17,032 results match your criteria inclusion complex

Differential diagnosis of acute traumatic hip pain in the elderly.

Acta Orthop Belg 2021 Mar;87(1):1-7

Elderly patients who present with an inability to weight bear following a fall, with normal radiographs, should be appropriately investigated to rule out an occult hip fracture (OHF). We aim to identify both the range and incidence of the differential diagnosis of acute traumatic hip pain in a large series of patients investigated for OHF. A retrospective analysis of consecutive patients investigated for an OHF with magnetic resonance imaging (MRI) was performed. Read More

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The effectiveness of acupoint application of traditional Chinese medicine in treating primary dysmenorrhea: A protocol for meta-analysis and data mining.

Medicine (Baltimore) 2021 Jun;100(24):e26398

Changchun University of Chinese Medicine, No. 1035, Boshuo Rd, Jingyue Economic Development District, Changchun 130117, China.

Background: Primary dysmenorrhea (PD) is a functional disease of the female reproductive system, which has adverse effects on patients' physical and mental health and quality of life. At present, acupoint application of traditional Chinese medicine (TCM) as adjuvant therapy is undergoing clinical trials in different medical centers. However, there is no systematic review or meta-analysis to evaluate the efficacy of acupoint application of TCM in the treatment of PD. Read More

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CAV1 rs7804372 (T29107A) polymorphism might be a potential risk for digestive cancers: A protocol for systematic review and meta analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26186

Department of Medical Technology, Jiangsu College of Nursing, Huai an, Jiangsu, China.

Background: Caveolin-1 (CAV1) is an essential structural component of caveolae, regulates cellular processes through complex cellular signaling pathways, and influences tumorigenicity. However, the role of the CAV1 (rs7804372) polymorphism in digestive cancers remains inconclusive. The meta-analysis was performed to evaluate the effect of CAV1 polymorphism on digestive cancer susceptibility and to provide a basis for precise treatment. Read More

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School-based HPV vaccination positively impacts parents' attitudes toward adolescent vaccination.

Vaccine 2021 Jun 11. Epub 2021 Jun 11.

Speciality of Child and Adolescent Health, Faculty of Medicine and Health, University of Sydney, NSW, Australia.

Introduction: This qualitative study aimed to explore parental attitudes, knowledge and decision-making about HPV vaccination for adolescents in the context of a gender-neutral school-based Australian National Immunisation Program (NIP).

Methods: Semi-structured interviews with parents of adolescents eligible for HPV vaccination were undertaken as part of an evaluation of a cluster-randomised controlled trial of a complex intervention in 40 schools (2013-2015). In this qualitative study, we purposively recruited a nested sample of parents from 11 schools across two Australian jurisdictions. Read More

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Sequential everolimus for angiomyolipoma associated with tuberous sclerosis complex: a prospective cohort study.

Orphanet J Rare Dis 2021 Jun 14;16(1):277. Epub 2021 Jun 14.

Department of Urology, the Third Medical Centre, Chinese PLA General Hospital, 69 Yong Ding Road, Beijing, 100039, China.

Background: To evaluate the efficacy, safety and health economics of sequential everolimus in treating angiomyolipoma (AML) associated with tuberous sclerosis complex (TSC).

Methods: In this prospective cohort study, patients met the inclusion criteria received standard or sequential treatment according to their willingness. All patients received an initial dose of everolimus (10 mg oral, once a day) for 3 months. Read More

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Enhanced solubility of Albendazole in Cyclodextrin Inclusion Complex: A Molecular Modeling Approach and Physicochemical Evaluation.

Curr Drug Deliv 2021 Jun 13. Epub 2021 Jun 13.

Laboratório de Tecnologia dos Medicamentos, Universidade Federal de Pernambuco, Recife/PE, Brazil.

Background: Albendazole (ABZ) is the drug of choice for the treatment of a variety of human and veterinary parasites. However, it has low aqueous solubility and low bioavailability. Cyclodextrins (CD) are pharmaceutical excipients with the ability to modulate the solubilization property of hydrophobic molecules. Read More

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Redox-responsive supramolecular polymeric networks having double-threaded inclusion complexes.

Chem Sci 2020 Mar 16;11(17):4322-4331. Epub 2020 Mar 16.

Department of Macromolecular Science, Graduate School of Science, Osaka University 1-1 Machikaneyama-cho Toyonaka Osaka 560-0043 Japan

Stimuli-responsive hydrogels have attracted attention as soft actuators that act similarly to muscles. In this work, hydrogel actuators controlled by host-guest interactions have been developed. The introduction of a 1:1 inclusion complex into a hydrogel is a popular design for achieving a change in cross-linking density. Read More

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Preparation of Astaxanthin Micelles Self-Assembled by a Mechanochemical Method from Hydroxypropyl β-Cyclodextrin and Glyceryl Monostearate with Enhanced Antioxidant Activity.

Int J Pharm 2021 Jun 11:120799. Epub 2021 Jun 11.

National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, PR China; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, PR China. Electronic address:

This research aimed to overcome the current challenges in the application of natural carotenoid antioxidants, such as their complex preparation processes, low bioavailability and poor drug stability. Herein, a mechanochemical method was used to prepare an inclusion complex (IC) that self-assembles into micelles in aqueous solution and achieves solid-phase loading of astaxanthin (AST). The NMR analysis, thermodynamics study, particle size analysis and electron microscopy image results showed that AST, hydroxypropyl β-cyclodextrin (HPβ-CD) and glyceryl monostearate (GMS) formed self-assembled micelles and maintained good stability in aqueous solution. Read More

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reversible tuning of chemical interface damping in single gold nanorod-based recyclable platforms through manipulation of supramolecular host-guest interactions.

Chem Sci 2021 Apr 15;12(20):7115-7124. Epub 2021 Apr 15.

Department of Chemistry, University of Ulsan 93 Daehak-ro, Nam-gu Ulsan 44610 Republic of Korea +82 52 712 8002 +82 52 712 8012.

Recently, chemical interface damping (CID) has been proposed as a new plasmon damping pathway based on interfacial hot-electron transfer from metal to adsorbate molecules. It has been considered essential, owing to its potential implications in efficient photochemical processes and sensing experiments. However, thus far, studies focusing on controlling CID in single gold nanoparticles have been very limited, and reversible tuning has remained a considerable challenge. Read More

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An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice.

Drug Deliv 2021 Dec;28(1):1120-1131

Molecular Cancer Biology Laboratory, Cellular Heterogeneity Research Center, Department of Biosystem, Sookmyung Women's University, Seoul, Korea.

Oral route colon-targeted drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC). However, CDDSs are challenging owing to the physiological and anatomical barriers associated with the gastrointestinal tract (GIT). In this study, we developed an effective enzyme-triggered controlled release system using curcumin-cyclodextrin (CD-Cur) inclusion complex as core and low molecular weight chitosan and unsaturated alginate resulting nanoparticles (CANPs) as shell. Read More

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December 2021

Nothing so practical as theory: a rapid review of the use of behaviour change theory in family planning interventions involving men and boys.

Reprod Health 2021 Jun 13;18(1):126. Epub 2021 Jun 13.

School of Nursing and Midwifery and Centre for Evidence and Social Innovation, Queen's University Belfast, Belfast, Northern Ireland, UK.

Background: There is growing recognition of the need for interventions that effectively involve men and boys to promote family planning behaviours. Evidence suggests that the most effective behavioural interventions in this field are founded on theoretical principles of behaviour change and gender equality. However, there are few evidence syntheses on how theoretical approaches are applied in this context that might guide best practice in intervention development. Read More

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Correlation between vitamin D levels and hard-to-heal wounds: a systematic review.

J Wound Care 2021 Jun;30(Sup6):S4-S10

Central Michigan University, Mt Pleasant, MI, US.

Objective: Hard-to-heal wounds are a major biological, psychological, social and financial burden on both individual patients and the broader health system. They are associated with a variety of comorbidities and have a complex aetiology, but are typically associated with nutritional deficiencies, such as low vitamin D levels. This systematic literature review evaluates the current research regarding the connection between inadequate vitamin D status and wound healing. Read More

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Should we start integrating genetic data in decision-making on device-aided therapies in Parkinson disease? A point of view.

Parkinsonism Relat Disord 2021 May 18;88:51-57. Epub 2021 May 18.

Center for Neurological Restoration, Cleveland Clinic Neurological Institute, OH, USA. Electronic address:

Parkinson disease (PD) is a complex heterogeneous neurodegenerative disorder. Association studies have revealed numerous genetic risk loci and variants, and about 5-10% suffer from a monogenic form. Because the presentation and course of PD is unique to each patient, personalized symptomatic treatment should ideally be offered to treat the most disabling motor and non-motor symptoms. Read More

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Increase in Mental Health Diagnoses Among Youth with Non-Fatal Firearm Injuries: Mental Health Diagnoses after Non-Fatal Firearm Injury.

Acad Pediatr 2021 Jun 10. Epub 2021 Jun 10.

Department of Pediatrics, College of Medicine, Medical University of South Carolina, 135 Rutledge Ave. MSC 561, Charleston, SC 29425, USA. Electronic address:

Background And Objectives: Firearm injury is a leading cause of mortality for US youth. For every youth who dies from a firearm injury, at least 4 more survive. Little is known about the mental health consequences of non-fatal firearm injury in youth. Read More

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Solid encapsulation of lauric acid into "empty" V-type starch: Structural characteristics and emulsifying properties.

Carbohydr Polym 2021 Sep 8;267:118181. Epub 2021 May 8.

School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou 510640, China. Electronic address:

Lauric acid was introduced into "Empty" V-type starch using a solid encapsulation method. The structural characteristics and emulsifying properties of the starch-fatty acid complex (SFAC) were explored as a function of the complexing temperature. X-ray diffraction and differential scanning calorimetry confirmed that SFAC was mainly composed of type-I amylose inclusion complexes. Read More

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September 2021

"You know, we can change the services to suit the circumstances of what is happening in the world": a rapid case study of the COVID-19 response across city centre homelessness and health services in Edinburgh, Scotland.

Harm Reduct J 2021 06 12;18(1):64. Epub 2021 Jun 12.

The Salvation Army, Homelessness Services Unit, Edinburgh, Scotland, UK.

Background: The COVID-19 pandemic has necessitated unprecedented changes in the way that health, social, and housing services are delivered to individuals experiencing homelessness and problem substance use. Protecting those at high risk of infection/transmission, whilst addressing the multiple health and social needs of this group, is of utmost importance. This study aimed to document the impact of the COVID-19 pandemic on individuals who were experiencing homelessness in one city centre in Scotland, and how services adapted in response. Read More

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Predictive value of change in effective arterial elastance in norepinephrine weaning: a retrospective study.

Ann Palliat Med 2021 Jun 7. Epub 2021 Jun 7.

Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: The weaning of vasopressors is usually an empirical choice made by clinicians. The aim of this study is to assess the predictive value of change in effective arterial elastance (ΔEa%) induced by fluid administration in early initiation of norepinephrine (NE) weaning.

Methods: Included were intensive care unit (ICU) septic shock patients with an indwelling pulmonary artery catheter who experienced initial resuscitation and required a fluid challenge. Read More

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Early Drain Removal is Safe in Patients With Low or Intermediate Risk of Pancreatic Fistula After Pancreaticoduodenectomy: A Multicenter, Randomized Controlled Trial.

Ann Surg 2021 Jun 11. Epub 2021 Jun 11.

Department of General Surgery, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China Department of General Surgery, Peking University First Hospital, Peking University, Beijing 100034, P.R China Department of General Surgery, Beijing Xuanwu Hospital, Capital Medical University, Beijing 100053, P.R China Department of Hepatobiliary & Pancreatic Surgical Oncology, Chinese People's Liberation Army, General Hospital, Beijing 100853, P.R China Department of Hepato-Biliary-Pancreatic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R China Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R China Department of Visceral, Vascular and Endocrine Surgery, Martin-Luther-University Halle-Wittenberg, 06120, Halle (Saale), Germany.

Objective: This multi-center randomized controlled trial (RCT) was designed to test the hypothesis that early drain removal (EDR) could decrease the incidence of grade 2-4 complications for patients undoing pancreaticoduodenectomy (PD) with low or intermediate risk of postoperative fistula (POPF).

Background: The safety and effects of EDR on postoperative complications after PD are still controversial.

Methods: A multi-center RCT at six tertiary referral hospitals was carried out (NCT03055676). Read More

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Occupational therapy addressing the ability to perform activities of daily living among persons living with chronic conditions: a randomised controlled pilot study of ABLE 2.0.

Pilot Feasibility Stud 2021 Jun 11;7(1):122. Epub 2021 Jun 11.

The Parker Institute, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: The ABLE intervention was developed to enhance the ability to perform activities of daily living (ADL) tasks among persons living with chronic conditions. ABLE is a generic, home-based, individualised, 8-week occupational therapy intervention program, developed to be delivered in Danish municipalities. In a previous study, the feasibility of ABLE was evaluated in terms of content and delivery. Read More

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Renovating Healthcare Facility Maintenance Planning: A Case Study From Walter Reed National Military Medical Center (WRNMMC).

HERD 2021 Jun 11:19375867211019749. Epub 2021 Jun 11.

Robbins MBA in Healthcare Administration, Hankamer School of Business, Baylor University, Waco, TX, USA.

Purpose: This article documents the development and implementation of a new approach for health facilities construction and maintenance planning, the use of a Facilities and Clinical Coordination (FCC) Council, at Walter Reed National Military Medical Center (WRNMMC).

Background: WRNMMC is preparing for the largest and most complex renovation project in recent Department of Defense history. There is sparse documentation demonstrating stepwise frameworks for the implementation of effective and efficient health facilities maintenance management tools and techniques. Read More

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Inclusion Complexes of Gold(I)-Dithiocarbamates with ß-Cyclodextrin: A Journey from Drug Repurposing towards Drug Discovery.

Chemistry 2021 Jun 10. Epub 2021 Jun 10.

DKFZ, Cancer Drug Development, In Neuenheimer Feld 280, 69120, Heidelberg, GERMANY.

We identified the gold(I)-dithiocarbamate (dtc) complex [Au(N,N-diethyl)dtc]2 as the active cytotoxic agent in the combination treatment of sodium aurothiomalate and disulfiram on a panel of cancer cell lines. In addition to demonstrating pronounced differential cytotoxicity to these cell lines, the gold complex showed no cross-resistance in therapy-surviving cancer cells. In the course of a medicinal chemistry campaign on this class of poorly soluble gold(I)-dtc complexes, we synthesized >35 derivatives and used x-ray crystallography to examine structural aspects of the dtc moiety. Read More

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Is the modified Ponseti method effective in treating atypical and complex clubfoot? A systematic review.

Int Orthop 2021 Jun 10. Epub 2021 Jun 10.

Department of Orthopedic Surgery, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Purpose: In 2006, Ponseti modified the standard technique to treat cases of "atypical" and "complex" clubfoot. To determine the outcomes of Ponseti's modified method to treat complex idiopathic clubfoot patients, we asked the following: (1) What is the deformity correction success rate? (2) What is the relapse rate after the correction? (3) What is the incidence of complications?

Materials And Methods: We performed a systematic review by searching the EMBASE, MEDLINE, Cochrane Library, and Web of Science databases from inception to March 1, 2021. All studies on idiopathic, complex, and atypical clubfoot that assessed Ponseti's modified technique were included. Read More

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Trends and Contributing Factors for Prescribing Antipsychotics in Newly Diagnosed Parkinson's Disease Patients: A Population-Based Study.

Khalid Orayj

Risk Manag Healthc Policy 2021 4;14:2443-2452. Epub 2021 Jun 4.

Clinical Pharmacy Department, School of Pharmacy, King Khalid University, Abha, Saudi Arabia.

Purpose: Psychosis is very common in later stages of Parkinson's disease (PD) patients, but its prevalence in newly diagnosed patients is not rare. The use of antipsychotics in PD patients is complex given their association with worsening Parkinsonian motor symptoms and increased mortality rate. This study aims to examine factors that affect the use of antipsychotics in newly diagnosed PD patients and to identify changes in prescribing over time. Read More

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Dispersion of metallic/ceramic matrix nanocomposite material through porous surfaces in magnetized hybrid nanofluids flow with shape and size effects.

Sci Rep 2021 Jun 10;11(1):12271. Epub 2021 Jun 10.

Department of Mathematics, Huzhou University, Huzhou, 313000, People's Republic of China.

Matrix nanocomposites are high performance materials possessing unusual features along with unique design possibilities. Due to extraordinary thermophysical characteristic contained by these matrix nanocomposites materials they are useful in several areas ranging from packaging to biomedical applications. Being an environment friendly, utilization of nanocomposites offer new technological opportunities for several sectors of aerospace, automotive, electronics and biotechnology. Read More

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Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.

Crit Care 2021 06 10;25(1):201. Epub 2021 Jun 10.

Research Center, CIUSSS du Nord-de-L'île-de-Montréal, Hôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, QC, Canada.

Background: β-adrenergic antagonists (BAAs) are used to treat cardiovascular disease such as ischemic heart disease, congestive heart failure, dysrhythmias, and hypertension. Poisoning from BAAs can lead to severe morbidity and mortality. We aimed to determine the utility of extracorporeal treatments (ECTRs) in BAAs poisoning. Read More

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Personal barriers to addressing intimate partner abuse: a qualitative meta-synthesis of healthcare practitioners' experiences.

BMC Health Serv Res 2021 Jun 9;21(1):567. Epub 2021 Jun 9.

Department of General Practice, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Healthcare practitioners (HCPs) play a crucial role in recognising, responding to, and supporting female patients experiencing intimate partner abuse (IPA). However, research consistently identifies barriers they perceive prevent them from doing this work effectively. These barriers can be system-based (e. Read More

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Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.

BMC Genomics 2021 Jun 9;22(1):432. Epub 2021 Jun 9.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Background: Circulating white blood cell and platelet traits are clinically linked to various disease outcomes and differ across individuals and ancestry groups. Genetic factors play an important role in determining these traits and many loci have been identified. However, most of these findings were identified in populations of European ancestry (EA), with African Americans (AA), Hispanics/Latinos (HL), and other races/ethnicities being severely underrepresented. Read More

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Bovine tuberculosis due to Mycobacterium bovis and other mycobacteria among water buffalo (Bubalus bubalis) from the Brazilian Amazon.

J Infect Dev Ctries 2021 May 31;15(5):736-741. Epub 2021 May 31.

Institute of Animal Health and Production, Federal Rural University of Amazonia, Belém, Brazil.

Introduction: Zoonotic tuberculosis is a disease of public health importance worldwide, especially in developing countries. The present study aimed to investigate the role played by Mycobacterium bovis and other mycobacteria as etiologic agents of bubaline tuberculosis (TB) in the Brazilian Amazon region.

Methodology: Granulomatous lesions suggestive of TB obtained from 109 buffaloes (n =109) during sanitary inspection at slaughter were subjected to histopathological evaluation, immunohistochemical (IHC) detection of Mycobacterium antigens, and to molecular tests (PCR) to detect hsp65, IS6110 and RD4 genes, which are specific to Mycobacterium spp. Read More

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Self-assembly of millimeter-scale magnetic particles in suspension.

Soft Matter 2021 Jun 9. Epub 2021 Jun 9.

Earth Science and Engineering, KAUST, Thuwal 23955-6900, Saudi Arabia.

Self-assembly is ubiquitous at all scales in nature. Most studies have focused on the self-assembly of micron-scale and nano-scale components. In this study, we explore the self-assembly of millimeter-scale magnetic particles in a bubble-column reactor to form 9 different structures. Read More

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Use of a quality improvement strategy to introduce co-design of the mental health discharge plan in rural and remote New South Wales.

Aust J Rural Health 2021 Jun 8. Epub 2021 Jun 8.

Western NSW Local Health District, Dubbo, NSW, Australia.

Problem: Patients have not traditionally partnered in the design of their discharge plans, with discharge summaries at times not completed. In rural settings, discharge planning communicates care to a complex geographic area with fragmented resources. Patients may also be socially disadvantaged, with relatives and friends sometimes excluded. Read More

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