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Optimizing the microstructure of a new machinable bioactive glass-ceramic.

J Mech Behav Biomed Mater 2021 Jul 13;122:104695. Epub 2021 Jul 13.

Vitreous Materials Laboratory, Materials Engineering Department, Federal University of São Carlos, São Carlos, SP, Brazil.

Objectives: This study aimed to optimize the crystallization process and the microstructure of a new bioactive glass-ceramic (GC) previously developed by our research group to obtain machinable glass-ceramics.

Methods: Differential scanning calorimetry (DSC) analyses were conducted to explore the characteristic temperatures and construct a semi-quantitative nucleation curve. The GC specimens were characterized by X-ray diffraction (XRD) and Rietveld refinement. Read More

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Remediation of contaminated dredged harbor sediments by combining hydrodynamic cavitation, hydrocyclone, and persulfate oxidation process.

J Hazard Mater 2021 Jul 6;420:126594. Epub 2021 Jul 6.

Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City, Taiwan. Electronic address:

A pilot-scale hybrid treatment system consisting of hydrodynamic cavitation (HC), hydrocyclone separator (HS), and sodium persulfate (PS), was employed for removing polycyclic aromatic hydrocarbons (PAHs) from dredged harbor sediments. The effectiveness of PAH degradation was studied by varying the inlet pressure (0-2.0 bar), PS dosage (or Σ[PAH] to [PS] mole ratio of 1:1-1:10) at HS inflow velocity of 2. Read More

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Resistin: A journey from metabolism to cancer.

Transl Oncol 2021 Jul 20;14(10):101178. Epub 2021 Jul 20.

National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune 411007, India. Electronic address:

Resistin, a small secretory molecule, has been implicated to play an important role in the development of insulin resistance under obese condition. For the past few decades, it has been linked to various cellular and metabolic functions. It has been associated with diseases like metabolic disorders, cardiovascular diseases and cancers. Read More

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Effect of eco-friendly pervious concrete with amorphous metallic fiber on evaporative cooling performance.

J Environ Manage 2021 Jul 20;297:113269. Epub 2021 Jul 20.

Department of Architecture and Architectural Engineering, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address:

Impervious pavements exist in large proportions in most cities owing to the high-impact development of the transportation infrastructure. However, this type of pavement causes environmental issues such as waterlogging, floods, and urban heat islands. Pervious concrete (PC), which is a novel pavement material characterized by a porous structure that allows water to percolate through it, is an important solution to these issues. Read More

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Vaginal temperature before calving assessed with wireless vaginal temperature sensor in dairy and beef cattle.

Theriogenology 2021 Jul 14;172:230-238. Epub 2021 Jul 14.

Kyushu Okinawa Agricultural Research Center, NARO, Kumamoto, Japan. Electronic address:

We evaluated the daily and hourly vaginal temperature changes and the relationships between the dams' breed and parity by using a commercially available vaginal temperature sensor in 72 Holstein (Hol) calvings and 101 Japanese Black (JB) calvings. Vaginal temperature sensors inserted 7-10 days before the expected calving day sounded two alerts: when the temperature fell below the threshold (Alert 1), and when the sensor reached the ambient temperature after falling out of the dam's vagina with the rupture of the allantoic sac (Alert 2). The durations from Alert 1 to Alert 2 (Time 1) and from Alert 2 to delivery (Time 2) were calculated. Read More

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The Impact of Incorporating Evidence-based Guidelines for Lumbar Fusion Surgery in Neurosurgical Resident Education.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery, Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania.

Background: Instrumented fusion procedures are essential in the treatment of degenerative lumbar spine disease to alleviate pain and improve neurologic function, but are being performed with increasing incidence and variability.

Objective: We implemented a training module for neurosurgery residents that is based on evidence-based criteria for lumbar fusion surgery and measured its effectiveness in the residents' decision making regarding whether patients should or should not undergo instrumented fusion.

Methods: The study design is a pretest versus posttest experiment conducted from September 2019 until July 2020 to measure improvement after formalized instruction on evidence-based guidelines. Read More

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Efficient biosynthesis of D-allulose in Bacillus subtilis through D-psicose 3-epimerase translation modification.

Int J Biol Macromol 2021 Jul 20;187:1-8. Epub 2021 Jul 20.

College of Light Industry and Food Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China; Sugar Industry Collaborative Innovation Center, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, China. Electronic address:

The combined catalysis of glucose isomerase (GI) and D-psicose 3-epimerase (DPEase) provided a convenient route for the direct synthesis of D-allulose from d-glucose, whose cost is lower than d-fructose. In the present research, the weak activity of DPEase was the key rate-limiting step and resulted in the accumulation of d-fructose in engineered Bacillus subtilis. Then, the 5'-untranslated region (5'-UTR) structure of the mRNA translational initiation region was optimized for the precise control of DPEase expression. Read More

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Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.

Chest 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, University of California, San Francisco, San Francisco, CA USA.

Background: Limited existing data suggest the novel coronavirus disease 2019 (Covid-19) may increase risk for venous thromboembolism (VTE) but information from large, ethnically diverse populations with appropriate controls are lacking.

Research Question: Does the rate of VTE among adults hospitalized with Covid-19 differ from matched hospitalized controls without Covid-19?

Study Design And Methods: We conducted a retrospective study among hospitalized adults with laboratory-confirmed Covid-19 and hospitalized adults without evidence of Covid-19 matched on age, gender, race/ethnicity, acute illness severity, and month of hospitalization between February-August 2020 from two integrated healthcare delivery systems with 36 hospitals. Outcomes included VTE (deep venous thrombosis or pulmonary embolism ascertained using diagnosis codes combined with validated natural language processing algorithms applied to electronic health records) and death from any cause at 30 days. Read More

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Does Variceal Drainage Affect Arteriovenous Malformation Obliteration and Hemorrhage Rates After Stereotactic Radiosurgery? A Case-Matched Analysis.

Neurosurgery 2021 Jul 22. Epub 2021 Jul 22.

Department of Neurological Surgery and Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background: Stereotactic radiosurgery (SRS) is widely accepted as a minimally invasive alternative to surgery in the management of arteriovenous malformations (AVMs). Dilated AVM outflow veins or varices may be caused by high-flow or partial outflow obstruction, which may increase the risk of a hemorrhage before or after SRS.

Objective: To compare the obliteration and hemorrhage risks in patients with and without AVM varices (AVMv). Read More

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Global cognitive performance at 4-year follow-up in individuals with atrial fibrillation-findings from The Irish Longitudinal Study on Ageing.

Age Ageing 2021 Jul 21. Epub 2021 Jul 21.

The Irish Longitudinal Study on Ageing, Trinity College, Dublin, Ireland.

Introduction: Atrial fibrillation (AF) has been proposed as a risk factor for cognitive impairment, even in the absence of a history of stroke. This study investigates whether AF is associated with increased risk of cognitive decline in a community-dwelling population of adults over the age of 50.

Methods: Data from the 1st and 3rd waves of The Irish Longitudinal Study on Ageing (TILDA) were used (4-year follow-up period). Read More

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Aiming for a bull's-eye: Targeting antifungals to fungi with dectin-decorated liposomes.

PLoS Pathog 2021 Jul 22;17(7):e1009699. Epub 2021 Jul 22.

Department of Microbiology, University of Georgia, Athens, Georgia, United States of America.

Globally, there are several million individuals with life-threatening invasive fungal diseases such as candidiasis, aspergillosis, cryptococcosis, Pneumocystis pneumonia (PCP), and mucormycosis. The mortality rate for these diseases generally exceeds 40%. Annual medical costs to treat these invasive fungal diseases in the United States exceed several billion dollars. Read More

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Spatio-temporal modelling for the evaluation of an altered Indian saline Ramsar site and its drivers for ecosystem management and restoration.

PLoS One 2021 22;16(7):e0248543. Epub 2021 Jul 22.

Department of Environmental Science, School of Earth Sciences, Central University of Rajasthan, Bandarsindri, Ajmer, Rajasthan, India.

Saline lakes occupy 44% and 23% of the volume and area of all lakes that are tending to suffer from extended dryness, reduced hydro period, or complete desiccation by 2025. The current study is conducted on Sambhar Salt Lake, the largest inland saline Ramsar, site of India, contributing to 9.86% of total salt production. Read More

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Factors associated with mortality in patients hospitalized with COVID-19: A prospective cohort in a Peruvian national referral hospital.

Medwave 2021 Jul 5;21(6):e8231. Epub 2021 Jul 5.

Escuela de Medicina, Universidad Científica del Sur, Lima, Perú. ORCID: 0000-0001-6386-6643.

Objectives: To describe and assess clinical characteristics and factors associated with mortality in adult patients with COVID-19 admitted to a national referral hospital in Peru.

Methods: We conducted a prospective cohort study that included hospitalized patients older than 18 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis. Patients with a positive rapid serological test on admission but no respiratory symptoms nor compatible images were excluded. Read More

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Online Search Trends Influencing Anti-Coagulation in COVID-19: An Observational Study.

JMIR Form Res 2021 Apr 11. Epub 2021 Apr 11.

Department of Infectious Diseases, Beaumont Hospital, Beaumont Road, Dublin, IE.

Background: Background: Early evidence of Coronavirus Disease (COVID-19) associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The rapid online spread of case reports was followed by online interim guidelines, discussions and worldwide online searches for further information. The impact of the global online search trends and online discussion on local approach to coagulopathy in COVID-19 patients has not been studied. Read More

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Changes in Burnout Among Oncology Physician Assistants Between 2015 and 2019.

JCO Oncol Pract 2021 Jul 22:OP2100051. Epub 2021 Jul 22.

Fox Chase Cancer Center, Philadelphia, PA.

Purpose: Burnout has significant implications for the individual provider, the oncology workforce, and the quality of care for patients with cancer. The primary aim of this study was to explore temporal changes in burnout among physician assistants (PAs) in oncology in 2019 compared with 2015.

Methods: Oncology PAs were surveyed to assess for burnout using the Maslach Burnout Inventory according to the same cross-sectional design of the study performed in 2015. Read More

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Elucidating the Role of Halides and Iron during Radiolysis-Driven Oxidative Etching of Gold Nanocrystals Using Liquid Cell Transmission Electron Microscopy and Pulse Radiolysis.

J Am Chem Soc 2021 Jul 22. Epub 2021 Jul 22.

Department of Chemistry, University of California-Berkeley, Berkeley, California 94720, United States.

Graphene liquid cell transmission electron microscopy (TEM) has enabled the observation of a variety of nanoscale transformations. Yet understanding the chemistry of the liquid cell solution and its impact on the observed transformations remains an important step toward translating insights from liquid cell TEM to benchtop chemistry. Gold nanocrystal etching can be used as a model system to probe the reactivity of the solution. Read More

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Changes in neural drive to calf muscles during steady submaximal contractions after repeated static stretches.

J Physiol 2021 Jul 22. Epub 2021 Jul 22.

Department of Integrative Physiology, University of Colorado, Boulder, CO, United States.

Key Points: Repeated static-stretching interventions consistently increase the range of motion about a joint and decrease total joint stiffness, but findings on the changes in muscle and connective-tissue properties are mixed. The influence of these stretch-induced changes on muscle function at submaximal forces is unknown. To address this gap in knowledge, we estimated the changes in neural drive to the plantar flexor muscles after a static-stretch intervention. Read More

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Patterns of psychiatric admission in Australian pregnant and childbearing women.

Soc Psychiatry Psychiatr Epidemiol 2021 Jul 22. Epub 2021 Jul 22.

Neuropsychiatric Epidemiology Research Unit, School of Population and Global Health, University of Western Australia, Nedlands, Australia.

Purpose: The early postnatal period is a time of increased risk for psychiatric admission. However, there is scope to further examine if this increase in risk extends to the entire perinatal period (pregnancy and first postnatal year), and how it compares to admission outside of the perinatal period.

Methods: Data were linked across birth and hospital admission registers from July 2000 to December 2009. Read More

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High anti-TNFα Concentrations are Not Associated With More Adverse Events in Pediatric Inflammatory Bowel Disease.

J Pediatr Gastroenterol Nutr 2021 Jul 20. Epub 2021 Jul 20.

The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Israel The institute of Gastroenterology, Nutrition and Liver diseases, Schneider Children's Hospital, Petach-Tikva, Israel The Ben-Gurion University of the Negev, Beer Sheva, Israel.

Abstract: Anti-tumor necrosis factor alpha (anti-TNFα) therapy is commonly used to treat refractory pediatric inflammatory bowel disease (IBD) and carry risks for adverse events. We aimed to assess the relationship between anti-TNFα trough concentrations (TC) and adverse events rate among pediatric patients with IBD. The medical records of pediatric patients with IBD who were treated with anti-TNFα agents from 2015 to 2020 and had sequential monitoring of TC were reviewed retrospectively for the presence of adverse events. Read More

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Efficacy and Cost-effectiveness of Promotion Methods to Recruit Participants to an Online Screening Registry for Alzheimer Disease Prevention Trials: Observational Study.

J Med Internet Res 2021 Jul 22;23(7):e26284. Epub 2021 Jul 22.

Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Web-based screening may be suitable for identifying individuals with presymptomatic latent diseases for recruitment to clinical studies, as such people do not often visit hospitals in the presymptomatic stage. The promotion of such online screening studies is critical to their success, although it remains uncertain how the effectiveness of such promotion can differ, depending on the different promotion methods, domains of interest, or countries of implementation.

Objective: The Japanese Trial-Ready Cohort (J-TRC) web study is our ongoing online screening registry to identify individuals with presymptomatic Alzheimer disease (AD), aimed at facilitating the clinical trials for AD prevention. Read More

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Comparative Study of Physicochemical Properties and Biocompatibility (L929 and MG63 Cells) of TiN Coatings Obtained by Plasma Nitriding and Thin Film Deposition.

ACS Biomater Sci Eng 2021 Jul 22. Epub 2021 Jul 22.

Graduate Program in Materials Science and Engineering (PPGMAT), University of Caxias do Sul (UCS), Francisco Getúlio Vargas 1130, Caxias do Sul, Rio Grande do Sul 95070-560 Brazil.

Ti6Al4V is one of the most lightweight, mechanically resistant, and appropriate for biologically induced corrosion alloys. However, surface properties often must be tuned for fitting into biomedical applications, and therefore, surface modification is of paramount importance to carry on its use. This work compares the interaction between two different cell lines (L929 fibroblasts and osteoblast-like MG63) and medical grade Ti6Al4V after surface modification by plasma nitriding or thin film deposition. Read More

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Energetics and optimal molecular packing for singlet fission in BN-doped perylenes: electronic adiabatic state basis screening.

Phys Chem Chem Phys 2021 Jul 22. Epub 2021 Jul 22.

Center for Nanosystems Chemistry, Julius-Maximilians-Universität Würzburg, Am Hubland, 97070, Würzburg, Germany.

Singlet fission has the potential to increase the efficiency of photovoltaic devices, but the design of suitable chromophores is notoriously difficult. Both the electronic properties of the monomer and the packing motif in the crystal have a big impact on the singlet fission efficiency. Using perylene as an example, it is shown that doping with boron and nitrogen not only helps to align the energy levels but also shifts the stacking position that is optimal for singlet fission. Read More

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A one-week internal medicine procedure rotation designed to increase procedural opportunities and competency.

Hosp Pract (1995) 2021 Jul 22. Epub 2021 Jul 22.

Division of Hospital Medicine, Department of Medicine, Oregon Health & Science University, Portland, Oregon.

Background: Mounting literature describes increased procedure volume and improvement in procedural skills following implementation of procedural curricula and standardized rotations, generally requiring at least two weeks and incorporating dedicated lecture and didactic efforts. It is unknown whether shorter rotations that feature self-directed curricula can achieve similar outcomes.

Methods: Housestaff participated in a one-week procedure rotation that coincided with pre-existing non-clinical blocks ("jeopardy"). Read More

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Enhancing the Magnetic Anisotropy in Low-Symmetry Dy-Based Complexes by Tuning the Bond Length.

Inorg Chem 2021 Jul 22. Epub 2021 Jul 22.

Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, PR China.

One mononuclear complex [Dy(Htpy)(NO)(acac)] () and a tpy-extended 1D chain {[Dy(CHOH)(NO)(tpy)]·CHOH} () (Htpy = 4'-(4-hydroxyphenyl)-2,2':6',2''-terpyridine, Hacac = acetylacetone) were successfully designed to investigate the effect of bond length tuning around the Dy cation on the magnetic dynamics of single-molecule magnets (SMMs). Interestingly, two magnetic entities possess the same local coordination sphere (NO-donor) as well as the configuration (Muffin, ) of dysprosium centers. Only a slight difference in structure results from purposefully substituting the acetylacetone ligand in with hydroxyl oxygen from tpy linkage and one methanol molecule in . Read More

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Probing Cerebral Metabolism with Hyperpolarized C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound.

ACS Chem Neurosci 2021 Jul 22. Epub 2021 Jul 22.

Advanced Imaging Research Center, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.

Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the BBB can be applied to promote the local delivery of hyperpolarized substrates. In this study, we investigated the effects of FUS on imaging brain metabolism using two hyperpolarized C-labeled substrates in rodents: [1-C]pyruvate and [1-C]glycerate. Read More

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Nurses competence in the reporting of medication-related incidents: An intervention study.

Nurs Open 2021 Jul 22. Epub 2021 Jul 22.

School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Objectives: Less than 5% of all harmful medicine-related incidents (MIs) or adverse drug reactions received by the Spanish Pharmacovigilance system are notified by Registered Nurses (RNs). The main objective of this study was to determine the impact of a multifaceted institutional intervention (MII) in patient safety on the reporting competence of medication incidents of hospital RNs.

Design: One-group pre-test-posttest design. Read More

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The Effect of Nixtamalization Extrusion Process and Tortillas Making on the Stability of Anthocyanins from Blue Corn through the Kinetic and Thermodynamic Parameters.

Plant Foods Hum Nutr 2021 Jul 22. Epub 2021 Jul 22.

Departamento de Biotecnología y Ciencias Alimentarias, Instituto Tecnológico de Sonora (ITSON), Sonora, 85000, Cd. Obregón, México.

The blue corn-based products are considered functional foods due to their high concentration of anthocyanins. The aim of this study was to estimate the kinetic and thermodynamic parameters of the thermal degradation of anthocyanins from extruded nixtamalized corn products. A comparative study of anthocyanins thermal stability in these matrices in a buffer solution (pH 2. Read More

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Theoretical investigations on mechanisms and kinetics of methylketene with O(P) reaction in the atmosphere.

J Mol Model 2021 Jul 21;27(8):228. Epub 2021 Jul 21.

Key Laboratory of Photoinduced Functional Materials, Mianyang Normal University, Mianyang, 621000, People's Republic of China.

The O(P)-initiated conversion mechanism and dynamics of CHCHCO were researched in atmosphere by executing density functional theory (DFT) computations. Optimizations of all the species and single-point energy computations were implemented at the B3LYP/6-311++G(d,p) and CCSD(T)/cc-pVTZ level, respectively. The explicit oxidation mechanism was introduced and discussed. Read More

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Enhanced photocatalytic activity, transport properties and electronic structure of Mn doped GdFeO synthesized using the sol-gel process.

Phys Chem Chem Phys 2021 Jul 22. Epub 2021 Jul 22.

Department of Physics, Bose Institute, 93/1, Acharya Prafulla Chandra Road, Kolkata 700 009, India.

In this work we have synthesized Mn doped GdFeO3 nano-particles using a green and facile sol gel method and studied their photocatalytic, optical, vibrational and electrical properties. The Rietveld refinement of the XRD profiles suggests that all the materials have an orthorhombic Pbnm crystal structure. The transmission electron microscope (TEM) images show the decrease of the average particle size from 140 to 80 nm with the Mn concentration. Read More

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Analyzing the Proliferation of Social Media Use Among Orthopaedic Surgery Residency Programs.

JB JS Open Access 2021 Jul-Sep;6(3). Epub 2021 Jul 19.

Department of Orthopaedics, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

Social media can influence how students and residents learn about and select graduate medical education programs. COVID-19-related travel restrictions forced residencies to adapt their recruitment strategies. The objective of our investigation was to characterize the prevalence of social media use by orthopaedic surgery residency programs and to examine any change over time before the COVID-19 pandemic and leading up to the 2020 to 2021 virtual interview season. Read More

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