Osteoarthritis Cartilage 2021 Sep 14. Epub 2021 Sep 14.
Faculty of Dentistry, McGill University, Montreal, Quebec, Canada; The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada; Departments of Anesthesiology, Pharmacology & Therapeutics, Neurology & Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Faculty of Medicine, Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA. Electronic address:
Objective: To examine the effect of running exercise on behavioral measures of pain and intervertebral disc (IVD) inflammation in the SPARC-null mouse model.
Methods: Male and female 8-month old SPARC-null and age-matched control mice received a home cage running wheel or a control, fixed wheel for 6 months. Behavioral assays were performed to assess axial discomfort (grip test) and radiating leg pain (von Frey, acetone tests) and voluntary running was confirmed. Read More