28,852 results match your criteria including younger


Nurturing Care for Early Childhood Development: Global Perspective and Guidance.

Indian Pediatr 2021 Nov;58 Suppl 1:S11-S15

Reproductive, Maternal, Newborn, Child and Adolescent Health and Healthy Ageing, World Health Organization, Regional Office for South-East Asia, New Delhi, India.

To develop to their full potential, all children need to receive nurturing care. This means that, starting in pregnancy, they are raised in a stable environment that is sensitive to their health and nutritional needs, with protection from threats, opportunities for early learning, and interactions that are responsive, emotionally supportive, and developmentally stimulating. Nurturing care ensures the foundations are laid early in life for an individual to survive and thrive. Read More

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November 2021

Holding on and letting go: Views about filial piety among adult children living in New Zealand.

J Clin Nurs 2021 Oct 22. Epub 2021 Oct 22.

School of Clinical Sciences, Nursing Department, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand.

Aims And Objectives: The study aimed to explore the perspectives of adult children about late-life living and care arrangements for their ageing immigrant parents living in New Zealand.

Background: Older immigrants' well-being is closely associated with filial relations and is often reliant on families as a main source of social, financial and emotional support. Research among migrant Asian adults has reported mixed findings regarding intergenerational perspectives of filial practices. Read More

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October 2021

Patterns and Predictors of Television Viewing and Computer Use Among Women Living in Socioeconomically Disadvantaged Neighborhoods: A Prospective Cohort Study.

J Phys Act Health 2021 Oct 22:1-14. Epub 2021 Oct 22.

Background: Socioeconomically disadvantaged women are at an increased risk of sedentary behaviors including television (TV) viewing and computer use, so identifying determinants of these behaviors is important.

Methods: Women (n = 4349) self-reported weekly TV and computer time (in minutes per week), sociodemographic, and health data at 3 time points (2007-2013). Mixed-effect negative binomial regression was used to determine the baseline determinants of TV viewing and computer use over time, adjusting for confounders. Read More

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October 2021

Score2: A New Updated Algorithm to Predict Cardiovascular Disease Risk in Europe.

J Cardiothorac Vasc Anesth 2021 Sep 24. Epub 2021 Sep 24.

Division of Interventional Cardiology, Cardiovascular Institute, Hospital Clinico San Carlos, Madrid, Spain.

The recently published guidelines of the European Society of Cardiology for the prevention of cardiovascular diseases presented in August 2021 at the virtual European Society of Cardiology congress recommend the use of the SCORE2 risk index instead of the classic SCORE risk index to calculate the cardiovascular risk (specifically, ten-year fatal and nonfatal risk) in a healthy population under the age of 70 years, with a level of evidence IB. This new risk index was developed with the collaboration of about 200 investigators, including 45 cohorts in 13 countries with 700,000 participants, and covers the known risk factors for heart and circulatory diseases such as age, sex, lipid levels, blood pressure, and smoking. In addition, it divides the countries into four groups of risk and uses a competing risk model, adjusting the risk for the probability of having another event, which enables better estimation of the risk of fatal and nonfatal events in a younger population (40-69 years). Read More

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September 2021

Clinical insights into the three-dimensional anatomy of cheek teeth in alpacas based on micro-computed tomography. Part 1: mandibular cheek teeth.

BMC Vet Res 2021 Oct 22;17(1):334. Epub 2021 Oct 22.

Department of Surgery and Anesthesiology of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Background: Despite dental disease being a common health concern in alpacas, important dental pathology including apical infection, remains poorly understood. Treatment options are limited compared to veterinary dentistry techniques in other species. The primary goal of this study was to increase understanding of the external and internal anatomy of mandibular cheek teeth to enable the development of tooth sparing techniques in this species. Read More

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October 2021

Trends in antipsychotic prescribing for approved and unapproved indications to Medicaid-enrolled youth in Philadelphia, Pennsylvania between 2014 and 2018.

BMC Psychiatry 2021 Oct 22;21(1):524. Epub 2021 Oct 22.

Penn Center for Mental Health, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, 3rd Floor, Philadelphia, PA, 19104, USA.

Background: Antipsychotic prescribing to Medicaid-enrolled youth has been the target of numerous policy initiatives, including prior authorization and quality monitoring programs, which often target specific populations. Whether these efforts have changed the level or composition of antipsychotic prescribing is unclear.

Methods: Using 2014-2018 administrative claims data for Medicaid enrollees aged 21 years and under in Philadelphia, Pennsylvania, we measured antipsychotic prescription fills overall and for youth without an approved indication (autism, bipolar disorder, or psychosis). Read More

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October 2021

Comparing the Fasting and Random-Fed Metabolome Response to an Oral Glucose Tolerance Test in Children and Adolescents: Implications of Sex, Obesity, and Insulin Resistance.

Nutrients 2021 Sep 25;13(10). Epub 2021 Sep 25.

Susan B Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.

As the incidence of obesity and type 2 diabetes (T2D) is occurring at a younger age, studying adolescent nutrient metabolism can provide insights on the development of T2D. Metabolic challenges, including an oral glucose tolerance test (OGTT) can assess the effects of perturbations in nutrient metabolism. Here, we present alterations in the global metabolome in response to an OGTT, classifying the influence of obesity and insulin resistance (IR) in adolescents that arrived at the clinic fasted and in a random-fed state. Read More

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September 2021

Factors Associated with Intention of Serbian Public Health Workers to Leave the Job: A Cross-Sectional, Population-Based Study.

Int J Environ Res Public Health 2021 Oct 11;18(20). Epub 2021 Oct 11.

Faculty of Medicine, Institute of Medical Statistics and Informatics, University of Belgrade, 11000 Belgrade, Serbia.

Recruitment and retention of public health workers (PHWs) is crucial for the optimal functioning of the public health system at a time of budget cuts and the threat of a pandemic. Individual and job-related variables were examined by univariate and multivariate logistic regression to identify predictors of the intention to leave a job during the COVID-19 outbreak among Serbian PHWs in 25 institutes of public health ( = 1663 respondents, of which 73.1% were female). Read More

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October 2021

Mothers' Use of Regulatory Talk with Toddlers in Chile and the US: How Do Cultural Values and Children's Gender Affect Mothers' Regulatory Talk at 12 and 30 Months?

Children (Basel) 2021 Sep 30;8(10). Epub 2021 Sep 30.

Psychology School, Pontificia Universidad Católica de Chile, Ave. Vicuna Mackenna 4860, Macul, Santiago 7820436, Chile.

Studies have shown that Chilean and US infants differ in their levels of self-regulation. One of the mechanisms of early socializing is the use of language, particularly mental state language. The current study seeks to deepen our knowledge of the ways in which mental state language is related to socialization processes in early childhood, including the ways both culture and children's gender influence a mothers' use of mental state talk. Read More

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September 2021

Prediction of Atrial Fibrillation Recurrence after Thoracoscopic Surgical Ablation Using Machine Learning Techniques.

Diagnostics (Basel) 2021 Sep 28;11(10). Epub 2021 Sep 28.

Heart Centre, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Thoracoscopic surgical ablation (SA) for atrial fibrillation (AF) has shown to be an effective treatment to restore sinus rhythm in patients with advanced AF. Identifying patients who will not benefit from this procedure would be valuable to improve personalized AF therapy. Machine learning (ML) techniques may assist in the improvement of clinical prediction models for patient selection. Read More

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September 2021

A Systematic Review of Focal Cartilage Defect Treatments in Middle-Aged Versus Younger Patients.

Orthop J Sports Med 2021 Oct 15;9(10):23259671211031244. Epub 2021 Oct 15.

Maastricht University Medical Center, Maastricht, the Netherlands.

Background: Focal cartilage defects are often debilitating, possess limited potential for regeneration, are associated with increased risk of osteoarthritis, and are predictive for total knee arthroplasty. Cartilage repair studies typically focus on the outcome in younger patients, but a high proportion of treated patients are 40 to 60 years of age (ie, middle-aged). The reality of current clinical practice is that the ideal patient for cartilage repair is not the typical patient. Read More

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October 2021

Mitochondrial Mutations in Ethambutol-Induced Optic Neuropathy.

Front Cell Dev Biol 2021 5;9:754676. Epub 2021 Oct 5.

Department of Ophthalmology, The Chinese People's Liberation Army General Hospital, The Chinese People's Liberation Army Medical School, Beijing, China.

Ethambutol-induced optic neuropathy (EON) is a well-recognized ocular complication in patients who take ethambutol as a tuberculosis treatment. The aim of the current study was to investigate the presence of mitochondrial mutations, including and Leber's hereditary optic neuropathy (LHON)-mitochondrial DNA (mtDNA), in patients with EON and to determine their effect on clinical features of these patients. All 47 patients underwent clinical evaluations, including best-corrected visual acuity, fundus examination, and color fundus photography; 37 patients were then followed up over time. Read More

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October 2021

Cerebral spinal fluid positive pertussis encephalopathy in infants: Case reports.

SAGE Open Med Case Rep 2021 15;9:2050313X211052446. Epub 2021 Oct 15.

Department of Pediatrics, Mayo Clinic, Rochester, MN, USA.

Pertussis has re-emerged in both developed and developing countries and is an ongoing public health problem, even in countries with high rates of vaccination. Pertussis encephalopathy is a known complication of the disease, but the pathophysiology of this complication and the role of the pertussis bacteria have not been elucidated. We report three confirmed cases of pertussis infant younger than 3 months of age with neurological complications including lethargy, encephalopathy, and seizures. Read More

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October 2021

Risk Factors for Sleepiness at the Wheel and Sleep-Related Car Accidents Among Patients with Obstructive Sleep Apnea: Data from the French Pays de la Loire Sleep Cohort.

Nat Sci Sleep 2021 5;13:1737-1746. Epub 2021 Oct 5.

Department of Respiratory and Sleep Medicine, University Hospital of Angers, Angers, France.

Purpose: We aimed to determine the risk factors of sleepiness at the wheel among patients with obstructive sleep apnea (OSA) and to determine factors that were independently associated with reported sleep-related near-miss accidents or car accidents.

Patients And Methods: This retrospective study was conducted on 843 OSA patients from the French Pays de la Loire sleep cohort database. Each patient completed surveys including anthropometric data, medical history, professional status, and data on alcohol and tobacco use. Read More

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October 2021

Latent Autoimmune Diabetes in Adults (LADA) and its Metabolic Characteristics among Yemeni Type 2 Diabetes Mellitus Patients.

Diabetes Metab Syndr Obes 2021 13;14:4223-4232. Epub 2021 Oct 13.

Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, Yemen.

Purpose: Although there is ample data about the prevalence of diabetes in the Middle East, little is known about the prevalence and features of autoimmune diabetes in this region. The aim of this study was to investigate the prevalence and metabolic characteristics of latent autoimmune diabetes in adults (LADA) amongst Yemeni Type 2 DM patients.

Patients And Methods: In this cross-section study, 270 Type 2 DM patients aged 30-70 years were recruited from the National Diabetes Center, Al-Thowra Hospital, Sana'a city, during the period November 2015 to August 2016. Read More

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October 2021

Establishing risk of vision loss in Leber hereditary optic neuropathy.

Am J Hum Genet 2021 Oct 12. Epub 2021 Oct 12.

School of Medicine, Menzies Institute for Medical Research, University of Tasmania, Hobart, 7005 TAS, Australia; Centre for Ophthalmology and Visual Science, Lions Eye Institute, University of Western Australia, 2 Verdun Street, Nedlands, 6009 WA, Australia. Electronic address:

We conducted an updated epidemiological study of Leber hereditary optic neuropathy (LHON) in Australia by using registry data to establish the risk of vision loss among different LHON mutations, sex, age at onset, and mitochondrial haplogroup. We identified 96 genetically unrelated LHON pedigrees, including 56 unpublished pedigrees, and updated 40 previously known pedigrees, comprising 620 affected individuals and 4,948 asymptomatic carriers. The minimum prevalence of vision loss due to LHON in Australia in 2020 was one in 68,403 individuals. Read More

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October 2021

Combinations of BMI and cardiorespiratory fitness categories: trends between 1995 and 2020 and associations with CVD incidence and mortality and all-cause mortality in 471 216 adults.

Eur J Prev Cardiol 2021 Oct 20. Epub 2021 Oct 20.

Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences, PO Box 5626, 114 86 Stockholm, Sweden.

Aims: To describe time trends in combinations of cardiorespiratory fitness (CRF) and body mass index (BMI) status, and to analyse their associations with cardiovascular disease (CVD) incidence and mortality and all-cause mortality.

Methods And Results: Prospective cohort study with data from occupational health screenings in Swedish employees, including n = 471 216 (aged 18-74 years) between 1995 and 2020, and n = 169 989 in risk analyses. Cardiorespiratory fitness was estimated from a submaximal cycle test. Read More

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October 2021

Laparoscopic Excision of Solitary Dysontogenetic Liver Cysts in Young Children: Technical Aspects and Outcome.

J Laparoendosc Adv Surg Tech A 2021 Oct 20. Epub 2021 Oct 20.

Department of Pediatric Surgery and Pediatric Urology, University Children's Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany.

Solitary dysontogenetic liver cysts are rare in young children. However, large cysts can cause symptoms and require therapy. Cyst excision is the therapeutic method least associated with cyst recurrence. Read More

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October 2021

The presentation of brain metastases in melanoma, non-small cell lung cancer, and breast cancer and potential implications for screening brain MRIs.

Breast Cancer Res Treat 2021 Oct 20. Epub 2021 Oct 20.

Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr., Tampa, FL, 33612, USA.

Purpose: This study assessed the presentation and institutional outcomes treating brain metastases (BM) of breast cancer (BC), non-small cell lung cancer (NSCLC), and melanoma origin.

Methods: Patients with brain metastases treated between 2014 and 2019 with primary melanoma, NSCLC, and BC were identified. Overall survival (OS) was calculated from dates of initial BM diagnosis using the Kaplan-Meier method. Read More

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October 2021

Variations in Quality of Care by Sex and Social Determinants of Health Among Younger Adults With Acute Myocardial Infarction in the US and Canada.

JAMA Netw Open 2021 Oct 1;4(10):e2128182. Epub 2021 Oct 1.

Department of Emergency Medicine, Yale University School of Medicine, New Haven, Connecticut.

Importance: Quality of care of young adults with acute myocardial infarction (AMI) may depend on health care systems in addition to individual-level factors such as biological sex and social determinants of health (SDOH).

Objective: To examine whether the quality of in-hospital and postacute care among young adults with AMI differs between the US and Canada and whether female sex and adverse SDOH are associated with a low quality of care.

Design, Setting, And Participants: This retrospective cohort analysis used data from 2 large cohorts of young adults (aged ≤55 years) receiving in-hospital and outpatient care for AMI at 127 centers in the US and Canada. Read More

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October 2021

Autologous protein solution: a promising solution for osteoarthritis?

EFORT Open Rev 2021 Sep 14;6(9):716-726. Epub 2021 Sep 14.

Department of Bioengineering, Imperial College London, London, UK.

Osteoarthritis (OA) is a global health issue with myriad pathophysiological factors and is one of the most common causes of chronic disability in adults due to pain and altered joint function.The end stage of OA develops from a destructive inflammatory cycle, driven by the pro-inflammatory cytokines interleukin-1β (IL-1β) and tumour necrosis factor alpha (TNFα).Owing to the less predictable results of total knee arthroplasty (TKA) in younger patients presenting with knee OA, there has been a surge in research evaluating less invasive biological treatment options, one of which is autologous protein solution (APS). Read More

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September 2021

Maternal feeding practices and toddlers' fruit and vegetable consumption: results from the DIT-Coombe Hospital birth cohort in Ireland.

Nutr J 2021 Oct 19;20(1):84. Epub 2021 Oct 19.

School of Biological Sciences, Technological University Dublin, Dublin, Ireland.

Background: Health benefits of fruit and vegetable have been well recognized. However, insufficient consumption of fruit and vegetable is prevalent among toddlers, and has become a global public health issue. Maternal feeding practices are potential factors influencing toddlers' dietary intake, including fruit and vegetable intake. Read More

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October 2021

Diagnostic utility of conventional transbronchial needle aspiration in older patients.

Eur Geriatr Med 2018 Apr 22;9(2):263-267. Epub 2018 Feb 22.

Department of Pulmonary Diseases, Hacettepe University, School of Medicine, Ankara, Turkey.

Background: In older patients, diagnosis and initial treatment should be considered as soon as possible because of high disease burden and complications. Conventional transbronchial needle aspiration (C-TBNA) is an important and safe method for the diagnosis of mediastinal lesions and staging lung cancer in the general population. We aimed to evaluate the diagnostic utility and complications of C-TBNA procedure in older patients aged ≥ 65 years. Read More

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Safety and efficacy of diagnostic flexible bronchoscopy in very old patients with lung cancer.

Eur Geriatr Med 2018 Apr 12;9(2):255-262. Epub 2018 Feb 12.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8560, Japan.

Introduction: Although there is a remarkable increase in diagnostic flexible bronchoscopy (FB) in old patients, safety and efficacy of FB in very old patients remain to be elucidated. In this study, we aimed to evaluate the complications and diagnostic yield of FB in patients aged ≥ 80 years with lung cancer compared with those aged < 80 years.

Materials And Methods: We retrospectively analysed the medical records of 668 consecutive patients, which included 89 patients aged ≥ 80 years (older group) and 579 patients aged < 80 years (younger group) who underwent bronchoscopy for the diagnosis or staging of lung cancer between April 2011 and March 2016. Read More

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Digital Health Literacy in Bipolar Disorder: International Web-Based Survey.

JMIR Ment Health 2021 Oct 19;8(10):e29764. Epub 2021 Oct 19.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Background: Web-based resources can support people with bipolar disorder (BD) to improve their knowledge and self-management. However, publicly available resources are heterogeneous in terms of their quality and ease of use. Characterizing digital health literacy (the skillset that enable people to navigate and make use of health information in a web-based context) in BD will support the development of educational resources. Read More

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October 2021

Spinal muscular atrophy: epidemiology and health burden in children - a Polish national healthcare database perspective before introduction of SMA-specific treatment.

Neurol Neurochir Pol 2021 Oct 19. Epub 2021 Oct 19.

Social Insurance Department, Warsaw School of Economics, Warsaw, Poland.

Introduction: Spinal muscular atrophy (SMA) is one of the most frequent autosomal recessive neuromuscular disorders. It leads to progressive muscle weakness, premature death or permanent ventilation. Significant disability, scoliosis, severe pulmonary infections and other problems require in- and outpatient medical care. Read More

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October 2021

Unruptured cerebral aneurysms in elderly patients: key challenges and management.

Ann Med 2021 Dec;53(1):1839-1849

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Unruptured cerebral aneurysms are increasingly identified in elderly patients as the global life expectancy continues to rise and non-invasive vascular imaging becomes more prevalent. The optimal management of unruptured aneurysms in elderly patients remains controversial. Variability in life expectancy, comorbidities and rupture risk coupled with heterogenous endovascular and surgical treatments contribute to a paucity of clear guidelines, and current management is highly individualized. Read More

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December 2021

Pharmacological Pain Treatment in 2012 and 2017 Among Older People with Major Neurocognitive Disorder.

Drugs Aging 2021 Oct 19. Epub 2021 Oct 19.

Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.

Background And Objective: Pain is highly prevalent among older people, and treatment is complicated because of comorbidities and polypharmacy. Among people with major neurocognitive disorder additional difficulties might arise. The aim of this study was to describe analgesic drug use in 2012 and 2017 and associated factors among older people with major neurocognitive disorder. Read More

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October 2021

Neuromyelitis Optica Spectrum Disorders in Africa: A Systematic Review.

Neurol Neuroimmunol Neuroinflamm 2021 Nov 18;8(6). Epub 2021 Oct 18.

From the Infectious Diseases Institute (A.K.M., D.B.M.), School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda; Department of Neurology (J.D., T.R., P.C., B.W.), Antwerp University Hospital, Edegem; Laboratory of Experimental Hematology (J.D., B.W.), Vaccine & Infectious Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp; Translational Neurosciences (J.D., T.R., P.C., B.W.), Faculty of Medicine and Health Sciences, University of Antwerp; University of Minnesota (P.R.B.), Minneapolis, MN; and Born Bunge Foundation (P.C.), University of Antwerp, Wilrijk, Belgium.

Background And Objectives: Neuromyelitis optica (NMO) is a CNS inflammatory disease that predominantly affects the optic nerves and the spinal cord. It is more frequent in Asian and African populations than in European ones. Data on epidemiology, clinical presentation, additional investigations, and treatment in the African continent are scarce. Read More

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November 2021

Drinking and social media use during the COVID-19 pandemic restrictions: A five-wave longitudinal study among workers in Finland.

J Med Internet Res 2021 Oct 13. Epub 2021 Oct 13.

Tampere University, Faculty of Social Sciences, Kalevantie 5, 33014 Tampere University, Tampere, FI.

Background: Background: The COVID-19 pandemic has restricted everyday life during 2020-2021. This has impacted alcohol consumption patterns and leisure activities, including the use of social media.

Objective: Objective: The aim of this study was to analyze whether social media use predicts increased risky drinking over time and during the COVID-19 pandemic restrictions. Read More

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October 2021