268,116 results match your criteria increased mortality


Factors associated with rebleeding after coil embolization in patients with aneurysmal subarachnoid hemorrhage.

J Cerebrovasc Endovasc Neurosurg 2021 Oct 26. Epub 2021 Oct 26.

Department of Neurosurgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, Korea.

Objective: Aneurysmal subarachnoid hemorrhage (aSAH) has a high mortality rate, and hemorrhage amounts and perioperative rebleeding importantly determines prognosis. However, despite adequate treatment, prognosis is poor in many ruptured aneurysm cases. In this study, we identified and evaluated factors related to perioperative rebleeding in patients with aSAH. Read More

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October 2021

Epidemiology of Underweight among Infants in Rural Burkina Faso.

Am J Trop Med Hyg 2021 Oct 25. Epub 2021 Oct 25.

Infant undernutrition is thought to contribute to growth failure and mortality. We evaluated the patterns in underweight in a population-based sample of children aged 1-11 months in rural northwestern Burkina Faso. Data were collected during the baseline assessment of a community-randomized trial evaluating mass azithromycin distribution in Nouna District, Burkina Faso. Read More

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October 2021

Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014.

Oral Oncol 2021 Oct 22;122:105583. Epub 2021 Oct 22.

Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark.

Objectives: Nasopharyngeal malignancies are reported having decreasing incidence and reduced mortality. This study provides a nationwide update of the incidence and survival in Denmark.

Materials And Methods: The Danish Cancer Registry (DCR) and Central Population Register (CPR) were used to identify all patients registered with nasopharyngeal malignancies between 1980 and 2014 in Denmark. Read More

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October 2021

Adequate short- and long-term pain control with non-opiate analgesics after microdirect laryngoscopy.

Am J Otolaryngol 2021 Oct 19;43(1):103267. Epub 2021 Oct 19.

Division of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, CT, USA.

Objective: In otolaryngology, it is important to minimize the use of opioids for post-operative analgesia given the rise in opioid abuse and mortality due to overdose in the United States. We sought to quantitatively determine the efficacy of non-opiate analgesia in postoperative pain management after microdirect laryngoscopy (MDL).

Methods: This is a single institution prospective study monitoring post-operative pain using a visual analog scale (VAS, 1-10). Read More

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October 2021

Improvement of goose embryonic and muscular developments by wider angle egg turning during incubation and the regulatory mechanisms.

Poult Sci 2021 Sep 16;100(12):101477. Epub 2021 Sep 16.

Laboratory of Animal Improvement and Reproduction, Institute of Animal Science, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China. Electronic address:

Egg turning during incubation plays important roles in achieving high hatching performance and gosling quality. The objective of this study was to improve embryonic and muscular developments so to achieve better gosling quality by wider egg turning angles during incubation, and to unravel the associated regulatory molecular mechanisms. In each of three consecutive incubations, 1,728 goose eggs were divided into 3 groups that were set in the same type of commercial incubators with turning angles adjusted differently to 50°, 60°, and 70°, respectively. Read More

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September 2021

Role of senescence in the chronic health consequences of COVID-19.

Transl Res 2021 Oct 22. Epub 2021 Oct 22.

Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN; Division of Geriatrics and Gerontology, Mayo Clinic, Rochester, MN. Electronic address:

While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long-Hauler's Syndrome or PACS (post-acute sequelae of SARS-CoV-2 infection). There is little known about risk factors or predictors of susceptibility for Long-Hauler's Syndrome, but older adults are at greater risk for severe outcomes and mortality from COVID-19. The pillars of aging (including cellular senescence, telomere dysfunction, impaired proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, genomic instability, progenitor cell exhaustion, altered intercellular communication, and epigenetic alterations) that contribute to age-related dysfunction and chronic diseases (the "Geroscience Hypothesis") may interfere with defenses against viral infection and consequences of these infections. Read More

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October 2021

Evaluation of early antibiotic use in non-severe COVID-19 patients without bacterial infection: Early antibiotic use in non-severe COVID-19.

Int J Antimicrob Agents 2021 Oct 22:106462. Epub 2021 Oct 22.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. Electronic address:

Objectives: The use of antibiotics was common in some countries during the early phase of COVID-19 pandemic, but adequate evaluation is so far lacking. This study aimed to evaluate the effect of early antibiotic use in non-severe COVID-19 patients admitted without bacterial infection.

Methods: This multi-center retrospective cohort study included 1,373 non-severe COVID-19 inpatients admitted without bacterial infection. Read More

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October 2021

Overview of Screening Eligibility in Patients Undergoing Ruptured AAA Repair from 2003-2019 in the Vascular Quality Initiative.

J Vasc Surg 2021 Oct 22. Epub 2021 Oct 22.

Division of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston MA. Electronic address:

Introduction: While efforts such as the Screening Abdominal Aortic Aneurysms Very Efficiently (SAAAVE) Act have improved access to abdominal aortic aneurysm (AAA) screening, certain high-risk populations are currently excluded from the guidelines yet may benefit from screening. We therefore examined all patients who underwent repair of ruptured AAA (rAAA) to characterize those who are ineligible for screening under current guidelines and evaluate the potential impact of these restrictions on their disease.

Methods: We identified patients undergoing rAAA repair in the Vascular Quality Initiative (VQI) database between 2003-2019. Read More

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October 2021

The Effect of Diabetes on Abdominal Aortic Aneurysm Growth Over Two Years.

J Vasc Surg 2021 Oct 22. Epub 2021 Oct 22.

Vanderbilt University Medical Center and Vanderbilt University School of Medicine, Department of Vascular Surgery, 1161 21(st) Avenue South, Nashville, TN 37232. Electronic address:

Introduction: Abdominal Aortic Aneurysm (AAA) is a common progressive disease and a significant cause of morbidity and mortality. Prior investigations have shown that diabetes mellitus (DM) may be relatively protective of AAA incidence and growth. The Non-invasive Treatment of Aortic Aneurysm Clinical Trial (N-TA3CT) is a contemporary study of small AAA growth which provides a unique opportunity to validate and explore the effect of DM on AAA. Read More

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October 2021

Patterns of cardiovascular diseases in COVID-19 patients admitted to tertiary cardiac care centre.

Indian Heart J 2021 Oct 22. Epub 2021 Oct 22.

Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore. Karnataka, India.

Objectives: To analyse the pattern of cardiovascular diseases (CVDs) in COVID-19 patients admitted to tertiary cardiac care centre.

Methods: We retrospectively analysed 511 adult patients admitted between July 1, 2020, and November 30, 2020, with COVID-19 infection and having either new onset or pre-existing CVD. Clinical features, electrocardiogram(ECG), echocardiography, chest X-ray, biomarkers, haematological and biochemical parameters were analysed. Read More

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October 2021

The outcomes of Clostridioides difficile infection in inpatient liver transplant population.

Transpl Infect Dis 2021 Oct 25. Epub 2021 Oct 25.

Gastroenterology and Transplant Hepatology, Henry Ford Health System, Detroit, MI.

Background: Chronic immunosuppression is a known cause of Clostridioides difficile which presents with colon infection. It is associated with increased mortality and morbidity. Our aim is to determine the inpatient outcomes of liver transplant patients with Clostridioides difficile infection (CDI) and trends in the last few years. Read More

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October 2021

Impact of smoking on cardiovascular outcomes in patients with stable coronary artery disease.

Eur J Prev Cardiol 2021 Oct;28(13):1460-1466

Montreal Heart Institute, Université de Montreal, Canada.

Aims: Smoking is a major preventable risk factor for cardiovascular disease and mortality. However, the 'smoker's paradox' suggests that it is associated with better survival after acute myocardial infarction. We aimed to investigate the impact of smoking on mortality and cardiovascular outcomes in patients with stable coronary artery disease. Read More

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October 2021

Physiological response of weaned piglets to two transport durations observed in a Canadian commercial setting.

J Anim Sci 2021 Oct 25. Epub 2021 Oct 25.

Ontario Veterinary College, University of Guelph, Department of Population Medicine, Guelph, Ontario, Canada.

Observational studies describing the impact of transport duration on weaned piglet welfare are limited. Current Canadian transport regulations are heavily informed by studies involving market hogs. Due to physiological differences between weaned piglets and market hogs, additional data on their response to transport are needed for age-specific evidence-based recommendations. Read More

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October 2021

Advanced Leiomyosarcoma of the Retroperitoneal Space in a Kidney Transplant Recipient with a History of Peritoneal Dialysis: A Case Report.

Am J Case Rep 2021 Oct 25;22:e933267. Epub 2021 Oct 25.

Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, Katowice, Poland.

BACKGROUND Leiomyosarcoma frequently occurs in patients who are on immunosuppressive therapy. It is the second most common sarcoma in this population and is often associated with Epstein-Barr virus (EBV) infection. We present a case of advanced leiomyosarcoma of the retroperitoneal space in a kidney transplant recipient and discuss additional risk factors for oncogenesis. Read More

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October 2021

High resuscitative endovascular balloon occlusion of the aorta procedural volume is associated with improved outcomes: An analysis of the AORTA registry.

J Trauma Acute Care Surg 2021 Nov;91(5):781-789

From the Department of Surgery, Rutgers New Jersey Medical School (E.G., D.H.L.), Newark, New Jersey; NYU Langone Department of Surgery, Division of Acute Care Surgery, Bellevue Hospital Center (B.N., M.K., C.DM., M.B.), New York, New York; Los Angeles County + University of Southern California Hospital (K.I.), Los Angeles, California; Los Angeles County + University of Southern California Medical Center, Division of Trauma/Surgical Critical Care, Los Angeles, California; R. Adams Cowley Shock Trauma Center/CSTARS (Center for the Sustainment of Trauma and Readiness Skills) (J.M., T.S., C.F., J.D.), University of Maryland, Baltimore, Maryland; Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine, University of Pennsylvania (M.Se.), Philadelphia, Pennsylvania; Memorial Hermann Texas Medical Center (L.M.), Department of Surgery, University of Texas Houston Medical School, San Antonio Military Medical Center/US Army Institute of Surgical Research (D.K.), San Antonio, Texas; and Ohio Health, Grant Medical Center (M.Sp.), Columbus, Ohio.

Background: The use of resuscitative endovascular balloon occlusion of the aorta (REBOA) is controversial. We hypothesize that REBOA outcomes are improved in centers with high REBOA utilization.

Methods: We examined the Aortic Occlusion in Resuscitation for Trauma and Acute Care Surgery registry over a 5-year period (2014-2018). Read More

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November 2021

Association Between Delay to Radical Prostatectomy and Clinically Meaningful Outcomes Among Patients with Intermediate- and High-Risk Localized Prostate Cancer.

J Urol 2021 Oct 25:101097JU0000000000002304. Epub 2021 Oct 25.

Department of Urology, Mount Sinai Hospital, Toronto, ON, Canada.

Purpose: There are limited data regarding the effect of treatment delays on important long-term outcomes among men with intermediate-/high-risk prostate cancer (PC).

Materials And Methods: We identified 3,962 men with intermediate-/high-risk disease from the SEARCH cohort treated with radical prostatectomy (RP) from 1988-2018. Cox proportional hazard models assessed the association between time from biopsy to RP (up to one-year) and time to castration resistant PC (CRPC), metastasis, and all-cause mortality. Read More

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October 2021

Changes Over Time in COVID-19 Severity and Mortality in Patients Undergoing Cancer Treatment in the United States: Initial Report From the ASCO Registry.

JCO Oncol Pract 2021 Oct 25:OP2100394. Epub 2021 Oct 25.

American Society of Clinical Oncology, Alexandria, VA.

Purpose: People with cancer are at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. ASCO's COVID-19 registry promotes systematic data collection across US oncology practices.

Methods: Participating practices enter data on patients with SARS-CoV-2 infection in cancer treatment. Read More

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October 2021

A comparative study on chitosan nanoparticle synthesis methodologies for application in aquaculture through toxicity studies.

IET Nanobiotechnol 2021 Jun 18;15(4):418-426. Epub 2021 Mar 18.

Centre for Ocean Research (DST-FIST Sponsored Centre), MoES-Earth Science & Technology Cell (Marine Biotechnological Studies), Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology, Chennai, India.

Chitosan nanoparticles (CSNPs) have been recently used for various applications in aquaculture, especially as drug carriers. The aim of this study was to synthesise and investigate a superlative method of CSNP synthesis for application in aquaculture through aquaculture-based toxicology screening methods. Two different methods were analysed: the first a direct ionic gelation method (A) and the other involving a low-molecular-weight chitosan microparticle intermediate method (B). Read More

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Initial experience with CytoSorb therapy in patients receiving left ventricular assist devices.

Artif Organs 2021 Oct 25. Epub 2021 Oct 25.

Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.

Background: The use of left ventricular assist devices (LVAD) in patients with advance heart failure is still associated with an important risk of immune dysregulation and infections. The aim of this study was to determine whether extracorporeal blood purification using the CytoSorb device benefits patients after LVAD implantation in terms of complications and overall survival.

Materials And Methods: Between August 2010 and January 2020, 207 consecutive patients underwent LVAD implantation, of whom 72 underwent CytoSorb therapy and 135 did not. Read More

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October 2021

A linear mixed model to estimate COVID-19-induced excess mortality.

Biometrics 2021 Oct 25. Epub 2021 Oct 25.

Data Science Institute (DSI), Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), Hasselt University, Hasselt, BE-3500, Belgium.

The Corona Virus Disease (COVID-19) pandemic has increased mortality in countries worldwide. To evaluate the impact of the pandemic on mortality, the use of excess mortality rather than reported COVID-19 deaths has been suggested. Excess mortality, however, requires estimation of mortality under non-pandemic conditions. Read More

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October 2021

Outcomes for paediatric acute leukaemia patients admitted to the paediatric intensive care unit.

Eur J Pediatr 2021 Oct 25. Epub 2021 Oct 25.

Paediatric Intensive Care Unit, Hospital Sant Joan de Déu, University of Barcelona, Passeig de Sant Joan de Déu, 2, 08950, Esplugues de Llobregat, Barcelona, Spain.

Children with acute leukaemia (AL) are a high-risk population for infections and life-threatening conditions requiring paediatric intensive care unit (PICU) admission, presenting an increased mortality rate. A few literature exists about PICU outcomes in this kind of patients, especially with haematopoietic stem cell transplant (HSCT) background. We investigated the clinical and epidemiological characteristics of these patients as well as their outcomes. Read More

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October 2021

Racial differences in the outcomes of IBD hospitalizations: a national population-based study.

Int J Colorectal Dis 2021 Oct 25. Epub 2021 Oct 25.

Department of Gastroenterology, John H Stroger Hospital of Cook County, Chicago, IL, 60612, USA.

Purpose: There are  scarce data describing the outcomes of hospitalized patients admitted with inflammatory bowel disease (IBD) stratified by race. In this retrospective cohort study, we evaluated the difference in outcomes between adult white and black patients hospitalized with a principal diagnosis of inflammatory bowel disease.

Methods: Data were obtained from the 2016 and 2017 National Inpatient Sample (NIS) database. Read More

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October 2021

Prognostic value of changes in high-sensitivity cardiac troponin T beyond biological variation in stable outpatients with cardiovascular disease: a validation study.

Clin Res Cardiol 2021 Oct 25. Epub 2021 Oct 25.

Zentrum für Innere Medizin, Klinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.

Objective: To evaluate the prognostic implications of longitudinal long-term changes beyond the biological variation of high-sensitivity cardiac troponin T (hs-cTnT) in outpatients with stable or asymptomatic cardiovascular disease (CV) and to assess possible differences in the prognostic value while using reference change value (RCV) and minimal important differences (MID) as metric for biological variation.

Methods: Hs-cTnT was measured at index visit and after 12 months in outpatients presenting for routine follow-up. The prognostic relevance of a concentration change of hs-cTnT values exceeding the biological variation defined by RCV and MID of a healthy population within the next 12 months following the stable initial period was determined regarding three endpoints: all-cause mortality (EP1), a composite of all-cause mortality, non-fatal myocardial infarction and stroke (EP2), and a composite of all-cause mortality, non-fatal myocardial infarction, stroke, hospitalization for acute coronary syndrome (ACS) or decompensated heart failure, and planned and unplanned percutaneous coronary interventions (PCI, EP3). Read More

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October 2021

Prognosis value of serum soluble ST2 level in acute ischemic stroke and STEMI patients in the era of mechanical reperfusion therapy.

J Neurol 2021 Oct 25. Epub 2021 Oct 25.

CarMeN Laboratory, INSERM U1060, Université de Lyon, Groupement Hospitalier Est, Bâtiment B13, 59 boulevard Pinel, 69500, Bron, France.

Background: Soluble form suppression of tumorigenicity 2 (sST2) is known to have prognostic value in ST-elevation myocardial infarction (STEMI) and could impact mortality after acute ischemic stroke (AIS). However, before considering sST2 as a therapeutic target, the kinetics of release and its association with adverse clinical events in both STEMI and AIS patients have to be determined.

Methods: We prospectively enrolled 251 STEMI patients, treated with primary percutaneous coronary intervention, and 152 AIS patients treated with mechanical thrombectomy. Read More

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October 2021

Stroke prevention with direct oral anticoagulants in high risk elderly atrial fibrillation patients at increased bleeding risk.

Eur Heart J Qual Care Clin Outcomes 2021 Oct 25. Epub 2021 Oct 25.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Background: Elderly atrial fibrillation (AF) patients with risk factors of bleeding are often considered ineligible for standard oral anticoagulants (OACs). The ELDERCARE-AF trial recently showed that edoxaban 15mg/day was superior to placebo for preventing stroke or systemic embolism and did not result in a significantly higher incidence of major bleeding.  Our aim was to investigate a real-world cohort of AF patients similar to the ELDERCARE-AF cohort, with regard to the impact of direct oral anticoagulant (DOAC) use compared to non-OAC use, in relation to clinical outcomes. Read More

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October 2021

Microsimulation Modelling in Food Policy: A Scoping Review of Methodological Aspects.

Adv Nutr 2021 Oct 25. Epub 2021 Oct 25.

Unit of Noncommunicable Diseases, Department of Public Health, Institute of Tropical Medicine, Nationalestraat 150, 2000-Antwerp, Belgium.

Food policies for the prevention and management of diet-related non-communicable diseases (NCDs) have been increasingly relying on microsimulation models (MSMs) to assess effectiveness. Given the increased uptake of MSMs, this review aims to provide an overview of the characteristics of MSMs that link diets with NCDs. A comprehensive review was conducted in PubMed and Web of Knowledge. Read More

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October 2021

Assessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials.

JAMA Intern Med 2021 Oct 25. Epub 2021 Oct 25.

Department of Medicine, Washington University School of Medicine in St Louis, St Louis, Missouri.

Importance: Although nonfatal myocardial infarction (MI) is associated with an increased risk of mortality, evidence validating nonfatal MI as a surrogate end point for all-cause or cardiovascular (CV) mortality is lacking.

Objective: To examine whether nonfatal MI may be a surrogate for all-cause or CV mortality in patients with or at risk for coronary artery disease.

Data Sources: In this meta-analysis, PubMed was searched from inception until December 31, 2020, for randomized clinical trials of interventions to treat or prevent coronary artery disease reporting mortality and nonfatal MI published in 3 leading journals. Read More

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October 2021

Evidence-based therapeutics for hyperglycemia in hospitalized noncritically ill patients.

Curr Med Res Opin 2021 Oct 25:1-27. Epub 2021 Oct 25.

Diabetes and Cardiovascular Risk Factor Unit, Department of Internal Medicine, University Hospital Juan Ramón Jimenez, Huelva, Spain.

Hyperglycemia in hospitalized patients, either with or without diabetes, is a common, serious, and costly healthcare problem. Evidence accumulated over 20 years has associated hyperglycemia with a significant increase in morbidity and mortality, both in surgical and medical patients. Based on this documented link between hyperglycemia and poor outcomes, clinical guidelines from professional organizations recommend the treatment of hospital hyperglycemia with a therapeutic goal of maintaining blood glucose levels less than 180 mg/dL. Read More

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October 2021

Development and Validation of an Improved Pathological Nodal Staging System in Men With Prostate Cancer.

J Urol 2021 Oct 25:101097JU0000000000002256. Epub 2021 Oct 25.

Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Prostate cancer pathological nodal staging uses a single category for all node-positive patients. We sought to improve risk stratification by creating and validating a novel pathological nodal staging system incorporating number of metastatic lymph nodes (+LNs).

Methods: 118,450 men who underwent radical prostatectomy (RP) for nonmetastatic prostate cancer in the National Cancer Database comprised our development cohort. Read More

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October 2021

Interventions targeted at women to encourage the uptake of cervical screening.

Cochrane Database Syst Rev 2021 Sep 6;9:CD002834. Epub 2021 Sep 6.

Department of Gynaecological Oncology, 1st Floor Maternity Unit, City Hospital Campus, Nottingham, UK.

Background: This is an update of the Cochrane review published in Issue 5, 2011. Worldwide, cervical cancer is the fourth commonest cancer affecting women. High-risk human papillomavirus (HPV) infection is causative in 99. Read More

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September 2021