181,478 results match your criteria increased bone

Secondary stability achieved in dental implants with a calcium-coated SLA surface and a chemically modified SLA surface placed without mechanical engagement: a preclinical study.

Clin Oral Implants Res 2021 Sep 21. Epub 2021 Sep 21.

Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, South Korea.

Objectives: To assess the osseointegration of calcium-coated (CS) and chemically modified, sandblasted, large-grit, acid-etched (MS) dental implants with a lack of primary mechanical stability.

Materials And Methods: Eighteen implants in CS and MS groups each were loosely placed in the mandible of 6 mongrel dogs and allowed to heal for 2, 4 and 8 weeks. Implant stability quotient (ISQ) and implant stability test (IST) values recorded periodically and bone-to-implant contact (BIC) and the number of Haversian canals per 1 mm measured histologically were statistically analyzed (p < 0. Read More

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September 2021

3D MRI Models of the Musculoskeletal System.

Mohammad Samim

Semin Musculoskelet Radiol 2021 Jun 21;25(3):388-396. Epub 2021 Sep 21.

Department of Radiology, NYU Langone Medical Center, New York, New York.

Computed tomography (CT) is most commonly used to produce three-dimensional (3D) models for evaluating bone and joint morphology in clinical practice. However, 3D models created from magnetic resonance imaging (MRI) data can be equally effective for comprehensive and accurate assessment of osseous and soft tissue structure morphology and pathology. The quality of 3D MRI models has steadily increased over time, with growing potential to replace 3D CT models in various musculoskeletal (MSK) applications. Read More

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Ablation of Collagen VI leads to the release of platelets with altered function.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

University of Pavia, Pavia, Italy.

Hemostatic abnormalities and impaired platelet function have been described in patients affected by connective tissue disorders. We observed a moderate bleeding tendency in patients affected by Collagen VI-related disorders and investigated the defects in platelet functionality whose mechanisms are unknown. We demonstrated that megakaryocytes express Collagen VI that is involved in the regulation of functional platelet production. Read More

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September 2021

Value of HSP90α in Lung Cancer Diagnosis and Recurrence Prediction: A Cohort Study.

Oncol Res Treat 2021 Sep 21:1-6. Epub 2021 Sep 21.

Department of Neurosurgery, University Medical Center Tuebingen, Tuebingen, Germany.

Purpose: In the current study, we tried to analyze the diagnostic value of HSP90α expression during the course of disease in patients treated with and without surgery.

Methods: Three hundred and twelve patients with lung cancer who referred to Qinhuangdao First Hospital from June 2016 to March 2021 were selected as the experimental group and 160 healthy individuals subjected as the control group in this cohort study. The ELISA method was used to detect the expression level of plasma HSP90α. Read More

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September 2021

Role of transient receptor potential channel 6 in the osteogenesis of periodontal ligament cells.

Int Immunopharmacol 2021 Sep 18;100:108134. Epub 2021 Sep 18.

Department of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, China. Electronic address:

Transient receptor potential channel 6 (TRPC6) is a receptor-operated Ca channel that plays an important role in Ca influx in the majority of non-excitable cells and influences calcium signalling and cellular responses. Therefore, the purpose of the present study was to gain insight into the role of TRPC6 in the osteogenesis of periodontal ligament cells (PDLCs). By western blot and immunohistochemical staining, the protein level of TRPC6 was found to be increased in a time-dependent manner during osteoblastic differentiation of PDLCs. Read More

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September 2021

Factors affecting gene expression associated with the skin color of black-bone chicken in Thailand.

Poult Sci 2021 Aug 19;100(11):101440. Epub 2021 Aug 19.

Department of Animal Science, Faculty of Agricultural, Khon Kaen University, Mueang Khon Kaen 40000, Thailand; Network Center for Animal Breeding and Omics Research, Faculty of Agricultural, Khon Kaen University, Mueang Khon Kaen 40000, Thailand.

The objective of this study was to investigate the effect of breed, sex, and age on the gene expression level of melanocortin 1 receptor (MC1R), DOPA chrome tautomerase (DCT), tyrosinase-related protein 1 (TYRP1), tyrosinase (TYR), and agouti signaling protein (ASIP) genes in Thai commercial chicken lines. All chicken have received Newscastle vaccination, and no antibiotics or any drugs were used in this study. Four chicken breeds including Black-Chinese, KU-Phuparn, Sri Mok, and Pradu Hang Dam were used in this study. Read More

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Bone and fat hormonal crosstalk with antiretroviral initiation.

Bone 2021 Sep 18:116208. Epub 2021 Sep 18.

Department of Cell & Molecular Medicine, Rush University Medical Center, Chicago, IL. Electronic address:

Background: Bone mineral density (BMD) loss and fat gain is common in people living with HIV (PLWH), particularly after initiating combination antiretroviral therapy (cART). Given the close metabolic interaction between bone and fat, we tested the hypotheses that changes in bone-derived hormones are associated with fat accumulation and changes in fat-derived hormones are associated with BMD loss following cART initiation.

Methods: HIV-seropositive subjects (n=15) initiating fixed dose cART of tenofovir disoproxil fumarate/emtricitabine/efavirenz (TDF/FTC/EFV) underwent dual x-ray absorptiometry (DXA) assessment pre-cART and again 12-months post-cART initiation. Read More

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September 2021

Hypophosphatasia: Vitamin B status of affected children and adults.

Bone 2021 Sep 18:116204. Epub 2021 Sep 18.

Department of Chemistry, Purdue University Fort Wayne, Fort Wayne, IN 46805, USA. Electronic address:

Hypophosphatasia (HPP) is the heritable dento-osseous disease caused by loss-of-function mutation(s) of the gene ALPL that encodes the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). TNSALP is a cell-surface homodimeric phosphomonoester phosphohydrolase expressed in healthy people especially in the skeleton, liver, kidneys, and developing teeth. In HPP, diminished TNSALP activity leads to extracellular accumulation of its natural substrates including inorganic pyrophosphate (PPi), an inhibitor of mineralization, and pyridoxal 5'-phosphate (PLP), the principal circulating form of vitamin B (B). Read More

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September 2021

Total Hip Arthroplasty with the Wagner Cone Femoral Stem in Patients with Crowe 4 Developmental Dysplasia of the Hip. A Retrospective Study.

J Arthroplasty 2021 Sep 18. Epub 2021 Sep 18.

Private Ortopedia Hospital, Hip Surgery Department, Cumhuriyet street No:64, Post code: 01130, Seyhan, Adana, Turkey.

Purpose: The aim of this study is to assess treatment of Crowe type IV hip dysplasia with the Wagner Cone femoral stem combined with transverse subtrochanteric shortening osteotomy and augmenting the osteotomy site using the intercalary segment as a strut autograft.

Methods: 127 hips of 91 patients diagnosed with Crowe type IV hip dysplasia and treated with total hip arthroplasty (THA) using the Wagner Cone stem combined with transverse subtrochanteric shortening osteotomy were retrospectively evaluated by clinical and radiographic outcomes as well as complications.

Results: The mean follow-up was 8. Read More

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September 2021

Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation model.

Transpl Immunol 2021 Sep 18:101467. Epub 2021 Sep 18.

Latner Thoracic Surgery Research Laboratories, University Health Network, Canada. Electronic address:

IL-17A is implicated in the pathogenesis of chronic lung allograft dysfunction, which limits survival after lung transplantation. While many cells express the IL-17 receptor A (IL-17RA) which is the main receptor for IL-17A, the cellular targets of IL-17A in development of post-transplant fibrosis are unknown. The purpose of this study was to determine whether IL-17RA expression by donor or recipient structural or bone marrow (BM) cells is required for the development of allograft fibrosis in a mouse intrapulmonary tracheal transplantation (IPTT) model. Read More

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September 2021

Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production.

Eur J Pharm Sci 2021 Sep 18:106013. Epub 2021 Sep 18.

Department of Orthopedics, Affiliated Hospital of Guizhou Medical University, Guiyang City, Guizhou Province, 550004, P. R. China.

Background: Doxorubicin (DOX) is widely used as an effective chemotherapy agent in human cancer. Our study aimed to explore the specific mechanism of DOX in osteoarthritis (OA).

Methods: A mouse OA model was established by destabilizing the medial meniscus (DMM), and the role of DOX was determined by intraperitoneally injecting 5 or 10 mg/kg DOX. Read More

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September 2021

Anticancer effects of melatonin via regulating lncRNA JPX-Wnt/β-catenin signalling pathway in human osteosarcoma cells.

J Cell Mol Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Osteosarcoma (OS) is a type of malignant primary bone cancer, which is highly aggressive and occurs more commonly in children and adolescents. Thus, novel potential drugs and therapeutic methods are urgently needed. In the present study, we aimed to elucidate the effects and mechanism of melatonin on OS cells to provide a potential treatment strategy for OS. Read More

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September 2021

CCL2 is a critical mechano-responsive mediator in crosstalk between osteoblasts and bone mesenchymal stromal cells.

FASEB J 2021 Oct;35(10):e21851

Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China.

It has been known that moderate mechanical loading, like that caused by exercise, promotes bone formation. However, its underlying mechanisms remain elusive. Here we showed that moderate running dramatically improved trabecular bone in mice tibias with an increase in bone volume fraction and trabecular number and a decrease in trabecular pattern factor. Read More

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October 2021

Increased Early Mortality in Bilateral Simultaneous TKA Using Conventional Instrumentation Compared with Technology-Assisted Surgery: A Study of 34,908 Procedures from a National Registry.

J Bone Joint Surg Am 2021 Sep 21. Epub 2021 Sep 21.

Australian Orthopaedic Association National Joint Replacement Registry, Adelaide, South Australia, Australia.

Background: Controversy exists regarding the safety of bilateral simultaneous total knee arthroplasty (BSTKA). When conventional instrumentation is used, the increased fat emboli that result from the insertion of intramedullary rods may increase the risk of perioperative complications. We hypothesized that the use of technology-assisted instrumentation (avoiding intramedullary involvement) would be associated with a lower rate of early postoperative death compared with the use of conventional instrumentation. Read More

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September 2021

Pulmonary Epithelioid Hemangioendothelioma: Imaging and Clinical Features.

J Comput Assist Tomogr 2021 Sep-Oct 01;45(5):788-794

From the Department of Radiology.

Objective: The aim of this study was to analyze the computed tomography (CT), fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), and clinical findings of pulmonary epithelioid hemangioendothelioma.

Methods: Eighteen patients were included. We reviewed CT and PET/CT features and clinical information. Read More

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September 2021

The miR-182/Myadm axis regulates hypoxia-induced pulmonary hypertension by balancing the BMP- and TGF-β-signalling pathways in an SMC/EC-crosstalk-associated manner.

Basic Res Cardiol 2021 Sep 21;116(1):53. Epub 2021 Sep 21.

Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing, 100050, China.

We recently identified oncologic miR-182 as a new regulator of pulmonary artery hypertension (PAH) that targets myeloid-associated differentiation marker (Myadm), which is expressed in bone marrow stem cells and multipotent progenitors. Both miR-182 and Myadm are expressed in the cardiopulmonary system and correlated with the balance between the bone morphogenetic protein (BMP) and the transforming growth factor (TGF)-β signalling pathways, which are disturbed in PAH. We hypothesize that miR-182/Myadm are involved in BMP-TGF-β-signalling way in PAH. Read More

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September 2021

The Natural History of Acute Radiation-induced H-ARS and Concomitant Multi-organ Injury in the Non-human Primate: The MCART Experience.

Health Phys 2021 Oct;121(4):282-303

University of Maryland, School of Medicine, Baltimore, MD.

Abstract: The dose response relationship and corresponding values for mid-lethal dose and slope are used to define the dose- and time-dependent parameters of the hematopoietic acute radiation syndrome. The characteristic time course of mortality, morbidity, and secondary endpoints are well defined. The concomitant comorbidities, potential mortality, and other multi-organ injuries that are similarly dose- and time-dependent are less defined. Read More

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October 2021

Clinical and molecular characterization of five Chinese patients with autosomal recessive osteopetrosis.

Mol Genet Genomic Med 2021 Sep 21:e1815. Epub 2021 Sep 21.

Department of Medical Genetics and Molecular Diagnostic Laboratory, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Osteopetrosis is characterized by increased bone density and bone marrow cavity stenosis due to a decrease in the number of osteoclasts or the dysfunction of their differentiation and absorption properties usually caused by biallelic variants of the TCIRG1 and CLCN7 genes.

Methods: In this study, we describe five Chinese children who presented with anemia, thrombocytopenia, hepatosplenomegaly, repeated infections, and increased bone density. Whole-exome sequencing identified five compound heterozygous variants of the CLCN7 and TCIRG1 genes in these patients. Read More

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September 2021

Increased circulating sclerostin levels in rheumatoid arthritis patients: an updated meta-analysis.

Z Rheumatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, China.

Background: Sclerostin, a regulator of bone metabolism and vascular calcification involved in regulating the Wnt/β-catenin signaling pathway, has been shown to be involved in the pathogenesis of rheumatoid arthritis (RA). However, current results regarding the circulating sclerostin level of RA patients are debatable. This study aimed to evaluate the circulating level of sclerostin in RA patients and briefly summarize its role. Read More

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September 2021

Distribution and Polarization of Hematogenous Macrophages Associated with the Progression of Intervertebral Disc Degeneration.

Spine (Phila Pa 1976) 2021 Sep 20. Epub 2021 Sep 20.

Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

Study Design: In vivo study using immunostaining and immunoblot analysis.

Objective: To determine the distribution of bone marrow-derived macrophages (BMDMs), macrophage polarization and cytokine expression in the process of intervertebral disc (IVD) degeneration.

Summary Of Background Data: Knowledge of the detailed distribution of exogeneous macrophages in the disc degeneration process is important for understanding the pathomechanisms and establishing novel therapeutic targets. Read More

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September 2021

Dancing Against falls iN Community-dwElling older adults (DANCE): a study protocol of a stratified, block-randomised trial.

Inj Prev 2021 Sep 20. Epub 2021 Sep 20.

Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Background: Unintentional falls among older adults are of primary importance due to their impact on quality of life. Falling accounts for 95% of hip fractures, leading to an approximately six times increased risk of death within the first 3 months. Furthermore, physical and cognitive parameters are risk factors for falls. Read More

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September 2021

Vancomycin Hydrochloride Loaded Hydroxyapatite Mesoporous Microspheres with Micro/Nano Surface Structure to Increase Osteogenic Differentiation and Antibacterial Ability.

J Biomed Nanotechnol 2021 Aug;17(8):1668-1678

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Biomedical Materials and Engineering Research Center of Hubei Province, Wuhan 430070, PR China.

As infection induced by the implant will lead to operation failure, the implant material must be endowed with certain antibacterial properties. Hydroxyapatite (HA) mesoporous microspheres have been widely used in bone repair due to their advantages, including simple synthesis, good osteogenic properties and drug loading capacity. In this study, vancomycin hydrochloride-loaded mesoporous hydroxyapatite microspheres with micro/nanosurface structures were synthesized to increase osteogenic differentiation and antibacterial ability. Read More

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Peri-implant distal clavicle fracture: Case report (overlaying plate fixation: Solution for peri-implant clavicle fractures).

Int J Surg Case Rep 2021 Sep 15;87:106411. Epub 2021 Sep 15.

Department of Shoulder and Elbow Surgery, Faculdade de Medicina do ABC, Santo André, Brazil; Medical Doctor-Shoulder and Elbow Surgeon, Brazil.

Introduction And Importance: Surgical treatment for clavicle injuries is indicated for displaced and shortened fractures. Osteosyntheses with plate fixation may present with complications in 6.3% to 8. Read More

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September 2021

Early Percutaneous Vertebroplasty Improves Bone-Cement Integration and Reduces Adjacent Fractures.

World Neurosurg 2021 Sep 17. Epub 2021 Sep 17.

Department of Orthopedics, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, No. 2, Min-Sheng Road, Dalin Town, Chia-Yi County 62247, Taiwan, R.O.C.; School of Medicine, Tzu Chi University, No. 701, Sec. 3, Chung Yang Road, Haulien City 970, Taiwan. Electronic address:

Background: Percutaneous vertebroplasty (PVP) is widely used for osteoporotic vertebral compression fractures (VCFs). However, the influence of PVP timing (early vs. late) on the development of adjacent vertebral fractures (AVFs), has rarely been discussed. Read More

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September 2021

Effect of Bone-Marrow-Derived Mesenchymal Stem Cells on the Healing of Bone Fractures.

J Interferon Cytokine Res 2021 Sep;41(9):336-346

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Benha University, Benha, Egypt.

This study was performed to evaluate the effectiveness of mesenchymal stem cells (MSCs) on bone healing and to assess the role of various chemical stimulants and mediators in healing. Forty female mice were randomly assigned to 4 groups (10 mice each) after the induction of fixed fractures: group I: received fixation only; group II: received phosphate-buffered saline (PBS); group III: received intralesion MSCs (IL-MSCs); and group IV: received intraperitoneal MSCs (IP-MSCs). Serum alkaline phosphatase (ALP) levels and the expression of the osteocalcin (), bone morphogenetic protein-2 (), and stromal-derived factor-1 () genes were measured. Read More

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September 2021

Combined Treatment of Bone Marrow Mesenchymal Stem Cells and Fasudil Promotes Neurovascular Remodeling and Neurological Function Recovery in Ischemic Stroke.

Appl Biochem Biotechnol 2021 Sep 20. Epub 2021 Sep 20.

Department of Neurology, The Second Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian, 116000, Liaoning, China.

Stroke remains a highly deadly and disabling disease with limited treatment tragedies due to the limitations of available treatments; novel therapies for stroke are needed. In this article, the synergistic results of dual bone marrow mesenchymal stem cells (BMSC) and fasudil treatment in rat models of ischemic stroke still require further identification. Sprague-Dawley rats were used to construct the middle cerebral artery, occlusion models. Read More

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September 2021

Osteoblast-Specific Wnt Secretion is Required for Skeletal Homeostasis and Loading-Induced Bone Formation in Adult Mice.

J Bone Miner Res 2021 Sep 20. Epub 2021 Sep 20.

Department of Orthopaedic Surgery and Musculoskeletal Research Center, Washington University School of Medicine, Saint Louis, Missouri, US.

Wnt signaling is critical to many aspects of skeletal regulation, but the importance of Wnt ligands in the bone anabolic response to mechanical loading is not well established. Recent transcriptome profiling studies by our lab and others show that mechanical loading potently induces genes encoding Wnt ligands, including Wnt1 and Wnt7b. Based on these findings, we hypothesized that mechanical loading stimulates adult bone formation by inducing Wnt ligand expression. Read More

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September 2021

Higher serum alkaline phosphatase value indicates the need for bone mineral density testing in non-metastatic prostate cancer patients undergoing androgen deprivation therapy.

Jpn J Clin Oncol 2021 Sep 20. Epub 2021 Sep 20.

Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

Purpose: Osteoporosis is a well-known adverse effect of androgen deprivation therapy for prostate cancer. This study aimed to reveal the factors associated with the diagnosis of osteoporosis in prostate cancer patients undergoing androgen deprivation therapy.

Methods: This retrospective cross-sectional study included 106 prostate cancer patients treated with androgen deprivation therapy. Read More

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September 2021

FRAX assessment in people ageing with HIV.

HIV Med 2021 Sep 19. Epub 2021 Sep 19.

Research and Development Department, Chelsea and Westminster Hospital, London, UK.

Objectives: Current British HIV Association (BHIVA) guidelines recommend the use of FRAX for the routine assessment of bone fracture risk in people living with HIV over 50 years of age every 3 years. Bone mineral density measurement with dual-energy X-ray absorptiometry (DXA) scan is recommended for those with increased fracture risk (FRAX major > 10%). Our objectives were to estimate the prevalence of and risk factors for osteoporosis in a population of PLWH aged > 50 years and assess the utility of FRAX in predicting the presence of DXA-proven osteoporosis in this cohort. Read More

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September 2021