112,055 results match your criteria incomplete

A language modeling-like approach to sketching.

Neural Netw 2021 Oct 2;144:627-638. Epub 2021 Oct 2.

Department of Information Engineering and Mathematics, University of Siena, Italy. Electronic address:

Sketching is a universal communication tool that, despite its simplicity, is able to efficiently express a large variety of concepts and, in some limited contexts, it can be even more immediate and effective than natural language. In this paper we explore the feasibility of using neural networks to approach sketching in the same way they are commonly used in Language Modeling. We propose a novel approach to what we refer to as "Sketch Modeling", in which a neural network is exploited to learn a probabilistic model that estimates the probability of sketches. Read More

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October 2021

Minimum reporting standards based on a comprehensive review of the zebrafish embryo teratogenicity assay.

Regul Toxicol Pharmacol 2021 Oct 12:105054. Epub 2021 Oct 12.

Shell Health, Shell International, B.V. Carel van Bylandtlaan 16, 2596, HR, The Hague, The Netherlands.

Reproductive toxicity chemical safety assessment involves extensive use of vertebrate animals for regulatory testing purposes. Although alternative methods such as the zebrafish embryo teratogenicity assay (identified in the present manuscript by the acronym ZETA) are promising for replacing tests with mammals, challenges to regulatory application involve lack of standardization and incomplete validation. To identify key protocol aspects and ultimately support to improve this situation, a comprehensive review of the literature on the level of harmonization / standardization and validation status of the ZETA has been conducted. Read More

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October 2021

Use of Midostaurin in Mixed Phenotype Acute Leukemia with FLT3 Mutation: A Case Series.

Eur J Haematol 2021 Oct 15. Epub 2021 Oct 15.

Centre de recherche du Centre hospitalier de l'Université de Montréal, Canada.

Mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia where blasts present phenotypes from more than one lineage. A poor prognostic has been associated with this disease and limited data is currently available to guide the choice of therapy. Regarding FLT3-positive MPAL, only one case treated with midostaurin has been published to date. Read More

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October 2021

[Assessment and operationalization of the characteristic "gender" in representative population-based surveys: challenges and implications with the example of the GeSiD study].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 Oct 15. Epub 2021 Oct 15.

Referat "Evaluation, Methoden, Forschungsdaten", Bundeszentrale für gesundheitliche Aufklärung (BZgA), Maarweg 149-165, 50825, Köln, Deutschland.

Representative quantitative surveys assess the participants' gender in order to allow for gender specific analyses of the research questions and to draw conclusions about the populations. This is important in order to develop information and interventions tailored to the target groups. However, although gender is no longer considered exclusively as a binary construct, it is still often surveyed through a binary variable with the response options woman/man or female/male. Read More

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October 2021

Nocturnal bladder emptying and quality of life in patients with spinal cord injury.

Eur J Phys Rehabil Med 2021 Oct 15. Epub 2021 Oct 15.

Department of Urology, Ghent University Hospital, Ghent, Belgium.

Background: Little is known about the relationship between sleep disruption due to nocturnal bladder emptying and quality of life in patients with spinal cord injury AIM: To evaluate the possible influence of number of nocturnal bladder emptyings, bladder emptying method and nocturnal incontinence on the quality of life of patients with spinal cord injury.

Design: Cross-sectional descriptive study.

Setting: In- and outpatient. Read More

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October 2021

The Craft of Generalism clinical skills and attitudes for whole person care.

J Eval Clin Pract 2021 Oct 15. Epub 2021 Oct 15.

Institute of Population Health Sciences, University of Liverpool, Liverpool, UK.

Rationale, Aims And Objectives: Generalists manage a broad range of biomedical and biographical knowledge as part of each clinical encounter, often in multiple encounters over time. The sophistication of this broad integrative work is often misunderstood by those schooled in reductionist or constructivist approaches to evidence. There is a need to describe the practical and philosophically robust ways that understanding about the whole person is formed. Read More

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October 2021

Development and validation of the Epilepsy Self-Stigma Scale.

Epilepsia Open 2021 Oct 15. Epub 2021 Oct 15.

Department of Psychiatry, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Objective: Self-stigma is the internalization of negative public attitudes and is often experienced by patients with epilepsy (PWE). Greater self-stigma is associated with lower self-esteem and hinders therapeutic behavior. The study aims were to develop an Epilepsy Self-Stigma Scale (ESSS) to assess self-stigma in PWE, and to examine the scale's reliability and validity. Read More

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October 2021

Evaluation of small airway function and its application in patients with chronic obstructive pulmonary disease (Review).

Exp Ther Med 2021 Dec 29;22(6):1386. Epub 2021 Sep 29.

Department of Pulmonary and Critical Care Medicine, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.

Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory disease characterized by incomplete reversible airflow limitation. The diagnosis of COPD is mainly based on pulmonary function examination. In recent years, it has been indicated that small airway dysfunction occurs in patients with all stages of COPD, even in high-risk smoking groups who have not yet met the diagnostic criteria for COPD. Read More

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December 2021

Fluid Attention in Education: Conceptual and Neurobiological Framework.

Front Psychol 2021 28;12:704443. Epub 2021 Sep 28.

Department of Psychological Sciences, Texas Tech University, Lubbock, TX, United States.

Attention is indispensable to our learning, performance, relationships, health, and daily life, and yet laboratory studies of attention have only scratched the surface of these lived varieties of attention. In this article, we begin with William James' theory of derived involuntary attention, which has largely been ignored in laboratory research. We then show that there is a gap in our attention vocabulary and the theory that underpins it, which depend on an incomplete voluntary/involuntary dichotomy. Read More

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September 2021

Deep Multi-path Network Integrating Incomplete Biomarker and Chest CT Data for Evaluating Lung Cancer Risk.

Proc SPIE Int Soc Opt Eng 2021 Feb 15;11596. Epub 2021 Feb 15.

Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, USA 37235.

Clinical data elements (CDEs) (e.g., age, smoking history), blood markers and chest computed tomography (CT) structural features have been regarded as effective means for assessing lung cancer risk. Read More

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February 2021

Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist.

Nat Commun 2021 Oct 14;12(1):6003. Epub 2021 Oct 14.

Institute for Comparative Genomics (ICG), Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada.

Cells replicate and segregate their DNA with precision. Previous studies showed that these regulated cell-cycle processes were present in the last eukaryotic common ancestor and that their core molecular parts are conserved across eukaryotes. However, some metamonad parasites have secondarily lost components of the DNA processing and segregation apparatuses. Read More

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October 2021

Possible Causes for Failure of Endodontic Surgery - A Retrospective Series of 20 Resurgery Cases.

Eur Endod J 2021 Aug;6(2):235-241

Department of Endodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA.

Objective: This study aimed to evaluate unsuccessful endodontic surgery cases for possible causes for treatment failure and evaluate if a nonsurgical retreatment (NSRTX) approach could have been a better alternative to resurgery.

Methods: Analyses of clinical and cone-beam computed tomography (CBCT) images, periapical radiographs, and chart documentation determined study parameters. Preoperative factors were age, sex, tooth type, signs and/or symptoms, presence of periapical radiolucency, previous root canal treatment, timeline since previous endodontic surgery, presence of posts, cores, and restorations. Read More

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Conservative management of long-standing traumatised maxillary central incisor with incomplete apex and severe internal resorption using triple antibiotic paste, mineral trioxide aggregate and fiber-reinforced composite.

BMJ Case Rep 2021 Oct 14;14(10). Epub 2021 Oct 14.

Paediatric and Preventive Dentistry, King George's Medical University Faculty of Dental Sciences, Lucknow, India

Traumatic dental injuries result in damage to many dental and periradicular structures. They can be conservatively managed depending on the extent of the injury. Maxillary central incisors are most commonly involved in traumatic dental injuries mainly because of their anterior and protrusive positioning. Read More

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October 2021

MRI-based Nomogram Predicts the Risk of Progression of Unresectable Hepatocellular Carcinoma After Combined Lenvatinib and anti-PD-1 Antibody Therapy.

Acad Radiol 2021 Oct 11. Epub 2021 Oct 11.

Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Rationale And Objectives: Combined immune and anti-angiogenic treatment has shown promising results for unresectable hepatocellular carcinoma (HCC), but with a high risk of early progression. In this study, we aimed to investigate whether pre-treatment magnetic resonance imaging (MRI) features and MRI-based nomogram could predict the risk of disease progression of unresectable HCC after first-line lenvatinib/anti-PD-1 antibody therapy.

Materials And Methods: Thirty-seven HCC participants with qualified pre-treatment contrast-enhanced MRI were enrolled. Read More

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October 2021

Ataxia Telangiectasia and Rad3-Related Activation by DNA Damage Mitigates Maladaptive Repair after Acute Kidney Injury.

Nephron 2021 Oct 14:1-4. Epub 2021 Oct 14.

Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

DNA damage is an important consequence of injury to the proximal tubule. The proximal tubule cell responds to this damage by mounting a DNA damage response (DDR). Two protein kinases, ataxia-telangiectasia mutated (ATM) or ataxia telangiectasia and Rad3-related (ATR), play an important role in this DDR. Read More

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October 2021

Elimination of cephalexin and doxycycline under low frequency ultrasound.

Ultrason Sonochem 2021 Oct 7;79:105777. Epub 2021 Oct 7.

Grupo GDCON, Facultad de Ingeniería, Sede de Investigación Universitaria (SIU), Universidad de Antioquia UdeA, Calle 70 # 52-21, Medellín, Colombia.

Cephalexin (CPX) and doxycycline (DOX) are two of the most used antibiotics to treat bacterial infections in human medicine, veterinary practices, animal husbandry, agriculture, aquaculture, among others. Nevertheless, due to their excessive consumption and incomplete absorption during their metabolization, they have been detected in different environmental matrices and the effluents of wastewater treatment plants, which reflects that conventional water treatment methods are not enough to eliminate this type of compounds. This paper presents the main results about the removal of the antibiotics CPX and DOX under low frequency (40 kHz) ultrasonic radiation (US). Read More

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October 2021

Predicting Duration of Outpatient Physical Therapy Episodes for Individuals with Spinal Cord Injury Based on Locomotor Training Strategy.

Arch Phys Med Rehabil 2021 Oct 11. Epub 2021 Oct 11.

Professor, Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine and Director, Center for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab, USA.

Objective: To characterize individuals with spinal cord injuries (SCI) who use outpatient physical therapy (PT) or community wellness services for locomotor training and predict the duration of services (DOS) controlling for demographic, injury, quality of life, and service and financial characteristics. We explore how DOS is related to locomotor strategy.

Design: Observational study of participants at four SCI Model Systems centers with survival Weibull regression model to predict DOS. Read More

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October 2021

Clinical Predictors of Mortality in Patients with Moderate to Severe Mitral Regurgitation.

Am J Med 2021 Oct 11. Epub 2021 Oct 11.

Division of Cardiovascular Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon. Electronic address:

Background: Mitral regurgitation is the most common form of valvular heart disease worldwide, however, there is an incomplete understanding of predictors of mortality in this population. This study sought to identify risk factors of mortality in a real-world population with mitral regurgitation.

Methods: All patients with moderate or severe mitral regurgitation were identified at a single center from 1/1/16 to 8/31/17. Read More

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October 2021

Characterizing Outcomes and Unmet Needs Among Patients in the United States with Mild-to-Moderate Plaque Psoriasis Using Prescription Topicals.

Dermatol Ther (Heidelb) 2021 Oct 14. Epub 2021 Oct 14.

Adult and Pediatric Dermatology, Overland Park, KS, USA.

Introduction: Topical therapies are considered first-line treatment in the management of plaque psoriasis (PSO). However, data on patient-reported outcomes for topicals are scarce. We designed a survey to record the treatment experience of patients with mild-to-moderate PSO using prescription topicals. Read More

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October 2021

Effectiveness of a Psychosocial Care Quality Improvement Strategy to Address Quality of Life in Patients With Cancer: The HuCare2 Stepped-Wedge Cluster Randomized Trial.

JAMA Netw Open 2021 Oct 1;4(10):e2128667. Epub 2021 Oct 1.

Medical Oncology Division, Department of Oncology, ASST of Cremona, Cremona, Italy.

Importance: Many patients with cancer who would benefit from psychosocial care do not receive it. Implementation strategies may favor the integration of psychosocial care into practice and improve patient outcomes.

Objective: To evaluate the effectiveness of the Humanization in Cancer Care (HuCare) Quality Improvement Strategy vs standard care as improvement of at least 1 of 2 domains (emotional or social function) of patient health-related quality of life at baseline and 3 months. Read More

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October 2021

Double nail of the second toe: A case report with sonographic and radiological correlation.

Pediatr Dermatol 2021 Oct 14. Epub 2021 Oct 14.

Dermatology Department, Hospital Universitario Puerta de Hierro, Majadahonda, Spain.

Double toenail is a rare abnormality that usually affects the fifth toe. It is considered as an inherited condition that may represent an incomplete form of polydactyly. Underlying bone abnormalities should be ruled out. Read More

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October 2021

Renal nerve stimulation: complete versus incomplete renal sympathetic denervation.

Blood Press 2021 Oct 14:1-10. Epub 2021 Oct 14.

Department of Cardiology, Isala Hospital, Zwolle, The Netherlands.

Purpose: Blood pressure (BP) reduction after renal sympathetic denervation (RDN) is highly variable. Renal nerve stimulation (RNS) can localize sympathetic nerves. The RNS trial aimed to investigate the medium-term BP-lowering effects of the use of RNS during RDN, and explore if RNS can check the completeness of the denervation. Read More

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October 2021

Eloquence-based reperfusion scoring and its ability to predict post-thrombectomy disability and functional status.

Interv Neuroradiol 2021 Oct 14:15910199211046424. Epub 2021 Oct 14.

Department of Neurosurgery, 7831University of South Florida, USA.

Background: Angiographic reperfusion after endovascular thrombectomy in acute ischemic stroke is commonly graded using volume-based reperfusion scores such as the modified thrombolysis in cerebral infarct score. The location of non-reperfused regions is not included in modified thrombolysis in cerebral infarct score. We studied the predictive ability of an eloquence-based reperfusion score. Read More

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October 2021

Secondary Subtrochanteric Fracture After Atypical Femoral Shaft Fracture Treated With Intramedullary Nail.

Cureus 2021 Aug 29;13(8):e17544. Epub 2021 Aug 29.

Orthopedics, Daegu Fatima Hospital, Daegu, KOR.

Intramedullary (IM) nail fixation is widely used for the treatment of atypical fractures of the femoral shaft. The configuration and location of proximal interlocking screws are unique to each nailing system and maybe transverse or oblique in direction. The authors experienced two cases of incomplete secondary fractures at the subtrochanteric region after IM nail fixation for atypical femoral shaft fractures. Read More

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Case Report: Cyclophosphamide in COVID-19 - when an absolute contraindication is an absolute necessity.

F1000Res 2021 19;10:829. Epub 2021 Aug 19.

Collegium Medicum, Jan Kochanowski University, Kielce, Poland.

Despite many studies on COVID-19, our knowledge of it remains incomplete. In some cases, treating SARS-CoV-2 infection concomitant with other diseases can be particularly challenging, as finding an appropriate treatment may involve some risks. A 34-year-old SARS-CoV-2 positive patient admitted due to fever, dyspnoea, haemoptysis and pneumonia, developed alveolar haemorrhage and acute kidney injury. Read More

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October 2021

Decline of unique Pontocaspian biodiversity in the Black Sea Basin: A review.

Ecol Evol 2021 Oct 7;11(19):12923-12947. Epub 2021 Sep 7.

Naturalis Biodiversity Center Leiden The Netherlands.

The unique aquatic Pontocaspian (PC) biota of the Black Sea Basin (BSB) is in decline. The lack of detailed knowledge on the status and trends of species, populations, and communities hampers a thorough risk assessment and precludes effective conservation. This paper reviews PC biodiversity trends in the BSB (Bulgaria, Romania, Moldova, Ukraine, and Russia) using endemic mollusks as a model group. Read More

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October 2021

Inactivation Converts Sulfonamides Into Bactericidal Compounds.

Front Microbiol 2021 27;12:698468. Epub 2021 Sep 27.

Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Folates are required for the biosynthesis of purines, thymine, methionine, glycine, and pantothenic acid, key metabolites that bacterial cells cannot survive without. Sulfonamides, which inhibit bacterial folate biosynthesis and are generally considered as bacteriostats, have been extensively used as broad-spectrum antimicrobials for decades. Here we show that, deleting in and other bacterial species converted sulfamethoxazole from a bacteriostat into a bactericide. Read More

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September 2021

Assessing Without Words: Verbally Incomplete Utterances in Complaints.

Front Psychol 2021 27;12:689443. Epub 2021 Sep 27.

Centre for Research on Bilingualism, Department of Swedish Language and Multilingualism, Stockholm University, Stockholm, Sweden.

This study investigates the use of verbally incomplete utterances in French-language complaints about third parties or situations. In these cases, a speaker initiates a turn with verbal means but stops talking before reaching lexico-syntactic completion. The utterance becomes recognizable as an expression of negative stance or as a precise negative assessment by virtue of the linguistic formatting of the turn-initiation, its position within the larger interactional context, and the speaker's accompanying bodily-visual displays and vocalizations. Read More

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September 2021

Evaluation of lacrimal drainage system in Pseudoexfoliation syndrome.

Eye (Lond) 2021 Oct 13. Epub 2021 Oct 13.

University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Department of Ophthalmology, Ankara, Turkey.

Purpose: To evaluate the prevalence of the obstruction of lacrimal drainage system (LDS) in patients with pseudoexfoliation (PXF) syndrome.

Materials And Methods: This cross-sectional study included 152 eyes of 76 consecutive patients with bilateral PXF syndrome and 170 eyes of 85 age and gender-matched controls. The LDS evaluation was performed based on dye disappearance test, slit-lamp examination, diagnostic probing, and irrigation test. Read More

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October 2021

Magnetic topological quantum chemistry.

Nat Commun 2021 Oct 13;12(1):5965. Epub 2021 Oct 13.

Department of Physics, Princeton University, Princeton, NJ, USA.

For over 100 years, the group-theoretic characterization of crystalline solids has provided the foundational language for diverse problems in physics and chemistry. However, the group theory of crystals with commensurate magnetic order has remained incomplete for the past 70 years, due to the complicated symmetries of magnetic crystals. In this work, we complete the 100-year-old problem of crystalline group theory by deriving the small corepresentations, momentum stars, compatibility relations, and magnetic elementary band corepresentations of the 1,421 magnetic space groups (MSGs), which we have made freely accessible through tools on the Bilbao Crystallographic Server. Read More

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October 2021