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Targeted Transcriptomic Analysis of C57BL/6 and BALB/c Mice During Progressive Chronic Infection Reveals Changes in Host and Parasite Gene Expression Relating to Neuropathology and Resolution.

Front Cell Infect Microbiol 2021 18;11:645778. Epub 2021 Mar 18.

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA, United States.

is a resilient parasite that infects a multitude of warm-blooded hosts and results in a lifelong chronic infection requiring continuous responses by the host. Chronic infection is characterized by a balanced immune response and neuropathology that are driven by changes in gene expression. Previous research pertaining to these processes has been conducted in various mouse models, and much knowledge of infection-induced gene expression changes has been acquired through the use of high throughput sequencing techniques in different mouse strains and post-mortem human studies. Read More

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When Does Educational Level Diversity Foster Team Creativity? Exploring the Moderating Roles of Task and Personnel Variability.

Front Psychol 2021 5;12:585849. Epub 2021 Mar 5.

School of Management, Zhejiang University, Hangzhou, China.

This study explores how the variability of the work environment shapes the impact of educational level diversity on team creativity. By adopting an integrative framework-"status characteristics-information elaboration" model as a theoretical lens, we propose and examine the moderating roles of task and personnel variability in educational level diversity-team creativity relationship. Utilizing multiple survey data collected from 90 knowledge work teams, the empirical results indicate that educational level diversity is more conducive to team creativity when teams are confronted with more variable tasks and when teams experience less frequent personnel changes. Read More

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Concept analysis of Perioperative Thirst for the development of a new nursing diagnosis.

Rev Bras Enferm 2021 3;74(1):e20200065. Epub 2021 Mar 3.

Universidade Estadual de Londrina. Londrina, Paraná, Brazil.

Objectives: to analyze the perioperative thirst concept for the development of a new diagnostic structure according to NANDA International.

Methods: a concept analysis study based on the framework proposed by Walker and Avant, instrumentalized through an integrative literature review based on SCOPUS, CINAHL, PUBMED, LILACS, and WOS. The elaboration of the diagnostic structure followed NANDA International guidelines. Read More

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Development of a Tool to Measure the Clinical Response to Biologic Therapy in Uncontrolled Severe Asthma: The FEV, Exacerbations, Oral Corticosteroids, Symptoms Score.

J Allergy Clin Immunol Pract 2021 Feb 4. Epub 2021 Feb 4.

Department of Respiratory Medicine, Hospital Universitario Son Espases-IdISBa-Ciberes, Palma de Mallorca, Spain.

Background: There is a lack of tools to quantify the response to monoclonal antibodies (mAbs) holistically in severe uncontrolled asthma patients.

Objective: To develop a valid score to assist specialists in this clinical context.

Methods: The score was developed in four subsequent phases: (1) elaboration of the theoretical model of the construct intended to be measured (response to mAbs); (2) definition and selection of items and measurement instruments by Delphi survey; (3) weight assignment of the selected items by multicriteria decision analysis using the Potentially All Pairwise RanKings of All Possible Alternatives methodology using the 1000minds software; and (4) face validity assessment of the obtained score. Read More

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February 2021

Young adults with type 1 diabetes and their experiences with diabetes follow-up and participation in the DiaPROM pilot trial: A qualitative study.

Diabet Med 2021 Feb 5:e14535. Epub 2021 Feb 5.

Department of Health and Caring Sciences, Western Norway University of Applied Sciences, Bergen, Norway.

Aim: To explore young adults' experiences of outpatient follow-up appointments, completing electronic Patient-Reported Outcome Measures (PROMs), and using the Problem Areas In Diabetes (PAID) scale during the Diabetes Patient-Reported Outcome Measures (DiaPROM) pilot trial.

Methods: We performed a qualitative study among 19 young adults (aged 22-39 years) with type 1 diabetes who participated in the pilot trial. Between February and June 2019, we conducted individual, semi-structured telephone interviews with participants from the intervention and control arms. Read More

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February 2021

Pathways to plant domestication in Southeast Anatolia based on new data from aceramic Neolithic Gusir Höyük.

Sci Rep 2021 Jan 22;11(1):2112. Epub 2021 Jan 22.

Department of Prehistory, Istanbul University, Istanbul, 34134, Turkey.

Southeast Anatolia is home to some of the earliest and most spectacular Neolithic sites associated with the beginning of cultivation and herding in the Old World. In this article we present new archaeobotanical and zooarchaeological data from Gusir Höyük, an aceramic Neolithic habitation dating to the 12th-late 11th millennia cal BP. Our results show selective use of legume crop progenitors and nuts during the earlier part of this period, followed by the management of cereal and legume crop progenitors from the mid-11th millennium cal BP. Read More

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January 2021

Functional Neural Architecture Supporting Highly Superior Autobiographical Memory.

Brain Connect 2021 Feb 9. Epub 2021 Feb 9.

Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom.

The neural mechanisms of highly superior autobiographical memory (HSAM) are poorly understood. To shed light on the functional magnetic resonance imaging (fMRI)-informed neurobiology of this condition, in this study we characterize for the first time the neurofunctional architecture of a 20-year-old individual (B.B. Read More

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February 2021

Environmental risk assessment in agro-ecosystems: Revisiting the concept of receiving environment after the EFSA guidance document.

Salvatore Arpaia

Ecotoxicol Environ Saf 2021 Jan 21;208:111676. Epub 2020 Nov 21.

ENEA - Italian National Agency for New Technologies, Energy and Sustainable Economic Development. Research Centre Trisaia, S.S. 106 Jonica, km 419.5, I-75026 Rotondella MT, Italy. Electronic address:

The environmental risk assessment (ERA) for genetically modified plants (GMPs) is a prerequisite for commercial approval of these new varieties according to regulatory systems worldwide. The first country to regulate GM crops was the USA and the issue of possible environmental impacts was based on the principles used in risk assessment of pesticides. Two main pillars of this approach are the use of surrogate species for testing effects on non-target organisms using a tiered assessment with clear thresholds to indicate the need to move between tiers. Read More

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January 2021

In vitro selections with RNAs of variable length converge on a robust catalytic core.

Nucleic Acids Res 2021 01;49(2):674-683

Center for the Emergence of Life, NASA Ames Research Center, Moffett Field, CA 94035, USA.

In vitro selection is a powerful tool that can be used to understand basic principles of molecular evolution. We used in vitro selection to understand how changes in length and the accumulation of point mutations enable the evolution of functional RNAs. Using RNA populations of various lengths, we performed a series of in vitro experiments to select for ribozymes with RNA ligase activity. Read More

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January 2021

The Effects of Aversive Mood State on the Affective Anticipation and Perception: An Event-Related Potential Study.

Neuroscience 2021 03 25;458:133-140. Epub 2020 Dec 25.

School of Psychology, Shanghai University of Sport, Shanghai, China. Electronic address:

Deficits in the anticipation and experience of affective events represent a key risky factor for a variety of mental disorders, such as anxiety and depression. Here, we examined temporal dynamics underlying the modulations of the aversive mood state on neural responses of anticipating and perceiving affective pictures. Participants were asked to perform an affective cueing paradigm in both threat and safe contexts. Read More

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GluD2- and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells.

Neuron 2021 02 21;109(4):629-644.e8. Epub 2020 Dec 21.

Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address:

The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, but this hypothesis has not been causally tested in vivo in the mammalian brain. The presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex. Here we show that sparse but not global knockout of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular layer and overelaboration in the superficial molecular layer. Read More

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February 2021

Optogenetically-induced long term depression in the rat orbitofrontal cortex ameliorates stress-induced reversal learning impairment.

Neurobiol Stress 2020 Nov 24;13:100258. Epub 2020 Oct 24.

Department of Pharmacology and Center for Biomedical Neuroscience, UT Health San Antonio, 7703 Floyd Curl Dr, San Antonio, TX, 78229, USA.

Cognitive flexibility is a higher-order executive function that requires plasticity in neuronal circuits of the prefrontal cortex. Deficits in cognitive flexibility are prominent in a variety of psychiatric disorders, such as major depression, obsessive-compulsive disorder, and posttraumatic stress disorder. Chronic stress induces deficits in cognitive flexibility, perhaps through effects on plasticity, but the mechanism is not well understood. Read More

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November 2020

The Impacts of the Presence of an Unfamiliar Dog on Emerging Adults' Physiological and Behavioral Responses Following Social Exclusion.

Behav Sci (Basel) 2020 Dec 14;10(12). Epub 2020 Dec 14.

Social Psychology Unit, Institute of Psychology, University of Klagenfurt, 9020 Klagenfurt, Austria.

Research indicates that non-human attachment figures may mitigate the negative consequences of social exclusion. In the current experiment, we examined how the presence of an unfamiliar companion dog in the laboratory effects physiological and behavioral reactions in female emerging adults after social exclusion compared to inclusion. Results revealed the beneficial effects of the dog: Socially excluded participants in the company of a dog showed less aggressive behavior in response to the hot sauce paradigm compared to excluded participants in the control condition. Read More

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December 2020

Prophylaxis of Pain and Fractures within Feet in the Course of Osteoporosis: The Issue of Diagnosing.

Pain Res Manag 2020 29;2020:1391026. Epub 2020 Nov 29.

Department of Propaedeutic, Physical Diagnostics and Dental Physiotherapy, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Background: Considering the enormous risk of fractures in the course of osteoporosis in the area of the feet, an important aspect of prophylaxis is periodic and, in special cases, ongoing monitoring of defects and deformations as well as pressure distribution. The purpose of this article is to indicate the role of the examination of posture and pressure distribution during standing, postural balance, and gait, in the prevention of fatigue fractures in the course of osteoporosis, based on the literature review and examples of patients.

Methods: The manuscript consists of two parts; it has a review-analytical character. Read More

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The role of self-efficacy and information processing in weight loss during an mHealth behavioral intervention.

Digit Health 2020 Jan-Dec;6:2055207620976755. Epub 2020 Nov 30.

Holcombe Department of Electrical and Computer Engineering, Clemson University, Clemson, USA.

Self-efficacy (SE) and information processing (IP) may be important constructs to target when designing mHealth interventions for weight loss. The goal of this study was to examine the relationship between SE and IP with weight loss at six-months as part of the Dietary Interventions Examining Tracking with mobile study, a six-month randomized trial with content delivered remotely via twice-weekly podcasts. Participants were randomized to self-monitor their diet with either a mobile app (n = 42) or wearable Bite Counter device (n = 39). Read More

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November 2020

A Pilot Study of a Psychoeducational Group Intervention Delivered at Asylum Accommodation Centers-A Mixed Methods Approach.

Int J Environ Res Public Health 2020 12 1;17(23). Epub 2020 Dec 1.

Institution of Psychology and Social Work, Mid Sweden University, 831 25 Östersund, Sweden.

Asylum seekers suffer high levels of distress but have restricted access to mental health care. This paper constitutes an evaluation of a psycho-educational group intervention, called AMIN, which was provided at two asylum accommodation centers in Sweden. A mixed-methods approach was used. Read More

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December 2020

Children's Narrative Elaboration After Reading a Storybook Versus Viewing a Video.

Front Psychol 2020 16;11:569891. Epub 2020 Oct 16.

Psycholinguistics, Faculty of Arts and Humanities, Paderborn University, Paderborn, Germany.

Previous studies have found that narrative input conveyed through different media influences the structure and content of children's narrative retellings. Visual, televised narratives appear to elicit richer and more detailed narratives than traditional, orally transmitted storybook media. To extend this prior work and drawing from research on narrative elaboration, the current study's main goal was to identify the core plot component differences (the , , , , , and of a story) between children's retellings of televised versus traditional storybook narratives. Read More

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October 2020

TB-HIV co-infection: spatial and temporal distribution in the largest Brazilian metropolis.

Rev Saude Publica 2020 2;54:e112. Epub 2020 Nov 2.

Universidade de São Paulo . Faculdade de Saúde Pública . Departamento de Epidemiologia . São Paulo , SP , Brasil.

Objective: To describe the spatial and temporal distribution of TB-HIV co-infection, as well as the profile of the characteristics of the co-infected population in the municipality of São Paulo.

Methods: This is an ecological and time series study with data from the Tuberculosis Patient Control System (TBWeb), including all new cases of tuberculosis co-infected individuals with HIV living in the municipality from 2007 to 2015. Time trends of the disease were analyzed using Prais-Winsten regression. Read More

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November 2020

Understanding the Role of Silver Nanostructures and Graphene Oxide Applied as Surface Modification of TiO in Photocatalytic Transformations of Rhodamine B under UV and Vis Irradiation.

Materials (Basel) 2020 Oct 19;13(20). Epub 2020 Oct 19.

Department of Materials Technology and Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163, 90-236 Lodz, Poland.

This work is focused on photocatalytic properties of titanium dioxide thin coatings modified with silver nanostructures (AgNSs) and graphene oxide (GO) sheets which were analyzed in processes of chemical transformations of rhodamine B (RhB) under ultraviolet (UV) or visible light (Vis) irradiation, respectively. UV-Vis spectroscopy was applied to analyze the changes in the RhB spectrum during photocatalytic processes, revealing decolorization of RhB solution under UV irradiation while the same process coexisting with the transformation of RhB to rhodamine 110 was observed under Vis irradiation. The novelty of this study is the elaboration of a methodology for determining the parameters characterizing the processes occurring under the Vis irradiation, which enables the comparison of photocatalysts' activity. Read More

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October 2020

The cells involved in the pathological process of diabetic retinopathy.

Biomed Pharmacother 2020 Dec 11;132:110818. Epub 2020 Oct 11.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan 430022, China. Electronic address:

Diabetic retinopathy(DR) is an expanding global health problem, the exact mechanism of which has not yet been clarified clearly, new insights into retinal physiology indicate that diabetes-induced retinal dysfunction may be viewed as an impairment of the retinal neurovascular unit, including retinal ganglion cells, glial cells, endothelial cells, pericytes, and retinal pigment epithelium. Different retinal cells have unique structure and functions, while the interactions among which are less known. Cells are the basic unit of organism structure and function, their impairment could lead to abnormal physiological functions and even organ disorder. Read More

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December 2020

Searching for the past: Exploring the dynamics of direct and generative autobiographical memory reconstruction among young and cognitively normal older adults.

Mem Cognit 2021 04 23;49(3):422-437. Epub 2020 Sep 23.

Department of Psychology, University of Arizona, 1503 E University Blvd., Tucson, AZ, 85721, USA.

Episodic autobiographical memories (EAMs) can come to mind through two retrieval routes, one direct (i.e., an EAM is retrieved almost instantaneously) and the other generative (i. Read More

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drug discovery of IKK-β inhibitors from 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives based on QSAR, docking, molecular dynamics and drug-likeness evaluation studies.

J Biomol Struct Dyn 2020 Sep 18:1-17. Epub 2020 Sep 18.

Laboratoire de Physique et Chimie Théoriques, UMR CNRS 7019, Université de Lorraine, Nancy, France.

The Inhibitor of IKK-β (nuclear factor kappa B kinase subunit beta), a specific modulator of NF-κB (nuclear factor-κB), is considered a valid target to discover new active compounds for various cancers and rheumatoid arthritis treatment. In this study a series of thirty 2-amino-3-cyano-4-alkyl-6-(2-hydroxyphenyl) pyridine derivatives was involved for a quantitative structure activity relationship model (QSAR) elaboration which allows the prediction of the pIC50 values of new designed compounds. The model can be used to predict the activity of new compounds within its applicability domain. Read More

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September 2020

Physical Fitness, Exercise Self-Efficacy, and Quality of Life in Adulthood: A Systematic Review.

Int J Environ Res Public Health 2020 08 31;17(17). Epub 2020 Aug 31.

Department of Specifics Didactics, Faculty of Education Sciences, University of Córdoba Avenida San Alberto Magno, s/n, 14071 Córdoba, Spain.

The aim of the present work is the elaboration of a systematic review of existing research on physical fitness, self-efficacy for physical exercise, and quality of life in adulthood. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement guidelines, and based on the findings in 493 articles, the final sample was composed of 37 articles, which were reviewed to show whether self-efficacy has previously been studied as a mediator in the relationship between physical fitness and quality of life in adulthood. The results indicate that little research exists in relation to healthy, populations with the majority being people with pathology. Read More

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Validity study using factor analyses on the Defining Issues Test-2 in undergraduate populations.

PLoS One 2020 31;15(8):e0238110. Epub 2020 Aug 31.

Department of Educational Studies in Psychology, Research Methodology and Counseling, University of Alabama, Tuscaloosa, Alabama, United States of America.

Introduction: The Defining Issues Test (DIT) aimed to measure one's moral judgment development in terms of moral reasoning. The Neo-Kohlbergian approach, which is an elaboration of Kohlbergian theory, focuses on the continuous development of postconventional moral reasoning, which constitutes the theoretical basis of the DIT. However, very few studies have directly tested the internal structure of the DIT, which would indicate its construct validity. Read More

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October 2020

Biological Processes Highlighted in during the Sparkling Wines Elaboration.

Microorganisms 2020 Aug 11;8(8). Epub 2020 Aug 11.

Department of Microbiology, University of Cordoba, 14014 Cordoba, Spain.

Sparkling wines elaboration has been studied by several research groups, but this is the first report on analysis of biological processes according to the Gene Ontology terms (GO terms) and related to proteins expressed by yeast cells during the second fermentation of sparkling wines. This work provides a comprehensive study of the most relevant biological processes in P29, a sparkling wine strain, during the second fermentation under two conditions (without and with endogenous CO overpressure) in the middle and the end of second fermentation. Consequently, a proteomic analysis with the OFFGEL fractionator and protein identification with LTQ Orbitrap XL coupled to HPLC were performed. Read More

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Water and sediment budgets unveiling contrasting hydro-sedimentary patterns in a mountainous Mediterranean catchment.

Sci Total Environ 2020 Nov 17;745:140884. Epub 2020 Jul 17.

Fluvial Dynamics Research Group (RIUS), University of Lleida, E-25198 Lleida, Catalonia, Spain(1); Institut Català de Recerca de l'Aigua (ICRA), E-17003 Girona, Catalonia, Spain; Faculty of Forest Sciences and Natural Resources, Universidad Austral de Chile, Valdivia, Chile.

Mountain regions have a key role in the generation of runoff, and in the production and transfer of sediments to fluvial networks, especially in Mediterranean catchments where these processes are affected by marked changes in climate and land use (i.e. global change). Read More

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November 2020

Maternal Reminiscing and Autobiographical Memory Features of Mother-Child Dyads in a Cross-Cultural Context.

Child Dev 2020 Nov 5;91(6):2160-2177. Epub 2020 Aug 5.

Monash University.

Maternal reminiscing styles and mother-child memory features were examined in a cross-cultural context. Fifty-five Chinese (Guangzhou, China) and 48 Australian (Melbourne, Australia) mother-child dyads (child age: 3-6 years) independently retrieved autobiographical memories and jointly discussed past events. Australian mothers used greater elaborative and supportive reminiscing and provided more specific memories than Chinese mothers. Read More

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November 2020

Pictorial Campaigns on Intimate Partner Violence Focusing on Victimized Men: A Systematic Content Analysis.

Front Psychol 2020 9;11:1450. Epub 2020 Jul 9.

Inclusive Policy Lab, UNESCO, Dakar, Senegal.

Men who are victimized in their intimate different-sex (DS) and same-sex (SS) relationships often report not having information to help them escape their abusive situations. To overcome this lack of information, public awareness campaigns have been created. But thus far, there is no clear understanding of how these campaigns reflect theoretical principles central to improve message effectiveness and avoid undesired negative effects. Read More

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Arsenic Directs Stem Cell Fate by Imparting Notch Signaling Into the Extracellular Matrix Niche.

Toxicol Sci 2020 10;177(2):494-505

Department of Environmental and Occupational Health.

Compromise of skeletal muscle metabolism and composition may underlie the etiology of cardiovascular and metabolic disease risk from environmental arsenic exposures. We reported that arsenic impairs muscle maintenance and regeneration by inducing maladaptive mitochondrial phenotypes in muscle stem cells (MuSC), connective tissue fibroblasts (CTF), and myofibers. We also found that arsenic imparts a dysfunctional memory in the extracellular matrix (ECM) that disrupts the MuSC niche and is sufficient to favor the expansion and differentiation of fibrogenic MuSC subpopulations. Read More

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October 2020