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Botulinum toxin A promotes the transdifferentiation of primary keloid myofibroblasts into adipocyte-like cells.

Authors:
Xing Dai Tiechi Lei

Basic Clin Pharmacol Toxicol 2021 Sep 27. Epub 2021 Sep 27.

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.

Keloid is a type of unusually raised scar. Botulinum toxin A (BTX-A) has a great application potential in keloids treatment. Here, we investigated the functional role of BTX-A in keloids. Read More

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September 2021

Infliximab use in the Netherlands: Uptake and characteristics of originator and biosimilars over time.

Br J Clin Pharmacol 2021 Sep 27. Epub 2021 Sep 27.

PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.

Aims: The objective of this retrospective cohort study was to provide an overview of the utilization of originator and biosimilar infliximab in the Netherlands.

Methods: All infliximab dispensings were selected from the PHARMO In-patient Pharmacy Database from 2002-2018. Descriptive analyses were performed in order to characterise initiators and to describe switching patterns over time. Read More

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September 2021

ethanol crude extract from sequential maceration induces lipid accumulation and inflammatory suppression in RAW264.7 macrophages.

Food Funct 2021 Sep 27. Epub 2021 Sep 27.

Department of Transfusion Medicine and Clinical Microbiology, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.

(AP), an edible mushroom, is continuously being studied due to the medicinal properties. In this study, AP crude extracts from three sequential extraction, starting from hexane (APH), ethanol (APE) and water (APW), were examined for their anti-inflammatory activity and lipid accumulation property in macrophages. APE treatment was found to increase lipid droplet accumulation in both RAW264. Read More

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September 2021

Real-Time Computer-Aided Detection for colorectal neoplasia or only small polyps?

JMIR Med Inform 2021 Sep 23. Epub 2021 Sep 23.

University Hospitals of North Midlands NHS Trust, Newcastle Road, Stoke on Trent, GB.

Unstructured: Adenoma detection rate is the constant subject of research but quality improvement with a link to better attention to all polyps detection, has a chance to reduce interval colorectal cancers rates. Thus a presented point of view at an integrating computer-aided detection (CADe) of polyps with high-accuracy in real time colonoscopy challenges a quality improvement in performance of colonoscopy. Colonoscopy with the integration of deep learning methodology, artificial intelligence (AI) with computer - aided detection system (CADe) have been assessed for bowel cancer screening in an effort to enhance adenoma detection rates. Read More

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September 2021

Evidence for increased neuromuscular drive following spinal manipulation in individuals with subacromial pain syndrome.

Clin Biomech (Bristol, Avon) 2021 Sep 21;90:105485. Epub 2021 Sep 21.

Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 E. Alcazar Street, CHP155, Los Angeles, CA 90089; USA. Electronic address:

Background: Thoracic spinal manipulation can improve pain and function in individuals with shoulder pain; however, the mechanisms underlying these benefits remain unclear. Here, we evaluated the effects of thoracic spinal manipulation on muscle activity, as alteration in muscle activity is a key impairment for those with shoulder pain. We also evaluated the relationship between changes in muscle activity and clinical outcomes, to characterize the meaningful context of a change in neuromuscular drive. Read More

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September 2021

Spatial-temporal evolution of coupling relationship between land development intensity and resources environment carrying capacity in China.

J Environ Manage 2021 Sep 24;301:113778. Epub 2021 Sep 24.

College of Public Administration, Huazhong University of Science and Technology, Wuhan, Hubei, 430074, China. Electronic address:

Land development poses challenges to the sustainable use of resources and environmental health in regions. This study explores the coupling relationship and its spatial-temporal evolution trend between land development intensity and resources environment carrying capacity of 31 provinces in China from 2005 to 2017. The information entropy method, coupling degree model, and coupling coordination degree model are used to calculate the index weight, coupling degree, and coupling coordination degree. Read More

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September 2021

Remediation of petroleum-contaminated soil by ball milling and reuse as heavy metal adsorbent.

J Hazard Mater 2021 Sep 21;424(Pt A):127305. Epub 2021 Sep 21.

School of Environmental and Safety Engineering, Changzhou University, Changzhou 213164, PR China; Jiangsu Petrochemical Safety and Environmental Protection Engineering Research Center, Changzhou 213164, PR China.

A simple mechanochemical (MC) method is used to treat petroleum-contaminated soil and prepare a heavy metal adsorbent in one step. XRD, Raman, FT-IR, VSM, BET, and XPS were used to characterize the adsorbent. After MC treatment, the dissolved total petroleum hydrocarbons of the adsorbent is less than 1 mg·L, and a porous structure and carbonization phenomenon are evident. Read More

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September 2021

Low-cost silica based ceramic supported thin film composite hollow fiber membrane from guinea corn husk ash for efficient removal of microplastic from aqueous solution.

J Hazard Mater 2021 Sep 20;424(Pt A):127298. Epub 2021 Sep 20.

Advanced Membrane Technology Research Centre (AMTEC), School of Chemical and Energy Engineering, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia.

In this study, an economic silica based ceramic hollow fiber (HF) microporous membrane was fabricated from guinea cornhusk ash (GCHA). A silica interlayer was coated to form a defect free silica membrane which serves as a support for the formation of thin film composite (TFC) ceramic hollow fiber (HF) membrane for the removal of microplastics (MPs) from aqueous solutions. Polyacrylonitrile (PAN), polyvinyl-chloride (PVC), polyvinylpyrrolidone (PVP) and polymethyl methacrylate (PMMA) are the selected MPs The effects of amine monomer concentration (0. Read More

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September 2021

A bibliometric analysis of paramedicine publications using the Scopus database: 2010-2019.

Int Emerg Nurs 2021 Sep 24;59:101077. Epub 2021 Sep 24.

Department of Paramedicine, Monash University, 47-49 Moorooduc Hwy, Frankston, Victoria 3199, Australia.

Background: Paramedicine is an evolving profession undergoing increases in scholarly activity and peer-reviewed publications. This study aims to complete the first extensive bibliometric examination of the worldwide paramedicine literature.

Method: Scopus was utilised to search for paramedicine-based articles published in peer-reviewed journals between 2010 and 2019 inclusive. Read More

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September 2021

Dissolved oxygen variation in the North China Plain river network region over 2011-2020 and the influencing factors.

Chemosphere 2021 Sep 23;287(Pt 3):132354. Epub 2021 Sep 23.

State Key Laboratory on Environmental Aquatic Chemistry, Research Center for Eco-Environmental Science, Chinese Academy of Science, P. O. Box 2871, Beijing, 100085, PR China.

The 2011-2020 data of dissolved oxygen (DO) and nutrients-total phosphorus (TP), solution reactive phosphorus (SRP), total nitrogen (TN), ammoniacal nitrogen (NH-N), and chemical oxygen demand (COD)-in the North China Plain river network region were analyzed. Moreover, the DO variation trend and the influencing factors were investigated. The results showed that between 2011 and 2020, the DO concentration steadily increased from <3 mg L to >5 mg L. Read More

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September 2021

The effects of glucose-6-phosphate dehydrogenase deficiency on benzene-induced hematotoxicity in mice.

Ecotoxicol Environ Saf 2021 Sep 24;226:112803. Epub 2021 Sep 24.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education of China, School of Public Health, Southeast University, Nanjing 210009, China. Electronic address:

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency. Our previous study revealed the level of G6PD changed in wild type (WT) mice after benzene exposure. In this study, the pentose phosphate pathway (PPP) in regulation of benzene-induced hematotoxicity was investigated and other potential pathways were discovered in a G6PD deficiency mouse model. Read More

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September 2021

Impact of plasma reactive species on the structure and functionality of pea protein isolate.

Food Chem 2021 Sep 15;371:131135. Epub 2021 Sep 15.

Food Science and Nutrition Department, University of Minnesota, 1334 Eckles Ave, Saint Paul, MN 55108, United States. Electronic address:

The impact of plasma-produced reactive oxygen and nitrogen species, in particular O, NO, HO and OH, on the structure and functionality of pea protein isolate (PPI) was evaluated. Reactive species were produced through a combination of controlled measurements and plasma treatments. Pronounced structural and functional effects were observed upon treatment with reactive species at pH 2. Read More

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September 2021

Antioxidant capacity of phenolic compounds separated from tea seed oil in vitro and in vivo.

Food Chem 2021 Sep 15;371:131122. Epub 2021 Sep 15.

College of Food Science and Engineering, Yangzhou University, 225127 Yangzhou, Jiangsu Province, China. Electronic address:

Tea seed oil is rich in phenols with good antioxidant capacity. However, the antioxidant capacity evaluation of tea seed oil polyphenols is not deep enough, which mainly focusing on the evaluation of the chemical system. Thirty-nine phenols were tentatively identified by UPLC-ESI-MS/MS analysis, including flavonoids and phenolic acids. Read More

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September 2021

Effects from disruption of mitochondrial electron transport chain function on bull sperm motility.

Theriogenology 2021 Sep 20;176:63-72. Epub 2021 Sep 20.

Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, United States. Electronic address:

Sperm mitochondrial function is essential for normal physiology and fertility, but the importance of mitochondrial activity to support specific sperm functions, such as motility, varies between species. It was previously believed that mitochondrial function was not necessary for bull sperm motility [1]; however, this theory is contradicted by recently reported findings that the upper fraction of bull sperm swim-up preparations had both high motility and elevated mitochondrial oxygen consumption rates [2]. The objective of this study was to investigate the relationship between mitochondrial function and motility in bull sperm. Read More

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September 2021

Abandoned, lost and discarded fishing gear 'ghost nets' are increasing through time in Northern Australia.

Mar Pollut Bull 2021 Sep 24;173(Pt A):112959. Epub 2021 Sep 24.

CSIRO Oceans and Atmosphere, Hobart, Tasmania, Australia; Centre for Marine Socioecology (CMS), Institute for Marine and Antarctic Studies, 20 Castray Esplanade, Battery Point, Hobart, Tasmania, Australia.

The remote Gulf of Carpentaria (GoC) represents 10% of Australia's coastline. This large, shallow sea supports high-value fishing activities and habitat for threatened species, and is a sink for abandoned, lost and discarded fishing gear (ALDFG) 'ghost nets', most originating from fishing activities outside of Australia's Exclusive Economic Zone. With growing concerns about the plastic waste along the world's coastlines, we retrospectively analyzed ghost net sighting information from four aerial surveys across 15 years, to investigate whether densities of ghost nets are changing through time or in space. Read More

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September 2021

Combination of azacytidine and curcumin is a potential alternative in decitabine-resistant colorectal cancer cells with attenuated deoxycytidine kinase.

Biochem Biophys Res Commun 2021 Sep 22;578:157-162. Epub 2021 Sep 22.

Department of Pharmaceutics, Kobe Pharmaceutical University, 4-19-1 Motoyamakita, Higashinada, Kobe, 658-8558, Japan.

Decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor is a novel anti-cancer drug regulating epigenetic mechanisms. Similar to conventional anti-cancer drugs, drug resistance to DAC also has been reported, resulting in tumor recurrence. Our previous study using colorectal cancer HCT116 cells found the decrease in deoxycytidine kinase (dCK) (activation enzyme of DAC) and the increase in cytidine deaminase (inactivation enzyme of DAC) in acquired DAC-resistant HCT116 (HCT116/DAC) cells. Read More

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September 2021

Time since SARS-CoV-2 infection and humoral immune response following BNT162b2 mRNA vaccination.

EBioMedicine 2021 Sep 24;72:103589. Epub 2021 Sep 24.

Department of Internal Medicine, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam 1081 HV, the Netherlands. Electronic address:

Background: To optimise the use of available SARS-CoV-2 vaccines, some advocate delaying second vaccination for individuals infected within six months. We studied whether post-vaccination immune response is equally potent in individuals infected over six months prior to vaccination.

Methods: We tested serum IgG binding to SARS-CoV-2 spike protein and neutralising capacity in 110 healthcare workers, before and after both BNT162b2 messenger RNA (mRNA) vaccinations. Read More

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September 2021

NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study: Serum NfL predicts relapse-free progression.

EBioMedicine 2021 Sep 24;72:103590. Epub 2021 Sep 24.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

Background: Easily accessible biomarkers enabling the identification of those patients with multiple sclerosis (MS) who will accumulate irreversible disability in the long term are essential to guide early therapeutic decisions. We here examine the utility of serum neurofilament light chain (sNfL) for forecasting relapse-free disability progression and conversion to secondary progressive MS (SPMS) in the prospective Neurofilamentandlongtermoutcome inMS (NaloMS) cohort.

Methods: The predictive ability of sNfL at Baseline and sNfL follow-up (FU)/ Baseline (BL) ratio with regard to disability progression was assessed within a development cohort (NaloMS, n=196 patients with relapsing-remitting MS (RRMS) or clinically isolated syndrome) and validated with an external independent cohort (Düsseldorf, Essen, n=204). Read More

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September 2021

Absence of significant clinical benefit for a systematic routine creatine phosphokinase measurement in asymptomatic patients treated with anti-programmed death protein (ligand) 1 immune checkpoint inhibitor to screen cardiac or neuromuscular immune-related toxicities.

Eur J Cancer 2021 Sep 23;157:383-390. Epub 2021 Sep 23.

Drug Development Department (DITEP), Gustave Roussy, Université Paris-Sud, Université Paris-Saclay, F-94805, Villejuif, France. Electronic address:

Aim: Despite unprecedented results of anti-programmed death protein (ligand) 1 (PD-(L)1) immune checkpoint inhibitor in the oncology's armamentarium, immune-related adverse events (irAEs) represent a therapeutic hurdle. Currently, there is no consensual recommendation on a routinely monitored biomarker to early detect irAE. Biological markers such as serum creatine phosphokinase (CPK) are commonly used to measure muscular tissue injury. Read More

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September 2021

Prevalence of Intimate Partner Violence Among Men Who Have Sex With Men: An Updated Systematic Review and Meta-Analysis.

Sex Med 2021 Sep 24;9(6):100433. Epub 2021 Sep 24.

Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China. Electronic address:

Introduction: Intimate partner violence (IPV) among men who have sex with men (MSM) has become a serious and widespread public health issue, which might result in low quality of life and increase the global burden of diseases.

Aim: To quantitatively estimate the pooled prevalence of IPV and its specific forms (physical violence, sexual violence and emotional violence) among MSM.

Methods: Databases of PubMed, Cochrane Library, CINAHL, MEDLINE, PsycINFO, CNKI, WANFANG Data, and Weipu (CQVIP) Data were searched for identified studies published between January 1990 and August 2020. Read More

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September 2021

Molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under neutral pH.

J Colloid Interface Sci 2021 Sep 11;607(Pt 2):1163-1172. Epub 2021 Sep 11.

College of Chemistry and Bioengineering, Shandong University of Science and Technology, Qingdao, Shandong 266590, China. Electronic address:

Glycoproteins play vital roles in living organisms and often serve as biomarkers for some disease. However, due to the low content of glycoprotein in biological fluids, selective detection of glycoproteins is still a challenging issue that needs to be addressed. In this study, molecularly imprinted colloidal array with multi-boronic acid sites for glycoprotein detection under physiological pH was proposed. Read More

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September 2021

Molecular-functionalized engineering of porous carbon nitride nanosheets for wide-spectrum responsive solar fuel generation.

J Colloid Interface Sci 2021 Sep 8;607(Pt 2):1061-1070. Epub 2021 Sep 8.

School of Resources and Environmental Engineering, Wuhan University of Technology, Wuhan 430070, China. Electronic address:

Carbon nitride (CN) is a promising metal-free photocatalyst for solar-to-energy conversion, but bulk carbon nitride (BCN) shows insufficient light absorption, sluggish photocarrier transfer and moderate activity for photocatalysis. Herein, a facile strategy to significantly increase solar spectrum absorption of the functionalized porous carbon nitride nanosheets (MFPCN) via molecule self-assembly engineering coupled thermal polymerization is reported. This strategy can greatly enhance the wide-solar-spectrum absorption of MFPCN up to 1000 nm than most reported carbon nitride-based photocatalysts. Read More

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September 2021

Adolescent depression symptoms and e-cigarette progression.

Drug Alcohol Depend 2021 Sep 20;228:109072. Epub 2021 Sep 20.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Background: Depression symptoms are associated with the initiation of cigarette smoking and progression to regular use. Whether similar relationships exist between depression symptoms and adolescent e-cigarette progression has not been firmly established.

Methods: This prospective longitudinal survey study measured the relationship between depression symptoms and e-cigarette use among 1822 adolescents from four public high schools outside of Philadelphia, PA. Read More

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September 2021

Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells.

Mitochondrion 2021 Sep 24. Epub 2021 Sep 24.

Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address:

The weightlessness or microgravity, a physical factor in space, may adversely affect the health of the space travellers or astronauts. The knowledge about the effect of microgravity on human cancer cells is very limited and poorly understood. Here, we employed rotary cell culture system (RCCS) to induce simulated microgravity (SMG) and examined its effects on human promyelocytic leukemic HL-60 cells. Read More

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September 2021

Perceived impacts of Urban Heat Island phenomenon in a tropical metropolitan city: Perspectives from stakeholder dialogue sessions.

Sci Total Environ 2021 Sep 14;806(Pt 1):150331. Epub 2021 Sep 14.

Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia.

The stakeholders' perceptions on the impacts of Urban Heat Island (UHI) are critical for reducing exposure and influencing their response to interventions that are aimed at encouraging a behaviour change. A proper understanding of the UHI impacts on the society, economy and environment is deemed an essential motivating factor for the stakeholders to work towards UHI mitigations in the local context. This study adopted an inductive qualitative approach using Stakeholder Dialogue Sessions (SDSs) to assess the perceived impacts of UHI among various stakeholders, comprising policy makers, academicians, developers and Non-Governmental Organizations (NGO), in a tropical metropolitan city. Read More

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September 2021

Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids.

Sci Total Environ 2021 Sep 15;806(Pt 1):150328. Epub 2021 Sep 15.

The Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine, School of Public Health, Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Microplastic particles (MP) has been detected in the environment widespread. Human beings are inevitably exposed to MP via multiple routines. However, the hazard identifications, as direct evidence of exposure and health risk, have not been fully characterized in human beings. Read More

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September 2021

The Effect of Short-Term High-Caloric Feeding and Fasting on Bone Microarchitecture.

Bone 2021 Sep 24:116214. Epub 2021 Sep 24.

Neuroendocrine Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114.

Background: States of chronic overnutrition and undernutrition are both associated with impaired bone health and increased fracture risk but there are no data on bone microarchitecture following short-term controlled nutritional challenges.

Objective: The purpose of our study was to evaluate the impact of short-term high-caloric feeding and fasting on bone microarchitecture. We hypothesized that both high-caloric feeding and fasting would have negative effects on microarchitecture. Read More

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September 2021

Bone adaptation to mechanical loading in mice is affected by circadian rhythms.

Bone 2021 Sep 24:116218. Epub 2021 Sep 24.

Research Centre, Shriners Hospital for Children-Canada, Montreal, Canada; Department of Pediatric Surgery, McGill University, Montreal, Canada; Department of Experimental Surgery, McGill University, Montreal, Canada. Electronic address:

Physical forces are critical for successful function of many organs including bone. Interestingly, the timing of exercise during the day alters physiology and gene expression in many organs due to circadian rhythms. Circadian clocks in tissues, such as bone, express circadian clock genes that target tissue-specific genes (clock-controlled genes), resulting in tissue-specific rhythmic gene expression. Read More

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September 2021

Greater psychological readiness to return to sport, as well as greater present and future knee-related self-efficacy can increase the risk for an ACL re-rupture: a matched cohort study.

Arthroscopy 2021 Sep 24. Epub 2021 Sep 24.

Sportrehab Sports Medicine Clinic, Stampgatan 14, SE-411 01 Gothenburg, Sweden; Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Box 455, SE-405 30 Gothenburg, Sweden; Sahlgrenska Sports Medicine Center, Gothenburg, Sweden. Electronic address:

Purpose: The purpose of this study was to determine the psychological characteristics and strength outcomes of patients who sustained an early ACL re-rupture after their primary ACL reconstruction and cross-sectionally compare them with a matched cohort of patients who did not sustain a re-injury during the first 2 years after primary ACL reconstruction.

Methods: In this matched cohort study, data for quadriceps and hamstring strength and three hop tests and answers to standardized patient-reported outcomes (the Anterior Cruciate Ligament Return to Sport after Injury scale (ACL-RSI) and a short version of the Knee Self-Efficacy Scale (K-SES)) were extracted from a rehabilitation outcome- registry. Data for patients suffering a re-rupture were extracted and patients were matched in terms of sex, age and activity level with patients not suffering an ACL re-rupture within 2 years of primary reconstruction. Read More

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September 2021

Aging Aggravates the Progression of Muscle Degeneration after Rotator Cuff Tears in Mice.

Arthroscopy 2021 Sep 24. Epub 2021 Sep 24.

Department of Orthopedic Surgery, National Defense Medical College, Saitama, Japan. Electronic address:

Purpose: The purpose of this study was to evaluate the impact of aging on muscle degeneration after rotator cuff tear (RCT) in mice.

Methods: Young (12-week-old) and aged (50-to-60-week-old) female C57BL/6 mice were used (N = 29 for each group). The rotator cuff was transected, and the proximal humerus was removed to induce degeneration of the rotator cuff muscles. Read More

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September 2021