1,028,712 results match your criteria increasing aquatic


[Lifestyle changes for stroke prevention].

Dtsch Med Wochenschr 2021 Jun 15;146(12):787-792. Epub 2021 Jun 15.

Changes of lifestyle have a substantial effect on stroke prevention, especially in high-risk patients. Maintaining a healthier lifestyle can have greater effects than most pharmacological therapies of cardiovascular prevention. For example, increasing the amount of physical activity, adopting a healthy diet, limiting alcohol consumption and quitting smoking are associated with a 70 % decrease in stroke risk. Read More

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Identifying genomic regions targeted during eggplant domestication using transcriptome data.

J Hered 2021 Jun 15. Epub 2021 Jun 15.

Biological Sciences, University of Southampton, Southampton, UK.

Identifying genes and traits that have diverged during domestication provides key information of importance for maintaining and even increasing yield and nutrients in existing crops. A 'bottom up' population genetics approach was used to identify signatures of selection across the eggplant genome, to better understand the process of domestication. RNA-seq data was obtained for four wild eggplants (Solanum insanum L. Read More

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An improved ultrasonic coda wave method for concrete behavior monitoring under various loading conditions.

Ultrasonics 2021 Jun 8;116:106498. Epub 2021 Jun 8.

College of Automotive and Mechanical Engineering, Changsha University of Science and Technology, Changsha, Hunan 410114, China.

Monitoring of concrete behavior is an important task to evaluate the safety of concrete structures. This paper proposes a new stretching factor accumulation method based on the stepwise coda wave interference (CWI) to accurately calculate the relative velocity change Δv/v. The Δv/v and residual decorrelation coefficient K are used to study the concrete behavior in step loading experiment and short-time fixed loading experiment. Read More

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Promoting corn stover degradation via sequential processing of steam explosion and cellulase/lactic acid bacteria-assisted ensilage.

Bioresour Technol 2021 Jun 10;337:125392. Epub 2021 Jun 10.

Animal Science and Technology College, Beijing University of Agriculture, Beijing 102206, China. Electronic address:

To improve the utilization efficiency of corn stover , steam explosion pretreatment and cellulase/lactic acid bacteria-assisted ensilage storage were conducted in sequence, mainly focusing on morphological structure, lignocellulose fraction, cellulose accessibility and degradation profile. The results showed that there was a synergistic effect of steam explosion and ensilage storage, where hemicellulose of corn stover was partly degraded during steam explosion processing (70%) or ensilage storage (20-40%). Meanwhile, its morphological structure was apparently broken, increasing cellulose accessibility (2. Read More

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Antibiotic-induced disruption of the microbiome exacerbates chemotherapy-induced diarrhoea and can be mitigated with autologous faecal microbiota transplantation.

Eur J Cancer 2021 Jun 12;153:27-39. Epub 2021 Jun 12.

Department of Medical Microbiology, University Medical Centre Groningen, The University of Groningen, Groningen, the Netherlands.

Background: Chemotherapy is well documented to disrupt the gut microbiome, leading to poor treatment outcomes and a heightened risk of adverse toxicity. Although strong associations exist between its composition and gastrointestinal toxicity, its causal contribution remains unclear. Our inability to move beyond association has limited the development and implementation of microbial-based therapeutics in chemotherapy adjuncts with no clear rationale of how and when to deliver them. Read More

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Progress in the study of D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) reversing multidrug resistance.

Colloids Surf B Biointerfaces 2021 Jun 8;205:111914. Epub 2021 Jun 8.

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

Currently, multidrug resistance (MDR) is one of the major reasons for failure in clinical cancer chemotherapy. Overexpression of the ATP binding cassette (ABC) transporter P-glycoprotein (P-gp), which significantly increases the efflux of anticancer drugs from tumor cells, enhances MDR. In the past few decades, four generations of P-gp inhibitors have appeared. Read More

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Activity of glutathione S-transferase and its π isoenzyme in the context of single nucleotide polymorphism in the GSTP1 gene (rs1695) and tobacco smoke exposure in the patients with acute pancreatitis and healthy subjects.

Biomed Pharmacother 2021 Jun 12;140:111589. Epub 2021 Jun 12.

Department of Biomedical and Environmental Analyses, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw 50-556, Poland. Electronic address:

Oxidative stress associated with the course of acute pancreatitis (AP) can cause changes in the involvement of antioxidants, which can result in the increased production of free radicals with pro-inflammatory potential. Through its noncatalytic activity, the glutathione S-transferase and its π isoenzyme (GST-π), apart from cellular xenobiotics detoxification, are involved in the regulation of cellular signalling, metabolism and apoptosis. This study aimed to evaluate the impact of SNP rs1695 in the GSTP1 gene on GST and GST-π activity in healthy subjects and patients with acute pancreatitis (AP). Read More

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Effects of dynamic adsorption on bubble formation and coalescence in partitioned-EDGE devices.

J Colloid Interface Sci 2021 Jun 4;602:316-324. Epub 2021 Jun 4.

Wageningen University, Food Process Engineering Group, Bornse Weilanden 9, 6708 WG Wageningen, The Netherlands. Electronic address:

Hypothesis: Dynamic adsorption effects can play a crucial role in bubble formation and stabilization. We hypothesize that microfluidic tools provide direct insights to these effects, and that the final bubble size depends on the intersection of time scales for bubble formation versus adsorption of proteins.

Experiments: We use a microfluidic device to study Laplace pressure-driven formation of bubbles that are stabilized by whey proteins. Read More

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Nanonewton scale adhesion force measurements on biotinylated microbeads with a robotic micropipette.

J Colloid Interface Sci 2021 Jun 3;602:291-299. Epub 2021 Jun 3.

ELTE Eötvös Loránd University, Department of Biological Physics, Budapest, Hungary; CellSorter Company for Innovations, Erdőalja út 174, H-1037 Budapest, Hungary. Electronic address:

Binding force between biomolecules has a crucial role in most biological processes. Receptor-ligand interactions transmit physical forces and signals simultaneously. Previously, we employed a robotic micropipette both in live cell and microbead adhesion studies to explore the adhesion force of biomolecules such as cell surface receptors including specific integrins on immune cells. Read More

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Variations of antibiotic resistome in swine wastewater during full-scale anaerobic digestion treatment.

Environ Int 2021 Jun 12;155:106694. Epub 2021 Jun 12.

SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, University Town, Guangzhou 510006, China. Electronic address:

Anaerobic digesters have been widely used to treat wastewaters in livestock farms. With the increasing risk of antibiotic resistance originated from livestock husbandry, removal of antibiotics and antibiotic resistance genes (ARGs) via anaerobic digesters deserved more attention. Here we investigated the removal of antibiotics and ARGs in swine wastewater by three on-farm full-scale anaerobic digesters, including buried biogas digester (BBD), up-flow anaerobic sludge blanket (UASB) and high density polyethylene covered biogas digester (HDPE-BD). Read More

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Insight into the inhibitory mechanism of soluble ionic liquids on the transport of TiO nanoparticles in saturated porous media: Roles of alkyl chain lengths and counteranion types.

J Hazard Mater 2021 Jun 10;418:126367. Epub 2021 Jun 10.

Henan Joint International Research Laboratory of Environmental Pollution Control Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China. Electronic address:

Column experiments were carried out to investigate the transport of TiO nanoparticles (nTiO) in water-saturated porous media in the presence of various imidazolium-based ionic liquids (ILs) with different alkyl chain lengths and counteranions. The results indicated that the effects of ILs on nTiO transport were considerably dependent upon IL species. In general, the transport-inhibition effects increased with the increasing length of branched alkyl chain on the ILs (i. Read More

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Anti-flagellin IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound murine models in a non-type-specific mode.

Mol Immunol 2021 Jun 12;136:118-127. Epub 2021 Jun 12.

Medicinal Plants Research Center, Shahed University, Tehran, Iran.

Pseudomonas aeruginosa (PA) is one of the most dominant causes of nosocomial infections in burn patients. Increasing emergence of antibiotic-resistant strains highlights the need for novel antimicrobial agents. Flagellin, the main component protein of flagellum, is determined as the major antigen interacting with anti-P. Read More

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Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation.

Int Immunopharmacol 2021 Jun 11;98:107856. Epub 2021 Jun 11.

Department of Traditional Chinese Medicine, the First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu 241000, China; Research Center of Integration of Traditional Chinese and Western Medicine, Wannan Medical College, Wuhu 241000, China; Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, Wuhu 241000, China. Electronic address:

Supplement of nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide adenine dinucleotide (NAD) has gained prominence due to the significant anti-aging potentials of nicotinamide phosphoribosyltransferas (NAMPT)/NAD signaling. Because over-expression of NAMPT is deeply implicated in inflammatory arthritis, we investigated the effects of NMN supplement on rats with adjuvant-induced arthritis (AIA). Tested rats were given oral treatment of NMN at 200 mg/kg/day for 25 days. Read More

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Comparison of the sorption capacity of basic, acid, direct and reactive dyes by compost in batch conditions.

J Environ Manage 2021 Jun 12;294:113005. Epub 2021 Jun 12.

Department of Soil Science and Agricultural Chemistry, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain. Electronic address:

Research on biosorption of organic dyes is an important subject for the development of clean technologies for the treatment of textile wastewater. In this work, the process of sorption of four textile dyes of different natures, namely Basic Violet 10 (BV10), Acid Red 27 (AR27), Direct Blue 151 (DB151) and Reactive Violet 4 (RV4) onto two composts, pine bark compost and municipal solid waste compost, has been studied. For this, sorption kinetics and equilibrium sorption at different solution pH values (3. Read More

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Hybrid power generation for increasing water and energy securities during drought: Exploring local and regional effects in a semi-arid basin.

J Environ Manage 2021 Jun 12;294:112989. Epub 2021 Jun 12.

Division of Impacts, Adaptation and Vulnerabilities - DIIAV, Brazilian Institute for Space Research - INPE, São José Dos Campos, SP, Brazil.

Reservoirs of hydropower plants (HPP) can amend water, energy, and food security in semi-arid regions. However, during severe droughts, the priority of energy demand leads to critical conditions of water availability. To reduce water use for energy, one possible measure is the adoption of solar power, an abundant energy source in semi-arid regions. Read More

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Promoting cross-regional collaboration in antimicrobial stewardship: Findings of an infectious diseases working group survey in Arab countries of the Middle East.

J Infect Public Health 2021 Apr 24;14(7):978-984. Epub 2021 Apr 24.

American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Background: Antimicrobial resistance is a significant global issue that presents an increasing threat to patients' wellbeing. Although a global concern, the emergence of multi-drug resistant organisms is of particular significance in the Middle East. In recent years, this region has seen an alarming increase in antimicrobial resistance presenting a major challenge to physicians managing various infectious diseases. Read More

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Effect of plastic film mulching and film residues on phthalate esters concentrations in soil and plants, and its risk assessment.

Environ Pollut 2021 Jun 9;286:117546. Epub 2021 Jun 9.

State Key Laboratory of Grassland Agroecosystems, Institute of Arid Agroecology, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China. Electronic address:

The application of plastic film mulching can greatly improve dryland productivity, while the release of toxic phthalate esters (PAEs) from the plastic film has generated concern. This study investigated the effects of mulched plastic film and residual plastic film on the PAE concentrations in the soil-crop system and assessed the risks to people eating crop products. The PAEs concentration in the 0-25 cm soil layer of plastic mulched farmland was 0. Read More

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Facile and rapid detection of SARS-CoV-2 antibody based on a noncompetitive fluorescence polarization immunoassay in human serum samples.

Biosens Bioelectron 2021 Jun 5;190:113414. Epub 2021 Jun 5.

Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, 060-8628, Japan; Innovative Research Centre for Preventive Medical Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan; Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address:

Antibody detection methods for viral infections have received broad attention due to the COVID-19 pandemic. In addition, there remains an ever-increasing need to quantitatively evaluate the immune response to develop vaccines and treatments for COVID-19. Here, we report an analytical method for the rapid and quantitative detection of SARS-CoV-2 antibody in human serum by fluorescence polarization immunoassay (FPIA). Read More

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Early detection of cognitive decline in mild cognitive impairment and Alzheimer's disease with a novel eye tracking test.

J Neurol Sci 2021 Jun 3;427:117529. Epub 2021 Jun 3.

Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan. Electronic address:

Due to an increasing number of dementia patients, the development of a rapid and sensitive method for cognitive assessment is awaited. Here, we examined the usefulness of a novel and short (3 min) eye tracking device to evaluate the cognitive function of normal control (NC, n = 52), mild cognitive impairment (MCI, n = 52), and Alzheimer's disease (AD, n = 70) subjects. Eye tracking total score declined significantly in MCI (**p < 0. Read More

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The who, what and when of drug driving in Queensland: Analysing the results of roadside drug testing, 2015-2020.

Accid Anal Prev 2021 Jun 12;159:106231. Epub 2021 Jun 12.

Road Safety Research Collaboration, University of the Sunshine Coast, 90 Sippy Downs Dr, Sippy Downs, Queensland 4556, Australia. Electronic address:

Roadside Drug Testing (RDT) is the primary strategy utilised in Australia to detect and deter drug driving. RDT operations have been expanding and evolving in Queensland since their introduction in 2007, with the number of tests increasing by 5.63 times between 2009 and 2019. Read More

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Methodology for altering omega-3 EPA+DHA and omega-6 linoleic acid as controlled variables in a dietary trial.

Clin Nutr 2021 May 12;40(6):3859-3867. Epub 2021 May 12.

Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background & Aims: Increasing dietary intake of n-3 EPA+DHA and lowering dietary n-6 LA is under investigation as a therapeutic diet for improving chronic pain syndromes as well as other health outcomes. Herein we describe the diet methodology used to modulate intake of n-3 and n-6 PUFA in a free living migraine headache population and report on nutrient intake, BMI and diet acceptability achieved at week 16 of the intensive diet intervention and week 22 follow-up time-point.

Methods: A total of 178 participants were randomized and began one of three diet interventions: 1) a high n-3 PUFA, average n-6 PUFA (H3) diet targeting 1500 mg EPA+DHA/day and 7% of energy (en%) from n-6 linoleic acid (LA), 2) a high-n-3 PUFA, low-n-6 PUFA (H3L6) targeting 1500 mg EPA+DHA/day and <1. Read More

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From hospital unit to intestinal failure center: Twenty years of history.

Clin Nutr 2021 Apr 27;40(6):3787-3792. Epub 2021 Apr 27.

Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Care, Jagiellonian University, Krakow, Poland.

Aim: Home parenteral nutrition (HPN) is one of the most demanding medical therapies as it is the only option for patients for intestinal failure (IF). No unequivocal policy on how to start and progress with HPN has ever been presented. The IF Center at the Stanley Dudrick's Memorial Hospital in Skawina is one of the biggest centers in Poland, celebrating its twentieth birthday last year. Read More

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Postpartum ultrasound for the diagnosis of obstetric anal sphincter injury.

Am J Obstet Gynecol MFM 2021 Jun 12:100421. Epub 2021 Jun 12.

Department of Obstetrics, Gynecology, and Neonatology, Sydney Medical School Nepean, University of Sydney, Kingswood, New South Wales, Australia.

This review presents the available data on the diagnosis of obstetric anal sphincter injury (OASI) by postnatal ultrasound imaging. There is increasing evidence that anal sphincter tears are often missed after childbirth and, even when diagnosed, often sub- optimally repaired, with a high rate of residual defects after reconstruction. Even after postpartum diagnosis and primary repair, 25-50% of patients will have persistent anal incontinence (AI). Read More

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Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer.

Mol Cell Proteomics 2021 Jun 12:100115. Epub 2021 Jun 12.

Department of Gastrointestinal Surgery, National Clinical Research Center for Geriatrics and Department of General Practice, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, 610041, China. Electronic address:

The occurrence and prevalence of colorectal cancer (CRC) is closely associated with age. More than 90% of CRC patients are diagnosed after 50 years old. However, CRC incidence of young individuals has been increasing since 1990s as overall CRC frequency declining. Read More

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Pitfalls in HLA ligandomics - How to catch a li(e)gand.

Mol Cell Proteomics 2021 Jun 12:100110. Epub 2021 Jun 12.

Immatics Biotechnologies GmbH, Paul-Ehrlich-Str. 15-17, 72076 Tübingen, Germany; Immatics US, Inc. 2201 W. Holcombe Blvd., Suite 205, Houston, Texas 77030, USA. Electronic address:

Knowledge about the peptide repertoire presented by human leukocyte antigens (HLA) holds the key to unlock target-specific cancer immunotherapies like adoptive cell therapies or bispecific T cell engaging receptors. Therefore, comprehensive and accurate characterization of HLA peptidomes by mass spectrometry (immunopeptidomics) across tissues and disease states is essential. With growing numbers of immunopeptidomics datasets and the scope of peptide identification strategies reaching beyond the canonical proteome, the likelihood for erroneous peptide identification as well as false annotation of HLA-independent peptides as HLA ligands is increasing. Read More

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Ethnomedicine and Neuropsychopharmacology in Mesoamerica.

J Ethnopharmacol 2021 Jun 12:114243. Epub 2021 Jun 12.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042, Monserrato CA, Italy. Electronic address:

Ethnopharmacological Relevance: The burden of disease caused by mental and neurological disorders is increasing globally, to a disproportionate degree in Latin America. In contrast to the many psychoactive plants with a use history in Mesoamerican cultures, the translation to the wider population of knowledge around numerous botanicals used contemporarily by indigenous Mesoamerican societies to treat psychological and neurological disorders did not receive the same attention.

Material And Methods: We used the previously published Mesoamerican Medicinal Plant Database to extract species and associated botanical drugs used as treatments for illnesses associated with the nervous system by Mesoamerican cultures in Belize, Guatemala, and Mexico. Read More

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Chemoattractants driven and microglia based biomimetic nanoparticle treating TMZ-resistant glioblastoma multiforme.

J Control Release 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address:

Currently, clinical treatment for temozolomide (TMZ)-resistant glioblastoma multiforme (GBM) is still a difficult problem. The aim of this paper is to set up a new GBM-targeted drug delivery system to treat TMZ-resistant GBM. Zoledronate (ZOL) not only induces apoptosis of TMZ-resistant GBM cells by down-regulation of farnesyl pyrophosphate synthetase (FPPS) but also increases the proportion of M1-type GBM associated macrophages (GAM). Read More

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Future prospects for mitosis-targeted antitumor therapies.

Biochem Pharmacol 2021 Jun 12:114655. Epub 2021 Jun 12.

Dept. Biochemistry, Molecular and Cell Biology, University of Zaragoza and IIS Aragón, Spain. Electronic address:

Dysregulation of cell cycle progression is a hallmark of cancer cells. In recent years, efforts have been devoted to the development of new therapies that target proteins involved in cell cycle regulation and mitosis. Novel targeted antimitotic drugs include inhibitors of aurora kinase family, polo-like kinase 1, Mps1, Eg5, CENP-5 and the APC/cyclosome complex. Read More

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Global analysis of a cancer model with drug resistance due to Lamarckian induction and microvesicle transfer.

J Theor Biol 2021 Jun 12:110812. Epub 2021 Jun 12.

Bolyai Institute, University of Szeged, Szeged H-6720, Hungary.

Development of resistance to chemotherapy in cancer patients strongly effects the outcome of the treatment. Due to chemotherapeutic agents, resistance can emerge by Darwinian evolution. Besides this, acquired drug resistance may arise via changes in gene expression. Read More

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The impact of weather and increased atmospheric CO from 1892 to 2016 on simulated yields of UK wheat.

J R Soc Interface 2021 Jun 16;18(179):20210250. Epub 2021 Jun 16.

Computational and Analytical Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

Climate change effects on UK winter wheat grain yield are complex: warmer temperature, negative; greater carbon dioxide (CO) concentration, positive; but other environmental variables and their timing also affect yield. In the absence of long-term experiments where temperature and CO concentration were manipulated separately, we applied the crop simulation model Sirius with long-term daily meteorological data (1892-2016) for Rothamsted, Hertfordshire, UK (2007-2016 mean growing season temperature 1.03°C warmer than 1892-1991), and CO concentration over this period, to investigate the separate effects of historic CO and weather on simulated grain yield in three wheat cultivars of the modern era. Read More

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