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Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments.

Wound Repair Regen 2021 Jun 22. Epub 2021 Jun 22.

Department of Surgery, Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Diabetes is a systemic disease in which the body cannot regulate the amount of sugar, namely glucose, in the blood. High glucose toxicity has been implicated in the dysfunction of diabetic wound healing, following insufficient production (Type 1) or inadequate usage (Type 2) of insulin. Chronic non-healing diabetic wounds are one of the major complications of both types of diabetes, which are serious concerns for public health and can impact the life quality of patients significantly. Read More

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[Naturopathy and complementary medicine in small animal science - definitions and contents].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2021 Jun 22;49(3):206-210. Epub 2021 Jun 22.

Klinik für Geburtshilfe, Gynäkologie und Andrologie der Groß- und Kleintiere mit Tierärztlicher Ambulanz, Justus-Liebig-Universität Gießen.

Naturopathic and complementary procedures attain increasing popularity in veterinary medicine. A common understanding of definitions and contents of these fields is crucial for communication between pet owners and veterinarians. This paper reviews the existing definitions and the various contents of naturopathy and complementary veterinary medicine as well as their assigned treatment options. Read More

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Cannabis use of patients with inflammatory bowel disease in Germany: a cross-sectional survey.

Z Gastroenterol 2021 Jun 22. Epub 2021 Jun 22.

Department for Internal and Integrative Medicine, Sozialstiftung Bamberg, Bamberg, Germany.

Background And Aims:  Progressive legalization and increasing utilization of medical cannabis open up potential new applications, including for inflammatory bowel disease (IBD). This study aimed to collect current figures on the use of and experience with cannabis among IBD patients in Germany.

Methods:  A 71-item questionnaire was mailed to a randomly selected representative sample of 1000 IBD patients. Read More

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The asymmetric learning rates of murine exploratory behavior in sparse reward environments.

Neural Netw 2021 Jun 6;143:218-229. Epub 2021 Jun 6.

Tokyo Denki University, Saitama, 350-0394, Japan.

Goal-oriented behaviors of animals can be modeled by reinforcement learning algorithms. Such algorithms predict future outcomes of selected actions utilizing action values and updating those values in response to the positive and negative outcomes. In many models of animal behavior, the action values are updated symmetrically based on a common learning rate, that is, in the same way for both positive and negative outcomes. Read More

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Polyhydroxyalkanoates (PHAs) degradation by the newly isolated marine Bacillus sp. JY14.

Chemosphere 2021 Jun 12;283:131172. Epub 2021 Jun 12.

Department of Biological Engineering, College of Engineering, Konkuk University, Seoul, Republic of Korea; Institute for Ubiquitous Information Technology and Application, Konkuk University, Seoul, Republic of Korea. Electronic address:

Polyhydroxyalkanoates (PHAs) are bioplastic substitutes for petroleum-derived plastics that may help to reduce the increasing environmental impact of plastic pollution. Among them, polyhydroxybutyrate (PHB) is a promising biopolymer, incentivizing many researchers to search for PHB-producing and PHB-degrading bacteria for improved PHB utilization. Many novel PHB-producing microorganisms have been discovered; however, relatively few PHB-degrading bacteria have been identified. Read More

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Guideline interval: A new time interval in the diagnostic pathway for symptomatic cancer.

Cancer Epidemiol 2021 Jun 19;73:101969. Epub 2021 Jun 19.

College House, University of Exeter Medical School, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK. Electronic address:

Background: A standard measure of the cancer diagnostic pathway, diagnostic interval, is the time from "first presentation of cancer" to diagnosis. Cancer presentation may be unclear in patients with multimorbidity or non-specific symptoms, signs or test results ("features"). We propose an alternative, guideline interval, with a more certain start date; namely, when the patient first meets suspected-cancer criteria for investigation or referral. Read More

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Fish muscle processing into seafood products reduces β-parvalbumin allergenicity.

Food Chem 2021 Jun 16;364:130308. Epub 2021 Jun 16.

Institute of Physical-Chemistry Rocasolano, Spanish National Research Council, 28006 Madrid, Spain. Electronic address:

Fish is one of the eight major foods causing type-I food allergy, and the prevalence of its allergy is increasing in part due to changes in consumption habits. One of the main drivers for these changes has been the processing developments transforming the fish muscle into seafood products. Most fish allergic patients react to the Ca-binding protein β-parvalbumin (β-PV) abundant in muscle. Read More

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Is perceived control of depression related to therapy outcome for depression? A longitudinal study.

J Psychiatr Res 2021 Jun 15;140:504-511. Epub 2021 Jun 15.

Department of Psychiatry, Diakonhjemmet Hospital, Oslo, Norway; Clinical Neuroscience Research Group, Department of Psychology, University of Oslo, Oslo, Norway.

Background: The present study followed a group of patients over a two-year period after they had received a cognitive behavioral psychoeducational intervention targeting patients' ability to cope with depression. The main aims were to examine whether a change in both depressive symptoms and in the perceived control of depression occurred and the relationship between depressive symptoms and perceived control.

Methods: Using a prospective longitudinal design, a sample of 183 patients was assessed at four time points during a two-year period. Read More

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Insensitivity of dental pulp stem cells migration to substrate stiffness.

Biomaterials 2021 Jun 15;275:120969. Epub 2021 Jun 15.

Inserm UMR-S1121, Centre de Recherche en Biomédecine de Strasbourg (CRBS), 1 rue Eugène Boeckel, 67084, Strasbourg, France; Université de Strasbourg, Faculté de Chirurgie Dentaire, 8 rue Sainte Elisabeth, 67000, Strasbourg, France; Fédération de Médecine Translationnelle, Strasbourg, France. Electronic address:

Dental pulp stem cells (DPSCs) are a promising cell source for regeneration of dental pulp. Migration is a key event but influence of the microenvironment rigidity (5 kPa at the center of dental pulp to 20 GPa for the dentin) is largely unknown. Mechanical signals are transmitted from the extracellular matrix to the cytoskeleton, to the nuclei, and to the chromatin, potentially regulating gene expression. Read More

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Effect of housing system and feed restriction on meat quality of medium-growing chickens.

Poult Sci 2021 Apr 27;100(8):101223. Epub 2021 Apr 27.

Department of Nutrition Physiology and Animal Product Quality, Institute of Animal Science, Czech Republic.

The aim of the study was to evaluate the differences in meat quality of 420 Hubbard JA757 cockerels in relation to the housing system (litter and mobile box) and level of mixed feed (ad libitum [AL], reducing the level by 20% [R20] and 30% [R30]). Three groups of chickens were housed in litter boxes for the entire fattening period (stocking density: 0.094 m/bird). Read More

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Hemoptysis in a patient with pulmonary aspergilloma and type 2 diabetes mellitus: A rare case in an Indonesian adult.

Int J Surg Case Rep 2021 Jun 18;84:106125. Epub 2021 Jun 18.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Electronic address:

Background: The success rate of surgery on aspergilloma is quite low since aspergilloma generally spreads throughout the lung cavity.

Case Presentation: A 45-year-old woman with a past history of type 2 diabetes mellitus presented with chronic hemoptysis. Clinical presentation and work up revealed a left lung aspergilloma, with x-ray and CT-scan showing a mass in the upper lobe of left lung and FNAB showing Aspergillus sp. Read More

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Durable electromagnetic interference (EMI) shielding ramie fabric with excellent flame retardancy and Self-healing performance.

J Colloid Interface Sci 2021 May 29;602:810-821. Epub 2021 May 29.

State Key Laboratory of Fire Science, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, People's Republic of China; Suzhou Key Laboratory of Urban Public Safety, Suzhou Institute for Advanced Study, University of Science and Technology of China, 166 Ren'ai Road, Suzhou, Jiangsu 215123, People's Republic of China. Electronic address:

Although more and more attention has been paid to electromagnetic interference (EMI) shielding fabric materials due to increasing electromagnetic waves pollution, little attention to their fire safety behavior and durability in practical use. Herein, durable EMI shielding ramie fabric with flame retardant and self-healing performance were fabricated by depositing ammonium polyphosphate (APP)/polyethyleneimine (PEI) layer, MXene sheets and polycaprolactone (PCL) layer. The resultant multifunctional fabric could self-extinguish and the peak heat release rate (pHRR) value reduced about 74. Read More

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Preschoolers are capable of fine-grained implicit cognitive control: Evidence from development of the context-specific proportion congruency effect.

J Exp Child Psychol 2021 Jun 19;210:105211. Epub 2021 Jun 19.

Laboratoire de Psychologie Cognitive (UMR 7290), Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université, 13331 Marseille, France.

Whereas much of the developmental literature has focused on the difficulties of young children in regulating their behavior, an increasing base of evidence suggests that children may be capable of surprisingly flexible engagement of cognitive control when based on implicit experience with the situation. One of the most fine-grained examples of implicit cognitive control in adults is the context-specific proportion congruency (CSPC) effect-the finding that interference in a conflict task is reduced for stimuli that are presented in a context (e.g. Read More

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Does Chair of Surgery Gender Influence Divisional or Residency Program Director Gender Diversity?

J Surg Res 2021 Jun 19;267:224-228. Epub 2021 Jun 19.

Department of Surgery, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background: Workplace diversity is beneficial and results in new ideas and improved performance. Within surgery leadership, the gender gap is improving, but still present. Given the increasing number of women surgery department chairs, we aimed to examine the association of surgery chair gender with division and residency program director gender. Read More

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Increasing pregnancy duration, fetal and early postnatal growth in LMIC: The importance of a gut microbiome that exploits dietary staples.

EBioMedicine 2021 Jun 19;69:103449. Epub 2021 Jun 19.

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia. Electronic address:

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Management of vascular complications following facial hyaluronic acid injection: high-dose hyaluronidase protocol: a technical note.

J Stomatol Oral Maxillofac Surg 2021 Jun 19. Epub 2021 Jun 19.

Department of ENT and Maxillofacial surgery, Head and Neck Institute, University Hospital of Nice, France.. Electronic address:

Aesthetic medicine has experienced major developments in recent years, which is illustrated by the increasing number of hyaluronic acid injected in the area of facial rejuvenation. Although considered low risk, it can rarely result in arterial embolization with potentially major aesthetic and functional consequences. These vascular complications range from livedo to skin necrosis to permanent blindness. Read More

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Severe Maternal Morbidity and Mortality During Delivery Hospitalization of Class I, II, III, and Super Obese Women.

Am J Obstet Gynecol MFM 2021 Jun 19:100420. Epub 2021 Jun 19.

Yale School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut.

Background: Previous studies show that obesity predisposes patients to higher risks of adverse pregnancy outcomes. Data on the relationship between increasing degrees of obesity and risks of severe maternal morbidity (SMM), including mortality, are limited.

Objective: We examined the association of increasing classes of obesity, especially super obesity, with the risk of SMM and mortality at the time of delivery hospitalization. Read More

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Pharmacokinetics and pharmacodynamics of antibiotics in cystic fibrosis: a narrative review.

Int J Antimicrob Agents 2021 Jun 19:106381. Epub 2021 Jun 19.

Department of Internal Medicine, Pharmacology & Toxicology Unit, University of Genoa, Viale Benedetto XV, 2 -16132, Genoa, Italy; Clinical Pharmacology Unit, EO Ospedali Galliera, Mura delle Cappuccine, 14 - 16128, Genoa, Italy. Electronic address:

Cystic fibrosis affects several organs, predisposing patients to severe bacterial respiratory infections, including those caused by methicillin-resistant Staphylococcus aureus. Cystic fibrosis is also associated with a wide spectrum of pathological changes that can significantly affect the absorption, distribution, metabolism and/or elimination of several drugs, including antibacterial agents. Awareness of the pharmacokinetic derangements in patients with cystic fibrosis is, therefore, mandatory for the optimization of antibiotic therapy. Read More

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Using a stepwise approach to simultaneously develop and validate Machine Learning based prediction models: Stepwise model development and validation.

J Clin Epidemiol 2021 Jun 19. Epub 2021 Jun 19.

Department of Epidemiology, Medisch Spectrum Twente, Enschede, the Netherlands.

Accurate diagnosis of a disease is essential in healthcare. Prediction models, based on classical regression techniques, are widely used in clinical practice. Machine Learning (ML) techniques might be preferred in case of a large amount of data per patient and relatively limited numbers of subjects. Read More

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Anti-inflammatory Pharmacotherapy for the Prevention of Cystoid Macular Edema after Cataract Surgery.

Am J Ophthalmol 2021 Jun 19. Epub 2021 Jun 19.

Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland; Institute for Research in Ophthalmology, Foundation for Ophthalmology Development, Poznan Poland. Electronic address:

Purpose: To elucidate strategies for and controversies surrounding the use of anti-inflammatory medications after uneventful cataract surgery, with a focus on the prevention of irreversible vision loss due to cystoid macular edema (CME).

Design: Perspective.

Methods: Expert commentary on the management of inflammation after cataract surgery. Read More

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Light-inducible deformation of mitochondria in live cells.

Cell Chem Biol 2021 Jun 8. Epub 2021 Jun 8.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China; Shun Hing Institute of Advanced Engineering (SHIAE), The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China. Electronic address:

Mitochondria, the powerhouse of the cell, are dynamic organelles that undergo constant morphological changes. Increasing evidence indicates that mitochondria morphologies and functions can be modulated by mechanical cues. However, the mechano-sensing and -responding properties of mitochondria and the relation between mitochondrial morphologies and functions are unclear due to the lack of methods to precisely exert mechano-stimulation on and deform mitochondria inside live cells. Read More

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Effects of high-frequency temperature variabilities on the morbidity of chronic obstructive pulmonary disease: Evidence in 21 cities of Guangdong, South China.

Environ Res 2021 Jun 19:111544. Epub 2021 Jun 19.

School of Geography and Planning, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: While temperature changes have been confirmed as one of the contributory factors affecting human health, the association between high-frequency temperature variability (HFTV, i.e., temperature variation at short time scales such as 1, 2, and 5 days) and the hospitalization of chronic obstructive pulmonary disease (COPD) was rarely reported. Read More

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Assessing the Difference in Learning Gain between a Mixed Reality Application and Drawing Screencasts in Neuroanatomy.

Anat Sci Educ 2021 Jun 22. Epub 2021 Jun 22.

Medical Physics Laboratory, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Augmented, mixed and virtual reality applications and content have surged into the higher education arena, thereby allowing institutions to engage in research and development projects to better understand their efficacy within curricula. However, despite the increasing interest, there remains a lack of robust empirical evidence to justify the mainstream acceptance of this approach as an effective and efficient learning tool. In this study, the impact of a mixed reality application focused on long spinal cord sensory and motor pathways is explored in comparison to an existing resource already embedded within an active curriculum (e. Read More

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Natural history of small asymptomatic kidney and residual stones over a long-term follow-up: Systematic review over 25 years.

BJU Int 2021 Jun 22. Epub 2021 Jun 22.

Department of Urology, University Hospital Southampton, Tremona Road, Southampton, UK.

Introduction: Incidental identification of small, asymptomatic renal calculi has risen with increasing high-resolution imaging. The natural history of such stones and small residual fragments remains unclear, however kidney stone disease (KSD) demands growing healthcare resource utilisation with wide-ranging costs of treatment and varying management recommendations.

Materials And Methods: We systematically reviewed the natural history of small asymptomatic kidney and residual stones using the Cochrane and PRISMA methodology. Read More

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Appendiceal pseudomyxoma peritonei: predictors of recurrence and iterative surgery.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Aim: Appendiceal pseudomyxoma peritonei (PMP) is a rare entity, with recurrence rates up to 26% despite optimal cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Evidence specific to PMP originating from non-infiltrative appendiceal mucinous neoplasms (Low grade - LAMN and high grade - HAMN) is lacking. The aim of this study was to identify patterns of recurrence and predictive factors for patients appropriate for iterative surgery. Read More

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Change in children's perception of cancer in the last 10 years in Japan.

Pediatr Int 2021 Jun 22. Epub 2021 Jun 22.

Department of Medical Education, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu-shi, Mie, 514-8507, Japan.

Background: Social awareness on cancer can be changed with cancer education and proper distribution of cancer information. This study addressed the current situation and historical change of children's perception of cancer.

Methods: Questionnaire surveys were conducted among healthy school children aged 10 to 15 years in 2008 and 2018. Read More

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Taxonomic and functional homogenization of farmland birds along an urbanization gradient in a tropical megacity.

Glob Chang Biol 2021 Jun 22. Epub 2021 Jun 22.

Institute of Agricultural Sciences in the Tropics, Department of Ecology of Tropical Agricultural Systems, University of Hohenheim, 70599, Stuttgart, Germany.

Urbanization is a major driver of land use change and biodiversity decline. While most of the ongoing and future urbanization hot spots are located in the Global South, the impact of urban expansion on agricultural biodiversity and associated functions and services in these regions has widely been neglected. Additionally, most studies assess biodiversity responses at local scale (α-diversity), however, ecosystem functioning is strongly determined by compositional and functional turnover of communities (β-diversity) at regional scales. Read More

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Shift in place of tanning bed use from tanning salons to spa, fitness, and beauty facilities: A trend perspective.

Photodermatol Photoimmunol Photomed 2021 Jun 22. Epub 2021 Jun 22.

Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty Mannheim, Heidelberg University, 68167, Mannheim, Germany.

While the number of tanning salons is declining, previous research described an increasing trend of using tanning beds (TBs) in fitness studios. The authors discussed that the presence of TBs in fitness studios might strengthen the misconception that use of TBs is healthy. The same is true for TBs in facilities such as swimming pools, saunas, hotels, and cosmetic salons that aim to promote well-being. Read More

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Proven COVID-19-associated pulmonary aspergillosis in patients with severe respiratory failure.

Mycoses 2021 Jun 22. Epub 2021 Jun 22.

Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, Pathology Unit, University of Padova, Medical School, Padova, Italy.

Background: An increasing number of reports have described the COVID-19 associated pulmonary aspergillosis (CAPA) as being a further contributing factor to mortality. Based on a recent consensus statement supported by international medical mycology societies, it has been proposed to define CAPA as possible, probable, or proven on the basis of sample validity and thus diagnostic certainty. Considering current challenges associated with proven diagnoses there is pressing need to study the epidemiology of proven CAPA. Read More

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Protective Role of DHEAS in Age-related Changes in Bone Mass and Fracture Risk: A Mendelian Randomization Study.

J Clin Endocrinol Metab 2021 Jun 22. Epub 2021 Jun 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: Dehydroepiandrosterone sulfate (DHEAS) from the adrenal cortex substantially decreases with age, which may accelerate osteoporosis. However, the association of DHEAS with bone mineral density (BMD) and fracture is inconclusive. We conducted a Mendelian randomization (MR) analysis to investigate the role of DHEAS in age-related changes in BMD and fracture risk. Read More

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