4,411 results match your criteria including periodontitis

Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis.

J Biol Chem 2021 Jan 8;296:100263. Epub 2021 Jan 8.

Institut für Biochemie und Biotechnologie, Charles-Tanford-Proteinzentrum, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany; ZIK HALOmem, Charles-Tanford-Proteinzentrum, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. Electronic address:

The development of a targeted therapy would significantly improve the treatment of periodontitis and its associated diseases including Alzheimer's disease, rheumatoid arthritis, and cardiovascular diseases. Glutaminyl cyclases (QCs) from the oral pathogens Porphyromonas gingivalis, Tannerella forsythia, and Prevotella intermedia represent attractive target enzymes for small-molecule inhibitor development, as their action is likely to stabilize essential periplasmic and outer membrane proteins by N-terminal pyroglutamination. In contrast to other microbial QCs that utilize the so-called type I enzymes, these oral pathogens possess sequences corresponding to type II QCs, observed hitherto only in animals. Read More

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January 2021

Molecular subgroup of periodontitis revealed by integrated analysis of the microbiome and metabolome in a cross-sectional observational study.

J Oral Microbiol 2021 Mar 25;13(1):1902707. Epub 2021 Mar 25.

Department of Oral Microbiology, School of Dentistry, Pusan National University, Busan, South Korea.

: Periodontitis (PT) is a multifactorial, chronic inflammatory disease that can have heterogeneous clinical presentations. The oral microbiome and its metabolites have been implicated as the causes and regulators of PT pathogenesis. In this study, we assessed the oral microbiome and its metabolome in PT patients to clarify the interactions between the microbiome and its metabolites. Read More

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Development and optimization of a rapid colorimetric membrane immunoassay for .

J Microbiol Biotechnol 2021 Apr 5. Epub 2021 Apr 5.

Department of Bioscience and Biotechnology, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.

) is a major bacterial pathogen that causes periodontitis, a chronic inflammatory disease of tissues around the teeth. Periodontitis is known to be related to other diseases, such as oral cancer, Alzheimer's disease, and rheumatism. Thus, a precise and sensitive test to detect is necessary for the early diagnosis of periodontitis. Read More

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The recent advances in scaffolds for integrated periodontal regeneration.

Bioact Mater 2021 Oct 18;6(10):3328-3342. Epub 2021 Mar 18.

Center for Dental and Craniofacial Research, Columbia University Medical Center, 630 W. 168 St., VC12-212, New York, NY, 10032, USA.

The periodontium is an integrated, functional unit of multiple tissues surrounding and supporting the tooth, including but not limited to cementum (CM), periodontal ligament (PDL) and alveolar bone (AB). Periodontal tissues can be destructed by chronic periodontal disease, which can lead to tooth loss. In support of the treatment for periodontally diseased tooth, various biomaterials have been applied starting as a contact inhibition membrane in the guided tissue regeneration (GTR) that is the current gold standard in dental clinic. Read More

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October 2021

Systemic and Extraradicular Bacterial Translocation in Apical Periodontitis.

Front Cell Infect Microbiol 2021 19;11:649925. Epub 2021 Mar 19.

Laboratory of Periodontal Biology, Faculty of Dentistry, Universidad de Chile, Santiago, Chile.

Apical periodontitis is an inflammatory disease of microbial etiology. It has been suggested that endodontic bacterial DNA might translocate to distant organs blood vessels, but no studies have been conducted. We aimed first to explore overall extraradicular infection, as well as specifically by spp; and their potential to translocate from infected root canals to blood through peripheral blood mononuclear cells. Read More

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The Role of Neutrophil Extracellular Traps in Periodontitis.

Front Cell Infect Microbiol 2021 18;11:639144. Epub 2021 Mar 18.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Periodontitis is a chronic, destructive disease of periodontal tissues caused by multifaceted, dynamic interactions. Periodontal bacteria and host immunity jointly contribute to the pathological processes of the disease. The dysbiotic microbial communities elicit an excessive immune response, mainly by polymorphonuclear neutrophils (PMNs). Read More

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Lipopolysaccharide Preparation Derived From Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than by Differentially Activating TLR2/4-Mediated NF-κB/STAT3 Signaling Pathways.

Front Cell Infect Microbiol 2021 18;11:606986. Epub 2021 Mar 18.

Department of Periodontology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Alzheimer's disease (AD) is a degenerative disease of the central nervous system with unclear etiology and pathogenesis. In recent years, as the infectious theory and endotoxin hypothesis of AD has gained substantial attention, several studies have proposed that (), one of the main pathogenic bacteria of chronic periodontitis, and the lipopolysaccharide (LPS) of may lead to AD-like pathological changes and cognition impairment. However, research on the relationship between -LPS and neuroinflammation is still lacking. Read More

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Periodontal status in children with primary immunodeficiencies.

J Periodontal Res 2021 Apr 3. Epub 2021 Apr 3.

Centre for Oral Immunobiology & Regenerative Medicine & Centre for Oral Clinical Research, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, Queen Mary University London, London, UK.

Objective: This study aimed to assess associations between neutrophil-related primary immunodeficiencies (PIDs) and the presence of periodontal disease and other oral diseases and response to periodontal treatment.

Background: Presence of neutrophil-related PIDs is thought to be a major risk factor for development of periodontitis.

Methods: This study had both a cross-sectional and cohort design. Read More

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The Influence of Diet on Oxidative Stress and Inflammation Induced by Bacterial Biofilms in the Human Oral Cavity.

Materials (Basel) 2021 Mar 16;14(6). Epub 2021 Mar 16.

Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

The article is a concise compendium of knowledge on the etiology of pathogenic microorganisms of all complexes causing oral diseases. The influence of particular components of the diet and the role of oxidative stress in periodontal diseases were described. The study investigated the bacteriostatic effect of the diet of adults in in vivo and in vitro tests on the formation of bacterial biofilms living in the subgingival plaque, causing diseases called periodontitis. Read More

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Impact of the Diet on the Formation of Oxidative Stress and Inflammation Induced by Bacterial Biofilm in the Oral Cavity.

Materials (Basel) 2021 Mar 12;14(6). Epub 2021 Mar 12.

Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland.

The diet is related to the diversity of bacteria in the oral cavity, and the less diverse microbiota of the oral cavity may favor the growth of pathogenic bacteria of all bacterial complexes. Literature data indicate that disturbances in the balance of the bacterial flora of the oral cavity seem to contribute to both oral diseases, including periodontitis, and systemic diseases. If left untreated, periodontitis can damage the gums and alveolar bones. Read More

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Antibiotic Use in Periodontal Therapy among French Dentists and Factors Which Influence Prescribing Practices.

Antibiotics (Basel) 2021 Mar 15;10(3). Epub 2021 Mar 15.

Department of Periodontology, School of Dentistry, University of Lille, Place de Verdun, 59000 Lille, France.

The aim of the present survey is to investigate the use of antibiotics during periodontal therapy among French dentists with a focus on exploring potential differences between various groups of practitioners. A self-administered questionnaire was distributed to different groups of practitioners including members of (i) the French Society of Periodontology and Implantology; (ii) the College of University Teachers in Periodontology and, (iii) private practitioners participating in the French general dental practice-based research network. 272 questionnaires were included in the analysis. Read More

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Effects of Erythromycin on Osteoclasts and Bone Resorption via DEL-1 Induction in Mice.

Antibiotics (Basel) 2021 Mar 17;10(3). Epub 2021 Mar 17.

Division of Microbiology and Infectious Diseases, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, Japan.

Macrolides are used to treat various infectious diseases, including periodontitis. Furthermore, macrolides are known to have immunomodulatory effects; however, the underlying mechanism of their action remains unclear. DEL-1 has emerged as an important factor in homeostatic immunity and osteoclastogenesis. Read More

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Limonoid Triterpene, Obacunone Increases Runt-Related Transcription Factor 2 to Promote Osteoblast Differentiation and Function.

Int J Mol Sci 2021 Mar 2;22(5). Epub 2021 Mar 2.

Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul 02447, Korea.

Root bark of Turcz. has been widely used as a traditional medicine and is a well-known anti-inflammatory agent. We isolated limonoid triterpene, obacunone (Obac) from the dried root bark of . Read More

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Microbial biodiversity of natural toothbrushes in Mali.

New Microbes New Infect 2021 Mar 3;40:100844. Epub 2021 Feb 3.

Aix Marseille Université. IRD, MEPHI, IHU-Méditerranée Infection, Marseille, France.

Different oral hygiene practices are used to overcome endemic diseases such as dental caries and oral infections. In Mali (Africa), natural plant-based toothbrushes are used for eliminating bacterial biofilm. The repertoire of microorganisms associated with natural toothbrushes is unknown. Read More

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The circadian clock gene : Role in COVID-19 and periodontitis.

Chronobiol Int 2021 Apr 1:1-6. Epub 2021 Apr 1.

Department of Pharmacology, Faculty of Pharmacy, Near East University, Nicosia, Cyprus.

The physiological processes of most living organisms follow a rhythmic pattern, which is controlled by the interaction between environmental cues and the internal circadian timing system. Different regulatory circadian genes are expressed in most cells and tissues, and disruptions in the sleep-wake cycle affect these genes, which may result in metabolic disorders and cause alterations of the immune system. The manifestations of these disrupted genes are evident in inflammatory conditions such as periodontitis and some viral diseases, including COVID-19. Read More

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Influence of scaler tip design on root surface roughness, tooth substance loss and patients' pain perception: an in vitro and a randomised clinical trial.

BMC Oral Health 2021 Mar 31;21(1):169. Epub 2021 Mar 31.

Department of Restorative Dentistry, Faculty of Dentistry, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia.

Background: The influence of scaler tip design on root surface roughness, tooth substance loss and patients' pain perception is investigated.

Methods: This article was divided into the following parts: Part 1 Surface roughness and substance loss: an in vitro study, which involves intact extracted teeth sectioned and treated using a piezoelectric ultrasonic device (PM200 EMS Piezon, Switzerland) with a conventional scaler tip (FS-407) and a Perio Slim (PS) scaler tip (Perio Slim DS-016A). All sectioned samples for tooth surface roughness (n = 20) and tooth substance loss (n = 46) analyses were measured and compared using a 3D surface texture analyser and scanning electron microscope (SEM) respectively, at baseline and following scaling. Read More

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Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis.

Phytother Res 2021 Mar 28. Epub 2021 Mar 28.

Department of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Inflammatory osteolysis as a consequence of chronic bacterial infection underlies several lytic bone conditions, such as otitis media, osteomyelitis, septic arthritis, periodontitis, periprosthetic infection, and aseptic loosening of orthopedic implants. In consideration of the lack of effective preventive or treatments options against infectious osteolysis, the exploitation of novel pharmacological compounds/agents is critically required. The present study assessed the effect of protocatechualdehyde (PCA), a natural occurring polyphenolic compound with diverse biological activities including but not limited to antibacterial and antiinflammatory properties, on nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis in vitro and lipopolysaccharide (LPS)-induced bone loss in vivo. Read More

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Interactions Between Neutrophils and Periodontal Pathogens in Late-Onset Periodontitis.

Front Cell Infect Microbiol 2021 12;11:627328. Epub 2021 Mar 12.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, China.

Late-onset periodontitis is associated with a series of inflammatory reactions induced by periodontal pathogens, such as , a keystone pathogen involved in periodontitis. Neutrophils are the most abundant leukocytes in the periodontal pocket/gingival crevice and inflamed periodontal tissues. They form a "wall" between the dental plaque and the junctional epithelium, preventing microbial invasion. Read More

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The oralome and its dysbiosis: New insights into oral microbiome-host interactions.

Comput Struct Biotechnol J 2021 27;19:1335-1360. Epub 2021 Feb 27.

Kapila Laboratory, Orofacial Sciences Department, School of Dentistry, University of California, San Francisco (UCSF), San Francisco, CA, USA.

The oralome is the summary of the dynamic interactions orchestrated between the ecological community of oral microorganisms (comprised of up to approximately 1000 species of bacteria, fungi, viruses, archaea and protozoa - the oral microbiome) that live in the oral cavity and the host. These microorganisms form a complex ecosystem that thrive in the dynamic oral environment in a symbiotic relationship with the human host. However, the microbial composition is significantly affected by interspecies and host-microbial interactions, which in turn, can impact the health and disease status of the host. Read More

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February 2021

Analysis of Plasma Homocysteine Levels in Patients with Chronic Periodontitis Before and After Nonsurgical Periodontal Therapy Using High-Performance Liquid Chromatography.

Contemp Clin Dent 2020 Jul-Sep;11(3):266-273. Epub 2020 Nov 26.

Department of Periodontics and Implantology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Introduction: Homocysteine (Hcy), an inflammatory biomarker, is a sulfur-containing amino acid. Elevated levels of plasma Hcy are evident in various inflammatory conditions and have been described as an independent risk factor for cardiovascular disease. The literature has also stated that a similar association could exist between the chronic periodontitis and plasma-Hcy levels, in otherwise systemically healthy individuals. Read More

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November 2020

How strong is the link between periodontitis and stroke?

Evid Based Dent 2021 01;22(1):10-11

Oral Sciences, Glasgow Dental Hospital and School, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

Data sources PubMed, Scopus, Web of Science, The Cochrane Library, LILACS, OpenGrey and Google Scholar. No language restriction applied; studies conducted until September 2018.Study selection Observational studies in humans exposed and not exposed to periodontitis, in which the primary outcome was the risk of cerebrovascular accident, including haemorrhagic and ischaemic attacks (transient ischaemic attack and ischaemic stroke). Read More

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January 2021