9,160 results match your criteria incorporating multiple


A multidimensional and multi-period analysis of safety on roads.

Accid Anal Prev 2021 Sep 22;162:106401. Epub 2021 Sep 22.

Universidade Federal de Pernambuco, Recife, PE 50670-901, Brazil. Electronic address:

This paper proposes a multidimensional and multi-period analysis of safety on roads. It aggregates different road safety performance indicators observed over different periods for which multicriteria and multi-period approaches are used. The criticality of a road depends on the interaction of various factors, such as human factors, causes of accidents and their severity levels, and the characteristics/states of the roads. Read More

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September 2021

Health-Related Quality of Life and Its Contributors According to a Preference-Based Generic Instrument in Cirrhosis.

Hepatol Commun 2021 Sep 24. Epub 2021 Sep 24.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China.

It is essential to determine contributors around impairment in health-related quality of life (HRQoL) in patients with cirrhosis aiming at improving health care and therapeutic strategy. Studies simultaneously incorporating disease severity based on biochemical parameters and other physical/psychological effects (i.e. Read More

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September 2021

Start with reducing sedentary behavior: A stepwise approach to physical activity counseling in clinical practice.

Patient Educ Couns 2021 Sep 13. Epub 2021 Sep 13.

Baker Heart and Diabetes Institute, Melbourne, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.

Recently, sedentary behavior recommendations have been included in the public health guidelines of multiple countries, pointing to new opportunities for prevention of chronic disease as well as a potential strategy for initiating long-term behavior change.

Objective: To propose an evidence-informed approach to physical activity counseling that starts with a focus on reducing sedentary time.

Methods: We put forward a case for addressing changes in sedentary behavior in clinical practice using a narrative review. Read More

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September 2021

Phase and dark field imaging with mesh-based structured illumination and polycapillary optics.

Med Phys 2021 Sep 23. Epub 2021 Sep 23.

Department of Physics, University at Albany, 1400 Washington Ave, Albany, NY, 12222, USA.

Purpose: X-ray phase and dark field imaging have been shown to improve the diagnostic capabilities of x-ray systems. However, these methods have found limited clinical use due to the need for multiple precision gratings with limited field of view or requirements on x-ray coherence that may not be easily translated to clinical practice. This work aims to develop a practicable x-ray phase and dark field imaging system that could be translated and practiced in the clinic. Read More

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September 2021

Platelet lysate functionalized GelMA microspheres for improving angiogenesis in endodontic regeneration.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Chengdu Shiliankangjian Biotechnology Co., Ltd.. Electronic address:

Rapid angiogenesis is one of the challenges in endodontic regeneration. Recently, tailored polymeric microsphere system that loaded pro-angiogenic growth factors (GFs) is promising in facilitating vascularization in dental pulp regeneration. In addition, the synergistic effect of multiple GFs is considered more beneficial, but combination usage of them is rather complex and costly. Read More

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September 2021

Ongoing Transformation in the Field of Intellectual and Developmental Disabilities: Taking Action for Future Progress.

Intellect Dev Disabil 2021 Oct;59(5):380-391

Marc J. Tassé, The Ohio State University.

There has been a significant transformation in the field of intellectual and developmental disabilities (IDD) over the last 5 decades. Although this transformation has profoundly influenced multiple stakeholders, the field is currently at a critical juncture and facing a number of social and political challenges. Given the relevance of the question, "where is the field of IDD and where do we go," the present article describes the field's transformation, and suggests future action steps to facilitate and sustain the transformation. Read More

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October 2021

Incorporating metadata in HIV transmission network reconstruction: A machine learning feasibility assessment.

PLoS Comput Biol 2021 Sep 22;17(9):e1009336. Epub 2021 Sep 22.

Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, San Diego, California, United States.

HIV molecular epidemiology estimates the transmission patterns from clustering genetically similar viruses. The process involves connecting genetically similar genotyped viral sequences in the network implying epidemiological transmissions. This technique relies on genotype data which is collected only from HIV diagnosed and in-care populations and leaves many persons with HIV (PWH) who have no access to consistent care out of the tracking process. Read More

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September 2021

Dengue virus serotype 1 conformational dynamics confers virus strain-dependent patterns of neutralization by polyclonal sera.

J Virol 2021 Sep 22:JVI0095621. Epub 2021 Sep 22.

Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Dengue virus co-circulates globally as four serotypes (DENV1-4) that vary up to 40% at the amino acid level. Viral strains within a serotype further cluster into multiple genotypes. Eliciting a protective tetravalent neutralizing antibody response is a major goal of vaccine design, and efforts to characterize epitopes targeted by polyclonal mixtures of antibodies are ongoing. Read More

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September 2021

An Overview of Organoid and 3-Dimensional Models in Multiple Myeloma.

Authors:
Cesar Rodriguez

Cancer J 2021 May-Jun 01;27(3):239-246

From the Wake Forest University and Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC.

Abstract: Multiple myeloma is a hematological malignancy of differentiated B cells that resides primarily in bone marrow niches. Its interaction with the microenvironment is known to provide a survival advantage and plays an important role in drug resistance. Despite the increased efficacy of new treatment drugs, clinical results oftentimes fall short of in vitro observations, and this disease remains incurable. Read More

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September 2021

Can a sleep disorder intervention-embedded self-management programme contribute to improve management of diabetes? A pilot single-arm pretest and post-test study.

BMJ Open 2021 Sep 21;11(9):e045783. Epub 2021 Sep 21.

Chronic Care and Family Nursing, Division of Nursing Science, Graduate School of Biomedical and Health Sciences, Hiroshima University Graduate School, Hiroshima, Japan.

Objective: To investigate the efficacy and feasibility of a self-management programme incorporating a sleep intervention for improving diabetes outcomes.

Design: A single-arm pre-test and post-test study was conducted within a community setting in Hiroshima, Japan.

Participants: Participants were aged 52-74 years and diagnosed with type 2 diabetic nephropathy stages 1-3. Read More

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September 2021

ReScribe: An Unrestrained Tool Combining Multiplex Recombineering and Minimal-PAM ScCas9 for Genome Recoding .

ACS Synth Biol 2021 Sep 22. Epub 2021 Sep 22.

Laboratory of Systems and Synthetic Biology, Wageningen University & Research, Wageningen 6708 WE, The Netherlands.

Genome recoding enables incorporating new functions into the DNA of microorganisms. By reassigning codons to noncanonical amino acids, the generation of new-to-nature proteins offers countless opportunities for bioproduction and biocontainment in industrial chassis. A key bottleneck in genome recoding efforts, however, is the low efficiency of recombineering, which hinders large-scale applications at acceptable speed and cost. Read More

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September 2021

Comparison of the current abattoir surveillance system for detection of paratuberculosis in Australian sheep with quantitative PCR tissue strategies using simulation modelling.

Prev Vet Med 2021 Sep 15;196:105495. Epub 2021 Sep 15.

Faculty of Science, Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia. Electronic address:

Abattoir surveillance for Johne's disease monitoring in Australia has provided valuable feedback to producers about their flock's disease status since its commencement in 1999. The current surveillance system relies on the identification of gross lesions in sheep carcases at an abattoir, followed by sampling and histopathology testing. This manual inspection system has not been adapted to meet the changing disease situation, as infection prevalence levels have declined over time due to vaccination. Read More

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September 2021

ZnO-POM Cluster Sub-1 nm Nanosheets as Robust Catalysts for the Oxidation of Thioethers at Room Temperature.

J Am Chem Soc 2021 Sep 21. Epub 2021 Sep 21.

Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Two-dimensional (2D) zinc oxides have attracted more and more research interests due to their unique properties. Yet, it remains a great challenge to limit the thickness to the sub-1 nm scale and further combine with other components to obtain 2D hybrid zinc oxide (ZnO)-based sub-1 nm materials. Herein, a versatile strategy was successfully developed to realize the controllable preparation of ZnO-polyoxometalate (POM)-based 2D hybrid sub-1 nm nanosheet (HSNS) superstructures by incorporating three kinds of molybdenum-based POM clusters into the zinc oxide system. Read More

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September 2021

Preterm birth among women with and without severe acute respiratory syndrome coronavirus 2 infection.

Acta Obstet Gynecol Scand 2021 Sep 21. Epub 2021 Sep 21.

Department of Obstetrics and Gynecology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.

Introduction: Studies directly comparing preterm birth rates in women with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are limited. Our objective was to determine whether preterm birth was affected by SARS-CoV-2 infection within a large integrated health system in New York with a universal testing protocol.

Material And Methods: This retrospective cohort study evaluated data from seven hospitals in New York City and Long Island between March 2020 and June 2021, incorporating both the first and second waves of the coronavirus disease 2019 (COVID-19) pandemic in the USA. Read More

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September 2021

Robustness of deep learning segmentation of cardiac substructures in non-contrast computed tomography for breast cancer radiotherapy.

Med Phys 2021 Sep 20. Epub 2021 Sep 20.

Department of Radiation Oncology, Washington University in St Louis School of Medicine, St. Louis, Missouri.

Purpose: To develop and evaluate deep learning based auto-segmentation of cardiac substructures from non-contrast planning computed tomography (CT) images in patients undergoing breast cancer radiotherapy and to investigate the algorithm sensitivity to out-of-distribution data such as CT image artifacts.

Methods: Nine substructures including Aortic Valve (AV), Left Anterior Descending (LAD), Tricuspid Valve (TV), Mitral Valve (MV), Pulmonic Valve (PV), Right Atrium (RA), Right Ventricle (RV), Left Atrium (LA) and Left Ventricle (LV) were manually delineated by a radiation oncologist on non-contrast CT images of 129 patients with breast cancer; among them 90 were considered in-distribution data, also named 'clean' data. The image/label pairs of 60 subjects were used to train a 3D deep neural network while the remaining 30 were used for testing. Read More

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September 2021

SARS-CoV-2 serology across scales: a framework for unbiased seroprevalence estimation incorporating antibody kinetics and epidemic recency.

medRxiv 2021 Sep 14. Epub 2021 Sep 14.

Serosurveys are a key resource for measuring SARS-CoV-2 cumulative incidence. A growing body of evidence suggests that asymptomatic and mild infections (together making up over 95% of all infections) are associated with lower antibody titers than severe infections. Antibody levels also peak a few weeks after infection and decay gradually. Read More

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September 2021

Clinical Practice Guidelines for the Management of Patients With Cleft Lip and Palate: A Systematic Quality Appraisal Using the Appraisal of Guidelines for Research and Evaluation II Instrument.

J Craniofac Surg 2021 Sep 20. Epub 2021 Sep 20.

Department of Otorhinolaryngology Perelman School of Medicine, University of Pennsylvania Drexel University College of Medicine, Philadelphia, PA Department of Pediatrics, University of Texas Health Science Center-San Antonio, San Antonio, TX Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.

Abstract: Patients with cleft lip and/or palate require complex and longitudinal care by a multidisciplinary cleft team. Unfortunately, delivery of cleft care is often fragmented, and care practices can vary significantly. Multiple clinical practice guidelines (CPGs) have been proposed to provide a standardized framework for cleft care delivery. Read More

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September 2021

Gene-gene interaction analysis incorporating network information via a structured Bayesian approach.

Stat Med 2021 Sep 20. Epub 2021 Sep 20.

School of Statistics and Management, Shanghai University of Finance and Economics, Shanghai, China.

Increasing evidence has shown that gene-gene interactions have important effects in biological processes of human diseases. Due to the high dimensionality of genetic measurements, interaction analysis usually suffers from a lack of sufficient information and has unsatisfactory results. Biological network information has been massively accumulated, allowing researchers to identify biomarkers while taking a system perspective, conducting network selection (of functionally related biomarkers), and accommodating network structures. Read More

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September 2021

Psychological Interventions for the Treatment of Chronic Pain in Adults.

Psychol Sci Public Interest 2021 Sep;22(2):52-95

VA Connecticut Healthcare System, West Haven, Connecticut.

The high prevalence and societal burden of chronic pain, its undertreatment, and disparities in its management have contributed to the acknowledgment of chronic pain as a serious public-health concern. The concurrent opioid epidemic, and increasing concern about overreliance on opioid therapy despite evidence of limited benefit and serious harms, has heightened attention to this problem. The biopsychosocial model has emerged as the primary conceptual framework for understanding the complex experience of chronic pain and for informing models of care. Read More

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September 2021

Spalling-Induced Liftoff and Transfer of Electronic Films Using a van der Waals Release Layer.

Small 2021 Sep 20:e2102668. Epub 2021 Sep 20.

Air Force Research Laboratory, Sensors Directorate, WPAFB, OH, 45433, USA.

Heterogeneous integration strategies are increasingly being employed to achieve more compact and capable electronics systems for multiple applications including space, electric vehicles, and wearable and medical devices. To enable new integration strategies, the growth and transfer of thin electronic films and devices, including III-nitrides, metal oxides, and 2D materials, using 2D boron nitride (BN)-on-sapphire templates are demonstrated. The van der Waals (vdW) BN layer, in this case, acts as a preferred mechanical release layer for precise separation at the substrate-film interface and leaves a smooth surface suitable for vdW bonding. Read More

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September 2021

A Bayesian method for synthesizing multiple diagnostic outcomes of COVID-19 tests.

R Soc Open Sci 2021 Sep 15;8(9):201867. Epub 2021 Sep 15.

JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.

The novel coronavirus disease 2019 (COVID-19) has spread worldwide and threatened human life. Diagnosis is crucial to contain the spread of SARS-CoV-2 infections and save lives. Diagnostic tests for COVID-19 have varying sensitivity and specificity, and the false-negative results would have substantial consequences to patient treatment and pandemic control. Read More

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September 2021

Cognitive health after menopause: Does menopausal hormone therapy affect it?

Best Pract Res Clin Endocrinol Metab 2021 Aug 17:101565. Epub 2021 Aug 17.

Department of Obstetrics and Gynecology, University Hospital of Zürich, Frauenklinikstrasse 10, 8091, Zürich, Switzerland. Electronic address:

Dementia is a pandemic chronic non-communicable disease. 10 in 100 women above age 65 will be diagnosed with dementia, primarily Alzheimer's disease (AD). Apart from age and hereditary risk factors, there are multiple acquired risk and protective factors. Read More

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Life expectancy estimates based on comorbidities and frailty to inform preventive care.

J Am Geriatr Soc 2021 Sep 18. Epub 2021 Sep 18.

Department of Oncology, Division of Biostatistics and Bioinformatics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Long-term prognostication is important to inform preventive care in older adults. Existing prediction indices incorporate age and comorbidities. Frailty is another important factor in prognostication. Read More

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September 2021

Supramolecular self-assembled DNA nanosystem for synergistic chemical and gene regulations on cancer cells.

Angew Chem Int Ed Engl 2021 Sep 17. Epub 2021 Sep 17.

Tianjin University, Chemistry Department, Room 328, Building 54, 300350, Tianjin, CHINA.

Incorporating multiple molecular interactions within a system to realize the metabolic reprogramming of cancer cells is prospected to be of great potential in cancer therapy. Herein, we report a supramolecular self-assembled DNA nanosystem, which reprogrammed the cellular antioxidant system via synergistic chemical and gene regulations. In the nanosystem, amphipathic telluroether was coordinated with Mn(II) to self-assemble into micelle, on which a siNrf2 integrated DNA network was assembled. Read More

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September 2021

Machine learning to investigate superficial white matter integrity in early multiple sclerosis.

J Neuroimaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.

Background And Purpose: This study aims todetermine the sensitivity of superficial white matter (SWM) integrity as a metric to distinguish early multiple sclerosis (MS) patients from healthy controls (HC).

Methods: Fractional anisotropy and mean diffusivity (MD) values from SWM bundles across the cortex and major deep white matter (DWM) tracts were extracted from 29 early MS patients and 31 age- and sex-matched HC. Thickness of 68 cortical regions and resting-state functional-connectivity (RSFC) among them were calculated. Read More

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September 2021

Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1.

PLoS Comput Biol 2021 Sep 16;17(9):e1008513. Epub 2021 Sep 16.

Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Melbourne, Australia.

The PI3K/MTOR signalling network regulates a broad array of critical cellular processes, including cell growth, metabolism and autophagy. The mechanistic target of rapamycin (MTOR) kinase functions as a core catalytic subunit in two physically and functionally distinct complexes mTORC1 and mTORC2, which also share other common components including MLST8 (also known as GβL) and DEPTOR. Despite intensive research, how mTORC1 and 2 assembly and activity are coordinated, and how they are functionally linked remain to be fully characterized. Read More

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September 2021

Clustering Lifestyle Risk Behaviors among Vietnamese Adolescents and Roles of School: A Bayesian Multilevel Analysis of Global School-Based Student Health Survey 2019.

Lancet Reg Health West Pac 2021 Oct 30;15:100225. Epub 2021 Jul 30.

Hanoi University of Public Health, Hanoi, 100000, Vietnam.

Background: Adolescence is a vulnerable period for many lifestyle risk behaviors. In this study, we aimed to 1) examine a clustering pattern of lifestyle risk behaviors; 2) investigate roles of the school health promotion programs on this pattern among adolescents in Vietnam.

Methods: We analyzed data of 7,541 adolescents aged 13-17 years from the 2019 nationally representative Global School-based Student Health Survey, conducted in 20 provinces and cities in Vietnam. Read More

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October 2021

Comparative Metabolomics of Fruits and Leaves in a Hyperdiverse Lineage Suggests Fruits Are a Key Incubator of Phytochemical Diversification.

Front Plant Sci 2021 30;12:693739. Epub 2021 Aug 30.

Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.

Interactions between plants and leaf herbivores have long been implicated as the major driver of plant secondary metabolite diversity. However, other plant-animal interactions, such as those between fruits and frugivores, may also be involved in phytochemical diversification. Using 12 species of , we conducted untargeted metabolomics and molecular networking with extracts of fruits and leaves. Read More

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Considering intervention intensity in habitat restoration planning: An application to Pacific salmon.

J Environ Manage 2021 Sep 6;299:113536. Epub 2021 Sep 6.

Northwest Fisheries Science Center, 2725 Montlake Blvd. East, Seattle, WA, 98112, USA; Pacific Marine Environmental Laboratory, 7600 Sand Point Way NE, Seattle, WA, 98115, USA.

Habitat restoration is a key strategy for recovering imperiled species, and planning habitat restoration activities cost effectively can help advance recovery objectives. Habitat restoration planning involves decisions about where and when to undertake restoration, and what type of restoration to undertake. This article focuses on decisions about the amount of restoration to undertake for a given type, location, and time, termed intervention intensity. Read More

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September 2021

A Multiplex Noninvasive Salivary Antibody Assay for SARS-CoV-2 Infection and Its Application in a Population-Based Survey by Mail.

Microbiol Spectr 2021 Sep 15:e0069321. Epub 2021 Sep 15.

U.S. Environmental Protection Agencygrid.418698.a, Chapel Hill, North Carolina, USA.

Noninvasive salivary antibody immunoassays can enable low-cost epidemiological surveillance of infections. This study involved developing and validating a multiplex suspension immunoassay on the Luminex platform to measure immunoglobulin G (IgG) responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid and spike (S) proteins, and the spike protein's S1 and S2 subunits and receptor binding domain. Multiple versions of these recombinant proteins acquired from commercial and noncommercial sources were evaluated. Read More

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September 2021