176,760 results match your criteria including quality


Carvacrol, citral and α-terpineol essential oil incorporated biodegradable films for functional active packaging of Pacific white shrimp.

Food Chem 2021 May 30;363:130252. Epub 2021 May 30.

Department of Packaging and Materials Technology, Faculty of Agro-Industry, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand; Center for Advanced Studies for Agriculture and Food, Kasetsart University, 50 Ngam Wong Wan Rd., Latyao, Chatuchak, Bangkok 10900, Thailand. Electronic address:

Biodegradable poly(butylene adipate terephthalate) and poly(lactic acid) (PBAT/PLA) blend films compounded with carvacrol, citral and α-terpineol essential oils (EOs) were produced for food packaging via blown-film extrusion. PBAT/PLA interacted with citral and α-terpineol via hydrogen bonding and carbonyl groups. Microstructures and barrier properties against water vapor and oxygen were modified depending on types and concentrations (3% and 6%) of EOs. Read More

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Emerging biomarkers of delayed graft function in kidney transplantation.

Transplant Rev (Orlando) 2021 May 26;35(4):100629. Epub 2021 May 26.

Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, Italy. Electronic address:

Delayed Graft Function (DGF) is one of the most common early complications in kidney transplantation, associated with poor graft outcomes, prolonged post-operative hospitalization and higher rejection rates. Given the severe shortage of high-quality organs for transplantation, DGF incidence is expected to raise in the next years because of the use of nonstandard kidneys from Extended Criteria Donors (ECD) and from Donors after Circulatory Death (DCD). Alongside conventional methods for the evaluation of renal allograft [e. Read More

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Differential lncRNA expression profiling of cognitive function in middle and old aged monozygotic twins using generalized association analysis.

J Psychiatr Res 2021 Jun 2;140:197-204. Epub 2021 Jun 2.

Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Denmark; Unit of Human Genetics, Department of Clinical Research, University of Southern Denmark, Denmark. Electronic address:

Cognitive impairment is the most prominent symptom in neurodegenerative disorders affecting quality of life and mortality. However, despite years of research, the molecular mechanism underlying the regulation of cognitive function and its impairment is poorly understood. This study aims to elucidate the role of long non-coding RNAs (lncRNAs) expression and lncRNA-mRNA interaction networks, by analyzing lncRNA expression in whole blood samples of 400 middle and old aged monozygotic twins in association with cognitive function using both linear models and a generalized correlation coefficient (GCC) to capture the diverse patterns of correlation. Read More

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Evaluation of an in-hospital recreation room for hospitalised children and their families.

J Pediatr Nurs 2021 Jun 9;61:191-198. Epub 2021 Jun 9.

School of Women's and Children's Health, UNSW Sydney, Kensington, New South Wales 2031, Australia; Kids Cancer Centre, Sydney Children's Hospital, High Street, Randwick, New South Wales 2031, Australia.

Objective: Many children's hospitals have established 'recreation rooms' to help reduce distress among hospitalised children and families. We investigated recreation rooms in two Australian children's hospitals to determine: 1) families' first use of the room (including discovery and delays); 2) characteristics of families accessing the room; 3) parents' positive and negative associations with the room; and 4) parents' most and least valued aspects of the room.

Method: Using a concurrent mixed methods design, parents completed questionnaires (Restorative Experiences Tool, Parenting Stress Index-Short Form, Paediatric Quality of Life Inventory) and an optional interview. Read More

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Widely targeted metabolomics analysis of white peony teas with different storage time and association with sensory attributes.

Food Chem 2021 May 30;362:130257. Epub 2021 May 30.

Zhejiang University Tea Research Institute, 866 Yuhangtang Road, Hangzhou 310058, China. Electronic address:

The sensory features of white peony teas (WPTs) significantly change with storage age; however, their comprehensive associations with composition are still unclear. This study aimed to clarify the sensory quality-related chemical changes in WPTs during storage. Liquid chromatography-tandem mass spectrometry based on widely targeted metabolomics analysis was performed on WPTs of 1-13 years storage ages. Read More

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Improving Vaccination for Young Children (IVY): A Stepped-Wedge Cluster Randomized Trial.

Acad Pediatr 2021 Jun 9. Epub 2021 Jun 9.

Vanderbilt University Medical Center, Department of Pediatrics, 1211 Medical Center Dr, Nashville, TN 37232, Nashville, Tennessee, United States. Electronic address:

Background: High childhood vaccination rates are critical for public health. We hypothesized that implementation of a vaccine education and quality improvement (QI) program, Improving Vaccinations for Young Children (IVY), would improve childhood vaccine rates.

Methods: Eight pediatric practices (3 academic-based, 5 community-based) were randomized to implement IVY within a stepped-wedge cluster randomized trial (SWCRT) in middle Tennessee. Read More

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Short-term and Long-term Psychological Impact and Quality of Life of Patients Undergoing Orthognathic Surgery.

Biomed J 2021 Jun 9. Epub 2021 Jun 9.

Department of Craniofacial Research Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan, Taiwan.

Background: Orthognathic Surgery (OGS) is a surgery for patients with dento-facial deformity but not all patients are satisfied with its outcome. The purpose of this study is to find out the short-term and long-term psychological impact and quality-of-life of OGS.

Methods: 77 participants receiving OGS and 32 age and gender-matched controls were enrolled. Read More

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Circadian clock genes as promising therapeutic targets for autoimmune diseases.

Autoimmun Rev 2021 Jun 9:102866. Epub 2021 Jun 9.

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Electronic address:

Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis (RA), often exhibit substantial circadian oscillations, and circadian rhythm is involved in the onset and progression of autoimmune diseases. Read More

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Heart rate variability biofeedback in chronic disease management: a systematic review.

Complement Ther Med 2021 Jun 9:102750. Epub 2021 Jun 9.

Laboratoire IRISSE EA4075, UFR des Sciences de l'Homme et de l'Environnement, Université de la Réunion, Le Tampon, La Réunion, France. Electronic address:

Background: Heart rate variability biofeedback (HRVB) is a non-pharmacological intervention used in the management of chronic diseases.

Method: A systematic search was performed according to eligibility criteria including adult chronic patients, HRVB as main treatment with or without control conditions, and psychophysiological outcomes as dependent variables.

Results: In total, 29 articles were included. Read More

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Improved Physician Understanding of Patient End-Of-Life Preferences: A Quality Improvement Project.

J Pain Symptom Manage 2021 Jun 9. Epub 2021 Jun 9.

Section of Cardiovascular Medicine, Yale New Haven Health Bridgeport Hospital.

Background: Code status (CS) orders lack a universal definition. We aimed to improve provider understanding of order options.

Measures: Provider's knowledge of CS terminology, ease of understanding CS orders and ease of starting CS discussions. Read More

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HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content.

Reprod Toxicol 2021 Jun 9;103:96-107. Epub 2021 Jun 9.

Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria; Department of Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Osun State, Nigeria.

Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly, anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have been shown to impair male fertility. Read More

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Recommendations for planning and delivery of radical radiotherapy for localized urothelial carcinoma of the bladder.

Radiother Oncol 2021 Jun 9. Epub 2021 Jun 9.

Department of Radiotherapy, Institut Bergonié, Bordeaux, France. Electronic address:

Purpose: Curative radio-chemotherapy is recognized as a standard treatment option for muscle-invasive bladder cancer (MIBC). Nevertheless, the technical aspects for MIBC radiotherapy are heterogeneous with a lack of practical recommendations.

Methods And Materials: In 2018, a workshop identified the need for two cooperative groups to develop consistent, evidence-based guidelines for irradiation technique in the delivery of curative radiotherapy. Read More

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The protective effect of Nano-selenium against cadmium-induced cerebellar injury via the heat shock protein pathway in chicken.

Food Chem Toxicol 2021 Jun 9:112332. Epub 2021 Jun 9.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P.R. China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, P.R. China; Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, Northeast Agricultural University, Harbin 150030, P.R. China. Electronic address:

Cadmium (Cd) is one of the toxic environmental heavy metals that poses health hazard to animal due to its toxicity. Nano-Selenium (Nano-Se) is a Nano-composite form of Se, which has emerged as promising therapeutic agent for its protective roles against heavy metals-induced toxicity. Heat shock proteins (HSPs) play a critical role in cellular homeostasis. Read More

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Disparate genetic variants associated with distinct components of cowpea resistance to the seed beetle Callosobruchus maculatus.

Theor Appl Genet 2021 Jun 12. Epub 2021 Jun 12.

Department of Biology, Utah State University, Logan, UT, 84322, USA.

Key Message: Polygenic genome-wide association mapping identified two regions of the cowpea genome associated with different components of resistance to its major post-harvest pest, the seed beetle Callosobruchus maculatus. Cowpea (Vigna unguiculata) is an important grain and fodder crop in arid and semi-arid regions of Africa, Asia, and South America, where the cowpea seed beetle, Callosobruchus maculatus, is a serious post-harvest pest. Development of cultivars resistant to C. Read More

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Exploring family members' and health care professionals' perceptions on ICU diaries: a systematic review and qualitative data synthesis.

Intensive Care Med 2021 Jun 12. Epub 2021 Jun 12.

Intensive Care Unit of the Hospital da Mulher, Rua Barão de Cotegipe, 1153, Roma, Salvador, BA, 40411-900, Brazil.

Purpose: Although the intensive care unit (ICU) diary has been proposed as a tool for preventing psychiatric symptoms in survivors of critical illness, relatives and health care providers may benefit from it too. This study aims to summarize the current qualitative evidence on families' and health care professionals' experiences of writing in and reading the ICU diaries.

Methods: We searched MEDLINE, OVID, Embase, and EBSCOhost from inception to February 2021, and included all the studies that presented any qualitative finding regarding relatives' and health care providers' experiences of writing in and reading an ICU diary. Read More

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Metal Sulfide Photocatalysts for Lignocellulose Valorization.

Adv Mater 2021 Jun 12:e2007129. Epub 2021 Jun 12.

State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.

Transition metal sulfides are an extraordinarily vital class of semiconductors with a wide range of applications in the photocatalytic field. A great number of recent advances in photocatalytic transformations of lignocellulosic biomass, the largest renewable carbon resource, into high-quality fuels and value-added chemicals has been achieved over metal sulfide semiconductors. Herein, the progress and breakthroughs in metal-sulfide-based photocatalytic systems for lignocellulose valorization with an emphasis on selective depolymerization of lignin and oxidative coupling of some important bioplatforms are highligted. Read More

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Mechanistic Computational Model for Extrapolating In vitro Thyroid Peroxidase (TPO) Inhibition Data to Predict Serum Thyroid Hormone Levels in Rats.

Toxicol Sci 2021 Jun 12. Epub 2021 Jun 12.

Center for Computational Toxicology and Exposure, Research Triangle Park, NC.

High throughput (HTP) in vitro assays are developed to screen chemicals for their potential to inhibit thyroid hormones (THs) synthesis. Some of these experiments, such as the thyroid peroxidase (TPO) inhibition assay, are based on thyroid microsomal extracts. However, the regulation of thyroid disruption chemicals (TDCs) is based on THs in vivo serum levels. Read More

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Ecological factors and post-transplant outcomes: Causation or correlation?

Am J Transplant 2021 Jun 12. Epub 2021 Jun 12.

Division of Surgery, University of Iowa, Iowa City, IA, USA.

Social determinants of health (SDOH), defined by the World Health Organization as "the conditions in which people are born, work, live, and age, and the wider set of forces and systems shaping the conditions of daily life", are widely acknowledged to contribute to variation in health outcomes. The Healthy People 2030 framework identifies an individual's neighborhood as one of the five key areas of SDOH. The neighborhoods where people live can influence health outcomes through a variety of pathways, including access to transportation, availability of healthy foods and physical activity spaces, rates of crime and violence, and prevalence of poor air and water quality. Read More

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The association between wearable activity monitor metrics and performance status in oncology: a systematic review.

Support Care Cancer 2021 Jun 12. Epub 2021 Jun 12.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Purpose: The expanding armamentarium of wearable activity monitors (WAMs) offers new opportunities to supplement physician-assessed performance status (PS) with real-life patient activity data. These data could guide clinical decision making or serve as a measure of treatment outcome. However, information on the association between physical activity (PA) and sedentary behavior (SB) monitored with wearables (i. Read More

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AMPK activates Parkin independent autophagy and improves post sepsis immune defense against secondary bacterial lung infections.

Sci Rep 2021 Jun 11;11(1):12387. Epub 2021 Jun 11.

Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294-0012, USA.

Metabolic and bioenergetic plasticity of immune cells is essential for optimal responses to bacterial infections. AMPK and Parkin ubiquitin ligase are known to regulate mitochondrial quality control mitophagy that prevents unwanted inflammatory responses. However, it is not known if this evolutionarily conserved mechanism has been coopted by the host immune defense to eradicate bacterial pathogens and influence post-sepsis immunosuppression. Read More

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Effect of Strength Versus Strength and Endurance Upper Limb Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A RANDOMIZED CLINICAL TRIAL.

J Cardiopulm Rehabil Prev 2021 Jun 10. Epub 2021 Jun 10.

Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus (Drs Karagiannis and Savva and Ms Matheou); Aspetar, Orthopaedic and Sports Medicine Hospital, Doha, Qatar (Dr Korakakis); Respiratory Clinic, Nicosia General Hospital, Nicosia, Cyprus (Dr Adamide); Private Doctor, Nicosia, Cyprus (Dr Georgiou); Physiotherapy Department, Nicosia General Hospital, and Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus (Ms Prodromou); and School of Medicine, European University Cyprus, Nicosia, Cyprus (Dr Xanthos).

Purpose: Pulmonary rehabilitation (PR) including exercise training improves muscle strength, exercise capacity, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, the evidence of the effect of upper limb exercise training (ULET) on activities of daily living (ADL) is sparse. This study investigated the effect of two different types of ULET on ADL in addition to standard PR. Read More

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Harnessing life's slings and arrows: The science and opportunities for mindfulness meditation during a global pandemic and beyond.

Psychosom Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Epidemiology, Brown University School of Public Health Mindfulness Center at Brown University Department of Psychiatry, University of Wisconsin-Madison Center for Healthy Minds, University of Wisconsin-Madison Department of Psychology, Carnegie Mellon University.

Abstract: We are at a difficult time in history with societal increases in stress, loneliness, and psychopathology, along with high rates of obesity, sedentary lifestyles, and chronic pain. Mindfulness interventions offer promise to address these societal issues. However, in order to make best use of the opportunities revealed by our current challenges, we must: (1) tackle these issues head-on with inclusive, innovative, and creative experimental designs and interventions, and (2) collectively adhere to rigorous, high quality methods so as to provide an evidence-based integration of mindfulness interventions into mainstream medicine and public health. Read More

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Gut Microbiota in Psychiatric Disorders: A Systematic Review.

Psychosom Med 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital, Huddinge, Sweden Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden Department of Public Health, Section for Health Services Research, University of Copenhagen, Denmark Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, USA Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, USA.

Objective: This systematic review sought to comprehensively summarize gut microbiota research in psychiatric disorders following PRISMA guidelines.

Methods: Literature searches were performed on databases using keywords involving gut microbiota and psychiatric disorders. Articles in English with human participants up until 13th of February 2020 were reviewed. Read More

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Efficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):916-925. Epub 2021 Jun 11.

Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan

Background And Objectives: Patients with kidney failure have a high risk of cardiovascular disease due to cardiac remodeling, left ventricular fibrosis, and hyperaldosteronism, all of which can be potentially mitigated by mineralocorticoid receptor antagonists. However, because of the fear of hyperkalemia, the use of mineralocorticoid receptor antagonists in patients with kidney failure is limited in current clinical practice, and few studies have investigated the efficacy and safety. Thus, we aimed to determine the benefits and side effects of mineralocorticoid receptor antagonists in patients with kidney failure treated with dialysis. Read More

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What risks to sustainability are identified throughout care bundle implementation and how can they be addressed? A mixed methods case study.

BMJ Open 2021 Jun 11;11(6):e048815. Epub 2021 Jun 11.

Department of Research and Development, London North West University Healthcare NHS Trust, Harrow, UK.

Objectives: Despite national guidance on how to identify and treat heart failure (HF), variation in HF care persists across UK hospitals. Care bundles have been proposed as a mechanism to deliver reliable optimal care for patients; however, specific challenges to sustain care bundles in practice have been highlighted. With few studies providing insight into how to design or implement care bundles to optimise sustainability, there is little direction for practitioners seeking to ensure long-term impact of their initiatives. Read More

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Diet and physical activity in pregnancy to prevent gestational diabetes: a protocol for an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation.

BMJ Open 2021 Jun 11;11(6):e048119. Epub 2021 Jun 11.

WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Introduction: Mothers with gestational diabetes mellitus (GDM) are at increased risk of pregnancy-related complications and developing type 2 diabetes after delivery. Diet and physical activity-based interventions may prevent GDM, but variations in populations, interventions and outcomes in primary trials have limited the translation of available evidence into practice. We plan to undertake an individual participant data (IPD) meta-analysis of randomised trials to assess the differential effects and cost-effectiveness of diet and physical activity-based interventions in preventing GDM and its complications. Read More

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Non-clinical assessment of cell therapy products: the perspective from five Asian countries/regions based on regulatory guidelines and the underpinning rationales.

Cytotherapy 2021 Jun 9. Epub 2021 Jun 9.

Translational Medicine, Novartis Institutes for BioMedical Research, Novartis Pharma K.K., Tokyo, Japan.

Background Aims: Cell-based regenerative medicine is an innovative field that can potentially alter the overall survival and quality of life of patients with devastating diseases. Several cell therapy products (CTPs) have been approved within the last two decades, and more are under development. The establishment of an effective developmental strategy in accordance with the regulatory bodies of each country/region is crucial for fast delivery of each respective CTP. Read More

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Sodium-Glucose Cotransporter-2 Inhibitors and Risk of Diabetic Ketoacidosis Among Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Can J Diabetes 2021 Apr 28. Epub 2021 Apr 28.

Department of Medicine, Sinai Health System and the University of Toronto, Toronto, Ontario, Canada; Department of Medicine, General Internal Medicine, University of Toronto, Toronto, Ontario, Canada.

Objectives: The magnitude and precision regarding the risk of diabetic ketoacidosis (DKA) with sodium-glucose cotransporter-2 (SGLT2) inhibitors is unclear. Thus, we examined the risk of DKA with SGLT2 inhibitors in both observational studies and large clinical trials.

Methods: Searches were performed in PubMed, Embase, CENTRAL and Google Scholar (from inception to April 15, 2019) without language restrictions, including conference proceedings and reference lists. Read More

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Effects of Medical Masks on Voice Assessment During the COVID-19 Pandemic.

J Voice 2021 May 9. Epub 2021 May 9.

Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: Voice assessment is of great significance to the evaluation of voice quality. Our study aims to explore the effects of medical masks on healthy people in acoustic, aerodynamic and formant parameters during the COVID-19 pandemic. In addition, we also attempted to verify the differences between different sexes and ages. Read More

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Don't forget about the future: The impact of including future costs on the cost-effectiveness of adult pneumococcal conjugate vaccination with PCV13 in the Netherlands.

Vaccine 2021 Jun 8. Epub 2021 Jun 8.

Erasmus School of Health Policy and Management, Erasmus University Rotterdam, the Netherlands.

Background: When vaccines increase longevity, vaccinated people may experience costs and benefits during added life-years. These future benefits and costs may include increased productivity as well as medical and non-medical costs. Such impacts should be considered in cost-effectiveness analyses (CEA) of vaccines but are often omitted. Read More

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