6,915 results match your criteria increase ogtt

Plasma glycated CD59 predicts postpartum glucose intolerance after gestational diabetes.

Eur J Endocrinol 2021 Sep 1. Epub 2021 Sep 1.

J Halperin, Divisions of Hematology, Bringham and Women's Hospital, Harvard Medical School, Boston, United States.

Aims: To assess whether in women with gestational diabetes mellitus (GDM), postpartum plasma glycated CD59 (pGCD59) levels predict conversion to glucose intolerance diagnosed with an oral glucose tolerance test (OGTT).

Methods: Blood levels of pGCD59 were measured in a case-control study of 105 women with GDM who underwent a 75g OGTT three months postpartum. The 35 postpartum glucose intolerant cases were individually matched for age, BMI, ethnic origin and parity with 70 women with GDM but normal postpartum OGTT (controls). Read More

View Article and Full-Text PDF
September 2021

Could consumption of yam () or its extract be beneficial in controlling glycaemia - A Systematic Review.

Br J Nutr 2021 Sep 15:1-32. Epub 2021 Sep 15.

Division of Food, Nutrition and Dietetics, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, LE12 5RD.

Yam (Dioscorea spp.) and its associated extracts have been shown to possess a variety of biological activities and identified as beneficial in the control of glycaemia in patients with Type II Diabetes Mellitus (T2DM). The objective was to conduct a systematic search of the literature to investigate whether yam and its extract can improve glycaemia and whether consumption of yam could be beneficial for managing T2DM. Read More

View Article and Full-Text PDF
September 2021

Supplemental Watermelon Juice Attenuates Acute Hyperglycemia-Induced Macro-and Microvascular Dysfunction in Healthy Adults.

J Nutr 2021 Sep 11. Epub 2021 Sep 11.

Pennington Biomedical Research Center, Vascular Metabolism Laboratory, Baton Rouge, LA, USA.

Background: Acute hyperglycemia reduces NO bioavailability and causes macro- and microvascular dysfunction. Watermelon juice (WMJ) is a natural source of the amino acid citrulline, which is metabolized to form arginine for the NO cycle and may improve vascular function.

Objectives: We examined the effects of 2 weeks of WMJ compared to a calorie-matched placebo (PLA) to attenuate acute hyperglycemia-induced vascular dysfunction. Read More

View Article and Full-Text PDF
September 2021

Effect of CAX1a TILLING mutations on photosynthesis performance in salt-stressed Brassica rapa plants.

Plant Sci 2021 Oct 4;311:111013. Epub 2021 Aug 4.

Department of Plant Physiology, Faculty of Sciences, University of Granada, 18071, Granada, Spain. Electronic address:

Salinity is an important environmental factor that reduces plant productivity in many world regions. It affects negatively photosynthesis causing a growth reduction. Likewise, calcium (Ca) is crucial in plant stress response. Read More

View Article and Full-Text PDF
October 2021

Plasma lipidomics in early pregnancy and risk of gestational diabetes mellitus: a prospective nested case-control study in Chinese women.

Am J Clin Nutr 2021 Sep 3. Epub 2021 Sep 3.

Department of Epidemiology & Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Lipid metabolism plays an important role in the pathogenesis of diabetes. There is little evidence regarding the prospective association of the maternal lipidome with gestational diabetes mellitus (GDM), especially in Chinese populations.

Objectives: We aimed to identify novel lipid species associated with GDM risk in Chinese women, and assess the incremental predictive capacity of the lipids for GDM. Read More

View Article and Full-Text PDF
September 2021

Continuous Glucose Monitoring in Women with Normal OGTT in Pregnancy.

J Diabetes Res 2021 23;2021:9987646. Epub 2021 Aug 23.

Department of Obstetrics and Gynecology, Catholic University of Sacred Heart, Fondazione Polclinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Continuous glucose monitoring (CGM) might be an effective tool to improve glycemic control in gestational diabetes mellitus (GDM). Few data are available about its utilization as a diagnostic tool to find potential alterations of glycemia in subjects with normal oral glucose tolerance test (OGTT). In this preliminary prospective real-life observational study, we aimed to analyze the glycemic pattern in normal and gestational diabetes mellitus (GDM) women by continuous glucose monitoring (CGM) in order to detect potential differences between the two groups and glycemic alterations despite a normal OGTT. Read More

View Article and Full-Text PDF

A reminder system for postpartum diabetes screening after gestational diabetes: a randomized clinical trial.

J Matern Fetal Neonatal Med 2021 Sep 1:1-5. Epub 2021 Sep 1.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Objective: To evaluate if a reminder postpartum screening system, providing patients with laboratory requisition on the postpartum ward followed by a telephone reminder one week prior to their 6 weeks appointment, would increase the diabetes mellitus screening rate.

Methods: Parallel group, open label, multicenter randomized trial. Patients were recruited between July 2015 and March 2016. Read More

View Article and Full-Text PDF
September 2021

Functional Status of Pancreatic and Cells in Type 2 Diabetes Mellitus Patients with Different Plasma Triglyceride Levels: A Retrospective Analysis.

Int J Endocrinol 2021 17;2021:9976067. Epub 2021 Aug 17.

NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Objective: To investigate the functional status of pancreatic and cells in Type 2 diabetes mellitus (T2DM) patients with different plasma triglyceride (TG) levels. TG levels can be prognostic markers for T2DM.

Methods: A total of 328 patients with T2DM were divided into three groups according to different TG levels: the TGL group: TG < 1. Read More

View Article and Full-Text PDF

Aldehyde Dehydrogenase Mutation Exacerbated High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease with Gut Microbiota Remodeling in Male Mice.

Biology (Basel) 2021 Aug 1;10(8). Epub 2021 Aug 1.

National Laboratory Animal Center, National Applied Research Laboratories, Taipei 115, Taiwan.

Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a critical enzyme involved in ethanol clearance in acetaldehyde metabolism and plays a key role in protecting the liver. The ALDH2*2 mutation causes a significant decrease in acetaldehyde scavenging capacity, leading to the accumulation of acetaldehyde after consuming alcohol. The prevalence of the ALDH2*2 variant is in 45% of Taiwanese individuals. Read More

View Article and Full-Text PDF

Statins Are Associated With Increased Insulin Resistance and Secretion.

Arterioscler Thromb Vasc Biol 2021 Aug 26:ATVBAHA121316159. Epub 2021 Aug 26.

Division of Cardiovascular Medicine, Stanford University, CA. (F. Abbasi, C.L., C.S.H., V.H., P.T., F. Abbas, G.R., J.W.K.).

Objective: Statin treatment reduces the risk of atherosclerotic cardiovascular disease but is associated with a modest increased risk of type 2 diabetes, especially in those with insulin resistance or prediabetes. Our objective was to determine the physiological mechanism for the increased type 2 diabetes risk. Approach and Results: We conducted an open-label clinical trial of atorvastatin 40 mg daily in adults without known atherosclerotic cardiovascular disease or type 2 diabetes at baseline. Read More

View Article and Full-Text PDF

Maternal Sleep and Related Pregnancy Outcomes: A Multicenter Cross-Sectional Study in 11 Provinces of Iran.

J Family Reprod Health 2021 Mar;15(1):53-60

Infectious Diseases Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Sleep disturbance during pregnancy is one of the most common maternal complaints. Not only does it play a crucial role in a mother's life, but also it comes with a multitude number of complications. This study aimed at assessing the association between sleep disturbance in pregnancy and maternal and child outcomes. Read More

View Article and Full-Text PDF

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.

Diabetologia 2021 Aug 21. Epub 2021 Aug 21.

Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand.

Aims/hypothesis: The minor A allele of rs373863828 (CREBRF p.Arg457Gln) is associated with increased BMI, but reduced risk of type 2 and gestational diabetes in Polynesian (Pacific peoples and Aotearoa New Zealand Māori) populations. This study investigates the effect of the A allele on insulin release and sensitivity in overweight/obese men without diabetes. Read More

View Article and Full-Text PDF

PM exposure and maternal glucose metabolism in early pregnancy: Associations and potential mediation of 25-hydroxyvitamin D.

Ecotoxicol Environ Saf 2021 Aug 17;224:112645. Epub 2021 Aug 17.

Global Health Institute, Fudan University, Shanghai 200032, China; Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:

Gestational diabetes mellitus (GDM) has become a new global epidemic with a rapidly increasing prevalence. Previous studies have suggested that air pollution is associated with GDM risk, but the results are inconsistent, and mechanistic studies are limited. Based on a hospital-based cohort, a total of 6374 participants were included in this study. Read More

View Article and Full-Text PDF

Associations Between Glucose Tolerance, Insulin Secretion, Muscle and Fat Mass in Cystic Fibrosis.

Clin Med Insights Endocrinol Diabetes 2021 13;14:11795514211038259. Epub 2021 Aug 13.

Cystic Fibrosis Centre Copenhagen, Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Background: A frequent comorbidity in cystic fibrosis (CF) is CF related diabetes (CFRD) caused by a gradual decline in insulin secretion. The reduction in the anabolic hormone, insulin, might explain the weight loss that precedes onset of CFRD. We investigated the association between muscle and fat mass in relation to glucose tolerance and insulin function. Read More

View Article and Full-Text PDF

Hypoglycemic effect of insulin-loaded hydrogel-nanogel composite on streptozotocin-induced diabetic rats.

Pharmazie 2021 Aug;76(8):364-371

Department of Endocrinology, Baoding NO.1 Central Hospital, Baoding, Hebei, China;, Email:

At present, how to increase insulin rapidly, availably and stably is still a conundrum in the treatment of diabetes mellitus. studies have shown that insulin can be released from hydrogel-nanogel composite according to the changes of glucose level. This study aimed to observe the glucose-lowering effects and evaluate the safety of the insulin-loaded hydrogel-nanogel composite in diabetic rats. Read More

View Article and Full-Text PDF

Carnitine Orotate Complex Ameliorates Insulin Resistance and Hepatic Steatosis Through Carnitine Acetyltransferase Pathway.

Diabetes Metab J 2021 Aug 19. Epub 2021 Aug 19.

Division of Endocrinology & Metabolism, Department of Internal Medicine, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu, Korea.

Background: Carnitine orotate complex (Godex) has been shown to decrease glycated hemoglobin levels and improve steatosis in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease. However, the mechanisms of Godex in glucose metabolism remain unclear.

Methods: Male C57BL/6J mice were divided into four groups: normal-fat diet, high-fat diet, a high-fat diet supplemented with intraperitoneal injection of (500 mg or 2,000 mg/kg/day) Godex for 8 weeks. Read More

View Article and Full-Text PDF

Effects of neuromuscular electrical stimulation on energy expenditure and postprandial metabolism in healthy men.

Appl Physiol Nutr Metab 2021 Aug 17. Epub 2021 Aug 17.

University of Bath, Centre for Nutrition, Exercise & Metabolism, Department for Health, Bath, Somerset, United Kingdom of Great Britain and Northern Ireland;

It is unclear whether NeuroMuscular Electrical Stimulation (NMES) has meaningful metabolic effects when users have the opportunity to self-select the intensity to one that can be comfortably tolerated. Nine healthy men aged 28 ± 9 y (mean ± SD) with a body mass index 22.3 ± 2. Read More

View Article and Full-Text PDF

Thirty days of combined consumption of a high-fat diet and fructose-rich beverages promotes insulin resistance and modulates inflammatory response and histomorphometry parameters of liver, pancreas, and adipose tissue in Wistar rats.

Nutrition 2021 Jun 30;91-92:111403. Epub 2021 Jun 30.

The Federal University of Minas Gerais, Department of Physical Education, Exercise Physiology Laboratory, Belo Horizonte, Brazil. Electronic address:

Objective: The aim of this study was to verify the effects of consumption of a high-fat diet (HFD) combined with fructose-rich beverages (FRT) in promoting metabolic and physiologic changes associated with insulin resistance.

Methods: Thirty-two male Wistar rats (250 ± 10 g) were randomly allocated into four groups (n = 8) that received either a standard diet (CON), HFD, FRT, or HFD + FRT for 30 d. Insulin sensitivity and glucose tolerance were evaluated using the insulin tolerance test (ITT) and oral glucose tolerance test (OGTT). Read More

View Article and Full-Text PDF

Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats.

Brain Behav Immun 2021 Aug 11;98:86-100. Epub 2021 Aug 11.

Women's Health in Neuroscience Program, and Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University, Bryan, TX 77807, USA. Electronic address:

Prenatal alcohol exposure (PAE) can result in neurobehavioral anomalies, that may be exacerbated by co-occurring metabolic and immune system deficits. To test the hypothesis that the peripheral inflammation in adult PAE offspring is linked to poor glucose metabolism and neurocognitive deficits, pregnant Sprague-Dawley rats were exposed to ethanol vapor or ambient air during the latter half of gestation. We assessed, in adult offspring of both sexes, performance on a battery of neurocognitive behaviors, glucose tolerance, circulating and splenic immune cells by flow-cytometry, and circulating and tissue (liver, mesenteric adipose, and spleen) cytokines by multiplexed assays. Read More

View Article and Full-Text PDF

Fatty liver index as a predictor for type 2 diabetes in subjects with normoglycemia in a nationwide cohort study.

Sci Rep 2021 Aug 12;11(1):16453. Epub 2021 Aug 12.

Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.

Our aim was to evaluate whether fatty liver index (FLI) is associated with the risk of type 2 diabetes (T2DM) development within the Spanish adult population and according to their prediabetes status; additionally, to examine its incremental predictive value regarding traditional risk factors. A total of 2260 subjects (Prediabetes: 641 subjects, normoglycemia: 1619 subjects) from the [email protected] cohort study were studied. Read More

View Article and Full-Text PDF

Metformin Increases Protein Phosphatase 2A Activity in Primary Human Skeletal Muscle Cells Derived from Lean Healthy Participants.

J Diabetes Res 2021 28;2021:9979234. Epub 2021 Jul 28.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

Objective: To investigate if PP2A plays a role in metformin-induced insulin sensitivity improvement in human skeletal muscle cells. . Eight lean insulin-sensitive nondiabetic participants (4 females and 4 males; age: 21. Read More

View Article and Full-Text PDF

Intestinal-derived FGF15 protects against deleterious effects of vertical sleeve gastrectomy in mice.

Nat Commun 2021 08 6;12(1):4768. Epub 2021 Aug 6.

Department of Surgery, University of Michigan, Ann Arbor, MI, USA.

Bariatric surgeries such as the Vertical Sleeve Gastrectomy (VSG) are invasive but provide the most effective improvements in obesity and Type 2 diabetes. We hypothesized a potential role for the gut hormone Fibroblast-Growth Factor 15/19 which is increased after VSG and pharmacologically can improve energy homeostasis and glucose handling. We generated intestinal-specific FGF15 knockout (FGF15) mice which were maintained on high-fat diet. Read More

View Article and Full-Text PDF

Mechanisms and Effect of Coptidis Rhizoma on Obesity-Induced Inflammation: In Silico and In Vivo Approaches.

Int J Mol Sci 2021 Jul 28;22(15). Epub 2021 Jul 28.

Department of Clinical Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.

Obesity is characterized as a chronic, low-grade inflammation state accompanied by the infiltration of immune cells into adipose tissue and higher levels of inflammatory cytokines and chemokines. This study aimed to investigate the mechanisms and effects of Coptidis Rhizoma (CR) on obesity and its associated inflammation. First, we applied a network pharmacology strategy to search the target genes and pathways regulated by CR in obesity. Read More

View Article and Full-Text PDF

Insulin Secretion Predicts the Response to Antidiabetic Therapy in Patients With New Onset Diabetes.

J Clin Endocrinol Metab 2021 Aug 3. Epub 2021 Aug 3.

Division of Diabetes, University of Texas Health Science Center and Texas Diabetes Institute, San Antonio, TX.

Aim: To identify predictors for individualization of antidiabetic therapy in patients with new onset T2DM.

Research Design And Methods: 261 drug naïve participants in the EDICT study, with new onset diabetes, were randomized in a single-center study to receive: (1) metformin followed by glipizide and then insulin glargine upon failure to achieve HbA1c <6.5%, or (2) initial triple therapy with metformin/pioglitazone/ exenatide. Read More

View Article and Full-Text PDF

Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor.

Intern Med 2021 1;60(15):2375-2383. Epub 2021 Aug 1.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

Objective Glucose-dependent insulinotropic polypeptide (GIP) is speculated to worsen growth hormone (GH) hypersecretion in acromegaly and to be a cause of paradoxical increases in GH (PI-GH) during 75-g oral glucose tolerance testing (75-g OGTT). Dipeptidyl peptidase-4 inhibitors (DPP4is), which increase the circulating concentration of active GIP, are frequently administered to diabetic patients, including those with acromegaly. We aimed to determine whether or not the administration of a DPP4i increases GH concentration, especially in patients demonstrating PI-GH during a DPP4i-OGTT, in which a DPP4i was administered immediately before 75-g OGTT. Read More

View Article and Full-Text PDF

Serum Tsukushi levels are elevated in newly diagnosed type 2 diabetic patients.

Diabetes Res Clin Pract 2021 Aug 27;178:108987. Epub 2021 Jul 27.

Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. Electronic address:

Aims: Tsukushi, a newly identified hepatokine, has been recently characterized as a potent modifier in lipid metabolism and energy homeostasis, but the role of Tsukushi in diabetes remains almost unknown. We detected for the first time the serum Tsukushi levels in newly diagnosed type 2 diabetes, exploring the relationship between Tsukushi and various metabolic parameters.

Methods: A total of 172 participants were recruited, including 86 patients with newly diagnosed type 2 diabetes and 86 subjects with normal glucose tolerance according to oral glucose tolerance test. Read More

View Article and Full-Text PDF

Chronic Sildenafil Therapy in the ZSF1 Obese Rat Model of Metabolic Syndrome and Heart Failure With Preserved Ejection Fraction.

J Cardiovasc Pharmacol Ther 2021 Jul 30:10742484211034253. Epub 2021 Jul 30.

Department of Surgery and Physiology, Faculty of Medicine, 26705University of Porto, Porto, Portugal.

Although decreased protein kinase G (PKG) activity was proposed as potential therapeutic target in heart failure with preserved ejection fraction (HFpEF), randomized clinical trials (RCTs) with type-5 phosphodiesterase inhibitors (PDE5i) showed neutral results. Whether specific subgroups of HFpEF patients may benefit from PDE5i remains to be defined. Our aim was to test chronic sildenafil therapy in the young male ZSF1 obese rat model of HFpEF with severe hypertension and metabolic syndrome. Read More

View Article and Full-Text PDF

The screening performance of glucose challenge test for gestational diabetes in twin pregnancies: a systematic review and meta-analysis.

J Matern Fetal Neonatal Med 2021 Jul 29:1-11. Epub 2021 Jul 29.

Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.

Background: The screening accuracy of the 50 g-glucose challenge test (50 g-GCT) for gestational diabetes (GDM) has been described in singleton pregnancies. Given the physiologic differences and greater increase in insulin resistance in twin compared with singleton pregnancies, the performance of the 50 g-GCT in twin pregnancies may differ.

Objectives: To perform a systematic review on the screening performance of the 50 g-GCT for gestational diabetes in twin pregnancies. Read More

View Article and Full-Text PDF

SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans.

Diabetes 2021 Jul 28. Epub 2021 Jul 28.

SCOHIA PHARMA Inc., Kanagawa, Japan

SCO-267 is a full agonist of the free fatty acid receptor 1 (GPR40), which regulates the secretion of islet and gut hormones. In this phase 1 study, we aimed to evaluate the clinical profile of single and multiple once-daily oral administration of SCO-267 in healthy adults and patients with diabetes. Plasma SCO-267 concentration was seen to increase in a dose-dependent manner after administration, and its plasma exposure was maintained for 24 h. Read More

View Article and Full-Text PDF

Impact of Low Frequency Electro-acupuncture on Glucose and Lipid Metabolism in Unmarried PCOS Women: A Randomized Controlled Trial.

Chin J Integr Med 2021 Jul 28. Epub 2021 Jul 28.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.

Objective: To explore the effect of electro-acupuncture (EA) on glucose and lipid metabolism in unmarried patients with polycystic ovary syndrome (PCOS).

Methods: Fifty-four PCOS patients were equally randomized into true acupuncture group and sham acupuncture group (control) for totally 16 weeks of treatment by random method with a computerized randomization program. Patients in true acupuncture group accepted traditional acupuncture methods with EA and two sets of acupoint groups were used alternatively. Read More

View Article and Full-Text PDF