25,415 results match your criteria increased 109

Risk factors associated with postoperative respiratory failure in tuberculous empyema patients.

Medicine (Baltimore) 2021 Jun;100(23):e25754

Department of Thoracic Surgery.

Abstract: Our objective was to identify independent risk factors for predicting which patients in the Chinese population would likely develop respiratory failure.A descriptive analysis was conducted of demographic and clinical data of patients with tuberculous empyema (TE) admitted to the Beijing Chest Hospital, Capital Medical University between January 2001 and January 2020. Risk factors associated with postsurgical respiratory failure in TE patients were identified based on results of analyses based on univariable and multivariable logistic regression models. Read More

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Cervical Endocrine Surgery With a Novel Opioid-Limited Perioperative Protocol.

Am Surg 2021 Jun 11:31348211025736. Epub 2021 Jun 11.

Department of General Surgery, 7005Beaumont Health System, Royal Oak, MI, USA.

Background: Recent studies have demonstrated that patients undergoing cervical endocrine surgery could be comfortably discharged with minimal opioid analgesia. However, no study to date has examined the efficacy of limiting administration of opioids intraoperatively. We have developed a novel protocol for patients undergoing cervical endocrine surgery that eliminates perioperative opioids. Read More

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[Celastrol alleviates sepsis-induced acute lung injury in rats by inhibiting the Toll-like receptor 4/nuclear factor-κB inflammatory pathway].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):541-545

Department of Intensive Care Unit, Jiangxi Provincial People's Hospital, Nanchang 330006, Jiangxi, China.

Objective: To investigate the protective effect and mechanism of celastrol in acute lung injury (ALI) of septic rats.

Methods: According to random number table, 24 male Sprague-Dawley (SD) rats were divided into control group (Con group), Sham operation group (Sham group), sepsis-induced ALI group by cecal ligation and perforation (CLP group) and celastrol intervention group (CLP+celastrol group, 2 mg/kg intraperitoneal administration 1 hour before surgery), 6 rats in each group. The abdominal aortic blood of the rats was collected for blood gas analysis 24 hours after the surgery, and then the rats were sacrificed and the lung tissues were taken to calculate the lung wet to dry weight ratio (W/D). Read More

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Effects of probiotics supplementation on the hormone and body mass index in perimenopausal and postmenopausal women using the standardized diet. A 5-week double-blind, placebo-controlled, and randomized clinical study.

Eur Rev Med Pharmacol Sci 2021 May;25(10):3859-3867

Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Szczecin, Poland.

Objective: The results of pioneering studies indicate that probiotics can alleviate menopausal symptoms (including cardiometabolic dysfunctions) and improve the quality of life of perimenopausal/postmenopausal women. However, the results of randomized control trials are scarce to evaluate whether the administration of probiotics could affect the balance of sex hormones during the menopause period.

Patients And Methods: In this randomized, double-blind, and placebo-controlled study, 48 perimenopausal and postmenopausal women received multispecies probiotic Sanprobi Barrier in a dose of 2. Read More

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Risk factors for the development of neonatal sepsis in a neonatal intensive care unit of a tertiary care hospital of Nepal.

BMC Infect Dis 2021 Jun 9;21(1):546. Epub 2021 Jun 9.

Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Kathmandu, Nepal.

Background: Sepsis is an overwhelming and life-threatening response to bacteria in bloodstream and a major cause of neonatal morbidity and mortality. Understanding the etiology and potential risk factors for neonatal sepsis is urgently required, particularly in low-income countries where burden of infection is high and its epidemiology is poorly understood.

Methods: A prospective observational cohort study was conducted between April 2016 and October 2017 in a level three NICU at a tertiary care hospital in Nepal to determine the bacterial etiology and potential risk factors for neonatal sepsis. Read More

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Interactivity Can Enhance the Effectiveness of Threat Appeals: Implications for Preventive Health Websites.

Soya Nah Jeeyun Oh

Health Commun 2021 Jun 9:1-11. Epub 2021 Jun 9.

The Stan Richards School of Advertising & Public Relations, The University of Texas at Austin.

Interactive health websites where threat appeals are incorporated have become a popular strategy to engage users in preventive health behaviors. The current study examines how website interactivity enhances the effectiveness of threat appeals and thus encourages preventive health behaviors in the context of an anti-sugar campaign. A single factor design experiment (N = 109) with two conditions (high vs. Read More

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Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.

Clin Pharmacol Drug Dev 2021 Jun 9. Epub 2021 Jun 9.

Clinical NCA & PK/PD, Nuventra, Inc., Durham, North Carolina, USA.

Napabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1. Napabucasin induces cell death in cancer cells, including cancer stem cells. This phase 1 study (NCT03411122) evaluated napabucasin drug-drug interaction potential for 7 cytochrome P450 (CYP) enzymes and the breast cancer resistance protein transporter/organic anion transporter 3. Read More

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Long-term safety and efficacy study of a medical device containing xyloglucan, pea protein reticulated with tannins and xylo-oligosaccharides, in patients with diarrhoea-predominant irritable bowel syndrome.

Therap Adv Gastroenterol 2021 30;14:17562848211020570. Epub 2021 May 30.

Servicio de Aparato Digestivo, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria San Carlos (IdISSC), Ciudad Universitaria s/n, Madrid 28040, Spain.

Background: Irritable bowel syndrome with diarrhoea (IBS-D) is a frequent problem associated with a significant socioeconomic implication. Increased gut permeability is an important pathophysiological mechanism. A medical device containing xyloglucan (XG), pea protein and tannins (PPT) from grape-seed extract, and xylo-oligosaccharides (XOS) has proven restoration of intestinal barrier function. Read More

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Spatial Distribution and Factors Associated with Multiple Sexual Partnerships among Reproductive-Aged Men in Ethiopia: A Spatial and Mixed-Effect Analysis of the 2016 Ethiopian Demographic and Health Survey.

HIV AIDS (Auckl) 2021 31;13:593-604. Epub 2021 May 31.

Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Though multiple sexual partnerships (MSPs) increase the risk of acquiring sexually transmitted diseases, such as HIV/AIDS, they are still common in sub-Saharan Africa, particularly in Ethiopia. Therefore, this study aimed to investigate spatial distribution and factors associated with MSPs among reproductive-age men in Ethiopia.

Methods: This study was based on Ethiopian Demographic and Health Survey 2016 data. Read More

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A cross-sectional evaluation of the relationship between social jetlag and diet quality.

Chronobiol Int 2021 Jun 8:1-12. Epub 2021 Jun 8.

Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara University , Ankara, Turkey.

The aim of this study was to compare anthropometric measures of obesity and sleep qualities in individuals with/without social jetlag (SJL). In addition, it was aimed to compare the energy, macronutrient intake and diet qualities of individuals with/without SJL during school and non-school days. This study comprised 710 university students with mean age 21. Read More

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Breast Density Notification: Current UK National Practice.

Clin Breast Cancer 2021 Jun 4. Epub 2021 Jun 4.

Radiology Department, St. Barts NHS Trust, London, United Kingdom.

Increased breast density is a risk factor for breast cancer and can mask cancer on mammography. This survey attempts to understand clinician views regarding breast density notification in the United Kingdom. Two separate breast density surveys were distributed to radiologists and breast surgeons between May 2019 and May 2020. Read More

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Improved efficacy/safety profile of factor XIa inhibitor BMS-724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys.

Res Pract Thromb Haemost 2021 May 28;5(4):e12524. Epub 2021 May 28.

Cardiovascular & Fibrosis Drug Discovery Biology Bristol Myers Squibb Princeton NJ USA.

Background: Inhibition of activated factor XI (FXIa) is a promising antithrombotic drug target. BMS-724296 is a selective, reversible, small-molecule inhibitor of human FXIa (K 0.3 nM). Read More

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Overexpressed exocyst complex component 3-like 1 spontaneously induces apoptosis.

Biomed Res 2021 ;42(3):109-113

Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine.

Exocyst complex component 3-like 1 (EXOC3L1), which regulates insulin secretion, is ubiquitously present in heart, lung, liver, spleen, kidney, muscle, cerebellum, pituitary, adrenal grand, and pancreatic islets. Its deduced amino acid sequence has 31% identity and 53% similarity with Sec6, so they are considered isoforms. Since Sec6 suppresses apoptosis via HSP27, we investigated the involvement of EXOC3L1 expression in apoptosis. Read More

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January 2021

Fatal case of TAFRO syndrome with unilateral adrenal hemorrhage in early-stage disease.

J Clin Exp Hematop 2021 ;61(2):109-113

Department of Oncology and Hematology, Nara Prefecture General Medical Center, Nara, Japan.

Thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, and organomegaly comprise TAFRO syndrome, which was proposed as a distinct clinical entity from iMCD without TAFRO syndrome (iMCD-NOS) due to its aggressive clinical course, refractoriness to corticosteroids, presence of thrombocytopenia, increased level of alkaline phosphatase, and normal level of gammaglobulin. However, diagnosing TAFRO syndrome in its early stages is challenging because it is rare and its diagnostic criteria are complicated. We describe a patient with TAFRO syndrome and adrenal hemorrhage who demonstrated a rapid decline in her clinical condition and did not respond to steroid pulse therapy, resulting in a fatal outcome. Read More

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January 2021

Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries.

Eur J Intern Med 2021 Jun 3. Epub 2021 Jun 3.

Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine; Shanghai, China; Department of Cardiology, Shanghai Tenth People's Hospital Chongming branch, Shanghai, China. Electronic address:

Background: Myocardial infarction with non-obstructive coronary arteries (MINOCA) has been and remained a puzzling heterogeneous entity. The index of microcirculatory resistance (IMR) is a quantitative and specific index for the assessment of microvascular function. However, the role of IMR in MINOCA has not yet been studied. Read More

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Gastric Intestinal Metaplasia in Mucosa Adjacent to Gastric Cancers Is Rarely Associated With the Aneuploidy That Is Characteristic of Gastric Dysplasia or Cancer.

Am J Surg Pathol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pathology, University of California at San Francisco, San Francisco, CA Department of Pathology, University of Washington, Seattle, WA Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL.

Most gastric cancers (GCs) are thought to develop via gastric intestinal metaplasia (GIM)-dysplasia-carcinoma pathway. Patients with extensive and/or incomplete GIM have been reported to have a higher risk of GC. GIM can also display dysplasia-like cytoarchitectural atypia limited to the bases of gastric pits without surface involvement. Read More

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Showcasing a General Surgery Residency Program During the COVID-19 Pandemic.

J Surg Educ 2021 May 6. Epub 2021 May 6.

Mayo Clinic, Department of Cardiac and Thoracic Surgery, Rochester, Minnesota. Electronic address:

Objective: The virtual interview season has challenged general surgery residency programs to recruit applicants through the loss of visiting clerkships, tours, and time with residents. Webinars, increased informal resident and faculty sessions, and live-narrated video tours are potential solutions. This study aimed to assess the effectiveness of these elements in virtually showcasing a residency program during the virtual interview season. Read More

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Comparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation.

Mayo Clin Proc 2021 06;96(6):1522-1529

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT; Center for Outcomes Research and Evaluation, New Haven, CT. Electronic address:

In 2013, the Food and Drug Administration approved the first transcatheter mitral valve repair (TMVr) device for degenerative mitral regurgitation for patients at prohibitive surgical risk. To better understand contemporary utilization trends and outcomes, we reviewed hospitalizations, identified using International Classification of Diseases, Ninth Revision and International Classification of Diseases, Tenth Revision codes, in which the patient underwent TMVr or mitral valve repair (MVr) with a diagnosis of mitral regurgitation, without stenosis, from the National (Nationwide) Inpatient Sample from 2014 to 2017. We included 10,020 hospitalizations in which the patient underwent TMVr and 5845 in which the patient underwent MVr and assessed trends in demographic characteristics, patient comorbidities, total hospital charges, and outcomes. Read More

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Correlating natural language processing and automated speech analysis with clinician assessment to quantify speech-language changes in mild cognitive impairment and Alzheimer's dementia.

Alzheimers Res Ther 2021 06 4;13(1):109. Epub 2021 Jun 4.

Winterlight Labs, Toronto, Canada.

Background: Language impairment is an important marker of neurodegenerative disorders. Despite this, there is no universal system of terminology used to describe these impairments and large inter-rater variability can exist between clinicians assessing language. The use of natural language processing (NLP) and automated speech analysis (ASA) is emerging as a novel and potentially more objective method to assess language in individuals with mild cognitive impairment (MCI) and Alzheimer's dementia (AD). Read More

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Appraisal of transthoracic echocardiography for opportunistic screening of abdominal aortic aneurysm.

Medicine (Baltimore) 2021 Jun;100(22):e26171

Department of Cardiology, TOBB Economics and Technology University Medical School, Ankara, Turkey.

Abstract: Abdominal aortic aneurysm is a life threatening disease. Most of the patients diagnosed incidentally because of the asymptomatic nature of this disease. This study aimed to determine the frequency of abdominal aortic aneurysm and evaluate the value of opportunistic screening during transthoracic echocardiography. Read More

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Thromboembolism after cardiac surgery in a patient with cancer-related thrombosis and severe thrombocytopenia: A case report.

Medicine (Baltimore) 2021 Jun;100(22):e26152

Department of Anesthesiology and Pain Medicine, Hanyang University Medical Center, Hanyang University College of Medicine, Seoul, Korea.

Rationale: Patients with cancer have elevated risk of both venous thromboembolism and bleeding compared with patients without cancer due to cancer- and patient-specific factors. Balancing the increased and competing risks of clotting and bleeding in these patients can be difficult because management of cancer-associated thrombosis requires anticoagulation despite its known increased risks for bleeding. The adjustment of blood transfusion or cessation of anticoagulants can be a challenge in surgical diagnosis or treatment of cancer patients with such an imbalanced coagulate status. Read More

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Angiotensin-converting enzyme-1 gene insertion/deletion polymorphism may be associated with COVID-19 clinical severity: a prospective cohort study.

Ann Saudi Med 2021 May-Jun;41(3):141-146. Epub 2021 Jun 1.

From the Department of Internal Medicine, Section of Rheumatology, Samsun Education and Research Hospital, Samsun, Turkey.

Background: Angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism may play a role in the pathogenesis of coronavirus-19 disease (COVID-19).

Objectives: Investigate the relationship between ACE I/D polymorphism and the clinical severity of COVID-19.

Design: Prospective cohort study. Read More

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Antenatal follow-up, anesthesia management and perinatal outcomes in pregnancy with renal transplant

Turk J Obstet Gynecol 2021 06;18(2):109-114

Gazi University Faculty of Medicine, Department of Obstetrics and Gynecology, Ankara, Turkey

Objective: Due to the recent increase in the successful pregnancies after renal transplant, the number of renal transplant recipients having vaginal or cesarean delivery possibly associated with high maternal, fetal and/or neonatal risk requiring team approach increased. We aimed to evaluate antenatal follow-up, perinatal outcomes, and anesthesia management in pregnancies with renal transplantation and to compare them with the current literature.

Materials And Methods: After ethics committee approval, renal transplant recipients who gave birth in our hospital between January 2010 and December 2019 were documented in this retrospective study. Read More

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Efficient absorptive removal of Cd(Ⅱ) in aqueous solution by biochar derived from sewage sludge and calcium sulfate.

Bioresour Technol 2021 May 27;336:125333. Epub 2021 May 27.

Office of Teaching Affairs, Guilin University of Technology, Guilin 541004, China.

Biochar derived from co-pyrolysis of sewage sludge and calcium sulfate was used to remove Cd(II) from aqueous solution. The results showed that the Cd(Ⅱ) adsorption better followed Freundlich model, and the maximum adsorption capacities were 109.0 mg/g (288 K), 127. Read More

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Hemostatic alterations linked to body fat distribution, fatty liver and insulin resistance.

Mol Metab 2021 May 31:101262. Epub 2021 May 31.

Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany.

Objective: Obesity, in particular visceral obesity, and insulin resistance emerged as major risk factors for severe Coronavirus Disease 2019 (COVID-19), which is strongly associated with hemostatic alterations. Since obesity and insulin resistance predispose to thrombotic diseases, we investigated the relationship between hemostatic alterations and body fat distribution in subjects at risk for type 2 diabetes.

Subjects And Methods: Body fat distribution (visceral and subcutaneous abdominal adipose tissue) and liver fat content of 150 subjects with impaired glucose tolerance and/or impaired fasting glucose was determined using magnetic resonance imaging and spectroscopy. Read More

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The role of loading in murine models of rotator cuff disease.

J Orthop Res 2021 Jun 3. Epub 2021 Jun 3.

Department of Orthopaedic Surgery, Columbia University Irving Medical Center, New York, New York, USA.

Rotator cuff disease pathogenesis is associated with intrinsic (e.g., age, joint laxity, muscle weakness) and extrinsic (e. Read More

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Factors Associated with Gender-Based Violence Perpetration by Male High School Students in Eastern Ethiopia.

J Interpers Violence 2021 Jun 2:8862605211021978. Epub 2021 Jun 2.

Centre For Women's Health Research, Faculty of Health and Medicine, University of Newcastle, Australia.

Gender-based violence (GBV) perpetration is a severe problem among youths in schools and the community at large. As most studies focused on adults, this study aimed to investigate factors associated with GBV by male high school students in eastern Ethiopia. An institutional based cross-sectional survey was conducted with 1,109 male students aged 15-24 years in eastern Ethiopia in December 2018 using self-administered WHO Multi-Country Study on Women's Health and Life Events and UN Multi-Country study on perpetration. Read More

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Acute T2*-Weighted Magnetic Resonance Imaging Detectable Cerebral Thrombosis in a Rat Model of Subarachnoid Hemorrhage.

Transl Stroke Res 2021 Jun 2. Epub 2021 Jun 2.

Department of Neurosurgery, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Subarachnoid hemorrhage (SAH) is associated with a high incidence of morbidity and mortality, particularly within the first 72 h after aneurysm rupture. We recently found ultra-early cerebral thrombosis, detectable on T2* magnetic resonance imaging (MRI), in a mouse SAH model at 4 h after onset. The current study examined whether such changes also occur in rat at 24 h after SAH, the vessels involved, whether the degree of thrombosis varied with SAH severity and brain injury, and if it differed between male and female rats. Read More

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Genetic diversity and effective population sizes of thirteen Indian cattle breeds.

Genet Sel Evol 2021 Jun 1;53(1):47. Epub 2021 Jun 1.

Centre for Genetic Analysis and Applications, School of Environmental and Rural Science, University of New England, Armidale, Australia.

Background: The genetic structure of a diverse set of 15 Indian indigenous breeds and non-descript indigenous cattle sampled from eight states was examined, based on 777 k single nucleotide polymorphism (SNP) genotypes obtained on 699 animals, with sample sizes ranging from 17 to 140 animals per breed. To date, this is the largest and most detailed assessment of the genetic diversity of Indian cattle breeds.

Results: Admixture analyses revealed that 109 of the indigenous animals analyzed had more than 1% Bos taurus admixture of relatively recent origin. Read More

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Implications of Argentine Tango for Health Promotion, Physical Well-Being as Well as Emotional, Personal and Social Life on a Group of Women Who Dance.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 41-200 Sosnowiec, Poland.

Background: The aim of the research was to determine the effect that dance has on the promotion of health, physical well-being, as well as the emotional, personal and social life of women who dance. In addition, the impact of the physical activity of long, often all-night dancing events on women's health was investigated. This included possible disturbances in their monthly cycle and circadian rhythm, taking into account symptoms of biological rhythm disturbances. Read More

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