3,543 results match your criteria incorporation ultrasound


Microwave hydrothermal processing of Undaria pinnatifida for bioactive peptides.

Bioresour Technol 2021 Sep 6;342:125882. Epub 2021 Sep 6.

CINBIO, Universidade de Vigo, Deparment of Chemical Engineering, Campus Ourense, Edificio Politécnico, As Lagoas s/n, 32004 Ourense, Spain. Electronic address:

Microwave hydrothermal processing was employed to obtain valuable gelling or bioactive fractions from U. pinnatifida, assessing the processing conditions following a biorefinery concept. It was identified a relevant impact on the antioxidant properties, sulfate, protein and oligosaccharides content, with the highest values above 200 °C, although the maximum in fucose was obtained at 160 °C. Read More

View Article and Full-Text PDF
September 2021

The Status of Interventional Radiology as a Specialty among Medical Students in India-Knowledge, Interest, and Exposure.

Indian J Radiol Imaging 2021 Apr 28;31(2):259-264. Epub 2021 Jul 28.

Division of Vascular Radiology, Department of Radiology, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom.

Interventional radiology (IR) is a young medical specialty where image guidance is utilized in minimally invasive procedures as a treatment option and/or as a diagnostic tool. There is an exponential increase in awareness and interest in IR amongst medical students. This trend is continuing despite lack of proportionate representation of IR in the current medical curriculum. Read More

View Article and Full-Text PDF

Fully Automated Placental Volume Quantification From 3DUS for Prediction of Small-for-Gestational-Age Infants.

J Ultrasound Med 2021 Sep 23. Epub 2021 Sep 23.

Penn Image Computing and Science Laboratory (PICSL), Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.

Objectives: Early placental volume (PV) has been associated with small-for-gestational-age infants born under the 10th/5th centiles (SGA10/SGA5). Manual or semiautomated PV quantification from 3D ultrasound (3DUS) is time intensive, limiting its incorporation into clinical care. We devised a novel convolutional neural network (CNN) pipeline for fully automated placenta segmentation from 3DUS images, exploring the association between the calculated PV and SGA. Read More

View Article and Full-Text PDF
September 2021

Digital subtraction angiography in cerebrovascular disease: current practice and perspectives on diagnosis, acute treatment and prognosis.

Acta Neurol Belg 2021 Sep 22. Epub 2021 Sep 22.

Neurovascular Imaging Laboratory, Clinical Sciences Stream, Ingham Institute for Applied Medical Research, Sydney, Australia.

Digital Subtraction Angiography (DSA) is the gold-standard imaging modality in acute cerebrovascular diagnosis. The role of DSA has become increasingly prominent since the incorporation of endovascular therapy in standards of care for acute ischemic stroke. It is used in the assessment of cerebral vessel patency; however, the therapeutic role of DSA from a prognostic standpoint merits further investigation. Read More

View Article and Full-Text PDF
September 2021

Focused Neck Ultrasound and Lymph Node Sampling by Respiratory Physicians in Suspected Lung Cancer.

Respiration 2021 Aug 11:1-6. Epub 2021 Aug 11.

Interventional Pulmonology Service, Department of Respiratory Medicine, University Hospitals Plymouth NHS Trust, Plymouth, United Kingdom.

Background: Malignant cervical lymphadenopathy in the setting of lung cancer represents N3 disease, and neck ultrasound (NUS) with sampling is described in the Royal College of Radiologists ultrasound training curriculum for the non-radiologists. This study reviews the incorporation of NUS +/- biopsy in the routine practice of a lung cancer fast-track clinic in the UK.

Methods: We retrospectively assessed 29 months of activity of a lung cancer fast-track clinic. Read More

View Article and Full-Text PDF

Assessment of Tau Pathology as Measured by 18F-THK5317 and 18F-Flortaucipir PET and Their Relation to Brain Atrophy and Cognition in Alzheimer's Disease.

J Alzheimers Dis 2021 Sep 9. Epub 2021 Sep 9.

Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Background: In Alzheimer's disease (AD), the abnormal aggregation of hyperphosphorylated tau leads to synaptic dysfunction and neurodegeneration. Recently developed tau PET imaging tracers are candidate biomarkers for diagnosis and staging of AD.

Objective: We aimed to investigate the discriminative ability of 18F-THK5317 and 18F-flortaucipir tracers and brain atrophy at different stages of AD, and their respective associations with cognition. Read More

View Article and Full-Text PDF
September 2021

Causes and classification of first unprovoked seizures and newly-diagnosed epilepsy in a defined geographical area- an all-comers analysis.

Seizure 2021 Aug 28;92:118-127. Epub 2021 Aug 28.

Department of Neurology, Cork University Hospital, Ireland; College of Medicine and Health, University College Cork, Ireland; FutureNeuro SFI Research Centre for Chronic and Rare Neurological Diseases hosted in RCSI, Dublin 2, Ireland.

Purpose: The ILAE recently updated the operational definition of epilepsy and the classifications of seizures and epilepsy incorporating aetiology into the classification framework. To date, these classifications have not been applied in any whole population incidence study.

Methods: Multiple overlapping methods of case identification were applied to a defined geographical area (population 542,868 adults and children) to identify all first unprovoked seizures and new diagnosis of epilepsy presenting during the calendar year 2017. Read More

View Article and Full-Text PDF

An emerging method in evaluation of reduced fetal movements using cerebroplacental ratio: A prospective case-control study.

J Obstet Gynaecol Res 2021 Sep 8. Epub 2021 Sep 8.

Department of Health Management and System Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, Kentucky, USA.

Aim: Nearly half of the patients with stillbirths experience reduced fetal movements (RFM) in the preceding week. The standardized evaluation will help reduce stillbirths. Placental dysfunction is the underlying pathophysiology for RFM and low cerebroplacental ratio (CPR). Read More

View Article and Full-Text PDF
September 2021

Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports: a retrospective, multi-cohort, diagnostic study.

Cancer Biol Med 2021 Sep 7. Epub 2021 Sep 7.

Department of Maxillofacial and Otorhinolaryngology Oncology, National Clinical Research Center for Cancer, Key Laboratory of Molecular Cancer Epidemiology of Tianjin, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.

Objective: Large volume radiological text data have been accumulated since the incorporation of electronic health record (EHR) systems in clinical practice. We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.

Methods: Sonographic EHR data were obtained from the EHR database. Read More

View Article and Full-Text PDF
September 2021

Evaluation of umbilical venous flow volume measured using ultrasound compared to circuit flow volume in the EXTra-uterine Environment for Neonatal Development (EXTEND) system in fetal sheep.

Prenat Diagn 2021 Sep 3. Epub 2021 Sep 3.

Fetal Heart Program, Cardiac Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Objective: To compare and validate umbilical venous flow volume (UVFV) measured at the intra-abdominal portion using ultrasound with actual flow volume of umbilical vein (UV) in fetal sheep sustained on the EXTrauterine Environment for Neonatal Development (EXTEND) system.

Methods: Circuit flow volume through the oxygenator was obtained using sensors. Ultrasound derived UVFV (ml/min) was calculated as (UV diameter [cm]/2) 3. Read More

View Article and Full-Text PDF
September 2021

Three-dimensional carpal arch morphology using robot-assisted ultrasonography.

IEEE Trans Biomed Eng 2021 Aug 30;PP. Epub 2021 Aug 30.

Objective: The morphology of the carpal arch implicates the available space for the median nerve within the carpal tunnel. The purposes of this study were to 1) reconstruct the three-dimensional (3D) carpal arch by robot-assisted ultrasonography with a linear array transducer using cadaveric hands, and 2) investigate the 3D morphological properties of the carpal arch.

Methods: An ultrasound probe with two-dimensional (2D) linear array was integrated on a robotic arm and maneuvered over the cadaveric carpal tunnels to scan the entire transverse carpal ligament and its osseous attachments to carpal bones. Read More

View Article and Full-Text PDF

[Relevance of right ventricle in the clinical management of pulmonary arterial hypertension].

Medicina (B Aires) 2021 ;81(4):624-636

Hospital de Alta Complejidad en Red EL Cruce - Néstor Kirchner, Instituto FLENI e Instituto Argentino de Diagnóstico y Tratamiento, Buenos Aires, Argentina.

Pulmonary arterial hypertension (PAH) requires structured processes of diagnosis and risk stratification, being the function of the right ventricle (RV) a hallmark prognosis determinant. The main therapeutic goals in PAH are to improve and try to revert RV dysfunction and maintaining a low risk. Currently, there are multiple treatments with different mechanisms of action, the combination of which in double or triple therapy has shown improved results compared to monotherapy. Read More

View Article and Full-Text PDF

Improving domain definition and outcome instrument selection: Lessons learned for OMERACT from imaging.

Semin Arthritis Rheum 2021 Oct 20;51(5):1125-1133. Epub 2021 Aug 20.

Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Amsterdam Rheumatology and Immunology Center, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objectives: Imaging is one of the most rapidly evolving fields in medicine. Unfortunately, many imaging technologies have been applied as measurement instruments without rigorous evaluation of the evidence supporting their truth, discriminatory capability and feasibility for that context of use. The Outcome Measures in Rheumatology (OMERACT) Filter 2. Read More

View Article and Full-Text PDF
October 2021

A retrospective single-centre analysis of the oncological impact of LI-RADS classification applied to Metroticket 2.0 calculator in liver transplantation: every nodule matters.

Transpl Int 2021 Sep;34(9):1712-1721

Department of General Surgery and Transplantation, Niguarda Ca' Granda Hospital, Milan, Italy.

Although the diagnostic value of Liver Imaging Reporting and Data System (LI-RADS) protocol is well recognized in clinical practice, its role in liver transplant (LT) setting is under-explored. We sought to evaluate the oncological impact of LI-RADS classification applied to Metroticket 2.0 calculator in a single-centre retrospective cohort of transplanted hepatocellular carcinoma (HCC) patients, exploring which LI-RADS subclasses need to be considered in order to grant the best Metroticket 2. Read More

View Article and Full-Text PDF
September 2021

Development of a standardized MRI protocol for pancreas assessment in humans.

PLoS One 2021 24;16(8):e0256029. Epub 2021 Aug 24.

Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.

Magnetic resonance imaging (MRI) has detected changes in pancreas volume and other characteristics in type 1 and type 2 diabetes. However, differences in MRI technology and approaches across locations currently limit the incorporation of pancreas imaging into multisite trials. The purpose of this study was to develop a standardized MRI protocol for pancreas imaging and to define the reproducibility of these measurements. Read More

View Article and Full-Text PDF

Oxford's clinical experience in the development of high intensity focused ultrasound therapy.

Int J Hyperthermia 2021 09;38(2):81-88

Green Templeton College, University of Oxford, Oxford, UK.

High Intensity Focused Ultrasound (HIFU) capably bridges the disciplines of surgery, oncology and biomedical engineering science. It provides the precision associated with a surgical tool whilst remaining a truly non-invasive technique. Oxford has been a centre for both clinical and preclinical research in HIFU over the last twenty years. Read More

View Article and Full-Text PDF
September 2021

[Strategic approach to pathological fractures].

Unfallchirurg 2021 Sep 16;124(9):687-694. Epub 2021 Aug 16.

Klinik für Tumororthopädie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland.

Pathological tumor-associated fractures are overall rare. They can occur in every age group and every bone. Although tumor-related fractures only form a small proportion of bone fractures, the early recognition of the cause of the fracture and treatment according to oncological guidelines are of enormous importance for affected patients. Read More

View Article and Full-Text PDF
September 2021

Nanofibers of Polyaniline and Cu(II)-l-Aspartic Acid for a Room-Temperature Carbon Monoxide Gas Sensor.

ACS Appl Mater Interfaces 2021 Aug 16;13(33):39791-39805. Epub 2021 Aug 16.

School of Electrical and Computer Engineering, Shiraz University, Shiraz 71456, Iran.

In the present study, the carbon monoxide (CO) sensing property of Cu(II)-l-aspartic acid nanofibers/polyaniline (PANI) nanofibers composite was investigated at room temperature. The nanofiber composite was formed through the ultrasound mixing of emeraldine salt PANI nanofibers and Cu(II)-l-aspartic acid nanofibers, which were synthesized by using a polymerization process and simple self-assembly method, respectively. The nanofibers composite demonstrated a branched structure in which the Cu(II)-l-aspartic acid nanofiber framework is similar to the trunk of a tree and the polyaniline nanofibers is like its branches. Read More

View Article and Full-Text PDF

Ultrasound: The New Stethoscope (Point-of-Care Ultrasound).

Anesthesiol Clin 2021 Sep 12;39(3):537-553. Epub 2021 Jul 12.

Department of Anesthesiology, University of Utah, 30 North 1900 East, Room 3C444 SOM, Salt Lake City, UT 84132, USA.

Advances in technology have led to more user-friendly ultrasound devices that allow for easy incorporation into daily perioperative practice, with the anesthesiologist serving as the sonographer. With appropriate knowledge and training, bedside ultrasound examinations can be used to better diagnose pathology and guide perioperative strategies. Cardiac ultrasound examination was the initial emphasis in anesthesiology, with now expansion into lung and gastric ultrasound imaging. Read More

View Article and Full-Text PDF
September 2021

Tissue Multiplex Analyte Detection in Anatomic Pathology - Pathways to Clinical Implementation.

Front Mol Biosci 2021 27;8:672531. Epub 2021 Jul 27.

Ultivue, Inc., Cambridge, MA, United States.

Multiplex tissue analysis has revolutionized our understanding of the tumor microenvironment (TME) with implications for biomarker development and diagnostic testing. Multiplex labeling is used for specific clinical situations, but there remain barriers to expanded use in anatomic pathology practice. We review immunohistochemistry (IHC) and related assays used to localize molecules in tissues, with reference to United States regulatory and practice landscapes. Read More

View Article and Full-Text PDF

Updated Experience of Infection: Diagnosis and Management in a Tertiary Care Center.

Open Forum Infect Dis 2021 Aug 1;8(8):ofab348. Epub 2021 Jul 1.

Department of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.

Background: Despite safety communications from the Food and Drug Administration (FDA) regarding the outbreak of infections (MCIs) from contaminated heater-cooler devices, new cases continue to be identified.

Methods: We retrospectively reviewed confirmed cases of MCI that were managed at Mayo Clinic sites (Arizona, Florida, and Minnesota) from 09/2015 to 01/2021. Clinical histories including prior cardiovascular surgery were recorded. Read More

View Article and Full-Text PDF

Simple ultrasonic-assisted approach to prepare polysaccharide-based aerogel for cell research and histocompatibility study.

Int J Biol Macromol 2021 Oct 8;188:411-420. Epub 2021 Aug 8.

Institute of Chemical Industry of Forestry Products, Chinese Academy of Forestry, Key Lab. of Biomass Energy and Material, Jiangsu Province, Nanjing 210042, China.

Salecan, a water-soluble microbial polysaccharide with attractive biocompatible characteristics, is very suitable for aerogel fabrication. However, the practical application of salecan-based aerogels for cell culture was limited by complicated preparation method, lack of cell anchorage signals, and the ability to modulate this properly. Here, a smart aerogel was designed by ultrasonic-assisted self-assembly of salecan and cationic starch (CAS) without any organic and toxic crosslinkers. Read More

View Article and Full-Text PDF
October 2021

Assessment of MRI technologists in acceptance and willingness to integrate artificial intelligence into practice.

Radiography (Lond) 2021 Aug 4. Epub 2021 Aug 4.

Medical Diagnostic Imaging Department, College of Health Sciences, University of Sharjah, Sharjah, United Arab Emirates. Electronic address:

Introduction: The integration of AI in medical imaging has tremendous exponential growth, especially in image production, image processing and image interpretation. It is expected that radiographers working across all imaging modalities have adequate knowledge as they are part of the end-user team. The current study aimed to investigate the knowledge, willingness and challenges facing the Magnetic Resonance Imaging (MRI) technologists in the integration of Artificial Intelligence (AI) into MRI practice. Read More

View Article and Full-Text PDF

Cyanine-5-Driven Behaviours of Hyperbranched Polymers Designed for Therapeutic Delivery Are Cell-Type Specific and Correlated with Polar Lipid Distribution in Membranes.

Nanomaterials (Basel) 2021 Jul 2;11(7). Epub 2021 Jul 2.

Australian Institute for Bioengineering & Nanotechnology, University of Queensland, St. Lucia, QLD 4072, Australia.

The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation of fluorophores or other entities. However, these interactions provide an intriguing insight into how selection of molecular components in multifunctional nanomedicines contributes to the overall biological fate of such materials. Here, we detail the internalisation behaviours of polymeric nanomedicines across a suite of cell types and extrapolate data for distinguishing the underlying mechanics of cyanine-5-driven interactions as they pertain to uptake and endosomal escape. Read More

View Article and Full-Text PDF

Effect of Washing Treatment on the Textural Properties and Bioactivity of Silica/Chitosan/TCP Xerogels for Bone Regeneration.

Int J Mol Sci 2021 Aug 2;22(15). Epub 2021 Aug 2.

Department of Condensed Matter Physics, Faculty of Science, University of Cadiz, 11510 Puerto Real, Spain.

Silica/biopolymer hydrogel-based materials constitute very attractive platforms for various emerging biomedical applications, particularly for bone repair. The incorporation of calcium phosphates in the hybrid network allows for designing implants with interesting biological properties. Here, we introduce a synthesis procedure for obtaining silica-chitosan (CS)-tricalcium phosphate (TCP) xerogels, with CS nominal content varying from 4 to 40 wt. Read More

View Article and Full-Text PDF

Mechanically Triggered Release of Functionally Diverse Molecular Payloads from Masked 2-Furylcarbinol Derivatives.

ACS Cent Sci 2021 Jul 14;7(7):1216-1224. Epub 2021 Jul 14.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

Polymers that release functional small molecules in response to mechanical force are appealing targets for drug delivery, sensing, catalysis, and many other applications. Mechanically sensitive molecules called mechanophores are uniquely suited to enable molecular release with excellent selectivity and control, but mechanophore designs capable of releasing cargo with diverse chemical functionality are limited. Here, we describe a general and highly modular mechanophore platform based on masked 2-furylcarbinol derivatives that spontaneously decompose under mild conditions upon liberation via a mechanically triggered reaction, resulting in the release of a covalently installed molecular payload. Read More

View Article and Full-Text PDF

Using AMANHI-ACT cohorts for external validation of Iowa new-born metabolic profiles based models for postnatal gestational age estimation.

J Glob Health 2021 17;11:04044. Epub 2021 Jul 17.

World Health Organization (MCA/MRD), Geneva, Switzerland.

Background: Globally, 15 million infants are born preterm and another 23.2 million infants are born small for gestational age (SGA). Determining burden of preterm and SGA births, is essential for effective planning, modification of health policies and targeting interventions for reducing these outcomes for which accurate estimation of gestational age (GA) is crucial. Read More

View Article and Full-Text PDF

Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: Toxicological effect of surface charge on human neuronal cells.

Int J Pharm 2021 Sep 27;607:120933. Epub 2021 Jul 27.

UCIBIO/REQUIMTE, MEDTECH, Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; FP-ENAS (UFP Energy, Environment and Health Research Unit), CEBIMED (Biomedical Research Centre), Faculty of Health Sciences, University Fernando Pessoa, 4249-004 Porto, Portugal. Electronic address:

Diazepam is commonly used in the management of epileptic seizures, although it has limitations that can be overcome by using formulations that are easier to administer and capable of directing the drug to the brain. In this field, it has been reported that the use of nanostructured lipid carriers (NLC) via intranasal (or via nose-to-brain) promotes the targeting of drugs to the brain, improving the effectiveness of therapy. The aim of this work was to optimize two diazepam-loaded NLC formulations for nose-to-brain delivery, one with positive surface charge and one with negative surface charge. Read More

View Article and Full-Text PDF
September 2021

Higher strength gain after hypoxic vs normoxic resistance training despite no changes in muscle thickness and fractional protein synthetic rate.

FASEB J 2021 08;35(8):e21773

Institute of Neuroscience, UCLouvain, Louvain-la-Neuve, Belgium.

Acute hypoxia has previously been suggested to potentiate resistance training-induced hypertrophy by activating satellite cell-dependent myogenesis rather than an improvement in protein balance in human. Here, we tested this hypothesis after a 4-week hypoxic vs normoxic resistance training protocol. For that purpose, 19 physically active male subjects were recruited to perform 6 sets of 10 repetitions of a one-leg knee extension exercise at 80% 1-RM 3 times/week for 4 weeks in normoxia (FiO : 0. Read More

View Article and Full-Text PDF

Comparison of MRI and CT in the Evaluation of Unilateral Maxillary Sinus Opacification.

Radiol Res Pract 2021 9;2021:5313196. Epub 2021 Jul 9.

Departments of Radiology, Northwick Park and Central Middlesex Hospitals, London North West University Healthcare NHS Trust, Watford Road, Harrow HA1 3UJ, UK.

Objectives: To evaluate the diagnostic performance of MRI compared with CT in differentiating neoplastic from infectious/inflammatory causes of complete unilateral maxillary sinus opacification (UMSO). Although MRI is increasingly used, no studies validate its utility compared to CT or nasal endoscopy in this context.

Methods: A retrospective analysis of 49 patients presenting with complete UMSO to a tertiary referral centre was performed, investigated with both CT and MRI. Read More

View Article and Full-Text PDF