63,166 results match your criteria independent predictor


Quantitative collateral assessment evaluated by cerebral blood volume measured by CT perfusion in patients with acute ischemic stroke.

J Stroke Cerebrovasc Dis 2021 Apr 17;30(7):105797. Epub 2021 Apr 17.

Department of Neurosurgery, Soka Municipal Hospital, 2-21-1, Soka, Soka city, Saitama 340-8560, Japan.

Objectives: Collateral status (CS) is considered a predictor of clinical outcome after reperfusion therapy (RT) in patients with acute ischemic stroke (AIS). We proposed a quantitative assessment of CS using cerebral blood volume (CBV) measured by computed tomography perfusion (CTP) imaging.

Materials And Methods: This retrospective study was approved by the Institutional Review Board. Read More

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Identification and validation of autophagy-related prognostic signature for head and neck squamous cell carcinoma.

Transl Oncol 2021 Apr 17;14(7):101094. Epub 2021 Apr 17.

Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430000, China. Electronic address:

Background: Many studies have demonstrated that autophagy plays a significant role in regulating tumor growth and progression. However, the effect of autophagy-related genes (ARGs) on the prognosis have rarely been analyzed in head and neck squamous cell carcinoma (HNSCC).

Methods: We obtained differentially expressed ARGs from HNSCC mRNA data in The Cancer Genome Atlas (TCGA) database. Read More

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Neutrophil-to-Lymphocyte Ratio is superior to other leucocyte-based ratios as a prognostic predictor in radiosurgically treated non-small cell lung cancer brain metastases patients under immunotherapy or targeted therapy.

World Neurosurg 2021 Apr 17. Epub 2021 Apr 17.

Department of Neurosurgery, Medical University of Vienna, Vienna, Austria. Electronic address:

Objective: The predictive value of pre-radiosurgery leucocyte-based prognostic ratios was investigated in a selected cohort of non-small cell lung cancer patients (NSCLC) patients with radiosurgically treated brain metastases (BM) and concomitant immunotherapy (IT) or targeted therapy (TT).

Methods: We performed a retrospective analysis of 166 NSCLC BM patients treated with Gamma Knife Radiosurgery. The Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Lymphocyte-to-Monocyte Ratio (LMR) were assessed within 14 days prior to radiosurgical treatment. Read More

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Effect of Tourniquet Use During Surgical Treatment of Open Fractures.

J Bone Joint Surg Am 2021 Mar 11. Epub 2021 Mar 11.

University of Maryland School of Medicine, Baltimore, Maryland.

Background: We sought to evaluate whether tourniquet use, with the resultant ischemia and reperfusion, during surgical treatment of an open lower-extremity fracture was associated with an increased risk of complications.

Methods: This is a retrospective cohort study of 1,351 patients who had an open lower-extremity fracture at or distal to the proximal aspect of the tibia and who participated in the FLOW (Fluid Lavage of Open Wounds) trial. The independent variable was intraoperative tourniquet use, and the primary outcome measures were adjudicated unplanned reoperation within 1 year of the injury and adjudicated nonoperative wound complications. Read More

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Clinical and urodynamic predictors of Q-tip test urethral hypermobility.

Minerva Obstet Gynecol 2021 Apr 20. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, University of Milano-Bicocca, Monza, Italy.

Background: Urodinamics and Q-tip test represent diagnostic tools for the assessment of stress urinary incontinence. The aim of the present study is to investigate the possibility to predict the Q-tip test urethral hypermobility on the basis of clinical and urodynamic parameters.

Methods: We analyzed all women performed urodynamics between 2008 and 2016 presenting urodynamic stress urinary incontinence. Read More

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Quantity and Quality of Skeletal Muscle as an Important Predictor of Clinical Outcomes in Patients with Esophageal Cancer Undergoing Esophagectomy after Neoadjuvant Chemotherapy.

Ann Surg Oncol 2021 Apr 19. Epub 2021 Apr 19.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.

Background: Sarcopenia was previously linked to clinical outcomes for several cancer types, including esophageal cancer (EC), but most studies only measured the quantity of skeletal muscle mass. We aim to assess the clinical significance of evaluating the quantity and quality of skeletal muscle in patients with EC who underwent neoadjuvant chemotherapy (NAC) followed by esophagectomy.

Methods: We included 333 consecutive patients with EC who underwent NAC followed by esophagectomy. Read More

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Four-Tier Pathologic Tumor Regression Grading System Predicts the Clinical Outcome in Patients Who Undergo Surgical Resection for Locally Advanced Pancreatic Cancer after Neoadjuvant Chemotherapy.

Gut Liver 2021 Apr 23. Epub 2021 Apr 23.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background/aims: Neoadjuvant chemotherapy is increasingly utilized in patients with borderline or locally advanced pancreatic cancer (LAPC). However, the pathologic evaluation of tumor regression is not routinely performed or well established. We aimed to evaluate the prognostic value of three tumor regression grading systems frequently used in LAPC and to determine the correlation between pathologic and clinical response. Read More

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Association of Infarct Volume Before Hemicraniectomy and Outcome After Malignant Infarction.

Neurology 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurology, University Hospital of Würzburg, Würzburg.

ObjectiveTo determine the impact of infarct volume before hemicraniectomy in malignant middle cerebral artery infarction (MMI) as an independent predictor for patient selection and outcome prediction, we retrospectively analyzed data of 140 patients from a prospective multi-center study.MethodsPatients from the DESTINY-Registry that underwent hemicraniectomy after ischemic infarction of >50% of the middle cerebral artery territory were included. Functional outcome according to the modified Rankin Scale (mRS) was assessed at 12 months. Read More

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An EPIC predictor of gestational age and its application to newborns conceived by assisted reproductive technologies.

Clin Epigenetics 2021 Apr 19;13(1):82. Epub 2021 Apr 19.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Gestational age is a useful proxy for assessing developmental maturity, but correct estimation of gestational age is difficult using clinical measures. DNA methylation at birth has proven to be an accurate predictor of gestational age. Previous predictors of epigenetic gestational age were based on DNA methylation data from the Illumina HumanMethylation 27 K or 450 K array, which have subsequently been replaced by the Illumina MethylationEPIC 850 K array (EPIC). Read More

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Prognostic utility of dynapenia in patients with cardiovascular disease.

Clin Nutr 2021 Apr 13;40(4):2210-2218. Epub 2020 Oct 13.

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Dynapenia, defined as age-associated loss of skeletal muscle strength, is associated with increased mortality rate, poor activities of daily living, and reduced quality of life. Therefore, dynapenia appears to be a better independent predictor of mortality than sarcopenia in the elderly. However, the prognostic utility of dynapenia in patients with cardiovascular disease (CVD) is not clear. Read More

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Examination of ECG characteristics of patients admitted to emergency department with conversive attack.

Am J Emerg Med 2021 Apr 14;48:110-113. Epub 2021 Apr 14.

Department of Psychiatry, Harran University Faculty of Medicine, Sanliurfa, Turkey.

Objective: Conversion disorder is defined as a disorder with one or more neurological symptoms that accompany psychological conflict, suggesting a physical disorder. It has been shown that patients with conversion disorder have an imbalance in the autonomic nervous system. There are only a limited number of studies that have examined how conversion disorder is related with surface ECG parameters. Read More

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Association of bioelectrical phase angle with aerobic capacity, complex gait ability and total fitness score in older adults.

Exp Gerontol 2021 Apr 16:111350. Epub 2021 Apr 16.

Department of Physical Activity, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.

Purpose: This study aimed to examine the association between whole-body or segmental phase angle (PhA) based on bioelectrical impedance analysis (BIA) and aerobic capacity (endurance), complex gait ability, and total fitness age score (FAS).

Methods: A total of 426 community-dwelling older adults (332 women and 94 men) aged 60 to 93 years participated in this study. PhA and appendicular skeletal mass index (ASMI) were obtained by an eight-electrode standing BIA. Read More

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The role of urine IgG in the progression of IgA nephropathy with a high proportion of global glomerulosclerosis.

Int Urol Nephrol 2021 Apr 19. Epub 2021 Apr 19.

Department of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong, China.

Background: IgA nephropathy (IgAN), the most common glomerulonephritis in the world, is an important cause of end-stage renal disease (ESRD). It is necessary to explore new prognostic markers for predicting the activity and progress of IgAN. There are few studies on new prognostic markers in IgAN patients with high proportion of glomerulosclerosis. Read More

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Seasonal affective disorder and engagement in physical activities among adults in Alaska.

Int J Circumpolar Health 2021 Dec;80(1):1906058

Department of Anthropology, University of Alaska Fairbanks, Fairbanks, AK, USA.

Seasonal affective disorder (SAD) is a type of depression in which symptoms occur during a particular season. While physical activity has been shown to improve symptoms for depression in general populations, the relationships between physical activity and experiences of seasonality and SAD remain underexplored. We conducted a survey with adult members of a recreational gym in Fairbanks, Alaska. Read More

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December 2021

A simplified acute kidney injury predictor following transcatheter aortic valve implantation: the ACEF score.

Kardiol Pol 2021 Apr 6. Epub 2021 Apr 6.

Background: Transcatheter aortic valve implantation ( is an effective, less invasive treatment alternative for symptomatic severe aortic stenosis ( Acute kidney injury ( following TAVI is a common complication and is associated with worse outcomes. ACEF age, creatinine, ejection fraction) score is a simple scoring method, including only three parameters; a ge, creatinine, and ejection fraction ( The score was well established in predicting AKI after coronary interventions.

Aims: We aimed to evaluate whether this simple scoring method, ACEF, may predict a development of AKI in patients who underwent TAVI. Read More

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Impaired High-Density Lipoprotein Function in Patients With Heart Failure.

J Am Heart Assoc 2021 Apr 17:e019123. Epub 2021 Apr 17.

Department of Pediatrics University of Groningen Groningen The Netherlands.

Background We recently showed that, in patients with heart failure, lower high-density lipoprotein (HDL) cholesterol concentration was a strong predictor of death or hospitalization for heart failure. In a follow-up study, we suggested that this association could be partly explained by HDL proteome composition. However, whether the emerging concept of HDL function contributes to the prognosis of patients with heart failure has not been addressed. Read More

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Impact of Oral Anticoagulation Therapy Versus Left Atrial Appendage Occlusion on Cognitive Function and Quality of Life in Patients With Atrial Fibrillation.

J Am Heart Assoc 2021 Apr 19:e019664. Epub 2021 Apr 19.

Texas Cardiac Arrhythmia InstituteSt. David's Medical Center Austin TX.

Background We compared the cognitive status and quality of life in patients with atrial fibrillation undergoing left atrial appendage occlusion (LAAO) or remaining on oral anticoagulation (OAC) after atrial fibrillation ablation. Methods and Results Cognition was assessed by the Montreal Cognitive Assessment (MoCA) survey at baseline and follow-up. Consecutive patients receiving LAAO or OAC after atrial fibrillation ablation were screened, and patients with a score of ≤17 were excluded from the study. Read More

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The extreme capsule and aphasia: proof-of-concept of a new way relating structure to neurological symptoms.

Brain Commun 2021 14;3(2):fcab040. Epub 2021 Mar 14.

Department of Neurology and Clinical Neurosciences, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.

We present anatomy-based symptom-lesion mapping to assess the association between lesions of tracts in the extreme capsule and aphasia. The study cohort consisted of 123 patients with acute left-hemispheric stroke without a lesion of language-related cortical areas of the Stanford atlas of functional regions of interest. On templates generated through global fibre tractography, lesions of the extreme capsule and of the arcuate fascicle were quantified and correlated with the occurrence of aphasia (=18) as defined by the Token Test. Read More

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Associations of Serum Cortisol with Cardiovascular Risk and Mortality in Patients Referred to Coronary Angiography.

J Endocr Soc 2021 May 10;5(5):bvab017. Epub 2021 Feb 10.

Department of Internal Medicine, Division of Nephrology, Medical University of Graz, 8036 Graz, Austria.

Context: Serum cortisol may be associated with cardiovascular risk factors and mortality in patients undergoing coronary angiography, but previous data on this topic are limited and controversial.

Objective: We evaluated whether morning serum cortisol is associated with cardiovascular risk factors, lymphocyte subtypes, and mortality.

Methods: This is a prospective cohort study performed at a tertiary care centre in south-west Germany between 1997 and 2000. Read More

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Sarcopenia is associated with blood transfusions in head and neck cancer free flap surgery.

Laryngoscope Investig Otolaryngol 2021 Apr 31;6(2):200-210. Epub 2021 Jan 31.

Department of Otolaryngology-Head and Neck Surgery Indiana University School of Medicine Indianapolis Indiana USA.

Objective: To determine if sarcopenia is a predictor of blood transfusion requirements in head and neck cancer free flap reconstruction (HNCFFR).

Methods: A single-institution, retrospective review was performed of HNCFFR patients with preoperative abdominal imaging from 2014 to 2019. Demographics, comorbidities (modified Charlson Comorbidity Index [mCCI]), skeletal muscle index (cm/m), oncologic history, intraoperative data, and 30-day postoperative complications (Clavien-Dindo score [CD]) were collected. Read More

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Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure.

Front Cardiovasc Med 2021 29;8:631807. Epub 2021 Mar 29.

Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan.

We aimed to assess the associations of CAVI with exercise capacity in heart failure (HF) patients. In addition, we further examined their prognosis. We collected the clinical data of 223 patients who had been hospitalized for decompensated HF and had undergone both CAVI and cardiopulmonary exercise testing. Read More

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Factors Associated With Positive Self-Rated Health: Comparing Older Adults in Brazil and in Portugal.

Front Public Health 2021 29;9:650294. Epub 2021 Mar 29.

Institute of Biomedical Sciences Abel Salazar (ICBAS), Center for Research in Health Technologies and Services (CINTESIS), University of Porto, Porto, Portugal.

Self-rated health is a multidimensional health indicator and a predictor of adverse events in old age. Answers to this assessment are influenced by social, cultural and personality factors. Exploring common and distinctive characteristics of Brazilian and Portuguese older adults aged 70 and over regarding positive self-rated health according to sociodemographic variables, to functional capacity, to independent performance of basic activities of daily living and to neuroticism, as well as analyzing associations between positive self-rated health and these variables. Read More

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The Gene Family Serves as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.

Front Oncol 2021 31;11:620126. Epub 2021 Mar 31.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

The cysteine-serine-rich nuclear protein () family has prognostic value for various cancers. However, the association between this proteins and prognosis of clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to determine the prognostic value of the family for patients with ccRCC. Read More

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Use of Electronic Health (eHealth) Among Saudi Type 2 Diabetic Patients and Its Association With Their Diabetic Self-Management: A Cross-Sectional Study.

Cureus 2021 Mar 14;13(3):e13882. Epub 2021 Mar 14.

Internal Medicine, Ibn Sina National College for Medical Studies, Jeddah, SAU.

Background Type 2 diabetes mellitus (T2DM) is a prevalent, chronic, non-communicable disease that requires continuous multidisciplinary health care. Electronic health (eHealth) refers to "the transfer of health information resources and health care services using different electronic platforms." This may have an effect on diabetes self-management (DSM). Read More

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Landscape of somatic mutations in breast cancer: new opportunities for targeted therapies in Saudi Arabian patients.

Oncotarget 2021 Mar 30;12(7):686-697. Epub 2021 Mar 30.

Genomics Research Department, Saudi Human Genome Project, King Fahad Medical City and King Abdulaziz City for Science and Technology, Riyadh, Kingdom of Saudi Arabia.

Breast cancer (BCa) ranks first in incidence rate among cancers in Arab females. The association between genetic polymorphisms in tumor suppressor genes and the risk of BCa has been studied in many ethnic populations with conflicting conclusions while Arab females and Saudi Arabian studies are still lacking. We screened a cohort of Saudi BCa patients by NGS using a bespoke gene panel to clarify the genetic landscape of this population, correlating and assessing genetic findings with clinical outcomes. Read More

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Cytotoxic T-lymphocyte infiltration and chemokine predict long-term patient survival independently of tumor mutational burden in triple-negative breast cancer.

Ther Adv Med Oncol 2021 5;13:17588359211006680. Epub 2021 Apr 5.

Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY 14263, USA.

Background: Cytotoxic T-lymphocyte (CTL) infiltration into tumor is a positive prognostic factor in breast cancer. High tumor mutational burden (TMB) is also considered as a predictor of tumor immunogenicity and response to immunotherapy. However, it is unclear whether the infiltration of functional CTL simply reflects the TMB or represents an independent prognostic value. Read More

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A Glycolysis-Based Long Non-coding RNA Signature Accurately Predicts Prognosis in Renal Carcinoma Patients.

Front Genet 2021 1;12:638980. Epub 2021 Apr 1.

Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: The prognosis of renal cell carcinoma (RCC) varies greatly among different risk groups, and the traditional indicators have limited effect in the identification of risk grade in patients with RCC. The purpose of our study is to explore a glycolysis-based long non-coding RNAs (lncRNAs) signature and verify its potential clinical significance in prognostic prediction of RCC patients.

Methods: In this study, RNA data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) database. Read More

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Age-Related Decline in Vertical Jumping Performance in Masters Track and Field Athletes: Concomitant Influence of Body Composition.

Front Physiol 2021 1;12:643649. Epub 2021 Apr 1.

German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany.

Vertical jumping power declines with advancing age, which is theoretically explicable by loss of muscle mass and increases in body fat. However, the results of previous cross-sectional studies remain inconsistent on these relationships. The present study included 256 masters athletes who competed at the 2018 track and field world championships in Málaga, Spain. Read More

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Baseline Choroidal Microvasculature Dropout as a Predictor of Subsequent Visual Field Progression in Open-Angle Glaucoma.

J Glaucoma 2021 Apr 15. Epub 2021 Apr 15.

Department of Ophthalmology, Konkuk University Medical Center, Seoul, Korea Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

Precis: CMvD is an independet predictor for overall and central visual field progression in OAG eyes.

Purpose: To investigate the impact of choroidal microvasculature dropout (CMvD) identified by optical coherence tomography angiography (OCT-A) at baseline on subsequent visual field (VF) progression in eyes with open-angle glaucoma (OAG).

Materials And Methods: This retrospective observational study included 80 OAG eyes with CMvD [CMvD(+)] and without CMvD [(CMvD(-)] at baseline (40 of each matched for both age [≤ 10▒y] and baseline VF severity [≤ 1▒dB]). Read More

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Transjugular intrahepatic portosystemic shunt in refractory ascites: clinical impact of left ventricular diastolic dysfunction.

Eur J Gastroenterol Hepatol 2021 Apr 16. Epub 2021 Apr 16.

Division of Gastroenterology Cardiology Unit Interventional Radiology Unit, San Giovanni Battista Hospital, Turin, Italy.

Background And Aims: Left ventricular diastolic dysfunction (LVDD) in cirrhotics are associated with circulatory dysfunction, hepatorenal syndrome (HRS) and heart failure in stressful conditions. Transjugular intrahepatic portosystemic shunt (TIPS) exacerbates the hyperdynamic circulation and challenges cardiac function. We evaluated the incidence and the impact of LVDD in cirrhotic candidates to TIPS for refractory ascites. Read More

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