13 results match your criteria increased ptx‑induced

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Molecular epidemiology of Bordetella pertussis and analysis of vaccine antigen genes from clinical isolates from Shenzhen, China.

Ann Clin Microbiol Antimicrob 2021 Aug 18;20(1):53. Epub 2021 Aug 18.

Shenzhen Center for Disease Control and Prevention, 8 Longyuan Road, Nanshan District, Shenzhen, China.

Background: Although pertussis cases globally have been controlled through the Expanded Programme on Immunization (EPI), the incidence of pertussis has increased significantly in recent years, with a "resurgence" of pertussis occurring in developed countries with high immunization coverage. Attracted by its fast-developing economy, the population of Shenzhen has reached 14 million and has become one of the top five largest cities by population size in China. The incidence of pertussis here was about 2. Read More

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Clinical predictor of postoperative hyperkalemia after parathyroidectomy in patients with hemodialysis.

Int J Surg 2018 May 13;53:1-4. Epub 2018 Mar 13.

Department of Otolaryngology, Guangdong General Hospital and Guangdong Academy of Medical Sciences, Guangzhou City, PR China.

Objective: Hyperkalaemia is one of the most common reasons for patients requiring emergency treatment. This study is to investigate the risk factors of postoperative hyperkalemia in renal failure patients undergoing parathyroidectomy with autotransplantation (PTXa).

Methods: One hundred and eight patients [ 54 men and 54 women; age, 45. Read More

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[Effect of ptxA and ptxB genes of phosphotransferase system on growth of Streptococcus mutans].

Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Jun;34(3):302-6

Objective: This study aims to evaluate the effect of ptxA and ptxB genes, which are important genes in the L-ascorbate phosphotransferase system (PTS) of Streptococcus mutans (S. mutans).

Methods: The ptxA-, ptxB-, and ptxAB-double deficient mutant as well as ptxAB-complemented strain were constructed. Read More

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Genetic Variation of Bordetella pertussis in Austria.

PLoS One 2015 16;10(7):e0132623. Epub 2015 Jul 16.

Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

In Austria, vaccination coverage against Bordetella pertussis infections during infancy is estimated at around 90%. Within the last years, however, the number of pertussis cases has increased steadily, not only in children but also in adolescents and adults, indicating both insufficient herd immunity and vaccine coverage. Waning immunity in the host and/or adaptation of the bacterium to the immunised hosts could contribute to the observed re-emergence of pertussis. Read More

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Genetic analysis of Bordetella pertussis isolates from the 2008-2010 pertussis epidemic in Japan.

PLoS One 2013 4;8(10):e77165. Epub 2013 Oct 4.

Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan ; Department of Pediatrics, St Marianna University School of Medicine, Kawasaki, Japan.

A large pertussis epidemic occurred between 2008 and 2010 in Japan. To investigate epidemic strains, we analyzed 33 Bordetella pertussis isolates from the epidemic period by sequencing virulence-associated genes (fim3, ptxP, ptxA, and prn) and performing multilocus variable-number tandem repeat analysis (MLVA), and compared these results with those of 101 isolates from non-epidemic, earlier and later time periods. DNA sequencing of the fim3 allele revealed that the frequency of fim3B was 4. Read More

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Insight into evolution of Bordetella pertussis from comparative genomic analysis: evidence of vaccine-driven selection.

Mol Biol Evol 2011 Jan 10;28(1):707-15. Epub 2010 Sep 10.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia.

Despite high vaccine coverage, pertussis incidence has increased substantially in recent years in many countries. A significant factor that may be contributing to this increase is adaptation to the vaccine by Bordetella pertussis, the causative agent of pertussis. In this study, we first assessed the genetic diversity of B. Read More

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January 2011

[Dynamics of changes in pathogenic characteristics of Bordetella pertussis strains].

Zh Mikrobiol Epidemiol Immunobiol 2009 Nov-Dec(6):7-11

Aim: To study pathogenic characteristics of B. pertussis strains isolated from patients during different periods of pertussis infection epidemic process.

Materials And Methods: Strains of B. Read More

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Changes in genetic diversity of the Bordetella pertussis population in the United Kingdom between 1920 and 2006 reflect vaccination coverage and emergence of a single dominant clonal type.

J Clin Microbiol 2009 Mar 21;47(3):680-8. Epub 2009 Jan 21.

Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom.

Pertussis (whooping cough) is a potentially fatal respiratory disease caused by the bacterium Bordetella pertussis. Despite effective vaccination programs, there has been concern in some developed countries that pertussis cases are on the increase. We characterized 703 clinical B. Read More

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Comparison of serological and real-time PCR assays to diagnose Bordetella pertussis infection in 2007.

J Clin Microbiol 2008 May 26;46(5):1672-7. Epub 2008 Mar 26.

Sanofi Pasteur, 2 Avenue Pont Pasteur, 69367 Lyon Cedex 07, France.

Bacterial culture for diagnosing pertussis infection has high specificity but poor sensitivity and is slow. Highly sensitive real-time PCR assays and single-serum pertussis serology have been developed to overcome these limitations, but there are few data available on the relative sensitivities and specificities of such assays for pertussis diagnosis. Using data on 195 participants (>or=7 years old) from an epidemiological study, we assessed the sensitivity, specificity, and performance (Youden index) for pertussis diagnosis of the pertussis toxin enzyme-linked immunosorbent assay (using single and paired serology) and of real-time PCR assays (using the IS481 and ptxA-Pr targets). Read More

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Antigenic divergence between Bordetella pertussis clinical isolates from Moscow, Russia, and vaccine strains.

Clin Vaccine Immunol 2007 Mar 3;14(3):234-8. Epub 2007 Jan 3.

Russian Federal Diphtheria Reference Laboratory, G. N. Gabrichevsky Institute of Epidemiology and Microbiology, 10 Admiral Makarov Str., Moscow 125212, Russia.

We analyzed temporal changes in the frequencies of the ptxA, prn, fim2, and fim3 alleles in Bordetella pertussis strains isolated from pertussis patients in Moscow, Russia, from 1948 to 2004. The three strains used for the whole-cell vaccine harbored the alleles ptxA2, ptxA4, prn1, fim2-1, and fim3A. Vaccine-type alleles of ptxA (ptxA2 and ptxA4) were characteristic for all prevaccination strains and for 96% of the strains isolated in the 1960s and 1970s. Read More

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Multitarget PCR for diagnosis of pertussis and its clinical implications.

J Clin Microbiol 2007 Feb 6;45(2):506-11. Epub 2006 Dec 6.

Microbiology Laboratory, Department of Laboratories and Pathology, A9601, Children's Hospital and Regional Medical Center, Seattle, WA 98105, USA.

PCR has greatly facilitated pertussis diagnosis due to the speed, sensitivity, and specificity of this assay compared to other detection methods. Various single-target PCR assays are currently utilized, but none is universally considered to be the "gold standard." Our aim was to assess the use of multitarget versus single-target PCR for the diagnosis of pertussis in clinical samples. Read More

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February 2007

Genotypic variation in the Bordetella pertussis virulence factors pertactin and pertussis toxin in historical and recent clinical isolates in the United Kingdom.

Infect Immun 2001 Sep;69(9):5520-8

Respiratory and Systemic Infection Laboratory, PHLS Central Public Health Laboratory, London, United Kingdom.

The reemergence of pertussis has been reported in several countries despite high vaccination coverage. Studies in The Netherlands and Finland have investigated polymorphism in the genes coding for two important virulence factors of Bordetella pertussis, pertactin and pertussis toxin, and identified the emergence and subsequent dominance in circulating strains of pertactin and toxin variants not found in the whole-cell vaccine (WCV). The study described here investigated whether such variation had occurred in the United Kingdom, which presently has low levels of pertussis. Read More

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September 2001

Calcium supplement necessary to correct hypocalcemia after total parathyroidectomy for renal osteodystrophy.

Int J Urol 2000 Feb;7(2):35-40

Department of Urology, Oita Medical University, Japan.

Background: Prediction of the extent of calcium supplement will facilitate safe and efficient management of hypocalcemia in the early postoperative stage of total parathyroidectomy with autotransplantation (PTXa) in patients with renal osteodystrophy.

Methods: The correlation between the extent of calcium deficiency, estimated by the amount of calcium supplement over 48 h after PTXa and using various parameters such as carboxy terminal parathyroid hormone (c-PTH), intact PTH (i-PTH), alkaline phosphatase (ALP), serum calcium, serum phosphorus, duration of hemodialysis, total weight of resected parathyroid glands and degree of subperiosteal resorption of the middle phalanx was examined in 49 patients who underwent PTX with subcutaneous autotransplantation. Bone mineral density (BMD) was also determined before, 3 months and 1 year after PTXa with dual energy X-ray absorptiometry (DEXA) in 13 patients. Read More

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February 2000
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