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Anxiety Levels and Solution-Focused Thinking Skills of Nurses and Midwives Working in Primary Care during the COVID-19 Pandemic: A Descriptive Correlational Study.

J Nurs Manag 2021 Apr 10. Epub 2021 Apr 10.

Department of Public Health Nursing, Faculty of Health Science, University of Kahraman Maraş Sütçü İmam, Kahramanmaraş, Turkey.

Aims: This study aimed to determine the state-trait anxiety levels and solution-focused thinking skills of primary care nurses/midwives during the COVID-19 pandemic, and to evaluate the factors affecting these variables and the determinants of state-trait anxiety levels.

Background: The COVID-19 outbreak has created intense anxiety in nurses/midwives that may affect the care they provide. Nurses and midwives may manage anxiety using solution-focused thinking skills. Read More

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Pre-intervention SNOT-22 scores predict outcomes in aspirin exacerbated respiratory disease.

Am J Otolaryngol 2021 Mar 31;42(5):103025. Epub 2021 Mar 31.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States of America.

Purpose: This study evaluated whether stratified preoperative, pre- aspirin desensitization (AD) sinonasal symptom scores predict postoperative, post-AD outcomes in Aspirin exacerbated respiratory disease (AERD).

Materials And Methods: Retrospective chart review of patients with aspirin challenge-proven AERD who underwent endoscopic sinus surgery followed by AD was performed. Preoperative, postoperative/pre-AD, and postoperative/post-AD sinonasal symptom scores were collected (22-item Sino-Nasal Outcomes Test, SNOT-22). Read More

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inhibitory effects of glucosamine, chondroitin and diacerein on human hepatic CYP2D6.

Drug Metab Pers Ther 2021 Apr 8. Epub 2021 Apr 8.

School of Pharmacy, International Medical University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000Kuala Lumpur, Malaysia.

Objectives: Glucosamine, chondroitin and diacerein are natural compounds commonly used in treating osteoarthritis. Their concomitant intake may trigger drug-natural product interactions. Cytochrome P450 (CYP) has been implicated in such interactions. Read More

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Knee Injury and Osteoarthritis Outcome Score: Validity and Reliability of an Indonesian Version.

Ochsner J 2021 ;21(1):63-67

Orthopaedic and Traumatology Department, Faculty of Medicine, Brawijaya University-Saiful Anwar General Hospital, Klojen, Malang, East Java, Indonesia.

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a useful diagnostic tool to assess knee ligament injury and osteoarthritis, but no validated Indonesian version of the KOOS was available. We used the forward-backward translation protocol to develop the Indonesian version of the KOOS. The translated questionnaire was administered twice to 51 subjects diagnosed with a knee ligament injury and osteoarthritis. Read More

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January 2021

Comparison of post-COVID depression and major depressive disorder.

medRxiv 2021 Apr 4. Epub 2021 Apr 4.

Background: During the COVID-19 pandemic rates of depressive symptoms are markedly elevated, particularly among survivors of infection. Understanding whether such symptoms are distinct among those with prior SARS-CoV-2 infection, or simply a nonspecific reflection of elevated stress, could help target interventions.

Method: We analyzed data from multiple waves of a 50-state survey that included questions about COVID-19 infection as well as the Patient Health Questionnaire examining depressive and anxious symptoms. Read More

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The relationship between breast milk intake and speech in children with cerebral palsy.

Turk J Med Sci 2021 Apr 6. Epub 2021 Apr 6.

Purpose: To assess the relationship between breast milk intake and speech functions in children with cerebral palsy.

Methods: We performed a cross-sectional, observational study of children with cerebral palsy aged over 4 years. The clinical features and the variables regarding breast milk intake were abstracted from medical records and mothers rewievs. Read More

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Factors Affecting State and Trait Anxiety of Relatives of Hospitalized Patients.

J Caring Sci 2021 Mar 1;10(1):9-14. Epub 2021 Mar 1.

Department of Nursing, School of Health and Caring Sciences, University of West Attica, Athens, Greece.

Hospitalization is a stressful event for both patients and relatives. The aim of the study was to explorefactors affecting state and trait anxiety of relatives of hospitalized patients. In this cross-sectional study, was enrolled a convenience sample of 222 relatives of hospitalized patients in a public hospital in Athens, Greece. Read More

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Assessment of Efficiency and Safety of Apatinib in Advanced Bone and Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis.

Front Oncol 2021 17;11:662318. Epub 2021 Mar 17.

Department of Oncology, Xijing Hospital, Air Force Medical University of PLA, Xian, China.

Background: Previous studies, both and , have established that apatinib has anti-tumor properties. However, insufficient empirical evidence of the efficacy and safety of apatinib has been published for bone and soft tissue sarcoma, the reported results differing widely. Here, we conducted a meta-analysis to assess the efficacy and toxicity of apatinib for the treatment of bone and soft tissue sarcoma. Read More

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Association of Pulmonary Hypertension With Inflammatory Markers and Volume Status in Hemodialysis Patients of End-Stage Renal Disease.

Cureus 2021 Mar 1;13(3):e13635. Epub 2021 Mar 1.

Clinical and Experimental Medicine, Central Drug Research Institute, Lucknow, IND.

Background and objectives Pulmonary hypertension (PH) is an independent risk factor for increased mortality, especially in patients undergoing hemodialysis (HD), but the mechanism of its development is unknown. This study aimed at evaluating volume overload and inflammation as potential variables to cause its development in patients undergoing maintenance hemodialysis. Materials and methods This was an observational cross-sectional study conducted on patients undergoing hemodialysis at a tertiary hospital in northern India. Read More

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Relation of exercise capacity to comprehensive physical functions in individuals with ischemic stroke.

NeuroRehabilitation 2021 Mar 28. Epub 2021 Mar 28.

Department of Rehabilitation Medicine, Chungnam National University Hospital, Daejeon, Republic of Korea.

Background: Impaired motor control, balance, muscle strength, and respiratory function may affect the exercise capacity related to motor performance and activities in individuals with stroke.

Objective: To identify a physical parameter that the exercise capacity has the most significant relationship among physical parameters related to motor function, trunk control, balance, and motor performance and activities in individuals with ischemic stroke.

Methods: In total, 241 ischemic stroke patients were recruited in this retrospective study. Read More

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Genetic evaluation of growth and reproductive performances of crossbred pigs reared under intensive system in tropical humid coastal climate.

Trop Anim Health Prod 2021 Apr 4;53(2):243. Epub 2021 Apr 4.

Animal Reproduction, ICAR-Central Coastal Agricultural Research Institute, Goa Velha, Goa, India.

Pig farming is one of the most economically viable options for the rural backward and resource-poor farmers in Asian countries. Growth rate and litter size are the most important traits based on which the crossbreeding programs are typically planned in commercial pig farming. The modern system of farming with high yielding improved pig germplasm helps in economic growth in piggery enterprises. Read More

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How sediment bacterial community shifts along the urban river located in mining city.

Environ Sci Pollut Res Int 2021 Apr 3. Epub 2021 Apr 3.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, No.1 Xikang Road, Nanjing, 210098, China.

Bacterial communities play critical roles in biogeochemical cycles and serve as sensitive indicators of environmental fluctuation. However, the influence of mineral resource exploitation on shaping the bacterial communities in the urban river is still ambiguous. In this study, high-throughput sequencing was used to determine the spatial distribution of the sediment bacterial communities along an urban river in the famous mining city Panzhihua of China. Read More

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Unravelling the Perspectives of Day and Night Traders in Selected Markets within a Sub-Saharan African City with a Malaria Knowledge, Attitude and Practice Survey.

Int J Environ Res Public Health 2021 Mar 26;18(7). Epub 2021 Mar 26.

Department of Community Health, University of Ghana Medical School, P.O. Box KB 4236 Accra, Ghana.

Background: Malaria is still endemic in sub-Saharan Africa, with a high disease burden. Misconceptions about malaria contribute to poor attitudes and practices, further increasing the burden in endemic countries. Studies have examined the knowledge, attitudes, and practices (KAP) of malaria among different populations. Read More

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The Association between Vigorous Physical Activity and Stress in Adolescents with Asthma.

Int J Environ Res Public Health 2021 Mar 26;18(7). Epub 2021 Mar 26.

Department of Taekwondo, College of Arts and Physical Education, Gachon University, Seongnam 13120, Korea.

Asthma is a very common condition that affects 5-10% of the global population, and its prevalence is increasing. Vigorous physical activity (PA) is effective in improving cardiorespiratory fitness and managing stress. This study aimed to investigate the association between vigorous PA and stress among Korean adolescents with asthma using large-scale survey data. Read More

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The Effect of Exogenous Beta-Hydroxybutyrate Salt Supplementation on Metrics of Safety and Health in Adolescents.

Nutrients 2021 Mar 5;13(3). Epub 2021 Mar 5.

The Applied Science and Performance Institute, Research Division, Tampa, FL 33607, USA.

The ketogenic diet is a high-fat, very low-carbohydrate, moderate-protein diet that will induce a state of ketosis, but because of its restrictive nature, it may be difficult to adhere to, especially in adolescents. Supplementing with exogenous beta-hydroxybutyrate salts may induce a state of temporary ketosis without any undesirable side effects, thereby promoting the benefits of ketosis and minimizing adherence requirements to a ketogenic diet. To date, beta-hydroxybutyrate supplementation in healthy adolescents has not been explored. Read More

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Consensus and Controversy in the Debate over the Biphasic Impact of Alcohol Consumption on the Cardiovascular System.

Nutrients 2021 Mar 25;13(4). Epub 2021 Mar 25.

Internal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700503 Iași, Romania.

In the past few decades, research has focused on the importance of addressing modifiable risk factors as a means of lowering the risk of cardiovascular disease (CVD), which represents the worldwide leading cause of death. For quite a long time, it has been considered that ethanol intake has a biphasic impact on the cardiovascular system, mainly depending on the drinking pattern, amount of consumption, and type of alcoholic beverage. Multiple case-control studies and meta-analyses reported the existence of a "U-type" or "J-shaped" relationship between alcohol and CVD, as well as mortality, indicating that low to moderate alcohol consumption decreases the number of adverse cardiovascular events and deaths compared to abstinence, while excessive alcohol use has unquestionably deleterious effects on the circulatory system. Read More

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A Comparison of the Colonic Microbiome and Volatile Organic Compound Metabolome of Infected and Non-Infected Horses: A Pilot Study.

Animals (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool L69 3GE, UK.

is a common equine tapeworm associated with an increased risk of colic (abdominal pain) in horses. Identification of parasite and intestinal microbiota interactions have consequences for understanding the mechanisms behind parasite-associated colic and potential new methods for parasite control. was diagnosed by counting of worms in the caecum post-mortem. Read More

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Salvage-Radiation Therapy and Regional Hyperthermia for Biochemically Recurrent Prostate Cancer after Radical Prostatectomy (Results of the Planned Interim Analysis).

Cancers (Basel) 2021 Mar 6;13(5). Epub 2021 Mar 6.

Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Radiation Oncology, 13353 Berlin, Germany.

Efforts to improve the outcome of prostate cancer (PC) patients after radical prostatectomy (RP) include adjuvant or salvage radiation therapy (SRT), but still up to 50% of patients develop a disease progression after radiotherapy (RT). Regional hyperthermia (HT) is well-known to improve tumor sensitivity to RT in several entities. Here we report on a planned interim analysis of tolerability and feasibility after recruitment of the first 50 patients of a trial combining SRT and HT. Read More

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Infection Alters Intestinal Morphology and Mucosal Innate Immunity in Moderately Malnourished Mice.

Nutrients 2021 Mar 11;13(3). Epub 2021 Mar 11.

Department of Biology, College of Arts and Sciences, Appalachian State University, 572 Rivers St, Boone, NC 28608, USA.

is a protozoan parasite which causes malarial disease in humans. Infections commonly occur in sub-Saharan Africa, a region with high rates of inadequate nutrient consumption resulting in malnutrition. The complex relationship between malaria and malnutrition and their effects on gut immunity and physiology are poorly understood. Read More

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Psychological impact of early miscarriage and client satisfaction with treatment: a comparison between expectant management and misoprostol treatment in a randomized controlled trial.

Ultrasound Obstet Gynecol 2021 Apr 2. Epub 2021 Apr 2.

Department of Care Sciences, Malmö University, Malmö, Sweden.

Objectives: To compare short- and long-term emotional distress (grief, anxiety, depressive symptoms) after early miscarriage in women randomized to expectant management or misoprostol treatment, and to compare satisfaction with treatment.

Methods: This is a randomized controlled trial (ClinicalTrials.gov ID: NCT01033903) comparing expectant management with misoprostol treatment of early miscarriage. Read More

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Validation and investigation of cross cultural equivalence of the Fremantle back awareness questionnaire - German version (FreBAQ-G).

BMC Musculoskelet Disord 2021 Apr 2;22(1):323. Epub 2021 Apr 2.

Faculty of Social Work and Health, University of Applied Sciences and Arts (HAWK), Hildesheim, Germany.

Background: Disrupted self-perception of the low back might contribute to chronic non-specific low back pain. The Fremantle back awareness questionnaire is a simple questionnaire to assess back specific self-perception. The questionnaire has recently been translated to German (FreBAQ-G). Read More

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Monitoring of the effects of a temporally limited heat stress on microbial communities in a shallow aquifer.

Sci Total Environ 2021 Mar 22;781:146377. Epub 2021 Mar 22.

Helmholtz Centre for Environmental Research - UFZ, Department of Isotope Biogeochemistry, 04318 Leipzig, Germany. Electronic address:

Aquifer thermal energy storage (ATES) is a key concept for the use of renewable energy resources. Interest in ATES performed at high temperature (HT-ATES; > 60 °C) is increasing due to higher energetic efficiencies. HT-ATES induces temperature fluctuations that exceed the natural variability in shallow aquifers, which could lead to adverse effects in subsurface ecosystems by altering the groundwater chemistry, biodiversity, and microbial metabolic activity, resulting in changes of the groundwater quality, biogeochemical processes, and ecosystem functions. Read More

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Source apportionment and health risk assessment of potentially toxic elements in soil from mining areas in northwestern China.

Environ Geochem Health 2021 Mar 31. Epub 2021 Mar 31.

School of Environmental & Municipal Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, China.

Soil contaminated with toxic elements from mining activities is a public health concern. In order to obtain a comprehensive understanding of the status and potential risks of inorganic toxic elements in soil resulting from mining activities, Cu, Pb, Cr, Zn, Ni, As, and Cd were selected to evaluate a total of 42 soil samples collected from Gannan mining areas in northwestern China. The concentrations of As and Cd were much higher than their respective background values, while the concentrations of the other elements fluctuated around their background values. Read More

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Menstrual phase and ambient temperature do not influence iron regulation in the acute exercise period.

Am J Physiol Regul Integr Comp Physiol 2021 Mar 31. Epub 2021 Mar 31.

School of Sport, Exercise and Nutrition, Massey University, New Zealand.

The current study investigated whether ambient heat augments the inflammatory and post-exercise hepcidin response in women, and if menstrual phase and/or self-pacing modulate these physiological effects. Eight trained females (age: 37±7 y; VOmax: 46±7 mL∙kg∙min; peak power output: 4.5±0. Read More

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Fears in preschoolers: translation, reliability and validity of the Fear Survey Schedule for Infant-Preschoolers (FSSIP) - Brazilian version.

Trends Psychiatry Psychother 2021 Mar 30. Epub 2021 Mar 30.

Hospital das Clínicas da Faculdade de Medicina de São Paulo.

Objective: The aim of this study was to translate the Fear Survey Schedule for Infants-Preschoolers (FSSIP) for Brazilian Portuguese and to examine its reliability and validity for assessing fears among Brazilian preschoolers.

Methods: Two-independent bilingual professionals conducted translation and back-translation of the original survey. The translated version was used to assess 152 preschool children divided in two groups: Clinical - 71 children referred for treatment for nighttime fear, and Control - 81 children enrolled in kindergarten who were not referred for any mental health service in the previous 6 months. Read More

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In silico studies of selected multi-drug targeting against 3CLpro and nsp12 RNA-dependent RNA-polymerase proteins of SARS-CoV-2 and SARS-CoV.

Netw Model Anal Health Inform Bioinform 2021 25;10(1):22. Epub 2021 Mar 25.

Department of Chemistry, University of Lagos, Akoka, Lagos, Nigeria.

An outbreak of a cluster of viral pneumonia cases, subsequently identified as coronavirus disease 2019 (COVID-19), due to a novel SARS-CoV-2 necessitates an urgent need for a vaccine to prevent infection or an approved medication for a cure. In our in silico molecular docking study, a total of 173 compounds, including FDA-approved antiviral drugs, with good ADME descriptors, and some other nucleotide analogues were screened. The results show that these compounds demonstrate strong binding affinity for the residues at the active sites of RNA-dependent RNA-polymerase (RdRp) modelled structures and Chymotrypsinlike cysteine protease (3CLpro) of the HCoV proteins. Read More

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Relationship between burnout and physical activity level among pre-clinical medical students.

J Pak Med Assoc 2021 Feb;71(Suppl 2)(2):S62-S68

Department of Community Medicine, Universitas Indonesia, Jakarta, Indonesia.

Objective: To identify the relationship between burnout stress and physical activity, specifically in pre-clinical medical students at Universitas Indonesia.

Methods: This cross-sectional study included 318 students selected by stratified random sampling. The Maslach Burnout Inventory General Survey was used to measure burnout stress, and the International Physical Activity Questionnaire Short Form was used for physical activity. Read More

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February 2021

Titanium Iodates with a Second-Harmonic-Generation Response.

Inorg Chem 2021 Mar 29. Epub 2021 Mar 29.

State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, Fujian, P. R. China.

Nonlinear-optical (NLO) crystal is an important photoelectric functional material. In this work, a new NLO titanium iodate, (HO)Ti(IO), along with Ti(IO) has been synthesized under facile conditions. The space group of (HO)Ti(IO) is the chiral noncentrosymmetric group 3 (No. Read More

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Remedial Training of the Less-Impaired Arm in Chronic Stroke Survivors With Moderate to Severe Upper-Extremity Paresis Improves Functional Independence: A Pilot Study.

Front Hum Neurosci 2021 12;15:645714. Epub 2021 Mar 12.

Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, United States.

The ipsilesional arm of stroke patients often has functionally limiting deficits in motor control and dexterity that depend on the side of the brain that is lesioned and that increase with the severity of paretic arm impairment. However, remediation of the ipsilesional arm has yet to be integrated into the usual standard of care for upper limb rehabilitation in stroke, largely due to a lack of translational research examining the effects of ipsilesional-arm intervention. We now ask whether ipsilesional-arm training, tailored to the hemisphere-specific nature of ipsilesional-arm motor deficits in participants with moderate to severe contralesional paresis, improves ipsilesional arm performance and generalizes to improve functional independence. Read More

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