29,241 results match your criteria increased intrinsic


Comprehensive analysis of the ErbB receptor family in pediatric nervous system tumors and rhabdomyosarcoma.

Pediatr Blood Cancer 2021 Sep 21:e29316. Epub 2021 Sep 21.

Gustave Roussy Cancer Center, Department of Pediatric and Adolescent Oncology, INSERM U1015, Université Paris Saclay, Villejuif, France.

Background: There is a paucity of knowledge regarding pediatric biomarkers, including the relevance of ErbB pathway aberrations in pediatric tumors. We investigated the occurrence of ErbB receptor aberrations across different pediatric malignancies, to identify patterns of ErbB dysregulation and define biomarkers suitable for patient enrichment in clinical studies.

Procedure: Tissue samples from 297 patients with nervous system tumors and rhabdomyosarcoma were analyzed for immunohistochemical expression or gene amplification of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). Read More

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September 2021

Temperature Dependence of Fundamental Photophysical Properties of [Eu(MeOH-)] Solvates and [Eu·DOTA(MeOH-)] Complexes.

J Phys Chem A 2021 Sep 21. Epub 2021 Sep 21.

Nano-Science Center and Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 København Ø, Denmark.

The trivalent lanthanide ions show optical transitions between energy levels within the 4f shell. All these transitions are formally forbidden according to the quantum mechanical selection rules used in molecular photophysics. Nevertheless, highly luminescent complexes can be achieved, and terbium(III) and europium(III) ions are particularly efficient emitters. Read More

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September 2021

Elevated levels of the -encoded ribonucleotide reductase counteract the toxicity caused by an increased abundance of the β clamp.

J Bacteriol 2021 Sep 20:JB0030421. Epub 2021 Sep 20.

Department of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

Expression of the -encoded β clamp at ≥10 fold higher than chromosomally expressed levels impedes growth by interfering with DNA replication. The β clamp (glutamic acid-to-lysine substitution at residue 202) binds to DNA polymerase III (Pol III) with higher affinity compared with the wild type clamp, suggesting that its failure to impede growth is independent of its ability to sequester Pol III away from the replication fork. Our results demonstrate that the strain underinitiates DNA replication due to insufficient levels of DnaA-ATP and expresses several DnaA-regulated genes at altered levels, including that encode the class 1a ribonucleotide reductase (RNR). Read More

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September 2021

Effect of Age on Job Satisfaction and Emotional Exhaustion of Primary School Teachers in Greece.

Eur J Investig Health Psychol Educ 2020 Jun 13;10(2):644-655. Epub 2020 Jun 13.

Faculty of Social Sciences, University of Ioannina, GR 45500 Ioannina, Greece.

The level of occupational burnout (OB) and job satisfaction (JS) was investigated in primary school teachers (n = 125) in the region of Epirus in Northwestern Greece. Teachers exhibited a high level of emotional exhaustion (EE), a medium level of depersonalization (DP), and a lack of personal accomplishment (PA). In our study, EE, which is a significant component of OB, varied according to intrinsic and extrinsic JS parameters. Read More

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The Th17/IL-17 Axis and Kidney Diseases, With Focus on Lupus Nephritis.

Front Med (Lausanne) 2021 3;8:654912. Epub 2021 Sep 3.

Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and hyperreactivity of the immune response at various levels, including hyperactivation of effector cell subtypes, autoantibodies production, immune complex formation, and deposition in tissues. The consequences of hyperreactivity to the self are systemic and local inflammation and tissue damage in multiple organs. Lupus nephritis (LN) is one of the most worrying manifestations of SLE, and most patients have this involvement at some point in the course of the disease. Read More

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September 2021

Ankle Injuries in Soccer Players: A Narrative Review.

Cureus 2021 Aug 16;13(8):e17228. Epub 2021 Aug 16.

Department of Physical Therapy, University Hospital, University of West Attica, Athens, GRC.

Soccer is one of the most popular sport, with many describing it as the "king of sports." In recent years, increased global participation in soccer has led to an inevitable increase in injury rates, especially in the lower extremities. Consequently, there is an increase in the epidemiology of soccer injuries, both in professionals and amateur athletes. Read More

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Expression of cancer cell-intrinsic PD-1 associates with PD-L1 and p-S6 and predicts a good prognosis in nasopharyngeal carcinoma.

J Cancer 2021 24;12(20):6118-6125. Epub 2021 Aug 24.

Department of Pathology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

Programmed cell death ligand 1 (PD-L1) is the ligand of programmed death 1 (PD-1), which is a host immunity inhibitory receptor. Expression of PD-L1 in diverse tumor types has been widely discussed, while there is little research about tumor intrinsic-PD-1. Phospho-S6 (p-S6) is an important downstream effector in the PI3K/AKT/mTOR pathway. Read More

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The Flavonoid Kurarinone Regulates Macrophage Functions via Aryl Hydrocarbon Receptor and Alleviates Intestinal Inflammation in Irritable Bowel Syndrome.

J Inflamm Res 2021 3;14:4347-4359. Epub 2021 Sep 3.

Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.

Background: Irritable bowel syndrome (IBS) is characterized with abdominal pain, bloating, and changes in bowel habits, and dealing with IBS is still a clinical challenge. The pathogenesis of IBS has been reported to be linked to low-grade mucosal inflammation, and macrophages contribute to the pathological process of this disease. Kurarinone (KAR), a flavanoid derived from , has been found medically effective in many inflammatory conditions and cancers. Read More

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September 2021

Responses of steroid estrogen biodegradation to cyanobacterial organic matter biodegradability in the water column of a eutrophic lake.

Sci Total Environ 2021 Sep 2;805:150058. Epub 2021 Sep 2.

State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing 210008, China. Electronic address:

The co-occurrence of cyanobacterial harmful algal blooms and contaminants is an increasing environmental concern in freshwater worldwide. Our field investigations coupled with laboratory incubations demonstrated that the microbial degradation potential of 17β-estradiol (E2) with estrone as the intermediate was primarily driven by increased dissolved organic matter (DOM) in the water column of a cyanobacterial bloom. To explain the intrinsic contribution of cyanobacterial-derived DOM (C-DOM) to estrogen biodegradation, a combination of methods including bioassay, ultrahigh-resolution mass spectrometry, and microbial ecology were applied. Read More

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September 2021

Early life stress induces anxiety-like behavior during adulthood through dysregulation of neuronal plasticity in the basolateral amygdala.

Life Sci 2021 Sep 15:119959. Epub 2021 Sep 15.

Laboratory of Fear and Anxiety Disorders, Institute of Life Science, Nanchang University, Nanchang 330031, China. Electronic address:

Aims: Early life stress (ELS) increases the risk of psychiatric diseases such as anxiety disorders and depression in later life. Hyperactivation of the basolateral amygdala (BLA) neurons plays a pivotal role in the pathogenesis of stress-related diseases. However, the functional roles of BLA neurons in ELS-induced anxiety disorders are not completely understood. Read More

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September 2021

Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex.

Sci Rep 2021 Sep 17;11(1):18562. Epub 2021 Sep 17.

Department of Psychology, New York University, New York, NY, 10003, USA.

Parieto-occipital alpha rhythms (8-12 Hz) underlie cortical excitability and influence visual performance. Whether the synchrony of intrinsic alpha rhythms in the occipital cortex can be entrained by transcranial magnetic stimulation (TMS) is an open question. We applied 4-pulse, 10-Hz rhythmic TMS to entrain intrinsic alpha oscillators targeting right V1/V2, and tested four predictions with concurrent electroencephalogram (EEG): (1) progressive enhancement of entrainment across time windows, (2) output frequency specificity, (3) dependence on the intrinsic oscillation phase, and (4) input frequency specificity to individual alpha frequency (IAF) in the neural signatures. Read More

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September 2021

Improving the robustness of MOLLI T1 maps with a dedicated motion correction algorithm.

Sci Rep 2021 Sep 17;11(1):18546. Epub 2021 Sep 17.

Hospital Clínic de Barcelona, Barcelona, Spain.

Myocardial tissue T1 constitutes a reliable indicator of several heart diseases related to extracellular changes (e.g. edema, fibrosis) as well as fat, iron and amyloid content. Read More

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September 2021

The PD-1 Regulatory Axis Inhibits T Cell-Independent B Cell Memory Generation and Reactivation.

J Immunol 2021 Sep 17. Epub 2021 Sep 17.

Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC

The inability of T cell-independent type 2 (TI-2) Ags to induce recall responses is a poorly understood facet of humoral immunity, yet critically important for improving vaccines. Using normal and VB1-8 transgenic mice, we demonstrate that B cell-intrinsic PD-1 expression negatively regulates TI-2 memory B cell (B) generation and reactivation in part through interacting with PDL1 and PDL2 on non-Ag-specific cells. We also identified a significant role for PDL2 expression on B in inhibiting reactivation and Ab production, thereby revealing a novel self-regulatory mechanism exists for TI-2 B This regulation impacts responses to clinically relevant vaccines, because PD-1 deficiency was associated with significantly increased Ab boosting to the pneumococcal vaccine after both vaccination and infection. Read More

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September 2021

The Development and Survival of Thymic Epithelial Cells Require TSC1-Dependent Negative Regulation of mTORC1 Activity.

J Immunol 2021 Sep 17. Epub 2021 Sep 17.

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;

Thymic epithelial cells (TECs) are critical for the development and generation of functionally competent T cells. Until now, the mechanism that regulates the survival of TECs is poorly understood. In the current study, we found that controls the homeostasis of medullary TECs (mTECs) by inhibiting lysosomal-mediated apoptosis pathway in mice. Read More

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September 2021

Inhibition of c-Jun N-terminal kinase signaling increased apoptosis and prevented the emergence of ALK-TKI-tolerant cells in ALK-rearranged non-small cell lung cancer.

Cancer Lett 2021 Sep 15;522:119-128. Epub 2021 Sep 15.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) have improved clinical outcomes in non-small cell lung cancer (NSCLC) harboring ALK- rearrangements. However, a small population of tumor cells survives due to adaptive resistance under drug pressure and ultimately acquires drug resistance. Thus, it is necessary to elucidate the mechanisms underlying the prevention of drug resistance to improve the prognosis of patients with ALK-rearranged NSCLC. Read More

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September 2021

Clinical and Molecular Findings after Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data.

Arthritis Care Res (Hoboken) 2021 Sep 17. Epub 2021 Sep 17.

Duke University Medical Center, Durham, NC, USA.

Objective: Among individuals with systemic sclerosis (SSc) randomized to cyclophosphamide (CYC, n=34) or hematopoietic stem cell transplantation (HSCT, n=33), we examined longitudinal trends of clinical, pulmonary function and quality of life measures while accounting for the influence of early failures on treatment comparisons.

Methods: Assuming data were missing at random, mixed effects regression models were used to estimate longitudinal trends for clinical measures when comparing treatment groups. Results were compared to observed means and to longitudinal trends estimated from shared parameter models, assuming data were missing not at random. Read More

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September 2021

Effects of N-Methyl-D-aspartate receptor (NMDAR) and Ca/calmodulin-dependent protein kinase IIα (CaMKIIα) on learning and memory impairment in depressed rats with different charge by modified electroconvulsive shock.

Ann Transl Med 2021 Aug;9(16):1320

Department of Anesthesiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: With the development of modified electroshock therapy (MECT), it has become necessary to increase the electric quantity in order to achieve a good antidepressant effect, but this increase will lead to more serious learning and memory impairment. The purpose of this study was to investigate the intrinsic mechanism of cognitive impairment induced by high-energy electroconvulsive shock (MECS, an animal model of MECT).

Methods: Rats were randomly divided into 6 groups: control (C, n=6), M0, M60, M120, M180, and M240 groups (MECS at 0, 60, 120, 180, and 240 mC stimulation intensity after 80 mg/kg propofol, with 12 rats in each group). Read More

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Ozone induces BEL7402 cell apoptosis by increasing reactive oxygen species production and activating JNK.

Ann Transl Med 2021 Aug;9(15):1257

Division of Vascular and Interventional Radiology, Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Oxidative stress is an important factor in the modulation of both tumorigenesis and anticancer responses. Ozone (O) is a strong oxidant that causes redox reactions and exerts anticancer effects in various types of cancer cells. However, the pathways involved in O-induced cell death are not well understood. Read More

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Synergistic Tumor Cytolysis by NK Cells in Combination With a Pan-HDAC Inhibitor, Panobinostat.

Front Immunol 2021 31;12:701671. Epub 2021 Aug 31.

Guangdong Immune Cell Therapy Engineering and Technology Research Center, Center for Protein and Cell-Based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Histone deacetylases (HDAC) are frequently overexpressed in tumors, and their inhibition has shown promising anti-tumor effects. However, the synergistic effects of HDAC inhibition with immune cell therapy have not been fully explored. Natural killer (NK) cells are cytotoxic lymphocytes for anti-tumor immune surveillance, with immunotherapy potential. Read More

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Possible regulation of P-glycoprotein function by adrenergic agonists in a vascular-luminal perfused preparation of small intestine.

J Pharm Sci 2021 Sep 13. Epub 2021 Sep 13.

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Okayama University, 1-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. Electronic address:

Although the functions of small intestine are largely regulated by enteric nervous system (ENS), an independent intrinsic innervation, as well as central nervous system (CNS), the neural regulation of drug absorption from the small intestine still remains to be clarified. To obtain some information on it, the effect of adrenergic agonists on P-glycoprotein (P-gp) function was investigated by utilizing a vascular-luminal perfused rat small intestine. Adrenaline significantly decreased the secretion of rhodamine-123 (R-123) into the intestinal lumen, but dibutyryl cAMP (DBcAMP) significantly enhanced R-123 secretion. Read More

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September 2021

Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.

PLoS Comput Biol 2021 Sep 16;17(9):e1009378. Epub 2021 Sep 16.

Neuronal Cell Biology Research Group, Eötvös Loránd University, Budapest, Hungary.

Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output functions are analyzed to quantify alterations in intrinsic excitability. However, it is rarely addressed, how such changes translate to the function of neurons when they operate under natural synaptic inputs. Read More

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September 2021

Tumor cell intrinsic TLR4 signaling promotes melanoma progression and metastatic dissemination.

Int J Cancer 2021 Sep 16. Epub 2021 Sep 16.

Laboratory for Experimental Dermatology, Department of Dermatology, University of Magdeburg, Magdeburg, Germany.

Most melanoma-associated deaths result from the early development of metastasis. Toll like receptor 4 (TLR4) expression on non-tumor cells is well known to contribute to tumor development and metastatic progression. The role of TLR4 expression on tumor cells however is less well understood. Read More

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September 2021

THE PLASTICITY OF NERVE FIBRES: THE PROLONGED EFFECTS OF POLARIZATION OF AFFERENT FIBRES.

J Neurophysiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Neuroscience and Physiology, Sahlgrenska Academy, grid.8761.8University of Gothenburg, Göteborg, Sweden.

The review surveys various aspects of the plasticity of nerve fibres, in particular the prolonged increase in their excitability evoked by polarization, focusing on a long-lasting increase in the excitability of myelinated afferent fibres traversing the dorsal columns of the spinal cord. We review the evidence that increased axonal excitability (i) follows epidurally applied direct current as well as relatively short (5 or 10 ms) current pulses and synaptically evoked intrinsic field potentials; (ii) critically depends on the polarization of branching regions of afferent fibres at the sites where they bifurcate and give off axon collaterals entering the spinal grey matter in conjunction with actions of extrasynaptic GABA membrane receptors; and (iii) shares the feature of being activity-independent with the short-lasting effects of polarization of peripheral nerve fibres. A comparison between the polarization evoked sustained increase in the excitability of dorsal column fibres and spinal motoneurons (plateau potentials) indicates the possibility that they are mediated by partly similar membrane channels (including non-inactivating type L Cav 1. Read More

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September 2021

The Long-term Effect of Dobutamine on Intrinsic Myocardial Function and Myocardial Injury in Septic Rats with Myocardial Dysfunction.

Shock 2021 Oct;56(4):582-592

Department of Pathophysiology, Key Laboratory of State Administration of Traditional Chinese Medicine of the People's Republic of China, School of Medicine, Jinan University, Guangzhou, Guangdong, China.

Abstract: Dobutamine (DOB) is recommended as an inotrope for septic patients with low cardiac output, but its long-term impact on sepsis-induced cardiomyopathy remains unclear. This study investigated the long-term effect of DOB on septic myocardial dysfunction and injury. Rats were exposed to cecal ligation and puncture (CLP), the intrinsic myocardial function, other organ functions, hemodynamics, inflammatory response, serum myocardial injury biomarkers, myocardial apoptosis, and vascular permeability were determined. Read More

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October 2021

B Cell Receptor Repertoire Analysis in Malaria-Naive and Malaria-Experienced Individuals Reveals Unique Characteristics of Atypical Memory B Cells.

mSphere 2021 Sep 15:e0072621. Epub 2021 Sep 15.

Department of Microbiology, Immunology and Molecular Genetics, Long School of Medicine, The University of Texas Health Science Center at San Antoniogrid.267309.9, San Antonio, Texas, USA.

Malaria, caused by parasites of the genus, is responsible for significant morbidity and mortality globally. Chronic Plasmodium falciparum exposure affects the B cell compartment, leading to the accumulation of atypical memory B cells (atMBCs). IgM-positive (IgM) and IgG atMBCs have not been compared in-depth in the context of malaria, nor is it known if atMBCs in malaria-experienced individuals are different from phenotypically similar B cells in individuals with no known history of exposure. Read More

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September 2021

Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: A population-based cohort study.

PLoS Med 2021 Sep 14;18(9):e1003097. Epub 2021 Sep 14.

Universidad de Ciencias Médicas de Matanzas, Matanzas, Cuba.

Background: The World Health Organization (WHO) has reframed health and healthcare for older people around achieving the goal of healthy ageing. The recent WHO Integrated Care for Older People (ICOPE) guidelines focus on maintaining intrinsic capacity, i.e. Read More

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September 2021

The nonlinear optical transition bleaching in tellurene.

Nanoscale 2021 Sep 14. Epub 2021 Sep 14.

Hunan Key Laboratory of Nanophotonics and Devices, School of Physics and Electronics, Central South University, 932 South Lushan Road, Changsha, Hunan 410083, P. R. China.

To date, outstanding linear and nonlinear optical properties of tellurene, caused by multiple two-dimensional (2D) phases and optical anisotropy, have attracted considerable interest for potential nanophotonics applications. In this work, the ultrafast nonlinear optical (NLO) properties of α-tellurene have been studied -scan and pump-probe techniques at a broadband spectral region. Typical saturable absorption and band filling effects are observed in tellurene due to the Pauli exclusion principle. Read More

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September 2021

Our experience of operated pediatric ureteropelvic junction obstruction patients.

Urologia 2021 Sep 14:3915603211046161. Epub 2021 Sep 14.

Department of Pediatric Surgery, Gazi University Faculty of Medicine, Ankara, Turkey.

Aims: Ureteropelvic junction obstruction (UPJO) may originate from extrinsic or intrinsic causes in children. The aim of this study is to present preoperative and postoperative data of our patients operated for UPJO.

Methods: A total of 64 patients who underwent open pyeloplasty were investigated retrospectively. Read More

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September 2021

Induced Pluripotent Stem Cells From Subjects With Primary Sclerosing Cholangitis Develop a Senescence Phenotype Following Biliary Differentiation.

Hepatol Commun 2021 Aug 25. Epub 2021 Aug 25.

Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA.

Primary sclerosing cholangitis (PSC) is a chronic fibroinflammatory disease of the biliary tract characterized by cellular senescence and periportal fibrogenesis. Specific disease features that are cell intrinsic and either genetically or epigenetically mediated remain unclear due in part to a lack of appropriate, patient-specific, in vitro models. Recently, our group developed systems to create induced pluripotent stem cell (iPSC)-derived cholangiocytes (iDCs) and biliary epithelial organoids (cholangioids). Read More

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Effect of infrared radiation on activity and conformation of polyphenol oxidase from Acetes chinensis.

J Food Sci 2021 Sep 14. Epub 2021 Sep 14.

College of Food Science and Technology, Zhejiang University of Technology, Hangzhou, China.

The aim of this paper was to study the effect of infrared radiation (IR) on the activity and conformation of polyphenol oxidase (PPO) in Acetes chinensis. In this paper, the specific activity of PPO was increased from 21.2 to 643. Read More

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September 2021