382,718 results match your criteria including risk

Underage Adolescents' Reactions to Adverts for Beer and Spirit Brands and Associations with Higher Risk Drinking and Susceptibility to Drink: A Cross-Sectional Study in the UK.

Alcohol Alcohol 2021 Apr 23. Epub 2021 Apr 23.

Cancer Policy Research Centre, Cancer Research UK, 2 Redman Place, London E20 1JQ, UK.

Aims: In the UK, adolescents under the minimum legal purchasing age (<18 years) are aware of a variety of alcohol marketing activities. It is therefore important to examine how such marketing appeals and how it might shape consumption. This study assessed the relationships between positive reactions to alcohol adverts and susceptibility to drink among never drinkers and higher-risk drinking among current drinkers. Read More

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High-dimensional characterization of post-acute sequalae of COVID-19.

Nature 2021 Apr 22. Epub 2021 Apr 22.

Clinical Epidemiology Center, Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, USA.

The acute clinical manifestations of COVID-19 are well characterized; however, its post-acute sequalae have not been comprehensively described. Here, we use the national healthcare databases of the US Department of Veterans Affairs to systematically and comprehensively identify 6-month incident sequalae including diagnoses, medication use, and laboratory abnormalities in 30-day survivors of COVID-19. We show that beyond the first 30 days of illness, people with COVID-19 exhibit higher risk of death and health resource utilization. Read More

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Factors Influencing Discussion of Cancer Genetic Testing with Health-Care Providers in a Population-Based Survey.

Public Health Genomics 2021 Apr 22:1-11. Epub 2021 Apr 22.

Department of Biostatistics, UT MD Anderson Cancer Center, Houston, Texas, USA.

Introduction: Discussion of cancer genetic testing with health-care providers (HCPs) is necessary to undergo testing to inform cancer risk assessment and prevention. Given the rapid evolution in genetic testing practice in oncology, we describe the current landscape of population-level cancer genetic testing behaviors.

Methods: A questionnaire including items regarding discussion of cancer genetic testing with HCPs was administered to a nonprobability sample (N = 2,029) of the Texas population. Read More

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Hamstring and Quadriceps Muscle Strength in Youth to Senior Elite Soccer: A Cross-Sectional Study Including 125 Players.

Int J Sports Physiol Perform 2021 Apr 22:1-7. Epub 2021 Apr 22.

Purpose: Increasing age, high quadriceps strength, and low hamstring muscle strength are associated with hamstring strain injury in soccer. The authors investigated the age-related variation in maximal hamstring and quadriceps strength in male elite soccer players from under-13 (U-13) to the senior level.

Methods: A total of 125 elite soccer players were included from a Danish professional soccer club and associated youth academy (first tier; U-13, n = 19; U-14, n = 16; U-15, n = 19; U-17, n = 24; U-19, n = 17; and senior, n = 30). Read More

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Gluteus maximus transfer and mass graft (Capsulorraphy) in recurrent hip dislocation with the history of total hip replacement: A case series.

Int J Surg Case Rep 2021 Apr 14;82:105890. Epub 2021 Apr 14.

Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia.

Introduction: Post THR dislocation has been a significant complication that interferes with the patient's life. Detection of risk factors, careful planning, proper operative procedures, and patient education is essential to prevent the incidence of dislocation. Several operative measures have been studied to achieve this, including the use of mesh for soft tissue procedures and capsulorraphy. Read More

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Work-related violence and depressive disorder among 955,573 employees followed for 6.99 million person-years. The Danish Work Life Course Cohort study: Work-related violence and depression.

J Affect Disord 2021 Mar 26;288:136-144. Epub 2021 Mar 26.

National Research Centre for the Working Environment, Copenhagen, Denmark; Section of Epidemiology, Department of Public Health, University of Copenhagen, Denmark; Department of Psychology, University of Copenhagen, Denmark.

Background: We examined the association between probability of work-related violence and first diagnosis of depressive disorder whilst accounting for the potential selection of individuals vulnerable to depression into occupations with high probability of work-related violence.

Methods: Based on a pre-published study protocol, we analysed nationwide register data from the Danish Work Life Course Cohort study, encompassing 955,573 individuals followed from their entry into the workforce, and free from depressive disorder before work-force entry. Depressive disorder was measured from psychiatric in- and outpatient admissions. Read More

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Fine particulate matter and body weight status among older adults in China: Impacts and pathways.

Health Place 2021 Apr 19;69:102571. Epub 2021 Apr 19.

School of Economics and Finance, Xi'an Jiaotong University, 710061 Xi'an, China.

Background: Population ageing and air pollution have become two major public health concerns in China. Longitudinal evidence on the body weight impacts of air pollution among older adults is rare. This study aims to investigate the impacts of ambient particulate matter with aerodynamic diameters ≤2. Read More

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A different perspective on the forensic science crisis.

Forensic Sci Int 2021 Apr 10;323:110779. Epub 2021 Apr 10.

Centre for Forensic Science, University of Technology Sydney, Australia.

Recurrent mentions of a forensic science crisis are reported in the literature. Some 15 years ago, the discussion was focused on the backlog problem. Other issues have been regularly debated since then, including the risk of error, need for independence, importance and risk of contextualisation, increasing fragmentation into separate processes and specialisations. Read More

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Fourth degree perineal tears: surgical repair technique in 10 steps.

J Gynecol Obstet Hum Reprod 2021 Apr 19:102151. Epub 2021 Apr 19.

Department of Gynecology and Obstetrics, Femme Mère Enfant University Hospital, 59 Boulevard Pinel, 69677 Lyon-Bron, France.; Claude Bernard University Lyon 1, avenue Rockfeller, 69008 Lyon.

Obstetrical anal sphincter injury (OASIS) may lead to significant comorbidities, including anal incontinence, rectovaginal fistula, and pain. A correct repair is required to avoid improper healing, as a persistent defect in the external anal sphincter after delivery can increase the risk of complications and worsening of symptoms following subsequent vaginal deliveries. Herein is described the surgical repair technique for a fourth degree perineal tear. Read More

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Development, item analysis, and initial reliability and validity of three forms of a multiple-choice mental health literacy assessment for college students (MHLA-c).

Psychiatry Res 2021 Mar 24;300:113897. Epub 2021 Mar 24.

New York State Psychiatric Institute, New York, NY, USA.

Despite increasing rates of mental health disorders among college students, there are a limited number of validated mental health literacy measures that can be quickly administered and scored in this population. We developed a 54-item multiple-choice measure, consisting of three forms with 18 items on each form. Our items focus on knowledge of more than 20 mental health disorders including their etiology, risk factors, diagnoses, symptoms, treatment, course, and outcome, as well as the application of this knowledge to real world situations. Read More

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Lactose intolerance: An update on its pathogenesis, diagnosis, and treatment.

Nutr Res 2021 Mar 21;89:23-34. Epub 2021 Mar 21.

ReGenera R&D International for Aging Intervention & San Babila Clinic, Milano, Italy. Electronic address:

Lactose intolerance has a high prevalence worldwide, ranging between 57% and 65%. It is caused by a reduction or loss of the activity of the intestinal enzyme lactase-phlorizin hydrolase, responsible for the digestion of lactose. This alteration determines an increased osmotic load in the small intestine and the fermentation of lactose by the bacterial flora, which leads to a high production of short-chain fatty acids and gas. Read More

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Device-related Infection in De Novo Transvenous Implantable Cardioverter-Defibrillator Medicare Patients.

Heart Rhythm 2021 Apr 19. Epub 2021 Apr 19.

Division of Infectious Diseases, Department of Medicine; Department of Cardiovascular Disease, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.

Background: Cardiac device infection is a serious complication of implantable cardioverter-defibrillator (ICD) placement and requires complete device removal with accompanying antimicrobial therapy for durable cure. Recent guidelines have highlighted the need to better identify patients at high risk of infection to assist in device selection.

Objective: To estimate the prevalence of infection in de novo transvenous (TV) ICD implants and assess factors associated with infection risk in a Medicare population. Read More

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Motoric cognitive risk syndrome, physio-cognitive decline syndrome, cognitive frailty and reversibility with dual-task exercise.

Exp Gerontol 2021 Apr 19:111362. Epub 2021 Apr 19.

Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA.

Introduction: Cognitive frailty (CF) is associated with dementia and disability. It was initially proposed in 2013 by the International Institute of Nutrition and Aging and the International Geriatrics Association. Over the years, there have been many emerging definitions e. Read More

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Bioactivity Profiling of Per- and Polyfluoroalkyl Substances (PFAS) Identifies Potential Toxicity Pathways Related to Molecular Structure.

Toxicology 2021 Apr 19:152789. Epub 2021 Apr 19.

Attagene, Inc., 7030 Kit Creek Rd, Morrisville, NC, 27560, USA.

Per- and polyfluoroalkyl substances (PFAS) are a broad class of hundreds of fluorinated chemicals with environmental health concerns due to their widespread presence and persistence in the environment. Several of these chemicals have been comprehensively studied for experimental toxicity, environmental fate and exposure, and human epidemiology; however, most chemicals have limited or no data available. To inform methods for prioritizing these data-poor chemicals for detailed toxicity studies, we evaluated 142 PFAS using an in vitro screening platform consisting of two multiplexed transactivation assays encompassing 81 diverse transcription factor activities and tested in concentration-response format ranging from 137 nM to 300 μM. Read More

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Pesticides expenditures by farming type and incidence of Parkinson disease in farmers: a French nationwide study.

Environ Res 2021 Apr 19:111161. Epub 2021 Apr 19.

Paris-Saclay University, Paris-Sud University, UVSQ, Center for Research in Epidemiology and Population Health (CESP), INSERM-U1018, Paul Brousse Hospital, Villejuif, France; Santé Publique France, The French Public Health Agency, Direction Santé Environnement Travail, Saint-Maurice, France. Electronic address:

Background: Professional pesticides exposure is associated with PD risk, but it remains unclear whether specific products, which strongly depend on farming type, are specifically involved. We performed a nationwide ecological study to examine the association of pesticides expenditures for the main farming types with PD incidence in French farmers.

Methods: We used the French National Health Insurance database to identify incident PD cases in farmers (2010-2015). Read More

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Air pollution, surrounding green, road proximity and Parkinson's disease: a prospective cohort study.

Environ Res 2021 Apr 19:111170. Epub 2021 Apr 19.

Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, Zhejiang, China; Department of Epidemiology and Biostatistics, And Cancer Institute of the Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China. Electronic address:

Background: Though growing evidence has linked air pollution to Parkinson's disease (PD), the results remain inconsistent. Less is known about the relevance of road proximity and surrounding green. We aimed to investigate the individual and joint associations of air pollution, road proximity and surrounding green with the incidence of PD in a prospective cohort study. Read More

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[Hybrid medicines in France. 2. Hybrid medicines: overviews in France and in Paris Public Hospitals].

Ann Pharm Fr 2021 Apr 19. Epub 2021 Apr 19.

Agence générale des équipements et produits de santé (AGEPS), Assistance publique - Hôpitaux de Paris (AP-HP), 7 rue du Fer à Moulin, 75005 Paris, France; Faculté de pharmacie, Université de Paris, 4 avenue de l'Observatoire, 75006 Paris, France; Institut droit et santé, Inserm UMRS 1145, Université de Paris, 45 rue des Saints-Pères, 75006 Paris, France.

Objectives: The aim of this study is to give an overview of hybrid medicines, term introduced in France by the Social Security Financing Act for 2019, with special attention to those available in Paris Public Hospitals (AP-HP), and to analyze their therapeutic values and economic issues.

Methods: Research by keywords on European and French health authorities' websites was done to provide a list of hybrid medicines. Then, an analysis of their profile and of their differences from reference medicinal products was done. Read More

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Risk of Transmitting Coronavirus Disease 2019 During Nebulizer Treatment: A Systematic Review.

J Aerosol Med Pulm Drug Deliv 2021 Apr 21. Epub 2021 Apr 21.

Durham Veterans Affairs Health Care System, Durham, North Carolina, USA.

There is an urgent need to understand the risk of viral transmission during nebulizer treatment of patients with coronavirus disease 2019 (COVID-19). To assess the risk of transmitting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), SARS, Middle East respiratory syndrome (MERS), and influenza with administration of drugs via nebulizer. We searched multiple electronic databases, including PubMed, China National Knowledge Infrastructure, Wanfang, preprint databases, and clinicaltrials. Read More

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Thorium-227-Labeled Anti-CD22 Antibody (BAY 1862864) in Relapsed/Refractory CD22-Positive Non-Hodgkin Lymphoma: A First-in-Human, Phase I Study.

Cancer Biother Radiopharm 2021 Apr 21. Epub 2021 Apr 21.

Department of Haematology, University College London Hospital, London, United Kingdom.

BAY 1862864 is an α-particle emitting thorium-227-labeled CD22-targeting antibody. This first-in-human dose-escalation phase I study evaluated BAY 1862864 in patients with CD22-positive relapsed/refractory B cell non-Hodgkin lymphoma (R/R-NHL). BAY 1862864 intravenous injections were administered at the starting thorium-227 radioactivity dose of 1. Read More

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Genetically-Determined Serum Calcium Levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank.

Circ Genom Precis Med 2021 Apr 22. Epub 2021 Apr 22.

Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

- Electrocardiographic (ECG) markers of ventricular depolarisation and repolarisation are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT and JT intervals in the general population. Here, we investigate whether serum calcium is a causal risk factor for changes in ECG measures using Mendelian Randomization (MR). Read More

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Fluoroquinolones as a trigger for rupture of abdominal aortic aneurysm. A case-crossover analysis.

Basic Clin Pharmacol Toxicol 2021 Apr 22. Epub 2021 Apr 22.

Elitary Research Centre of Individualised Medicine in Arterial Disease (CIMA), Odense University Hospital, Odense C, Denmark.

Fluoroquinolones (FQ) are associated with an increased risk of tendinopathy, including rupture. Our study aimed to investigate whether FQ use triggered the rupture of aortic aneurysms using a self-controlled design. We hypothesised that the use of FQ was associated with aortic rupture shortly after redeemed FQ prescriptions. Read More

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Dental Practice Management during COVID-19 times -Now and Beyond.

Int J Clin Pract 2021 Apr 22:e14251. Epub 2021 Apr 22.

AB Shetty Memorial Institute of Dental Sciences, India.

Aim: Coronavirus Disease 2019 (COVID-19) being declared a global public health emergency has become a significant challenge for all healthcare workers, including dentistry, recognized as a high-risk profession during these times. This consensus statement aims to highlight and provide guidelines necessary to be implemented for a clinical dental practice.

Materials And Methods: A total of nine conservative Dentists and Endodontists and one Oral and Maxillofacial Surgeon; with four panelists from government dental colleges, one each from the North, South, East, and West India and six resource persons from private colleges in South India, all of them being clinicians and administrators practicing dentistry since the inception of the pandemic, collaborated in this consensus statement. Read More

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Root canal retreatment: a retrospective investigation using regression and data mining methods for the prediction of technical quality and periapical healing.

J Appl Oral Sci 2021 19;29:e20200799. Epub 2021 Apr 19.

Universidade Federal do Rio Grande do Sul (UFRGS), Faculdade de Odontologia, Programa de Pós-graduação em Odontologia, Porto Alegre, Brasil.

Objectives: This study aimed to investigate patterns and risk factors related to the feasibility of achieving technical quality and periapical healing in root canal non-surgical retreatment, using regression and data mining methods.

Methodology: This retrospective observational study included 321 consecutive patients presenting for root canal retreatment. Patients were treated by graduate students, following standard protocols. Read More

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Recent Trends in Cardiovascular Mortality in Rio de Janeiro State Health Regions and Capital.

Arq Bras Cardiol 2021 Apr;116(4):763-771

Universidade Federal Fluminense - Departamento de Medicina Clínica, Niterói, RJ - Brasil.

Background: Cardiovascular disease (CVD) mortality, after several decades of decrease, has shown a tendency towards the stabilization in some countries, including Brazil and Rio de Janeiro state. This new tendency was not further analyzed by gender, age group and region of the Rio de Janeiro state.

Objective: To analyze the trends of premature and late mortality from CVD, ischemic heart disease (IHD) and cerebrovascular disease (CBVD) by gender in the city of Rio de Janeiro (capital) and the health regions of Rio de Janeiro state (from 1996 to 2016. Read More

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Carotid Artery Atherosclerotic Profile as Risk Predictor for Restenosis After Coronary Stenting.

Arq Bras Cardiol 2021 Apr;116(4):727-733

Universidade Estadual Paulista Julio de Mesquita Filho - Faculdade de Medicina Campus de Botucatu, Botucatu, SP - Brasil.

Background: The incidence of restenosis of the coronary artery after a bare-metal stent implant has been lower than in simple balloon angioplasty; however, it still shows relatively high rates.

Objective: The aim of this study was to find new risk indicators for in-stent restenosis using carotid ultrasonography, that, in addition to the already existing indicators, would help in decision-making for stent selection.

Methods: We carried out a cross-sectional prospective study including 121 consecutive patients with chronic coronary artery disease who had undergone percutaneous coronary intervention with repeat angiography in the previous 12 months. Read More

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Examining elevated blood pressure and the effects of diabetes self-management education on blood pressure among a sample of Marshallese with type 2 diabetes in Arkansas.

PLoS One 2021 22;16(4):e0250489. Epub 2021 Apr 22.

College of Medicine, University of Arkansas for Medical Sciences Northwest, Fayetteville, Arkansas, United States of America.

Introduction: Hypertension is a leading risk factor for heart attack and stroke. Undiagnosed hypertension increases the risk of heart attack and stroke. The risk of hypertension is increased for those with type 2 diabetes mellitus (T2DM). Read More

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Preventing COVID-19 spread in closed facilities by regular testing of employees-An efficient intervention in long-term care facilities and prisons?

PLoS One 2021 22;16(4):e0249588. Epub 2021 Apr 22.

Department of Applied Computer- and Biosciences, University of Applied Sciences Mittweida, Mittweida, Germany.

Background: Different levels of control measures were introduced to contain the global COVID-19 pandemic, many of which have been controversial, particularly the comprehensive use of diagnostic tests. Regular testing of high-risk individuals (pre-existing conditions, older than 60 years of age) has been suggested by public health authorities. The WHO suggested the use of routine screening of residents, employees, and visitors of long-term care facilities (LTCF) to protect the resident risk group. Read More

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