dislocations of the knee joint].

Zhongguo Gu Shang 2020 Dec;33(12):1134-41

Department of Orthopaedics, Huaxi Hospital of Sichuan, Chengdu 610041, Sichuan, China.

Objective: To investigate the clinical effects of individualized repair and reconstruction surgery for multiple ligament injury and dislocation of knee joint based on stage classification diagnosis.

Methods: From January 2018 to January 2019, 42 patients with multiple ligament injury and dislocation of the knee joint were treated. There were 27 males and 15 females, aged from 30 to 63 (47. Read More

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December 2020

Experiences of Bereaved Family Members Receiving Commemorative Paintings: A Qualitative Study.

JAMA Netw Open 2020 12 1;3(12):e2027259. Epub 2020 Dec 1.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.

Importance: Although family members of patients who die in the intensive care unit commonly experience long-term psychological distress, end-of-life bereavement support programs for such relatives are uncommon. Whether art influences the grief experience of families is largely unexplored.

Objective: To explore the influence of personalized paintings created to honor deceased critically ill patients on family members' bereavement experience. Read More

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December 2020

Examining the impact of a Healing Touch intervention to reduce posttraumatic stress disorder symptoms in combat veterans.

Psychol Trauma 2020 Nov 18;12(8):897-903. Epub 2020 May 18.

Tibor Rubin VA Medical Center.

Objective: This study examined the use of Healing Touch (HT), a biofield therapy, as an intervention in treating posttraumatic stress disorder (PTSD). It exemplifies the upswing of biofield (energy field) therapies that have been taking place recently for a number of clinical conditions, including cancer, pain, arthritis, movement restriction, and energy psychology. Theoretically, the human body is the physical aspect of an individualized field of energy (biofield) in which electrical activity functions as a complex, organized whole or system. Read More

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November 2020

Individualized Corneal Cross-linking With Riboflavin and UV-A in Ultrathin Corneas: The Sub400 Protocol.

Am J Ophthalmol 2021 04 30;224:133-142. Epub 2021 Jan 30.

Laboratory for Ocular Cell Biology, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland; Department of Ophthalmology, ELZA Institute, Dietikon, Switzerland; Department of Ophthalmology, Paulista School of Medicine, Federal University of Sao Paulo, Sao Paulo, Brazil; Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Purpose: To determine whether corneal cross-linking (CXL) with individualized fluence ("sub400 protocol") is able to stop keratoconus (KC) progression in ultrathin corneas with 12-month follow-up.

Design: Retrospective, interventional case series.

Methods: Thirty-nine eyes with progressive KC and corneal stromal thicknesses from 214 to 398 μm at the time of ultraviolet irradiation were enrolled. Read More

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Reconstruction of Bony Defects after Tumor Resection with 3D-Printed Anatomically Conforming Pelvic Prostheses through a Novel Treatment Strategy.

Biomed Res Int 2020 1;2020:8513070. Epub 2020 Dec 1.

Department of Orthopedic Surgery, Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China.

There has been an increasing interest and enormous applications in three-dimensional (3D) printing technology and its prosthesis, driving many orthopaedic surgeons to solve the difficult problem of bony defects and explore new ways in surgery approach. However, the most urgent problem is without an effective prosthesis and standard treatment strategy. In order to resolve these problems, this study was performed to explore the use of a 3D-printed anatomically conforming pelvic prosthesis for bony defect reconstruction following tumor resection and to describe a detailed treatment flowchart and the selection of a surgical approach. Read More

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December 2020

How to do it: treating the burnt auricle using Biobrane.

ANZ J Surg 2020 Dec 1. Epub 2020 Dec 1.

Department of Burns, Reconstructive and Plastic Surgery, Royal North Shore Hospital, Reserve Rd, Sydney, New South Wales, 2065, Australia.

Auricle burns remain a challenge for surgeons who must navigate the common and morbid complication of chondritis through often complex and painful dressing regimes. Our technique involving the application of Biobrane promotes healing, is individualized, single application and conducive to topical antimicrobial application. We find it is a simple and effective approach to treating the burnt auricle. Read More

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December 2020

Outcomes of management of displaced intra-articular calcaneal fractures.

Surgeon 2020 Nov 28. Epub 2020 Nov 28.

Department of Musculoskeletal Disorders, Faculty of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081, Baronissi, SA, Italy; Centre for Sports and Exercise Medicine, Barts and The London School of Medicine and Dentistry, Mile End Hospital, 275 Bancroft Road, London, E1 4DG, United Kingdom; Guy Hilton Research Centre, School of Pharmacy and Bioengineering, Keele University Faculty of Medicine, Stoke-on-Trent, Staffordshire, ST4 7QB, United Kingdom. Electronic address:

Despite the advances in operative management, displaced intra-articular calcaneal fractures (DIAFCs) are often associated with long term sequelae, permanent disability, a considerable reduction in quality of life, and a high socio-economic cost. Randomized controlled trials have shown that patient reported outcomes of surgery are no better than those of nonoperative management. Methodological flaws and selection bias may have influenced the results, however, and subgroup analysis showed that some patients could benefit from surgery, whilst patients' preference can be the decisive factor in choosing a management modality. Read More

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November 2020

Rehabilitation protocol after simultaneous anterior cruciate ligament reconstruction and high tibial osteotomy: introducing the concept of the individualized approach.

J Biol Regul Homeost Agents 2020 Jul-Aug;34(4 Suppl. 3):419-429. Congress of the Italian Orthopaedic Research Society

Department of Orthopaedics and Traumatology, University of Turin, Italy.

Postoperative rehabilitation after simultaneous anterior cruciate ligament reconstruction and opening wedge high tibial osteotomy is a complex concept. Different osteotomy techniques, extremely selected patients, high expectations in returning to previous sport activities, and the different individual physical profile and performances make traditional chronological criteria impractical and unfeasible. This study presents a novel rehabilitation in which functional objective criteria are considered the key factors for standardizing a 4-step protocol. Read More

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January 2021