5,510 results match your criteria incomplete spinal


Association of age with the timing of acute spine surgery-effects on neurological outcome after traumatic spinal cord injury.

Eur Spine J 2021 Sep 17. Epub 2021 Sep 17.

Clinical and Experimental Spinal Cord Injury Research (Neuroparaplegiology), Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Purpose: To investigate the association of age with delay in spine surgery and the effects on neurological outcome after traumatic spinal cord injury (SCI).

Methods: Ambispective cohort study (2011-2017) in n = 213 patients consecutively enrolled in a Level I trauma center with SCI care in a metropolitan region in Germany. Age-related differences in the injury to surgery interval and conditions associated with its delay (> 12 h after SCI) were explored using age categories or continuous variables and natural cubic splines. Read More

View Article and Full-Text PDF
September 2021

Anatomical Increased/Decreased Changes in the Brain Area Following Individuals with Chronic Traumatic Complete Thoracic Spinal Cord Injury.

Phys Ther Res 2021 1;24(2):163-169. Epub 2021 Apr 1.

Department of Rehabilitation Therapy, Chiba Rehabilitation Center, Japan.

Objectives: This study aimed to investigate anatomical changes in the brain following chronic complete traumatic thoracic spinal cord injury (ThSCI) using voxel-based morphometry (VBM). That is, it attempted to examine dynamic physical change following thoracic injury and the presence or absence of regions with decreased and increased changes in whole brain volume associated with change in the manner of how activities of daily living are performed.

Methods: Twelve individuals with chronic traumatic complete ThSCI (age; 21-63 years, American Spinal Injury Association Impairment Scale; grade C-D) participated in this study. Read More

View Article and Full-Text PDF

Comparative Analysis of Non-Full and Full Endoscopic Spine Technique via Interlaminar Approach for the Treatment of Degenerative Lumbar Spinal Stenosis: A Retrospective, Single Institute, Propensity Score-Matched Study.

Global Spine J 2021 Sep 16:21925682211039181. Epub 2021 Sep 16.

Department of TCM Orthopedics, Sixth Medical Center, PLA General Hospital, Beijing, People's Republic of China.

Study Design: Retrospective study.

Objective: To compare the clinical efficacy of posterior lumbar laminectomy decompression under full endoscopic technique (Endo-LOVE) and percutaneous endoscopic medial foraminal decompression (PE-MFD) in the treatment of degenerative lumbar spinal stenosis (DLSS).

Methods: Between April 2017 and April 2018, 96 patients with DLSS underwent Endo-LOVE or PE-MFD, including 58 with Endo-LOVE and 38 with PE-MFD. Read More

View Article and Full-Text PDF
September 2021

Subanalgesic morphine doses augment fentanyl analgesia by interacting with delta opioid receptors in male rats.

J Neurosci Res 2021 Sep 14. Epub 2021 Sep 14.

Anesthesiology Institute, Allegheny Health Network, Pittsburgh, PA, USA.

Opioids are commonly used for the treatment of postoperative and post-traumatic pain; however, their therapeutic effectiveness is limited by undesirable and life-threatening side effects. Researchers have long attempted to develop opioid co-administration therapies that enhance analgesia, but the complexity of opioid analgesia and our incomplete mechanistic understanding has made this a daunting task. We discovered that subanalgesic morphine doses (100 ng/kg-10 µg/kg) augmented the acute analgesic effect of fentanyl (20 µg/kg) following subcutaneous drug co-administration to male rats. Read More

View Article and Full-Text PDF
September 2021

Improved Physiological Gait in Acute and Chronic SCI Patients After Training With Wearable Cyborg Hybrid Assistive Limb.

Front Neurorobot 2021 26;15:723206. Epub 2021 Aug 26.

Department of General and Trauma Surgery, BG University Hospital Bergmannsheil, Bochum, Germany.

In recent years robotic devices became part of rehabilitation offers for patients suffering from Spinal Cord Injury (SCI) and other diseases. Most scientific publications about such devices focus on functional outcome. The aim of this study was to verify whether an improvement in physiological gait can be demonstrated in addition to the functional parameters after treatment with neurological controlled HAL® Robot Suit. Read More

View Article and Full-Text PDF

Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection.

Front Cell Neurosci 2021 26;15:730348. Epub 2021 Aug 26.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

Spinal cord injury (SCI) usually results in permanent functional impairment and is considered a worldwide medical problem. However, both motor and sensory functions can spontaneously recover to varying extents in humans and animals with incomplete SCI. This study observed a significant spontaneous hindlimb locomotor recovery in Sprague-Dawley rats at four weeks after post-right-side spinal cord hemisection at thoracic 8 (T8). Read More

View Article and Full-Text PDF

Variations in management of A3 and A4 cervical spine fractures as designated by the AO Spine Subaxial Injury Classification System.

J Neurosurg Spine 2021 Sep 10:1-14. Epub 2021 Sep 10.

11The Rothman Institute at Thomas Jefferson University, Philadelphia, Pennsylvania.

Objective: Optimal management of A3 and A4 cervical spine fractures, as defined by the AO Spine Subaxial Injury Classification System, remains controversial. The objectives of this study were to determine whether significant management variations exist with respect to 1) fracture location across the upper, middle, and lower subaxial cervical spine and 2) geographic region, experience, or specialty.

Methods: A survey was internationally distributed to 272 AO Spine members across six geographic regions (North America, South America, Europe, Africa, Asia, and the Middle East). Read More

View Article and Full-Text PDF
September 2021

Impact of fractional amplitude of low-frequency fluctuations in motor- and sensory-related brain networks on spinal cord injury severity.

NMR Biomed 2021 Sep 10:e4612. Epub 2021 Sep 10.

Department of Medical & Biological Engineering, Kyungpook National University, South Korea.

Spinal cord injury (SCI) can cause motor, sensory, and autonomic dysfunctions and may affect the cerebral functions. However, the mechanisms of plastic changes in the brain according to SCI severity remain poorly understood. Therefore, in the current study, we compared the brain activity of the entire neural network according to severity of SCI using fractional amplitude of low-frequency fluctuations (fALFF) analysis in resting-state functional magnetic resonance imaging (rs-fMRI). Read More

View Article and Full-Text PDF
September 2021

Pattern and outcome of traumatic spinal cord injury managed at University of Maiduguri Teaching Hospital, Nigeria: A retrospective study.

Niger Postgrad Med J 2021 Apr-Jun;28(2):139-144

Department of Medical Rehabilitation (Physiotherapy), Faculty of Allied Health Sciences, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, Nigeria.

Background: Understanding pattern and outcome of traumatic spinal cord injury (TSCI) will inform better management which expectedly would improve prognosis and minimise complications.

Methods: : A retrospective study was carried out on all managed TSCI cases from January 2009 to December 2018. Sociodemographic characteristics, injury type, cause and complications were extracted from patients' registers and case folders. Read More

View Article and Full-Text PDF
September 2021

Clinical characteristics and prognosis of spinal cord injury in individuals over 75 years old.

Neurocirugia (Astur : Engl Ed) 2021 Sep-Oct;32(5):209-216. Epub 2020 Oct 28.

Unidad de Lesionados Medulares, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain; Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Universidad de A Coruña, A Coruña, Spain.

Objective: To analyze the incidence and characteristics of traumatic spinal cord injury (SCI) in geriatric population of Galicia (Spain), hospital management and functional prognosis METHODS: Comparative retrospective study. Patients admitted with acute traumatic SCI during the time period between January 2010 and December 2016 were included. Two groups established: The elderly over and under 75 years of age, with the latter acting as a control group. Read More

View Article and Full-Text PDF
September 2021

Increased Ipsilateral M1 Activation after Incomplete Spinal Cord Injury Facilitates Motor Performance.

J Neurotrauma 2021 Sep 2. Epub 2021 Sep 2.

Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Incomplete spinal cord injury (SCI) may result in muscle weakness and difficulties with force gradation. Although these impairments arise from the injury and subsequent changes at spinal levels, changes have also been demonstrated in the brain. Blood-oxygen-level dependent (BOLD) imaging was used to investigate these changes in brain activation in the context of unimanual contractions with the first dorsal interosseous muscle. Read More

View Article and Full-Text PDF
September 2021

Polyglutamine diseases.

Curr Opin Neurobiol 2021 Sep 3;72:39-47. Epub 2021 Sep 3.

UCL Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK; UK Dementia Research Institute, University College London, London, WC1N 3BG, UK. Electronic address:

Polyglutamine diseases are a collection of nine CAG trinucleotide expansion disorders, presenting with a spectrum of neurological and clinical phenotypes. Recent human, mouse and cell studies of Huntington's disease have highlighted the role of DNA repair genes in somatic expansion of the CAG repeat region, modifying disease pathogenesis. Incomplete splicing of the HTT gene has also been shown to occur in humans, with the resulting exon 1 fragment most probably contributing to the Huntington's disease phenotype. Read More

View Article and Full-Text PDF
September 2021

Epidemiological changes in traumatic spinal cord injuries for the last 30 years (1990-2019) in South Korea.

Spinal Cord 2021 Aug 31. Epub 2021 Aug 31.

Department of Rehabilitation Medicine, National Rehabilitation Center, Seoul, South Korea.

Study Design: Retrospective descriptive study.

Objectives: To identify the characteristics of and epidemiological trends in traumatic spinal cord injuries (TSCIs) in Korea from 1990 to 2019.

Setting: National Rehabilitation Center affiliated with the Ministry of Health and Welfare in Korea. Read More

View Article and Full-Text PDF

Long-term core outcomes in cauda equina syndrome.

Bone Joint J 2021 Sep;103-B(9):1464-1471

Norfolk and Norwich University Hospital, Norwich, UK.

Aims: Cauda equina syndrome (CES) can be associated with chronic severe lower back pain and long-term autonomic dysfunction. This study assesses the recently defined core outcome set for CES in a cohort of patients using validated questionnaires.

Methods: Between January 2005 and December 2019, 82 patients underwent surgical decompression for acute CES secondary to massive lumbar disc prolapse at our hospital. Read More

View Article and Full-Text PDF
September 2021

Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury.

Exp Neurol 2021 Aug 28;346:113853. Epub 2021 Aug 28.

Neuroscience Graduate Program, The Ohio State University, Columbus, OH 43210, USA; Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH 43210, USA; School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH 43210, USA. Electronic address:

Experience-dependent white matter plasticity offers new potential for rehabilitation-induced recovery after neurotrauma. This first-in-human translational experiment combined myelin water imaging in humans and genetic fate-mapping of oligodendrocyte lineage cells in mice to investigate whether downhill locomotor rehabilitation that emphasizes eccentric muscle actions promotes white matter plasticity and recovery in chronic, incomplete spinal cord injury (SCI). In humans, of 20 individuals with SCI that enrolled, four passed the imaging screen and had myelin water imaging before and after a 12-week (3 times/week) downhill locomotor treadmill training program (SCI + DH). Read More

View Article and Full-Text PDF

Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series.

Animals (Basel) 2021 Aug 19;11(8). Epub 2021 Aug 19.

CIISA-Centro Interdisciplinar-Investigação em Saúde Animal, Faculdade de Medicina Veterinária, Av. Universidade Técnica de Lisboa, 1300-477 Lisboa, Portugal.

This case series study aimed to evaluate the safety, feasibility, and positive outcome of the neurorehabilitation multimodal protocol (NRMP) in 16 chronic post-surgical IVDD Hansen type I dogs, with OFS 0/DPP- ( = 9) and OFS 1/DPP+ ( = 7). All were enrolled in the NRMP for a maximum of 90 days and were clinically discharged after achieving ambulation. The NRMP was based on locomotor training, functional electrical stimulation, transcutaneous electrical spinal cord stimulation, and 4-aminopyridine (4-AP) pharmacological management. Read More

View Article and Full-Text PDF

A severe case of non-infective myositis six weeks post intramuscular injections of Onabotulinum toxin A (Botox) in a young man with tetraplegia: case report.

Spinal Cord Ser Cases 2021 Aug 24;7(1):76. Epub 2021 Aug 24.

Spinal Injuries Unit, Royal North Shore Hospital, St Leonards, NSW, Australia.

Introduction: Myositis of unknown aetiology might be a very rare complication of intramuscular injections of onabotulinum toxin A (Botox) for spasticity treatment.

Case Presentation: We describe a case of significant myositis of unknown aetiology in a 17-year-old man, who was admitted for rehabilitation 4 months after his initial spinal cord injury (SCI) as a result of a mountain bike accident. He has an incomplete tetraplegia, C4 AIS B international Standards for Neurological Classification for Spinal Cord Injury (ISNCSCI) [1] due to C5 vertebra 3 column fracture [2]. Read More

View Article and Full-Text PDF

Effect of the Timing of Surgery on Neurological Recovery for Patients with Incomplete Paraplegia Caused by Metastatic Spinal Cord Compression.

Ther Clin Risk Manag 2021 13;17:831-840. Epub 2021 Aug 13.

Department of Orthopaedics, Peking University First Hospital, Beijing, People's Republic of China.

Objective: This study aimed to investigate the effect of timing of surgery on neurological recovery for patients with metastatic spinal cord compression (MSCC).

Methods: According to the timing of surgery, 75 patients with incomplete paraplegia caused by MSCC were assigned to 3 groups: within 3 days (group A), between 4 days and 7 days (group B), and after 7 days (group C). -test, one-way ANOVA, Mann-Whitney -test, and Chi-square test were used to evaluate the difference in the improvement of American Spinal Injury Association Impairment Scale (AIS) and ambulatory status, the incidence of perioperative complications, surgical site infection, and the length of hospital stay between 3 groups. Read More

View Article and Full-Text PDF

A common yet undescribed MRI finding in newborns: posterior epidural space edema of the cervical and upper thoracic spine.

Neuroradiology 2021 Aug 18. Epub 2021 Aug 18.

Department of Radiology, Neuroradiology Section, University of Minnesota, Minneapolis, MN, USA.

Purpose: Posterior spinal epidural space (PSES) is a fat-containing space. We noted numerous spinal MRIs demonstrating T2-hyperintense thickening of the cervical/thoracic PSES in early newborns, resembling epidural edema. Our aim is to describe the appearance/frequency of this finding and explore any associations with delivery. Read More

View Article and Full-Text PDF

Lumbar spondylolysis - Current concepts review.

Authors:
Ujjwal K Debnath

J Clin Orthop Trauma 2021 Oct 30;21:101535. Epub 2021 Jul 30.

Professor of Orthopaedics, Jagannath Gupta Institute of Medical Sciences, Kolkata.

Lumbar pars interarticularis (PI) injury or spondylolysis occurs only in humans. This represents a stress fracture of the PI. Excessive loading in repetitive hyperextension is a significant risk factor and occurs most commonly at L5 followed by L4. Read More

View Article and Full-Text PDF
October 2021

Predictors of incomplete maternal satisfaction with neuraxial labor analgesia: A nationwide study.

Anaesth Crit Care Pain Med 2021 Aug 14;40(5):100939. Epub 2021 Aug 14.

Université de Paris, Center of Research in Epidemiology and StatisticS/CRESS/Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOPé), INSERM, INRA, F-75004 Paris, France; Midwifery School of Baudelocque, AP-HP, Université de Paris, F-75006 Paris, France.

Purpose: Neuraxial analgesia is effective and widely used during labour, but little is known about maternal satisfaction with its use. Our objectives were to assess the frequency of incomplete maternal satisfaction with neuraxial labour analgesia and its predictors.

Methods: We extracted data from the 2016 National Perinatal Survey, a cross-sectional population-based study including all births during one week in all French maternity units. Read More

View Article and Full-Text PDF

Therapeutic targets and nanomaterial-based therapies for mitigation of secondary injury after spinal cord injury.

Nanomedicine (Lond) 2021 Sep 17;16(22):2013-2028. Epub 2021 Aug 17.

Department of Bioengineering, Drug Design, Development & Delivery (4D) Laboratory, Clemson University, Clemson, SC 29634, USA.

Spinal cord injury (SCI) and the resulting neurological trauma commonly result in complete or incomplete neurological dysfunction and there are few effective treatments for primary SCI. However, the following secondary SCI, including the changes of microvasculature, inflammatory response and oxidative stress around the injury site, may provide promising therapeutic targets. The advances of nanomaterials hold promise for delivering therapeutics to alleviate secondary SCI and promote functional recovery. Read More

View Article and Full-Text PDF
September 2021

Bleeding and antithrombotic therapy during pregnancy in women with poor aPL-related obstetric outcomes: A survey of 1075 cases from EUROAPS registry∗.

Eur J Anaesthesiol 2021 09;38(9):916-922

From the Systemic Autoimmune Disease Unit, Department of Internal Medicine, Vall d'Hebron University Hospital, Department of Medicine, Universitat Autonoma (JA-R, JP-G), Internal Medicine Department, Althaia Healthcare University Network of Manresa, Systemic Autoimmune Disease Unit, Manresa (EE-V), High Risk Unit, Obstetric Department, Quirón University Hospital, Barcelona (RF-O), Internal Medicine Department, Miguel Servet University Hospital, Zaragoza, Spain (LS-C), Haematology Unit, Hippokration Hospital of Thessaloniki, Greece (EL), AP-HP, Hôpital Saint-Antoine, Service de Médecine Interne and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Sorbonne Universités, UPMC University, Paris (AM), Vascular and Coagulation Department, University Hospital Angers, Angers, France (CB), Rheumatology Unit, Department of Clinical and Experimental Medicine Azienda Ospedaliera, University of Padua, Padua (AR), Rheumatology and Clinical Immunology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili, Brescia (AT, CN), Department of Obstetrics and Gynaecology, Università di Torino, Torino, Italy (LM), Systemic Autoimmune Diseases Service, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain (GE), Department of Gynaecology, Gemmelli Hospital, Catholic University, Rome, Italy (SDeC), Autoimmune, Thrombophilic Diseases and Pregnancy Division, Dr Carlos G Durand Hospital, Buenos Aires, Argentina (OL, US), Obstetrics and Gynaecology Department, High Risk Unit, University Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (ELL), Immunorheumatology Research Laboratory, Istituto Auxologico Italiano (LT), Division of Rheumatology, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy (CC), Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua (VP), Pregnancy and Rheumatic Diseases Clinic Unit of Medicine and Clinical Immunology IRCCS Ospedale San Raffaele Università Vita-Salute San Raffaele, Milano, Italy (PR-Q, VC), Department of Obstetrics, Medical University Graz, Graz, Austria (KM-P), Department of Systemic Rheumatic Disease, V.A. Nasonova Research Institute of Rheumatology, Moscow, Russia (TR), Department of Gynecology Obstetrics and Urology, "Sapienza" University of Rome, Rome, Italy (ST) and Clinical Research Unit, Althaia Healthcare University Network of Manresa, Barcelona, Catalonia Central University, Manresa-Vic, Spain (AA).

Background: The combination of low-dose aspirin (LDA) and low-molecular-weight heparin (LMWH) until the end of gestation are the currently the accepted standard of care for the treatment of antiphospholipid-related obstetric disorders. In refractory cases, hydroxychloroquine (HCQ) can be added to this standard of care.

Objective: To evaluate the haemostatic safety of LDA and LMWH (medium to high prophylactic doses) during pregnancy and the puerperium in women with both full-blown obstetric antiphospholipid syndrome (OAPS) (Sydney criteria) and noncriteria - incomplete - OAPS. Read More

View Article and Full-Text PDF
September 2021

Accuracy of bioelectrical impedance analysis and skinfold thickness in the assessment of body composition in people with chronic spinal cord injury.

Spinal Cord 2021 Aug 12. Epub 2021 Aug 12.

Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

Study Design: Cross-sectional study.

Objectives: This study: (1) investigated the accuracy of bioelectrical impedance analysis (BIA) and skinfold thickness relative to dual-energy X-ray absorptiometry (DXA) in the assessment of body composition in people with spinal cord injury (SCI), and whether sex and lesion characteristics affect the accuracy, (2) developed new prediction equations to estimate fat free mass (FFM) and percentage fat mass (FM%) in a general SCI population using BIA and skinfolds outcomes.

Setting: University, the Netherlands. Read More

View Article and Full-Text PDF

Recombinant myelin oligodendrocyte glycoprotein quality modifies evolution of experimental autoimmune encephalitis in macaques.

Lab Invest 2021 Aug 10. Epub 2021 Aug 10.

Commissariat à l'Énergie Atomique (CEA), Institut de Biologie François Jacob, Molecular Imaging Research Center (MIRCen), Fontenay-aux-Roses, France.

Experimental autoimmune encephalitis (EAE) is a well-recognized model for the study of human acquired demyelinating diseases (ADD), a group of inflammatory disorders of the central nervous system (CNS) characterized by inflammation, myelin loss, and neurological impairment of variable severity. In rodents, EAE is typically induced by active immunization with a combination of myelin-derived antigen and a strong adjuvant as complete Freund's adjuvant (CFA), containing components of the mycobacterial wall, while myelin antigen alone or associated with other bacterial components, as lipopolysaccharides (LPS), often fails to induce EAE. In contrast to this, EAE can be efficiently induced in non-human primates by immunization with the recombinant human myelin oligodendrocyte glycoprotein (rhMOG), produced in Escherichia coli (E. Read More

View Article and Full-Text PDF

Measurement error and reliability of TMS metrics collected from biceps and triceps in individuals with chronic incomplete tetraplegia.

Exp Brain Res 2021 Aug 10. Epub 2021 Aug 10.

Plow Lab (ND 20), Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, ND20, Cleveland, OH, 44195, USA.

Transcranial magnetic stimulation (TMS) is used to investigate corticomotor neurophysiology associated with functional recovery in individuals with spinal cord injury (SCI). There is insufficient evidence about test-retest measurement properties of TMS in SCI. Therefore, we investigated test-retest agreement and reliability of TMS metrics representing corticomotor excitability, output, gain, map (representation), and inhibition in individuals with cervical SCI. Read More

View Article and Full-Text PDF

Robot-assisted gait training in individuals with spinal cord injury: A systematic review for the clinical effectiveness of Lokomat.

J Clin Neurosci 2021 Sep 26;91:260-269. Epub 2021 Jul 26.

Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.

Background: Spinal cord injury (SCI) is a critical medical condition that causes numerous impairments leading to accompanying disability. Robotic-assisted gait training (RAGT) offers many advantages, including the capability to increase the intensity and total duration of training while maintaining a physiological gait pattern. The effects of the RAGT 'Lokomat' on various impairments following SCI remain unclear. Read More

View Article and Full-Text PDF
September 2021

Lateral corticospinal tract and dorsal column damage: predictive relationships with motor and sensory scores at discharge from acute rehabilitation after spinal cord injury.

Arch Phys Med Rehabil 2021 Aug 6. Epub 2021 Aug 6.

Stanford University School of Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Palo Alto, CA USA.

Objective: to determine if lateral corticospinal tract (LCST) integrity demonstrates a significant predictive relationship with future ipsilateral lower extremity motor function (LEMS), and if dorsal column (DC) integrity demonstrates a significant predictive relationship with future light touch (LT) sensory function post SCI at time of discharge from inpatient rehabilitation.

Design: retrospective analyses of imaging and clinical outcomes.

Setting: University and academic hospital. Read More

View Article and Full-Text PDF

Treadmill training based on the overload principle promotes locomotor recovery in a mouse model of chronic spinal cord injury.

Exp Neurol 2021 Nov 8;345:113834. Epub 2021 Aug 8.

Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Electronic address:

Rehabilitative treatment, including treadmill training, is considered an important strategy for restoring motor function after spinal cord injury (SCI). However, many unexplained problems persist regarding the appropriate rehabilitative method and the mechanism underlying the beneficial effects of rehabilitation. Moreover, only a few preclinical studies have been performed on rehabilitative interventions for chronic SCI, although most patients have chronic injuries. Read More

View Article and Full-Text PDF
November 2021

Paving the way for a better management of pain in patients with spinal cord injury: An exploratory study on the use of Functional Electric Stimulation(FES)-cycling.

J Spinal Cord Med 2021 Aug 9:1-11. Epub 2021 Aug 9.

IRCCS Centro Neurolesi Bonino Pulejo, Messina, Italy.

Context/objective: Chronic pain is common in patients with spinal cord injury (SCI), for whom it negatively affects quality of life, and its treatment requires an integrated approach. To this end, lower limb functional electrical stimulation (FES) cycling holds promise.

Objective: To investigate pain reduction in a sample of patients with SCI by means of lower limb rehabilitation using FES cycling. Read More

View Article and Full-Text PDF