123,116 results match your criteria increases expression


Hepatic Regulator of G Protein Signaling 6 (RGS6) drives non-alcoholic fatty liver disease by promoting oxidative stress and ATM-dependent cell death.

Redox Biol 2021 Aug 28;46:102105. Epub 2021 Aug 28.

Centre of Biomedical Research, Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow, Uttar Pradesh, 226014, India. Electronic address:

The pathophysiological mechanism(s) driving non-alcoholic fatty liver disease, the most prevalent chronic liver disease globally, have yet to be fully elucidated. Here, we identify regulator of G protein signaling 6 (RGS6), up-regulated in the livers of NAFLD patients, as a critical mediator of hepatic steatosis, fibrosis, inflammation, and cell death. Human patients with high hepatic RGS6 expression exhibited a corresponding high inflammatory burden, pronounced insulin resistance, and poor liver function. Read More

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Voluntary running attenuates behavioural signs of low back pain: Dimorphic regulation of intervertebral disc inflammation in male and female SPARC-null mice.

Osteoarthritis Cartilage 2021 Sep 14. Epub 2021 Sep 14.

Faculty of Dentistry, McGill University, Montreal, Quebec, Canada; The Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada; Departments of Anesthesiology, Pharmacology & Therapeutics, Neurology & Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Faculty of Medicine, Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Objective: To examine the effect of running exercise on behavioral measures of pain and intervertebral disc (IVD) inflammation in the SPARC-null mouse model.

Methods: Male and female 8-month old SPARC-null and age-matched control mice received a home cage running wheel or a control, fixed wheel for 6 months. Behavioral assays were performed to assess axial discomfort (grip test) and radiating leg pain (von Frey, acetone tests) and voluntary running was confirmed. Read More

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September 2021

AMPK S-sulfuration contributes to HS donors-induced AMPK phosphorylation and autophagy activation in dopaminergic cells.

Neurochem Int 2021 Sep 14:105187. Epub 2021 Sep 14.

Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, 215123, China. Electronic address:

Hydrogen sulfide (HS) serves as a neuromodulator and regulator of neuroinflammation. It is reported to be therapeutic for Parkinson's disease (PD) animal and cellular models. However, whether it affects α-synuclein accumulation in dopaminergic cells, the key pathological feature in PD, is poorly understood. Read More

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September 2021

MUC5AC serves as the nexus for β-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance.

Gastroenterology 2021 Sep 14. Epub 2021 Sep 14.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.. Electronic address:

Background And Aims: A major clinical challenge for pancreatic cancer (PC) patients is metabolic adaptation. Neoplastic cells harboring molecular perturbations suffice for their increased anabolic demand and nucleotide biosynthesis to acquire chemoresistance. The mucin 5AC expressed de novo in malignant pancreas promotes cancer cell stemness and is significantly associated with poor patient survival. Read More

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September 2021

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy.

Am J Obstet Gynecol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA; Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, Florida, USA; Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, Florida, USA.

Physiologic, mechanical and immunologic alterations in pregnancy could potentially affect susceptibility to and severity of COVID-19 during pregnancy. Due to lack of comparable incidence data and challenges with disentangling differences in susceptibility from different exposure risks, data are insufficient to determine whether pregnancy increases susceptibility to SARS-CoV-2 infection. Data support pregnancy as a risk factor for severe disease associated with COVID-19; some of the best evidence comes from the Centers for Disease Control and Prevention's (CDC's) COVID-19 surveillance system, which reported that pregnant persons were more likely to be admitted to an intensive care unit (ICU), require invasive ventilation, require extracorporeal membrane oxygenation, and die compared with nonpregnant women of reproductive age. Read More

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September 2021

Knockout of nephron ATP6AP2 impairs proximal tubule function and prevents high fat diet induced obesity in male mice.

Endocrinology 2021 Sep 17. Epub 2021 Sep 17.

Division of Endocrinology, Department of Medicine, University of Virginia Health System.

ATP6AP2 expression is increased in the nephron during high fat diet (HFD) and its knockout (ATP6AP2 KO) reduces body weight (WT) in mice. We evaluated the contribution of ATP6AP2 to urinary glucose (UG) and albumin (Ualb) handling during HFD. We hypothesized that nephron ATP6AP2 KO increases UG and Ualb and minimizes HFD-induced obesity. Read More

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September 2021

Estimating the cost and value of functional changes in communication ability following telepractice treatment for aphasia.

PLoS One 2021 17;16(9):e0257462. Epub 2021 Sep 17.

Department of Speech, Language and Hearing Sciences, University of Florida, Gainesville, Florida, United States of America.

Context: Aphasia is a post-stroke condition that can dramatically impact a person with aphasia's (PWA) communication abilities. To date, few if any studies have considered the cost and cost-effectiveness of functional change in aphasia nor considered measures of patient's value for aphasia treatment.

Objective: To assess the cost, cost-effectiveness, and perceived value associated with improved functional communication in individuals receiving telerehabilitation treatment for aphasia. Read More

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September 2021

5-aza-2'-deoxycytidine induces apoptosis and inhibits tumour growth in vivo of FaDu cells, a specific HPVnegative HNSCC cell line.

PLoS One 2021 17;16(9):e0253756. Epub 2021 Sep 17.

Department of Human Biology, Faculty of Natural Science, University of Haifa, Haifa, Israel.

Head and neck cancer squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide, resulting in over 600,000 new diagnoses annually. Traditionally, HNCC has been related to tobacco and alcohol exposure; however, over the past decade, a growing number of head and neck cancers are attributed to human papillomavirus (HPV) infection. 5-Aza-2'-deoxycytidine (5-AzaD) was demonstrated as an effective chemotherapeutic agent for acute myelogenous leukaemia. Read More

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September 2021

WI12 interacts with DELLAs and mediates soybean cyst nematode resistance through hormone pathways.

Plant Biotechnol J 2021 Sep 17. Epub 2021 Sep 17.

University of Illinois Urbana-Champaign, Department of Crop Sciences.

The soybean cyst nematode (SCN) is one of the most important causes of soybean yield loss. The major source of genetic resistance to SCN is the Rhg1 repeat, a tandem copy number polymorphism of three genes; the roles of these genes are only partially understood. Moreover, nematode populations virulent on Rhg1-carrying soybeans are becoming more common, increasing the need to understand the most successful genetic resistance mechanism. Read More

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September 2021

Enhancing plant growth and biomass production by overexpression of GA20ox gene under control of a root preferential promoter.

Transgenic Res 2021 Sep 13. Epub 2021 Sep 13.

Institute of Biotechnology, Vietnam Academy of Science and Technology, A10 building, 18 Hoang Quoc Viet, Hanoi, Vietnam.

Overexpression of GA20 oxidase gene has been a recent trend for improving plant growth and biomass. Constitutive expression of GA20ox has successfully improved plant growth and biomass in several plant species. However, the constitutive expression of this gene causes side-effects, such as reduced leaf size and stem diameter, etc. Read More

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September 2021

Differential Iron Requirements for Osteoblast and Adipocyte Differentiation.

JBMR Plus 2021 Sep 26;5(9):e10529. Epub 2021 Jul 26.

Department of Medical and Molecular Genetics School of Medicine, Indiana University Indianapolis IN USA.

Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the balance of osteoblast and adipocyte differentiation, adversely affecting bone integrity. Read More

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September 2021

DAB2IP decreases cell growth and migration and increases sensitivity to chemotherapeutic drugs in colorectal cancer.

Ann Transl Med 2021 Aug;9(16):1317

Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Colorectal cancer (CRC) is one of the most common cancers worldwide with high rates of invasiveness and mortality. DAB2IP (DOC2/DAB2 interactive protein) is a member of the RAS-GTPase-activating protein (RAS-GAP) family that shows a suppressive effect on cancer progression, is downregulated in several cancers. However, the role of DAB2IP in CRC remains elusive. Read More

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FAT10 promotes hepatocellular carcinoma (HCC) carcinogenesis by mediating P53 degradation and acts as a prognostic indicator of HCC.

J Gastrointest Oncol 2021 Aug;12(4):1823-1837

The Second Department of Oncology, the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Background: With the advancement of hepatocellular carcinoma (HCC) treatment technology, the treatment options for HCC patients have increased. However, due to high heterogeneity, among other reasons, the five-year survival rate of patients is still very low. Currently, gene expression prognostic models can suggest more appropriate strategies for the treatment of HCC. Read More

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ω3PUFAs improve hepatic steatosis in postnatal overfed rats and HepG2 cells by inhibiting acetyl-CoA carboxylase.

Food Sci Nutr 2021 Sep 22;9(9):5153-5165. Epub 2021 Jul 22.

Department of Child Health Care Children's Hospital of Nanjing Medical University Nanjing China.

Postnatal overfeeding can lead to persistent increases in hepatic lipid synthesis and the risk of nonalcoholic fatty liver disease (NAFLD) in adulthood. The ω3 polyunsaturated fatty acids (ω3PUFAs) exhibit beneficial effects on NAFLD. Here, we employed a rat model and an in vitro HepG2 cell model to investigate whether fish oil (FO) affects hepatic lipid synthesis due to postnatal overfeeding. Read More

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September 2021

Differential Transcriptomic Regulation in Sweet Orange Fruit ( L. Osbeck) Following Dehydration and Rehydration Conditions Leading to Peel Damage.

Front Plant Sci 2021 31;12:732821. Epub 2021 Aug 31.

Department of Food Biotechnology, Institute of Agrochemistry and Food Technology-Consejo Superior de Investigaciones Cientificas (IATA-CSIC), Valencia, Spain.

Water stress is the most important environmental agent that contributes to the crop productivity and quality losses globally. In citrus, water stress is the main driver of the fruit peel disorders that impact the quality and market ability. An increasingly present post-harvest peel disorder is non-chilling peel pitting (NCPP). Read More

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Engineered Accumulation of Bicarbonate in Plant Chloroplasts: Known Knowns and Known Unknowns.

Front Plant Sci 2021 31;12:727118. Epub 2021 Aug 31.

Realizing Increased Photosynthetic Efficiency (RIPE), The Australian National University, Canberra, ACT, Australia.

Heterologous synthesis of a biophysical CO-concentrating mechanism (CCM) in plant chloroplasts offers significant potential to improve the photosynthetic efficiency of C plants and could translate into substantial increases in crop yield. In organisms utilizing a biophysical CCM, this mechanism efficiently surrounds a high turnover rate Rubisco with elevated CO concentrations to maximize carboxylation rates. A critical feature of both native biophysical CCMs and one engineered into a C plant chloroplast is functional bicarbonate (HCO ) transporters and vectorial CO-to-HCO converters. Read More

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7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder.

Sci Rep 2021 Sep 16;11(1):18519. Epub 2021 Sep 16.

Institute of Human Virology, Baltimore, MD, 21201, USA.

The combined antiretroviral therapy era has significantly increased the lifespan of people with HIV (PWH), turning a fatal disease to a chronic one. However, this lower but persistent level of HIV infection increases the susceptibility of HIV-associated neurocognitive disorder (HAND). Therefore, research is currently seeking improved treatment for this complication of HIV. Read More

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September 2021

A bacterial kinase phosphorylates OSK1 to suppress stomatal immunity in rice.

Nat Commun 2021 Sep 16;12(1):5479. Epub 2021 Sep 16.

Department of Plant Pathology, the Ministry of Agriculture Key Laboratory of Pest Monitoring and Green Management, and Joint Laboratory for International Cooperation in Crop Molecular Breeding, Ministry of Education, China Agricultural University, Beijing, China.

The Xanthomonas outer protein C2 (XopC2) family of bacterial effectors is widely found in plant pathogens and Legionella species. However, the biochemical activity and host targets of these effectors remain enigmatic. Here we show that ectopic expression of XopC2 promotes jasmonate signaling and stomatal opening in transgenic rice plants, which are more susceptible to Xanthomonas oryzae pv. Read More

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September 2021

Transmembrane H fluxes and the regulation of neural induction in .

Zygote 2021 Sep 17:1-12. Epub 2021 Sep 17.

Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China.

It has previously been reported that in ex vivo planar explants prepared from Xenopus laevis embryos, the intracellular pH (pHi) increases in cells of the dorsal ectoderm from stage 10.5 to 11.5 (i. Read More

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September 2021

Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.

Mol Brain 2021 Sep 16;14(1):143. Epub 2021 Sep 16.

Graduate Program in Neuroscience and Centre for Applied Neurogenetics, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada.

Vacuolar protein sorting 35 (VPS35) regulates neurotransmitter receptor recycling from endosomes. A missense mutation (D620N) in VPS35 leads to autosomal-dominant, late-onset Parkinson's disease. Here, we study the basic neurobiology of VPS35 and Parkinson's disease mutation effects in the D620N knock-in mouse and the effect of leucine-rich repeat kinase 2 (LRRK2) inhibition on synaptic phenotypes. Read More

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September 2021

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling.

Cell Commun Signal 2021 Sep 16;19(1):94. Epub 2021 Sep 16.

Institute of Biology, Department of Systems Biology, Otto-Von-Guericke University Magdeburg, Magdeburg, Germany.

Background: Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an essential mediator of pro- and anti-inflammatory processes. Dysregulated IL-6-induced intracellular JAK/STAT signalling is associated with severe inflammatory and proliferative diseases. Read More

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September 2021

Influence of HFD-induced precocious puberty on neurodevelopment in mice.

Nutr Metab (Lond) 2021 Sep 16;18(1):86. Epub 2021 Sep 16.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

Background: Precocious puberty is frequently associated with obesity, which will lead to long-term effects, especially on growth and reproduction. However, the effect of precocious puberty on children's neurodevelopment is still unknown.

Objectives: Here we evaluated the effect of High fat diet (HFD)-induced precocious puberty on neurodevelopment and behaviors of animals. Read More

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September 2021

Negative self-evaluation induced by acute stress indexed using facial EMG.

Psychoneuroendocrinology 2021 Aug 30;133:105402. Epub 2021 Aug 30.

Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Sweden.

Maladaptive stress responses are a key feature of several psychiatric disorders, but findings of stress effects on social behavior are inconsistent. Using a within-subject design, we investigated, in 35 healthy participants, the effects of acute stress on psychophysiological and behavioral responses during a simulated online social interaction task. Participants were exposed to established stress and non-stress exposure procedures in two separate sessions. Read More

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CIS-platin increases immune activity of monocytes and cytotoxic T-cells in a murine model of epithelial ovarian cancer.

Transl Oncol 2021 Sep 13;14(12):101217. Epub 2021 Sep 13.

Department of Ob/Gyn Dartmouth-Hitchcock Medical Center, Geisel School of Medicine, NH, USA. Electronic address:

Epithelial ovarian cancer (EOC) is an immunologically active malignancy, but thus far immune therapy has had limited success in clinical trials. One barrier to implementation of efficacious immune therapies is a lack of knowledge of the effect of chemotherapy on the monocyte-derived component of the immune infiltrate within the tumor. We utilized the ID8 murine EOC model to investigate alterations within tumor ascites that occur following administration of platinum chemotherapy. Read More

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September 2021

Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1.

J Nutr Biochem 2021 Sep 13:108862. Epub 2021 Sep 13.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan University, Wuhan, 430000, Hubei, P. R. China. Electronic address:

Lycopene (Ly) is a kind of hydrocarbon, which belongs to the family of tetraterpene carotene and exists in red fruits and vegetables. The decrease of capillary density and blood flow with age is a significant reason for the increase of mortality and morbidity. Herein, our study aims to explore the effects of Ly (a bioactive food compound) on vascular aging in vitro and in vivo and its potential mechanisms. Read More

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September 2021

Hypoxia/ischemia impairs CD33 (Siglec-3)/TREM2 signaling: Potential role in Alzheimer's pathogenesis.

Neurochem Int 2021 Sep 13;150:105186. Epub 2021 Sep 13.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211, Kuopio, Finland.

Recent genetic and molecular studies have indicated that the innate immune system, especially microglia, have a crucial role in the accumulation of β-amyloid plaques in Alzheimer's disease (AD). In particular, the CD33 receptor, also called Siglec-3, inhibits the TREM2 receptor-induced phagocytic activity of microglia. CD33 receptors recognize the α2,3 and α2,6-linked sialic groups in tissue glycocalyx, especially sialylated gangliosides in human brain. Read More

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September 2021

Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.

Cell Stem Cell 2021 Sep 15. Epub 2021 Sep 15.

The David H. Koch Institute for Integrative Cancer Research at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02140, USA.

Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells affect early-stage intestinal tumorigenesis. We show that a high-fat diet (HFD) reduces the expression of the major histocompatibility complex class II (MHC class II) genes in intestinal epithelial cells, including ISCs. This decline in epithelial MHC class II expression in a HFD correlates with reduced intestinal microbiome diversity. Read More

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September 2021

Histone demethylase LSD1 promotes RIG-I poly-ubiquitination and anti-viral gene expression.

PLoS Pathog 2021 Sep 16;17(9):e1009918. Epub 2021 Sep 16.

Frontier Science Center for Immunology and Metabolism, College of Life Sciences, Wuhan University, Wuhan, Hubei, China.

Under RNA virus infection, retinoic acid-inducible gene I (RIG-I) in host cells recognizes viral RNA and activates the expression of type I IFN. To investigate the roles of protein methyltransferases and demethylases in RIG-I antiviral signaling pathway, we screened all the known related enzymes with a siRNA library and identified LSD1 as a positive regulator for RIG-I signaling. Exogenous expression of LSD1 enhances RIG-I signaling activated by virus stimulation, whereas its deficiency restricts it. Read More

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September 2021

Mesenchymal stromal cell-secreted CCL2 promotes antibacterial defense mechanisms through increased antimicrobial peptide expression in keratinocytes.

Stem Cells Transl Med 2021 Sep 16. Epub 2021 Sep 16.

Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

Mesenchymal stromal cells (MSCs) from both humans and horses, which represent a clinically relevant translation animal model for human cutaneous wound healing, were recently found to possess antimicrobial properties against planktonic bacteria, and in the case of equine MSCs, also against biofilms. This, together with previous findings that human and equine MSCs promote angiogenesis and wound healing, makes these cells an attractive approach to treat infected cutaneous wounds in both species. The anti-biofilm activities of equine MSC, via secretion of cysteine proteases, have only been demonstrated in vitro, thus lacking information about in vivo relevance. Read More

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September 2021

Expression of CD10 in urothelial carcinoma of the bladder and its correlation with histopathological grade, pathological stage, and survival of patients.

J Cancer Res Ther 2021 Jul-Sep;17(4):887-892

Department of Surgery, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

Background: CD10 plays a role in signal transduction pathway and regulation of cell growth apoptosis, and therefore, it has been evaluated in different malignancies. The present study was conducted to study the immunoexpression of CD10 in urothelial carcinoma and to correlate it with histological grade, pathological stage, and survival of patients.

Materials And Methods: The study included 51 cases of urothelial carcinoma diagnosed on histopathology along with 50 controls having nonneoplastic urothelium. Read More

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September 2021