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Designing comprehensible healthcare public reports: An investigation of the use of narratives and tests of quality metrics to support healthcare public report sensemaking.

Appl Ergon 2021 May 3;95:103452. Epub 2021 May 3.

Department of Industrial Engineering, Clemson University, 110 Freeman Hall, Clemson, SC, 29634, USA.

A key challenge for designers of healthcare public reports is the development of a presentation format that accurately communicates the variability in the quality of care among healthcare systems. This study conducted in the United States explored whether presenting public report information within narratives and with tests of healthcare quality metrics supported the public report sensemaking process. The study involved 200 participants and employed a 2 (public report information presented in the standard format, presented within a narrative) * 2 (no tests of quality metrics added to standard report, metrics tests added) between-subjects experimental design. Read More

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Maximizing success in single-session EUS-directed transgastric ERCP: a retrospective cohort study to identify predictive factors of stent migration.

Gastrointest Endosc 2021 May 3. Epub 2021 May 3.

Thomas Jefferson University Hospital, Philadelphia, PA.

Background And Aims: EUS-directed transgastric ERCP (the EDGE procedure) is a simplified method of performing ERCP in Roux-en-Y gastric bypass patients. [1] The EDGE procedure involves placement of a lumen-apposing metal stent (LAMS) into the excluded stomach to serve as a conduit for passage of the duodenoscope for pancreatobiliary intervention. Originally a multistep process, urgent indications for ERCP have led to the development of single-session EDGE (SS-EDGE) with LAMS placement and ERCP performed in the same session. Read More

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Perceived built environment, health-related quality of life and health care utilization.

PLoS One 2021 6;16(5):e0251251. Epub 2021 May 6.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Previous research has shown that the built environment plays a crucial role for health-related quality of life (HRQoL) and health care utilization. But, there is limited evidence on the independence of this association from lifestyle and social environment. The objective of this cross-sectional study was to investigate these associations, independent of the social environment, physical activity and body mass index (BMI). Read More

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Covichem: A biochemical severity risk score of COVID-19 upon hospital admission.

PLoS One 2021 6;16(5):e0250956. Epub 2021 May 6.

Department of Biochemistry, Pellegrin Hospital, University Hospital of Bordeaux, Bordeaux, France.

Clinical and laboratory predictors of COVID-19 severity are now well described and combined to propose mortality or severity scores. However, they all necessitate saturable equipment such as scanners, or procedures difficult to implement such as blood gas measures. To provide an easy and fast COVID-19 severity risk score upon hospital admission, and keeping in mind the above limits, we sought for a scoring system needing limited invasive data such as a simple blood test and co-morbidity assessment by anamnesis. Read More

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Association between serum uric acid and left ventricular hypertrophy/left ventricular diastolic dysfunction in patients with chronic kidney disease.

PLoS One 2021 6;16(5):e0251333. Epub 2021 May 6.

Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Background: The level of serum uric acid (SUA) has been reported to be associated with left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD). However, this association remains unclear in patients with chronic kidney disease (CKD).

Methods: A total of 1025 patients with pre-dialysis CKD with preserved left ventricular systolic function were enrolled in this cross-sectional study. Read More

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Profiling malaria infection among under-five children in the Democratic Republic of Congo.

PLoS One 2021 6;16(5):e0250550. Epub 2021 May 6.

ICF, United States of America.

Introduction: In 2018, Malaria accounted for 38% of the overall morbidity and 36% of the overall mortality in the Democratic Republic of Congo (DRC). This study aimed to identify malaria socioeconomic predictors among children aged 6-59 months in DRC and to describe a socioeconomic profile of the most-at-risk children aged 6-59 months for malaria infection.

Materials And Methods: This study used data from the 2013 DRC Demographic and Health Survey. Read More

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Identification and immunoprofiling of key prognostic genes in the tumor microenvironment of hepatocellular carcinoma.

Bioengineered 2021 Dec;12(1):1555-1575

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Tumor microenvironment (TME) is involved in the occurrence and development of hepatocellular carcinoma (HCC), and immune cells in the TME have been implicated in its progression and treatment. However, the association of genes involved in the TME with HCC prognosis remains unclear. Thus, in this study, we obtained transcriptomic and clinicopathological data of patients with HCC from The Cancer Genome Atlas to identify key genes in TME associated with HCC prognosis. Read More

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December 2021

Central obesity, smoking habit and hypertension are associated with lower antibody titers in response to COVID-19 mRNA vaccine.

Diabetes Metab Res Rev 2021 May 6. Epub 2021 May 6.

Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161, Rome, Italy.

Aims: To explore variables associated with the serological response following COVID-19 mRNA vaccine.

Methods: Eighty-six healthcare workers adhering to the vaccination campaign against COVID-19 were enrolled in January-February 2021. All subjects underwent two COVID-19 mRNA vaccine inoculations (Pfizer/BioNTech) separated by three weeks. Read More

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Use of neck circumference as a predictor of cardiovascular risk in chronic kidney patients undergoing hemodialysis candidates for transplantation.

J Hum Nutr Diet 2021 May 6. Epub 2021 May 6.

Universidade Federal do Ceará.

Introduction: Patients undergoing hemodialysis have a great cardiovascular risk. Neck circumference is a simple and low-cost measure that can estimate this risk precociously.

Objective: To evaluate whether the cardiovascular risk obtained by Neck Circumference (NC) is associated with the main cardiometabolic risk factors in patients on hemodialysis treatment on waiting list for transplantation. Read More

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Relationship between maxillary central incisors and incisive canal (IC): a cone beam computed tomography study.

Folia Morphol (Warsz) 2021 May 6. Epub 2021 May 6.

Orthodontic Department, Faculty of Dentistry King Abdulaziz University, P.O. Box 80209, 21589 Jeddah, Saudi Arabia.

This study aimed to assess the relationship between the maxillary incisors and the incisive canal (IC) using cone-beam computed tomography (CBCT). Archived CBCTs from 120 subjects (60 males and 60 females, mean age: 34.2±13. Read More

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Radiomics complements clinical, radiological, and technical features to assess local control of colorectal cancer lung metastases treated with radiofrequency ablation.

Eur Radiol 2021 May 5. Epub 2021 May 5.

Department of Diagnostic and Interventional Oncological Imaging, Institut Bergonié, Regional Comprehensive Cancer of Nouvelle-Aquitaine, 229, cours de l'Argonne, F-33076, Bordeaux cedex, France.

Objectives: Radiofrequency ablation (RFA) of lung metastases of colorectal origin can improve patient survival and quality of life. Our aim was to identify pre- and per-RFA features predicting local control of lung metastases following RFA.

Methods: This case-control single-center retrospective study included 119 lung metastases treated with RFA in 48 patients (median age: 60 years). Read More

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Outpatient Management of Diabetic Hand Infections.

Cureus 2021 Apr 2;13(4):e14263. Epub 2021 Apr 2.

Surgery, Henry Ford Health System, Detroit, USA.

Purpose For many providers, hand infections among diabetic patients is a condition that necessitates focused inpatient care. These patients are believed to have decreased innate immunity to fight infection, a more virulent course, and difficulty with recovery. Diabetes is considered by some to represent an additional risk factor that can result in an unfavorable outcome if not managed in an aggressive manner. Read More

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Outcomes of hospitalized patients with COVID-19 according to level of frailty.

PeerJ 2021 13;9:e11260. Epub 2021 Apr 13.

Nursing School La Fe., Adscript center of Universidad de Valencia., Valencia, Valencia, Spain.

Background: The complications from coronavirus disease 2019 (COVID-19) have been the subject of study in diverse scientific reports. However, many aspects that influence the prognosis of the disease are still unknown, such as frailty, which inherently reduces resistance to disease and makes people more vulnerable. This study aimed to explore the complications of COVID-19 in patients admitted to a third-level hospital and to evaluate the relationship between these complications and frailty. Read More

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Development and characterization of a nano-drug delivery system containing vasaka phospholipid complex to improve bioavailability using quality by design approach.

Res Pharm Sci 2021 Feb 30;16(1):103-117. Epub 2020 Dec 30.

Divison of Pharmacognosy and Phytochemistry, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur-603 203, Chengalpattu (Dt), Tamil Nadu, India.

Background And Purpose: Vasicine is a potential bronchodilator and can be used for the effective management of asthma and bronchitis. It has low absorption in the gastrointestinal tract due to its poor solubility thereby low bioavailability. The objective of this research was to develop a novel drug delivery system of vasaka extract to improve its bioavailability by enhancing the solubility and absorption of vasicine. Read More

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February 2021

Preparation and characterization of ethylcellulose microspheres for sustained-release of pregabalin.

Res Pharm Sci 2021 Feb 30;16(1):1-15. Epub 2020 Dec 30.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Background And Purpose: Pregabalin is used in the treatment of epilepsy, chronic pain, and other psychological disorders. Preparation of pregabalin in the sustained-release formulation will enhance patient compliance and reduce the incidence of side effects. The aim of this study was to prepare sustained-release microspheres for pregabalin utilizing ethylcellulose and evaluate the processing factors that influence the fabrication and the performance of the prepared microspheres. Read More

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February 2021

Improvement in Atrial Fibrillation-Related Symptoms After Cardioversion: Role of NYHA Functional Class and Maintenance of Sinus Rhythm.

Clin Interv Aging 2021 29;16:739-745. Epub 2021 Apr 29.

Department of Cardiology, Hospital Universitari de Sant Joan.

Background: The European Heart Rhythm Association (EHRA) score is a proven and validated tool for assessing the symptoms of atrial fibrillation (AF). Little is known about the variables related to this score and how it changes after cardioversion.

Methods: We analyzed 744 patients undergoing elective cardioversion in whom AF-related symptoms were assessed at baseline and after 6 months of follow-up using the EHRA score. Read More

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Impact of Therapy & Age in Choroidal Cancers: A Retrospective Cohort Analysis of 7722 Patients from a US National Database.

Clin Ophthalmol 2021 28;15:1763-1774. Epub 2021 Apr 28.

Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.

Background: Collectively, choroidal cancers represent a vast array of histopathologically diverse constituencies with profound repercussions related to mortality and metastasis. Prognosticated factors provide utility in determining clinical management and outcome propensities. To date, measures to collectively characterize choroidal cancers as a class are not impressive. Read More

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Tumor-associated Stromal Cellular Density as a Predictor of Recurrence and Mortality in Breast Cancer: Results from Ethnically-diverse Study Populations.

Cancer Epidemiol Biomarkers Prev 2021 May 5. Epub 2021 May 5.

Division of Cancer Epidemiology and Genetics, National Cancer Institute.

Background: Tumor-associated stroma is comprised of fibroblasts, tumor infiltrating lymphocytes (TILs), macrophages, endothelial, and other cells, that interactively influence tumor progression through inflammation and wound repair. Although gene expression signatures reflecting wound repair predict breast cancer survival, it is unclear whether combined density of tumor-associated stromal cells, a morphological proxy for inflammation and wound repair signatures on routine hematoxylin and eosin (H&E)-stained sections, is of prognostic relevance.

Methods: By applying machine learning to digitized H&E-stained sections for 2,084 breast cancer patients from China (n=596; 24-55years), Poland (n=810; 31-75years), and the United States (n=678; 55-78years), we characterized tumor-associated stromal cellular density (SCD) as the percentage of tumor-stroma that is occupied by nucleated cells. Read More

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PROGNOSTIC VALUE OF CHARLSON COMORBIDITY INDEX IN ACUTE EMBOLIC LOWER LIMB ISCHAEMIA PATIENTS.

Ann Vasc Surg 2021 May 2. Epub 2021 May 2.

Angiology and Vascular Surgery Department, Centro Hospitalar e Universitário de Coimbra, EPE, Praceta Professor Mota Pinto, 3000-075 Coimbra, Portugal. Electronic address:

Introduction: Charlson Comorbidity Index (CCI) is commonly used in outcome studies to adjust for patient comorbid conditions but has not been specifically validated for use in acute embolic lower limb ischaemia (AELLI).

Objectives: The aim of this study was to access whether a high CCI score unadjusted (CCIu) and adjusted (CCIa) by age relates to major amputation and mortality after a first episode of AELLI.

Methods: The last 100 patients presenting with the first event of AELLI submitted to embolectomy at our Vascular Surgery Department were retrospectively evaluated. Read More

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The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs.

J Vet Intern Med 2021 May 5. Epub 2021 May 5.

Department of Cardiology, Anicura Istituto Veterinario Novara, Granozzo con Monticello, Italy.

Background: There is no commonly shared severity score for myxomatous mitral valve disease (MMVD) based on routinely acquired echocardiographic variables.

Hypothesis/objectives: To propose an easy-to-use echocardiographic classification of severity of MMVD in dogs.

Animals: Five hundred and sixty dogs with MMVD. Read More

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Serum potassium levels and prognosis in HBV-associated decompensated cirrhosis.

J Clin Lab Anal 2021 May 5:e23775. Epub 2021 May 5.

Department of Clinical Laboratory, Shengzhou People's Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China.

Background: Serum potassium disorders are commonly seen in patients with advanced cirrhosis and have a detrimental effect on clinical outcome, but its role in HBV-related decompensated cirrhosis (DeCi) is remained to be illustrated. We aim to assess the effects of serum potassium on outcomes in HBV-DeCi patients.

Methods: Retrospective study included 155 subjects. Read More

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Treatment strategies and predicting lymph node metastasis in elderly patients with papillary thyroid microcarcinoma.

Medicine (Baltimore) 2021 May;100(18):e25811

Department of Surgical Oncology, Shaanxi Provincial People's Hospital.

Abstract: This study aims to explore the prognostic variables for elderly papillary thyroid microcarcinoma (PTMC) patients as well as create a nomogram that could predict the occurrence of cervical lymph node metastasis (CLNM) on the basis of a large population database with high quality.A total of 5165 PTMC patients from Surveillance, Epidemiology, and End Results database database were enrolled in the study. In the meantime, we retrospectively collected 205 PTMC patients who underwent thyroidectomy in our medical center as an external control to test the accuracy of the model. Read More

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Platelet count patterns and patient outcomes in sepsis at a tertiary care center: Beyond the APACHE score.

Medicine (Baltimore) 2021 May;100(18):e25013

Department of Critical Care, King Saud University Medical City, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Abstract: Acute physiology and chronic health evaluation II (APACHE-II) scoring system is used to classify disease severity of patients in the intensive care unit. However, several limitations render the scoring system inadequate in identifying risk factors associated with outcomes. Little is known about the association of platelet count patterns, and the timing of platelet count and other hematologic parameters in predicting mortality in patients with sepsis. Read More

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Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis: An ENIGMA Working Group Mega-analysis.

JAMA Psychiatry 2021 May 5. Epub 2021 May 5.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.

Importance: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk.

Objective: To investigate baseline structural neuroimaging differences between individuals at CHR and healthy controls as well as between participants at CHR who later developed a psychotic disorder (CHR-PS+) and those who did not (CHR-PS-).

Design, Setting, And Participants: In this case-control study, baseline T1-weighted magnetic resonance imaging (MRI) data were pooled from 31 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group. Read More

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Quantile modeling through multivariate log-normal/independent linear regression models with application to newborn data.

Biom J 2021 May 5. Epub 2021 May 5.

Departamento de Estatística, Universidade de São Paulo, São Paulo, Brazil.

In this article, we propose and study the class of multivariate log-normal/independent distributions and linear regression models based on this class. The class of multivariate log-normal/independent distributions is very attractive for robust statistical modeling because it includes several heavy-tailed distributions suitable for modeling correlated multivariate positive data that are skewed and possibly heavy-tailed. Besides, expectation-maximization (EM)-type algorithms can be easily implemented for maximum likelihood estimation. Read More

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Psychometric Evaluation of a Big Five Personality State Scale for Intensive Longitudinal Studies.

Assessment 2021 May 5:10731911211008254. Epub 2021 May 5.

University of Pittsburgh, Pittsburgh, PA, USA.

Despite enthusiasm for using intensive longitudinal designs to measure day-to-day manifestations of personality underlying differences between people, the validity of personality state scales has yet to be established. In this study, we evaluated the psychometrics of 20-item and 10-item daily, Big Five personality state scales in three independent samples ( = 1,041). We used multilevel models to separately examine the validity of the scales for assessing personality variation at the between- and within-person levels. Read More

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Intranasal In Situ Gel of Apixaban-Loaded Nanoethosomes: Preparation, Optimization, and In Vivo Evaluation.

AAPS PharmSciTech 2021 May 4;22(4):147. Epub 2021 May 4.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Asyut, Egypt.

The present study was conducted to formulate ethosomal thermoreversible in situ gel of apixaban, an anticoagulant drug, for nasal delivery. Ethosomes were formed, of lecithin, cholesterol, and ethanol, by using thin-film hydration method. The prepared ethosomes were characterized by Zetasizer, transmission electron microscope, entrapment efficiency, and in vitro study. Read More

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PLEX: the best first-line treatment in nmosd attacks experience at a single center in Colombia.

Heliyon 2021 Apr 17;7(4):e06811. Epub 2021 Apr 17.

Neurology, Instituto Neurológico de Colombia (INDEC) Medellín, Colombia.

Objective: Primary outcome was to evaluate complete improvement at six months after acute treatment in NMOSD relapses.

Methods: Retrospective observational cohort study of patients with diagnosis of NMOSD admitted for acute attacks. We performed an explanatory analysis using the univariate, bivariate and multivariate logistic regression approach. Read More

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