164,897 results match your criteria increased glucose

Trimetazidine Protects from Mercury-Induced Kidney Injury.

Pharmacology 2021 Apr 13:1-9. Epub 2021 Apr 13.

Pharmacology, Faculty of Biochemical and Pharmaceutical Sciences. National University of Rosario, CONICET, Rosario, Argentina.

Introduction: The presence of mercury in the environment is a worldwide concern. Inorganic mercury is present in industrial materials, is employed in medical devices, is widely used in batteries, is a component of fluorescent light bulbs, and it has been associated with human poisoning in gold mining areas. The nephrotoxicity induced by inorganic mercury is a relevant health problem mainly in developing countries. Read More

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Elucidating the complementarity of resting-state networks derived from dynamic [F]FDG and hemodynamic fluctuations using simultaneous small-animal PET/MRI.

Neuroimage 2021 Apr 10:118045. Epub 2021 Apr 10.

Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen, Germany. Electronic address:

Functional connectivity (FC) and resting-state network (RSN) analyses using functional magnetic resonance imaging (fMRI) have evolved into a growing field of research and have provided useful biomarkers for the assessment of brain function in neurological disorders. However, the underlying mechanisms of the blood oxygen level-dependent (BOLD) signal are not fully resolved due to its inherent complexity. In contrast, [F]fluorodeoxyglucose positron emission tomography ([F]FDG-PET) has been shown to provide a more direct measure of local synaptic activity and may have additional value for the readout and interpretation of brain connectivity. Read More

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Cinacalcet as a surrogate therapy for diabetic cardiomyopathy in rats through AMPK-mediated promotion of mitochondrial and autophagic function.

Toxicol Appl Pharmacol 2021 Apr 10:115533. Epub 2021 Apr 10.

Physiology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Decreased activity of AMP-activated protein kinase (AMPK) is implicated in the pathogenesis of diabetic cardiomyopathy (DCM). Recent evidence suggests a crosstalk between cinacalcet and AMPK activation. This study investigated the effects of cinacalcet on cardiac remodeling and dysfunction in type 2 diabetic rats (T2DM). Read More

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Systemic and adipocyte transcriptional and metabolic dysregulation in Idiopathic Intracranial Hypertension.

JCI Insight 2021 Apr 13. Epub 2021 Apr 13.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.

Background: Idiopathic intracranial hypertension (IIH) is a condition predominantly affecting obese women of reproductive age. Recent evidence suggests that IIH is a disease of metabolic dysregulation, androgen excess and an increased risk of cardiovascular morbidity. Here we evaluate systemic and adipose specific metabolic determinants of the IIH phenotype. Read More

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Molecular Mechanisms of the Anti-obesity Properties of in Mice Fed a High-Fat Diet.

J Agric Food Chem 2021 Apr 13. Epub 2021 Apr 13.

Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan.

The overweight and obese population has skyrocketed, resulting in a high incidence of metabolic disorders. (AS) contains a variety of beneficial components, such as sulfur-containing polysaccharides (dietary fiber) and astaxanthin, which is considered to have anti-obesity potential. In this study, we investigated the effects and possible mechanisms of dietary AS on high-fat diet (HFD)-induced obesity in mice. Read More

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Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome.

Mol Neurobiol 2021 Apr 13. Epub 2021 Apr 13.

Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Health Science Center, 875 Monroe Avenue, Wittenborg Bldg, Room-231, Memphis, TN, 38163, USA.

Thrombolytic therapy has remained quite challenging in hyperglycemic patients for its association with poor prognosis and increased hemorrhagic conversions. We recently showed that tissue plasminogen activator (tPA)-induced cerebrovascular damage is associated with thioredoxin-interacting protein (TXNIP) upregulation, which has an established role in the detrimental effects of hyperglycemia. In the present work, we investigated whether verapamil, an established TXNIP inhibitor, may provide protection against hyperglycemic stroke and tPA-induced blood-brain barrier (BBB) disruption. Read More

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A systematic review and meta-analysis on the regulation of programmed cell death-1 on T-cells in type 2 diabetes.

Medicine (Baltimore) 2021 Apr;100(15):e25488

School of Laboratory Medicine and Medical Sciences (SLMMS), College of Health Sciences, University of KwaZulu-Natal, Durban.

Background: To assess T-cell exhaustion mediated by programmed cell death 1 (PD-1) pathway in patients living with type 2 diabetes (T2D).

Methods: MEDLINE and ProQuest electronic databases were searched for eligible studies from inception up to February 2020. The risk of bias and the quality of evidence were independently assessed by two reviewers using the modified Newcastle-Ottawa Scale adapted for cross-sectional studies and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool, respectively. Read More

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High glucose promotes the aging of human dental pulp cells through Wnt/beta-catenin signaling.

Dent Med Probl 2021 Jan-Mar;58(1):39-46

Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Iran.

Background: Diabetes is one of the most common metabolic diseases that disrupt the functioning of different body organs, including oral tissue. Some diabetic complications remain even after the control of the hyperglycemic condition. The adverse effect of hyperglycemia on the pulp structure and function has been shown previously. Read More

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[Opportunities and perspectives for bempedoic acid use in clinical practice].

G Ital Cardiol (Rome) 2021 Apr;22(4):22-27

U.O.C. Cardiologia Clinica e Riabilitativa, Presidio Ospedaliero San Filippo Neri, ASL Roma 1, Roma.

Bempedoic acid is a new lipid-lowering drug that inhibits cholesterol biosynthesis in liver cells selectively. Results from phase 2 and phase 3 studies showed a complementary effect on LDL-cholesterol lowering when combining bempedoic acid and ezetimibe without increasing side effects. Moreover, bempedoic acid seems to represent a good treatment option for the management of hypercholesterolemia, especially in patients at increased risk of cardiovascular events, such as patients with impaired glucose metabolism, elderly patients, patients with prior acute coronary syndrome, and patients with familial hypercholesterolemia. Read More

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Predictors of long-term mortality in acute ST-elevation myocardial infarction patients undergoing emergent coronary artery bypass graft surgery.

Turk Kardiyol Dern Ars 2021 Apr;49(3):191-197

Department of Cardiology, University of Health Sciences Turkey İstanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, İstanbul, Turkey.

Objective: Coronary artery bypass graft (CABG) surgery as a primary treatment for acute ST-elevation myocardial infarction (STEMI) is still debated. This study aimed to evaluate the predictors of long-term mortality in STEMI patients undergoing emergent CABG. To the best of our knowledge, this is the first study to evaluate the long-term mortality predictors in patients with STEMI revascularized by primary CABG. Read More

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Increasing selenium supply during the close-up dry period improves nutrient metabolism and attenuates inflammatory response after calving in dairy cows.

Jian Gong Min Xiao

Anim Sci J 2021 Jan;92(1):e13551

College of Life Science and Technology, Inner Mongolia Normal University, Hohhot, China.

The objective of this study was to investigate whether feeding selenium (Se)-replete cows a Se-yeast supplement in late pregnancy affects nutrient metabolism and inflammatory response during the periparturient period. Twenty cows were randomly assigned to two groups with 10 cows each. Cows in one group received Se-yeast at 0. Read More

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January 2021

Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer.

Oncol Rep 2021 Jun 13;45(6). Epub 2021 Apr 13.

Department of Surgery, Tohoku University Graduate School of Medicine, Seiryo‑machi, Aoba‑ku, Sendai 980‑8574, Japan.

Stomatin‑like protein 2 (SLP‑2) is associated with poor prognosis in several types of cancer, including pancreatic cancer (PC); however, the molecular mechanism of its involvement remains elusive. The present study aimed to elucidate the role of this protein in the development of PC. Human PC cell lines AsPC‑1 and PANC‑1 were transfected by a vector expressing SLP‑2 shRNA. Read More

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