Int J Antimicrob Agents 2021 Jun 19:106381. Epub 2021 Jun 19.
Department of Internal Medicine, Pharmacology & Toxicology Unit, University of Genoa, Viale Benedetto XV, 2 -16132, Genoa, Italy; Clinical Pharmacology Unit, EO Ospedali Galliera, Mura delle Cappuccine, 14 - 16128, Genoa, Italy. Electronic address:
Cystic fibrosis affects several organs, predisposing patients to severe bacterial respiratory infections, including those caused by methicillin-resistant Staphylococcus aureus. Cystic fibrosis is also associated with a wide spectrum of pathological changes that can significantly affect the absorption, distribution, metabolism and/or elimination of several drugs, including antibacterial agents. Awareness of the pharmacokinetic derangements in patients with cystic fibrosis is, therefore, mandatory for the optimization of antibiotic therapy. Read More