11,191 results match your criteria indicate ethanol

CO photoelectroreduction with enhanced ethanol selectivity by high valence rhenium-doped copper oxide composite catalysts.

J Colloid Interface Sci 2021 Apr 20;599:497-506. Epub 2021 Apr 20.

College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

CuO supported catalyst with high valence rhenium doping were specially studied for photoelectrocatalytic reduction of CO to small molecular alcohols, which were synthesized by nitrate thermal decomposition method on anatase TiO nanotube arrays (TiO-NTs). Photoelectrochemical measurements indicate that the high valence rhenium doping helps in improving the catalytic activity and selectivity of CuO supported catalysts. For the case of 6 wt% Re-doped CuO/TiO-NTs calcined at 723 K, the principal products are methanol and ethanol with yield up to 19. Read More

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J Pharmacol Exp Ther 2021 May 7. Epub 2021 May 7.

Pharmaceutical Sciences, University at Buffalo, United States

The drug of abuse, γ-hydroxybutyric acid (GHB), is commonly co-ingested with ethanol, resulting in a high incidence of toxicity and death. Our laboratory has previously reported that GHB is a substrate for the monocarboxylate transporters (MCT), necessary for its absorption, renal clearance, and tissue distribution, including across the blood-brain barrier. Our goal was to investigate the drug-drug interaction (DDI) between GHB-ethanol and evaluate MCT1 inhibition as a strategy to reverse toxicity. Read More

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Effects of advanced maternal age and acute prenatal alcohol exposure on mouse offspring growth and craniofacial phenotype.

Alcohol Clin Exp Res 2021 May 7. Epub 2021 May 7.

Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario.

Background: Prenatal alcohol exposure (PAE) can result in developmental defects including growth restriction, craniofacial anomalies and cognitive-behavioral deficits, though the presence and severity of these adverse outcomes varies dramatically. Preclinical animal models have demonstrated that dose and timing of PAE account for much but not all, of this phenotypic variation, suggesting that additional factors mitigate effects of PAE. Here we used a mouse model to investigate whether maternal age modulates the effects of PAE on the severity and variation of offspring growth and craniofacial outcomes. Read More

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Fenofibrate (a PPAR-α Agonist) Administered During Ethanol Withdrawal Reverts Ethanol-Induced Astrogliosis and Restores the Levels of Glutamate Transporter in Ethanol-Administered Adolescent Rats.

Front Pharmacol 2021 20;12:653175. Epub 2021 Apr 20.

Institute of Biomedical Sciences, Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile.

High-ethanol intake induces a neuroinflammatory response, which has been proposed as responsible for the maintenance of chronic ethanol consumption. Neuroinflammation decreases glutamate transporter (GLT-1) expression, increasing levels of glutamate that trigger dopamine release at the corticolimbic reward areas, driving long-term drinking behavior. The activation of peroxisome proliferator-activated receptor alpha (PPARα) by fibrates inhibits neuroinflammation, in models other than ethanol consumption. Read More

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Poisonings by substances of abuse at the Oslo Accident and Emergency Outpatient Clinic 2014-18.

Tidsskr Nor Laegeforen 2021 May 29;141(7). Epub 2021 Apr 29.

Background: Poisonings by substances of abuse are potentially dangerous and indicate risky substance use behaviour. To be prepared to handle patients with poisonings by substances of abuse, we need updated knowledge about the kinds of substances we can be expected to encounter. Most substance use-related poisonings in Oslo are treated at the OAEOC, and we describe the poisonings observed there in the period 2014-2018. Read More

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Organic contamination detection for isotopic analysis of water by laser spectroscopy.

Rapid Commun Mass Spectrom 2021 May 3:e9118. Epub 2021 May 3.

Global Institute for Water Security, School of Environment and Sustainability, University of Saskatchewan, 11 Innovation Boulevard, Saskatoon, SK, S7N 3H5, Canada.

Rationale: Hydrogen and oxygen stable isotope ratios (δ H, δ O, and δ O values) are commonly used tracers of water. These ratios can be measured by isotope ratio infrared spectroscopy (IRIS). However, IRIS approaches are prone to errors induced by organic compounds present in plant, soil, and natural water samples. Read More

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Evolution of Vehicle Emission Factors in a Megacity Affected by Extensive Biofuel Use: Results of Tunnel Measurements in São Paulo, Brazil.

Environ Sci Technol 2021 May 3. Epub 2021 May 3.

Departamento de Ciências Atmosféricas, Instituto de Astronomia, Geofísica e Ciências Atmosféricas, Universidade de São Paulo, São Paulo 05508-090, Brazil.

Since 2001, four emission measurement campaigns have been conducted in multiple traffic tunnels in the megacity of São Paulo, Brazil, an area with a fleet of more than 7 million vehicles running on fuels with high biofuel contents: gasoline + ethanol for light-duty vehicles (LDVs) and diesel + biodiesel for heavy-duty vehicles (HDVs). Emission factors for LDVs and HDVs were calculated using a carbon balance method, the pollutants considered including nitrogen oxides (NO), carbon monoxide (CO), and sulfur dioxide, as well as carbon dioxide and ethanol. From 2001 to 2018, fleet-average emission factors for LDVs and HDVs, respectively, were found to decrease by 4. Read More

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Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases.

Front Pharmacol 2021 15;12:653795. Epub 2021 Apr 15.

Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.

Danggui-Shayao-San (DSS) is a famous Traditional Chinese Medicine formula that used for treating pain disorders and maintaining neurological health. Recent studies indicate that DSS has neuroprotective effects against ischemic brain damage but its underlining mechanisms remain unclear. Herein, we investigated the neuroprotective mechanisms of DSS for treating ischemic stroke. Read More

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Effects of Microbial Inoculation and Storage Length on Fermentation Profile and Nutrient Composition of Whole-Plant Sorghum Silage of Different Varieties.

Front Microbiol 2021 13;12:660567. Epub 2021 Apr 13.

Department of Animal and Dairy Sciences, University of Wisconsin, Madison, WI, United States.

This study aimed to assess the effects of a heterofermentative microbial inoculant and storage length on fermentation profile, aerobic stability, and nutrient composition in whole-plant sorghum silage (WPSS) from different varieties. Experiment 1, a completely randomized design with a 2 × 3 factorial treatment arrangement, evaluated microbial inoculation [CON (50 mL distilled water) or LBLD ( DSM 21762, DSM 12856, and DSM 32074; 300,000 CFU/g of fresh forage)] and storage length (14, 28, or 56 d) in forage WPSS. The LBLD silage had lower pH compared to CON, and greater concentrations of succinic acid, ethanol, 1,2-propanediol (1,2-PD), 1-propanol, 2,3-butanediol and total acids. Read More

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Heterocyclic Schiff Bases of 3-Aminobenzanthrone and Their Reduced Analogues: Synthesis, Properties and Spectroscopy.

Molecules 2021 Apr 28;26(9). Epub 2021 Apr 28.

Department of Applied Chemistry, Institute of Life Sciences and Technology, Daugavpils University, LV-5401 Daugavpils, Latvia.

New substituted azomethines of benzanthrone with heterocyclic substituents were synthesized by condensation reaction of 3-aminobenzo[de]anthracen-7-one with appropriate aromatic aldehydes. The resulting imines were reduced with sodium borohydride to the corresponding amines, the luminescence of which is more pronounced in comparison with the initial azomethines. The novel benzanthrone derivatives were characterized by NMR, IR, MS, UV/Vis, and fluorescence spectroscopy. Read More

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Leaves and Fruits Preparations of L.: A Review on the Ethnopharmacological Uses and Implications in Inflammation and Infection.

Antibiotics (Basel) 2021 Apr 12;10(4). Epub 2021 Apr 12.

Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse 3, 3010 Bern, Switzerland.

There is an increasing interest in revisiting plants for drug discovery, proving scientifically their role as remedies. The aim of this review was to give an overview of the ethnopharmacological uses of L. (PlL) leaves and fruits, expanding the search for the scientific discovery of their chemistry, anti-inflammatory, antioxidative and antimicrobial activities. Read More

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Xanthohumol protect cognitive performance in diabetic model rats by inhibiting protein kinase B/nuclear factor kappa-B pathway.

Neuroreport 2021 May;32(8):651-658

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University.

Xanthohumol (XN, 2', 4', 4-trihydroxy-6'-methoxy-3'-prenylchalcone), a polyphenol chalcone from hops (Humulus lupulus), has received increasing attention due to its multiple pharmacologic activities. As an active component in beers, its presence has been suggested to be linked to the epidemiologic observation of the beneficial effect of regular beer drinking. But regarding cardiovascular and immunologic effects of polyphenols and ethanol, benefits of beer drinking in patients with diabetes were still in doubt. Read More

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leaf extract attenuates hepatic lipogenesis and adipogenesis.

Food Funct 2021 Apr 28. Epub 2021 Apr 28.

Department of Life Science, Bokjeong-dong, Sujung-gu, Sungnam-si, Gyeongg-do 461-701, Republic of Korea.

Annona muricata (graviola) is a medicinal plant that can be used to alleviate chronic human diseases by providing antioxidants and inducing immunomodulation. In this study, we found that treatment of AML12 hepatocytes with steam (SGE) and ethanol (EGE) extracts of graviola leaf downregulated the expression of fatty acid (FA) oxidation genes, including ACOX1, CPT1, and PPARα, with no change in the expression of FA synthesis genes. However, whereas EGE inhibited the differentiation and lipid accumulation of 3T3-L1 adipocytes and downregulated FA synthesis genes, no similar changes were observed in response to treatment with SGE. Read More

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Biphasic Effects of Ethanol Exposure on Waste Metabolites Clearance in the CNS.

Mol Neurobiol 2021 Apr 25. Epub 2021 Apr 25.

Laboratory of Neurovascular Inflammation and Neurodegeneration, Department of Biomedical Engineering, Center for Injury Bio Mechanics, Materials and Medicine, New Jersey Institute of Technology, Newark, NJ, 07102, USA.

We have shown that the effects of low-dose ethanol promote the clearance of waste metabolites, such as amyloid-beta (Aβ) proteins, from the brain through the perivascular space (PVS). We demonstrated that dilative reactivity of arterial smooth muscle and endothelial cells regulate this clearance. These findings indicate the importance of blood-brain barrier (BBB) transvascular clearance of large size metabolites from the central nervous system (CNS), where the lymphatic clearance system is absent. Read More

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Interleukin-6 participates in human pancreatic stellate cell activation and collagen I production via TGF-β1/Smad pathway.

Cytokine 2021 Apr 20:155536. Epub 2021 Apr 20.

Department of Hepatic Biliary Pancreatic Medicine, First Hospital of Jilin University, Changchun, China. Electronic address:

Pancreatic stellate cells (PSCs) play a key role in fibrogenesis during alcoholic chronic pancreatitis (ACP). Transforming growth factor-β1 (TGF-β1) is a major regulator of PSC activation and extracellular matrix production. Interleukin-6 (IL-6) has shown to participate in TGF-β1 production and rat PSC activation. Read More

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Noninvasive Detection of Ammonia in the Breath of Hemodialysis Patients Using a Highly Sensitive Ammonia Sensor Based on a Polypyrrole/Sulfonated Graphene Nanocomposite.

Anal Chem 2021 05 21;93(17):6706-6714. Epub 2021 Apr 21.

Department of Chemistry, Faculty of Basic Sciences, Tarbiat Modares University, P.O. Box 14115-175, Tehran, Iran.

In this work, we fabricated fast-responsive and highly sensitive chemiresistive sensors based on nanocomposites of polypyrrole and graphitic materials such as graphene oxide (GO), reduced graphene oxide (RGO), and sulfonated graphene (SRGO) by an in situ chemical oxidative polymerization method. The synthesized nanocomposites were characterized using field emission scanning electron microscopy (FESEM), energy-dispersive spectroscopy (EDS), Fourier transform infrared (FT-IR) spectroscopy, and X-ray diffraction (XRD). The effects of the operating temperature of different nanocomposites were investigated at four temperatures (28, 40, 50, and 60 °C), and the results were compared with that of the polypyrrole-based sensor. Read More

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Influence of vitamin D treatment on functional expression of drug disposition pathways in human kidney proximal tubule cells during simulated uremia.

Xenobiotica 2021 Apr 18:1-11. Epub 2021 Apr 18.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA.

Effects of cholecalciferol (VitD) and calcitriol (1,25-VitD), on the expression and function of major vitamin D metabolizing enzymes (cytochrome P450 [CYP]2R1, CYP24A1) and select drug transport pathways (P-gp, /OATP4C1) were evaluated in human kidney proximal tubule epithelial cells (hPTECs) under normal and uraemic serum conditions.hPTECs were incubated with 10% normal or uraemic serum for 24 h followed by treatment with 2% ethanol vehicle, or 100 and 240 nM doses of VitD, or 1,25-VitD for 6 days. The effects of treatment on mRNA and protein expression and functional activity of select CYP enzymes and transporters were assessedUnder uraemic serum, treatment with 1,25-VitD resulted in increased mRNA but decreased protein expression of CYP2R1. Read More

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BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells.

Ecotoxicol Environ Saf 2021 Jun 15;216:112210. Epub 2021 Apr 15.

Saint Mary's College of California, Department of Biology, Moraga, CA, USA. Electronic address:

Bisphenol A (BPA) is a ubiquitous industrial chemical found in everyday plastic products and materials. Due to scientific findings on the reproductive, developmental, and cellular defects caused by BPA and heightened public awareness, manufacturers have begun to use new chemicals in place of BPA in "BPA-free" products. These alternatives are chemical analogs of BPA and include dozens of new compounds that have undergone relatively little testing and oversight, including: bisphenol S (BPS), bisphenol AF (BPAF), and the recently developed tetramethyl bisphenol F (TMBPF; the monomer of valPure V70). Read More

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Vinasse from sugarcane bagasse (hemicellulose) acid hydrolysate and molasses supplemented: biodegradability and toxicity.

Ecotoxicology 2021 Apr 15. Epub 2021 Apr 15.

Department of General and Applied Biology, Institute of Biosciences, São Paulo State University (UNESP), Av. 24-A, 1515, CEP: 13506-900, Rio Claro, São Paulo, Brazil.

Vinasse sugarcane is a valuable byproduct of the ethanol production process, presenting a perspective of volume increase with the development of second generation ethanol (2GE). However, this byproduct needs new methods of treatment and management for sustainability. Besides that, 2GE vinasse can be associated with some compounds (such as furan derivatives, phenolic compounds and organic acids), depending on the process used to solubilize hemicellulose, which could compromise vinasse destination or utilization. Read More

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Kinetically Controlled Synthesis of Rhodium Nanocrystals with Different Shapes and a Comparison Study of Their Thermal and Catalytic Properties.

J Am Chem Soc 2021 Apr 14;143(16):6293-6302. Epub 2021 Apr 14.

School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

We report the synthesis of Rh nanocrystals with different shapes by controlling the kinetics involved in the growth of preformed Rh cubic seeds. Specifically, Rh nanocrystals with cubic, cuboctahedral, and octahedral shapes can all be obtained from the same cubic seeds under suitable reduction kinetics for the precursor. The success of such a synthesis also relies on the use of a halide-free precursor to avoid oxidative etching, as well as the involvement of a sufficiently high temperature to remove Br ions from the seeds while ensuring adequate surface diffusion. Read More

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Effect of quorum-sensing molecule 2-phenylethanol and ARO genes on Saccharomyces cerevisiae biofilm.

Appl Microbiol Biotechnol 2021 May 14;105(9):3635-3648. Epub 2021 Apr 14.

National Engineering Research Center for Biotechnology, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.

Biofilms are a form of microbial community that can be beneficial for industrial fermentation because of their remarkable environmental resistance. However, the mechanism of biofilm formation in Saccharomyces cerevisiae remains to be fully explored, and this may enable improved industrial applications for this organism. Although quorum-sensing (QS) molecules are known to be involved in bacteria biofilm formation, few studies have been undertaken with these in fungi. Read More

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Highly-efficient and stable photocatalytic activity of lead-free CsAgInCl double perovskite for organic pollutant degradation.

J Colloid Interface Sci 2021 Aug 29;596:376-383. Epub 2021 Mar 29.

Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, PR China.

Photocatalytic applications of halide perovskites have attracted increasing attention. However, lack of stability and lead toxicity of lead halide perovskites have hindered their applications. Metal halide double perovskite (DP) CsAgInCl is a stable, environment-friendly semiconductor with direct band gap, and then the best promising alternative to lead halide perovskites. Read More

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Chemogenetic manipulation of astrocytic signaling in the basolateral amygdala reduces binge-like alcohol consumption in male mice.

J Neurosci Res 2021 Apr 12. Epub 2021 Apr 12.

Department of Biological & Biomedical Sciences, North Carolina Central University, Durham, NC, USA.

Binge drinking is a common occurrence in the United States, but a high concentration of alcohol in the blood has been shown to have reinforcing and reciprocal effects on the neuroimmune system in both dependent and non-dependent scenarios. The first part of this study examined alcohol's effects on the astrocytic response in the central amygdala and basolateral amygdala (BLA) in a non-dependent model. C57BL/6J mice were given access to either ethanol, water, or sucrose during a "drinking in the dark" paradigm, and astrocyte number and astrogliosis were measured using immunohistochemistry. Read More

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Imipramine attenuates anxiety- and depressive-like effects of acute and prolonged ethanol-abstinence in male rats by modulating SERT and GR expression in the dorsal hippocampus.

Behav Brain Res 2021 Jun 9;408:113295. Epub 2021 Apr 9.

Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil; Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil; Instituto de Neurociências e Comportamento (INeC), Ribeirão Preto, SP, Brazil. Electronic address:

Aims: Considering that serotoninergic agents attenuate symptoms of anxiety and are used to treat depression, we investigated whether subchronic treatment with imipramine, a serotonin/noradrenaline reuptake inhibitor, would prevent the anxiogenic-like behaviour induced by acute and/or chronic ethanol withdrawal. We also investigated whether those changes were related to the disfunctioning of hypothalamic-pituitary-adrenal (HPA) axis and serotonergic neurotransmission.

Main Methods: 264 Male Wistar rats were treated with ethanol 6% (vol. Read More

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Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced cartilage degradation in rabbit articular cartilage explants.

J Food Biochem 2021 May 5;45(5):e13713. Epub 2021 Apr 5.

R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.

Alpinia oxyphylla is a widely used medicinal herb for diarrhea, gastralgia, tumors, hypertention, and cerebrovascular disorders. Here, we evaluated the chondroprotective effect of A. oxyphylla dried fruit ethanol extract (AOE) against cartilage degradation in rabbit articular cartilage explants. Read More

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Monascus pilosus YX-1125: An efficient digester for directly treating ultra-high-strength liquor wastewater and producing short-chain fatty acids under multiple-stress conditions.

Bioresour Technol 2021 Jul 26;331:125050. Epub 2021 Mar 26.

College of Environment and Ecology, Chongqing University, Chongqing 400044, China; State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing, 400044, China. Electronic address:

Ultra-high-strength liquor wastewater (UHS-LWW) is rich in organic matter, and the required treatment is expensive. Here, an extremophilic strain Monascus pilosus YX-1125 was isolated for the direct conversion of UHS-LWW to short-chain fatty acids (SCFAs). Strain YX-1125 is an efficient SCFA producer with carbohydrate metabolic flexibility under multiple-stress conditions. Read More

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Optimization of microwave assisted extraction of simmondsins and polyphenols from Jojoba (Simmondsia chinensis) seed cake using Box-Behnken statistical design.

Food Chem 2021 Mar 23;356:129670. Epub 2021 Mar 23.

Center for Sustainable Development, College of Arts and Sciences, Qatar University, Doha 2713, Qatar. Electronic address:

A closed-vessel microwave-assisted extraction (MAE) of simmondsins and polyphenols from defatted Jojoba cake using Box-Benkhen design with four independent variables (solvent/cake ratio, ethanol concentration, extraction time and microwave power) was investigated. ANOVA results showed that the obtained models were significant at 95% confidence level. Optimal extraction conditions were found for highest values of microwave power (500 W) and extraction time (15 min) and for moderate values of solvent to cake ratio (41 - 45 mL/g). Read More

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Spermidine Prevents Ethanol and Lipopolysaccharide-Induced Hepatic Injury in Mice.

Molecules 2021 Mar 22;26(6). Epub 2021 Mar 22.

Department of Biology, The Catholic University of America, Washington DC 20064, USA.

To date, there is no effective treatment for alcoholic liver disease, despite its prevalence world-wide. Because alcohol consumption is associated with oxidative stress-induced liver injury and pro-inflammatory responses, naturally occurring antioxidants and/or anti-inflammatories may be potential therapeutics. Spermidine is an abundant, ubiquitous polyamine that has been found to display strong antioxidant and anti-inflammatory properties. Read More

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A Highly Birefringent Photonic Crystal Fiber for Terahertz Spectroscopic Chemical Sensing.

Sensors (Basel) 2021 Mar 5;21(5). Epub 2021 Mar 5.

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

A photonic crystal fiber (PCF) with high relative sensitivity was designed and investigated for the detection of chemical analytes in the terahertz (THz) regime. To ease the complexity, an extremely simple cladding employing four struts is adopted, which forms a rectangular shaped core area for filling with analytes. Results of enormous simulations indicate that a minimum 87. Read More

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Influence of Extraction Solvent on the Phenolic Profile and Bioactivity of Two Species.

Molecules 2021 Mar 13;26(6). Epub 2021 Mar 13.

Centre of the Region Haná for Biotechnological and Agricultural Research, Department of Genetic Resources for Vegetables, Medicinal and Special Plants, Crop Research Institute, Šlechtitelů 29, 78371 Olomouc, Czech Republic.

The phenolic composition, as well as the antioxidant and antimicrobial activities of two poorly investigated species, Waldst. and the endemic Vis., were studied. Read More

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