42,686 results match your criteria indicated good


Long noncoding RNA LMO7DN inhibits cell proliferation by regulating the cell cycle in lung adenocarcinoma.

Pathol Res Pract 2021 May 10;223:153475. Epub 2021 May 10.

Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Electronic address:

In our previous study, we reported that the long noncoding RNA, LMO7 downstream neighbor (LMO7DN), has a strong prognostic value in lung adenocarcinoma (LUAD). In this study, we further investigated the role of LMO7DN in LUAD progression. LMO7DN was found to be expressed at low levels in LUAD tissues, and its high expression predicted good prognosis. Read More

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Improvement of quality and flavor of salted egg yolks by ultrasonic assisted cooking.

Ultrason Sonochem 2021 May 6;75:105579. Epub 2021 May 6.

School of Food and Biological Engineering, Hubei University of Technology, Wuhan 430068, Hubei, China; Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology/School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, Anhui, China. Electronic address:

Physicochemical, texture indexes, microstructure and volatiles were used to characterize the changes in quality, structure and flavor of cooked salted egg yolks (SEYs) with or without ultrasonic treatment. Experimental results indicated that ultrasonic significantly increased cooking (water) loss, oil exudation, lipids oxidation (TBARS), accelerated the doneness of cooked SEYs and then promoted the generation of volatiles. These results were further confirmed by the improvement of thermal stability, the changes in color, secondary structure of proteins, water distribution and mobility. Read More

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Exploring natural colorant behavior of husk of durum (Triticum durum Desf.) and bread (Triticum aestivum L.) wheat species for sustainable cotton fabric dyeing.

Environ Sci Pollut Res Int 2021 May 14. Epub 2021 May 14.

Department of Botany, Government College University Faisalabad, Faisalabad, 38000, Pakistan.

Revival of natural colorants in textile dyeing is one of the important strategies to reduce synthetic chemical-based environmental pollution. The study has been conducted to explore the coloring potential of durum (Triticum durum Desf.) and bread (Triticum astivum L. Read More

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Biodegradation of chlorpyrifos using isolates  from contaminated agricultural soil, its kinetic studies.

Sci Rep 2021 May 14;11(1):10320. Epub 2021 May 14.

Department of Environmental Science, Bahauddin Zakariya University, Multan, Pakistan.

Extensive pesticides use is negatively disturbing the environment and humans. Pesticide bioremediation with eco-friendly techniques bears prime importance. This study evaluates the bioremediation of chlorpyrifos in soil using indigenous Bacillus cereus Ct3, isolated from cotton growing soils. Read More

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Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions.

Nat Commun 2021 May 14;12(1):2835. Epub 2021 May 14.

Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing, China.

Fluorine-containing moieties show significant effects in improving the properties of functional molecules. Consequently, efficient methods for installing them into target compounds are in great demand, especially those enabled by metal-free catalysis. Here we show a diazaphospholene-catalyzed hydrodefluorination of trifluoromethylalkenes to chemoselectively construct gem-difluoroalkenes and terminal monofluoroalkenes by simple adjustment of the reactant stoichiometry. Read More

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Reductions in Management Distress Following a Randomized Distress Intervention Are Associated With Improved Diabetes Behavioral and Glycemic Outcomes Over Time.

Diabetes Care 2021 May 14. Epub 2021 May 14.

Department of Family and Community Medicine, University of California, San Francisco, San Francisco, CA.

Objective: To explore associations between reductions in diabetes distress (DD) and improvements in glycemic outcomes among adults with type 1 diabetes (T1D) in the context of a DD randomized clinical trial.

Research Design And Methods: Adults with T1D ( = 301) participated in a two-arm trial aimed at reducing DD (DD-focused OnTrack group vs. education-oriented KnowIt group). Read More

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Mechanical thrombectomy versus medical care alone in large ischemic core: An up-to-date meta-analysis.

Interv Neuroradiol 2021 May 14:15910199211016258. Epub 2021 May 14.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Objective: We compared outcomes and adverse events of thrombectomy versus medical management in acute ischemic stroke (AIS) patients with baseline large infarct core.

Methods: We searched Ovid MEDLINE(R) ALL, Cochrane Library Clinical Controlled Trials and EMBASE from inception to January 2021 for studies comparing thrombectomy and medical management alone in AIS patients who had ASPECTS <=7 or ischemic core volume >=50 ml. Imaging modalities to valuate ASPECTS and core volume were without restriction. Read More

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Quaternary ammonium silane-reinforced agar/polyacrylamide composites for packaging applications.

Int J Biol Macromol 2021 May 11. Epub 2021 May 11.

Department of Fiber System Engineering, Yeungnam University, South Korea. Electronic address:

Agar/polyacrylamide/quaternary ammonium silane-based (A/P/QAS-based) composite films were developed for food and biomedical packaging applications. The structural, optical, and surface morphological properties of the A/P and A/P/QAS composites were characterized by various characterization techniques in terms of thermogravimetric analysis, differential scanning calorimetry analyses, mechanical and rheological properties. Results showed that the 5% gravimetric loss (57. Read More

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Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins.

Org Lett 2021 May 14. Epub 2021 May 14.

Institute for Materials Chemistry and Engineering, Kyushu University, 6-1 Kasugakoen, Kasuga-shi, Fukuoka 816-8580, Japan.

A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. Read More

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Knowledge, Attitudes, and Beliefs Regarding the COVID-19 Pandemic Among Women in Kansas.

J Community Health 2021 May 14. Epub 2021 May 14.

Department of Obstetrics and Gynecology, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.

The COVID-19 pandemic brought forward the challenge of dispersing accurate medical information to the public rapidly. Credible and non-credible sources may impact public reactions to the virus. The purpose of this study is to assess those reactions of women located in or near Kansas. Read More

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-screened cationic dipeptides from scallop with synergistic gelation effect on ι-carrageenan.

Food Funct 2021 May 14. Epub 2021 May 14.

School of Food Science and Technology, Dalian Polytechnic University, Dalian Liaoning 116034, China. and National Engineering Research Center of Seafood, Dalian Liaoning 116034, China and Collaborative Innovation Center of Seafood Deep Processing, Dalian 116034, PR China.

In this paper, some cationic dipeptides from scallop (Patinopecten yessoensis) male gonads (SMGs), which can synergistically gel with ι-carrageenan (ι-C), were screened by the in silico approach. Fourteen protein sequences of SMGs were obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and nano liquid chromatography-mass spectrometry/mass spectrometry (nanoLC-MS/MS) analysis and were then hydrolyzed via in silico simulation. A total of 414 sequences were obtained with 56 duplicates, half of which were positively charged at pH 7. Read More

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Validity of a Modified Food and Nutrition Literacy (M-FNLIT) Questionnaire in Primary School Children in Iran.

Br J Nutr 2021 May 14:1-28. Epub 2021 May 14.

Department of Nutrition, School of Medicine, Mashhad University of medical Sciences, Mashhad, Iran.

The present study aimed to assess the relative validity and reliability of a modified Food and Nutrition Literacy (M-FNLIT) questionnaire in primary school children in the city of Mashhad. The study was conducted in four phases. In the first step, the content and face validity of the questionnaire was evaluated by Delphi consensus as well as interviewing the students. Read More

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Adaptation and validation of the main concept analysis of spoken discourse by native Japanese adults.

Clin Linguist Phon 2021 May 14:1-17. Epub 2021 May 14.

Department of Oto-Rhino-Laryngology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Many people with aphasia demonstrate problems of oral production at the discourse level. The Main Concept Analysis (MCA) for oral discourse production is a published evidence-based battery for quantifying the degree of presence, accuracy, completeness, and efficiency of targeted main concepts in oral discourse. In Japan, such a standardized tool specialized for assessing spoken discourse is currently lacking. Read More

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Trehalose supplementation enhanced the biocontrol efficiency of Sporidiobolus pararoseus Y16 through increased oxidative stress tolerance and altered transcriptome.

Pest Manag Sci 2021 May 13. Epub 2021 May 13.

School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, People's Republic of China.

Background: In the process of biological control, the antagonistic yeasts contend with various stresses that negatively influence yeasts' biocontrol efficiency. In the current study, we investigated the effect of trehalose supplementation on the biocontrol efficiency and oxidative stress tolerance of Sporidiobolus pararoseus Y16.

Results: S. Read More

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Microbiome Data Analysis by Symmetric Non-negative Matrix Factorization With Local and Global Regularization.

Front Mol Biosci 2021 27;8:643014. Epub 2021 Apr 27.

School of Education, Anyang Normal University, Anyang, China.

A network is an efficient tool to organize complicated data. The Laplacian graph has attracted more and more attention for its good properties and has been applied to many tasks including clustering, feature selection, and so on. Recently, studies have indicated that though the Laplacian graph can capture the global information of data, it lacks the power to capture fine-grained structure inherent in network. Read More

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Enhancement of Migration and Tenogenic Differentiation of Macaca Mulatta Tendon-Derived Stem Cells by Decellularized Tendon Hydrogel.

Front Cell Dev Biol 2021 27;9:651583. Epub 2021 Apr 27.

Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.

Decellularized tendon hydrogel from human or porcine tendon has been manufactured and found to be capable of augmenting tendon repair . However, no studies have clarified the effect of decellularized tendon hydrogel upon stem cell behavior. In the present study, we developed a new decellularized tendon hydrogel (T-gel) from Macaca mulatta, and investigated the effect of T-gel on the proliferation, migration and tenogenic differentiation of Macaca mulatta tendon-derived stem cells (mTDSCs). Read More

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Potential Mechanism Prediction of Herbal Medicine for Pulmonary Fibrosis Associated with SARS-CoV-2 Infection Based on Network Analysis and Molecular Docking.

Front Pharmacol 2021 12;12:602218. Epub 2021 Apr 12.

Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Coronavirus Disease 2019 (COVID-19) is still a relevant global problem. Although some patients have recovered from COVID-19, the sequalae to the SARS-CoV-2 infection may include pulmonary fibrosis, which may contribute to considerable economic burden and health-care challenges. Convalescent Chinese Prescription (CCP) has been widely used during the COVID-19 recovery period for patients who were at high risk of pulmonary fibrosis and is recommended by the Diagnosis and Treatment Protocol for COVID-19 (Trial Version sixth, seventh). Read More

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Identification and validation of signal recognition particle 14 as a prognostic biomarker predicting overall survival in patients with acute myeloid leukemia.

BMC Med Genomics 2021 May 13;14(1):127. Epub 2021 May 13.

Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Shuang Yong Road 6, Nanning, 530021, Guangxi, People's Republic of China.

Background: This study aimed to determine and verify the prognostic value and potential functional mechanism of signal recognition particle 14 (SRP14) in acute myeloid leukemia (AML) using a genome-wide expression profile dataset.

Methods: We obtained an AML genome-wide expression profile dataset and clinical prognostic data from The Cancer Genome Atlas (TCGA) and GSE12417 databases, and explored the prognostic value and functional mechanism of SRP14 in AML using survival analysis and various online tools.

Results: Survival analysis showed that AML patients with high SRP14 expression had poorer overall survival than patients with low SRP14 expression. Read More

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Outcomes and complications following minimally invasive excision of synovial cysts of the lumbar spine: A systematic review and meta-analysis.

Clin Neurol Neurosurg 2021 May 4;206:106667. Epub 2021 May 4.

University Hospitals Cleveland Medical Centre, Case Western Reserve University School of Medicine, Cleveland, OH, USA. Electronic address:

Objective: Lumbar synovial cysts (LSC) are one of the manifestations of spinal degenerative cascade. Spinal stenosis or presence of instability in these patients can lead to various symptoms and surgery is indicated following failure of non-operative management for symptomatic synovial cysts. Surgery when performed consists of either decompression with resection of cyst with our without fusion. Read More

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Radiolabeling and Evaluation of a Novel [TcN] Complex with Deferoxamine Dithiocarbamate as a Potential Agent for Bacterial Infection Imaging.

Bioorg Med Chem Lett 2021 May 10:128102. Epub 2021 May 10.

Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, P.R. China. Electronic address:

In order to find a Tc-labeled deferoxamine radiotracer for bacterial infection imaging, deferoxamine dithiocarbamate (DFODTC) was successfully synthesized and it was radiolabeled with [TcN] core to prepare the TcN(DFODTC) complex. TcN(DFODTC) was obtained with high radiochemical purity without further purification. The complex was lipophilic and exhibited good in vitro stability. Read More

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Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer.

Authors:
Hyukjai Shin

Adv Exp Med Biol 2021 ;1187:567-590

Hyanyang University College of Medicine, Ansan, Gyeonggi-do, South Korea.

Endoscopic oncoplastic breast surgery represents a minimal invasive approach with the aim of both safe excision of cancer and preserving the breast shape. It has less noticeable scar, excellent cosmetic outcomes, high patient satisfaction rate. Recently, relative long-term follow-up results have been reported to be very safe (Soybir and Fukuma, J Breast Health 11:52-58, 2015; Fan et al. Read More

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January 2021

Ni-Catalyzed radical cyclization of vinyl azides with cyclobutanone oxime esters to access cyanoalkyl containing quinoxalin-2(1)-ones.

Org Biomol Chem 2021 May 13. Epub 2021 May 13.

Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.

A nickel-catalyzed cascade addition/cyclization of 2-azido-N-arylacrylamides and cyclobutanone oxime esters for the construction of 3-cyanoalkylated quinoxalin-2(1H)-ones is developed. This reaction proceeds under mild conditions with good functional group tolerance and broad substrate scope. A preliminary mechanistic experiment indicated that the cyanoalkyl radical might be involved in this transformation. Read More

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Clinical Characteristics, Prognosis, and Nomogram for Esophageal Cancer Based on Adenosquamous Carcinoma: A SEER Database Analysis.

Front Oncol 2021 26;11:603349. Epub 2021 Apr 26.

Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Esophageal adenosquamous carcinoma (ASC) is a rare pathological type of cancer. Its clinical features and prognosis is poorly understood. The purpose of this study was to identify the characteristics of ASC patients and analyze the risk factors of esophageal carcinoma. Read More

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Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients' Perspectives and Attitudes.

J Pain Res 2021 5;14:1241-1250. Epub 2021 May 5.

Clinical Research, Vitamed Research, Palm Desert, CA, USA.

Introduction: Cannabis products have become easily available and accessible after decriminalization of cannabis for recreational and medicinal use in many states. Cannabidiol (CBD) has been of increasing interest to patients and is being used to self-medicate a variety of ailments. However, very limited information is available to patients and providers to form an educated opinion regarding its indicated use to treat the many conditions this substance has been implied to be helpful for. Read More

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Nanoparticles of Chitosan/Poly(D,L-Lactide-Co-Glycolide) Enhanced the Immune Responses of HCA59 Antigen in Model Mice.

Int J Nanomedicine 2021 4;16:3125-3139. Epub 2021 May 4.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China.

Background: Hepatocellular carcinoma-associated antigen 59 (HCA59) from excretory/secretory products of is known to have the ability to modulate the functions of host cells. However, its immunogenicities using different nanoparticles adjuvants remain poorly understood.

Purpose: The study aimed to select an efficient nanoparticle antigen delivery system, which could enhance the immune responses of HCA59 in mice. Read More

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The Inhibitory Effect of Icariin Nanoparticles on Angiogenesis in Pulmonary Fibrosis.

J Nanosci Nanotechnol 2021 Nov;21(11):5429-5435

Linyi Traditional Chinese Medicine Hospital, Liny! 276000, Shandong, PR China.

This study investigated icariin (ICA) nanoparticles on angiogenesis in rats with pulmonary fibrosis and its mechanism. First, icariin solid nanoliposomes (ICA-SLN) were prepared. The release of icariin nanoparticles was determined using a UV-Vis spectrophotometer, after which the plasma concentration of icariin nanoparticles in rats was determined. Read More

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November 2021

Canalicular Curettage to the Rescue: a report of three cases.

Nepal J Ophthalmol 2020 Jul;12(24):333-338

Sagarmatha Choudhary Eye Hospital, Lahan, Siraha, Nepal.

Introduction: Canalicular curettage is a surgical procedure used to remove canalicular contents and debris from canaliculi. It is usually indicated for chronic, persistent or recalcitrant canalicular diseases with no resolution of symptoms after conservative management. We describe 3 different cases of persistent canalicular diseases which needed canalicular curettage to rescue from the conditions leading to successful outcomes. Read More

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Characteristics and surgical outcomes of pediatric intracranial aneurysms in Romania.

Turk Neurosurg 2021 Feb 5. Epub 2021 Feb 5.

University of Medicine and Pharmacy Carol Davila, Department of Neurosurgery, Bucharest, Romania.

Aim: Pediatric aneurysms are rare, occurring in under 5% of cases, and their clinical presentation, rupture probability, location, and outcome differ from those in adults. The present study aimed to analyze the demographic characteristics and surgical outcomes of the largest series of patients with pediatric aneurysms reported in Romania, in consideration of the primary factors that lead to good long-term outcomes. Given that all cases involved ruptured aneurysms, we also investigated the ability of microsurgical clipping to prevent massive hemorrhage and aggravation of neurological deficits. Read More

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February 2021

Can physical activity levels and relationships with energy expenditure change the clinical aspects of sarcopenia and perceptions of falls among elderly women? Observational cross-sectional study.

Sao Paulo Med J 2021 May 10. Epub 2021 May 10.

MD, PhD. Professor and Coordinator of the Biomechanics and Musculoskeletal Rehabilitation Laboratory, Postgraduate Health Science Department, Medical School, Universidade Santo Amaro (UNISA), São Paulo (SP), Brazil; and Postdoctoral Student, Medical School, Universidade de São Paulo (USP), São Paulo (SP), Brazil.

Background: Physical activity (PA) is an effective strategy for managing sarcopenia in the elderly, but few studies have addressed PA levels regarding age-related changes.

Objective: To ascertain the effects of elderly women's PA levels on sarcopenia, physical performance, handgrip strength and perception of the risk of falling, and their relationship with energy expenditure.

Design And Setting: Observational cross-sectional study conducted in the southern region of the city of São Paulo, Brazil. Read More

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Efficacy and safety of dupilumab in two adolescents with severe atopic dermatitis.

Einstein (Sao Paulo) 2021 10;19:eRC6064. Epub 2021 May 10.

Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

We report the cases of two adolescent siblings with severe atopic dermatitis, who, despite weighing approximately 40kg, presented a good response to dupilumab with the off-label dose for individuals aged 12 years and weighing 60kg. Both had already used cyclosporine, azathioprine, methotrexate and oral corticosteroids for long periods, plus topical treatments with no adequate disease control. Skin lesions were constant and widespread, with frequent skin infections and very poor quality of life, with numerous physical and psychosocial consequences, such as dropping out of school activities due to severe itching, appearance and bullying. Read More

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