244 results match your criteria including cassia


Active Components from Prevent HIV-1 Entry by Distinct Mechanisms of Action.

Int J Mol Sci 2021 May 10;22(9). Epub 2021 May 10.

Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg.

is widely used in Sub-Saharan Africa for treating many diseases, including HIV-1 infection. We have recently described the chemical structures of 28 compounds isolated from an alcoholic crude extract of barks and roots of , and showed that six bioactive compounds inhibit HIV-1 infection. In the present study, we demonstrate that the six compounds block HIV-1 entry into cells: oleanolic acid, palmitic acid, taxifolin, piceatannol, guibourtinidol-(4α→8)-epiafzelechin, and a novel compound named as cassiabrevone. Read More

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Amoebicidal activity of extract and its effect on autophagy-related gene expression at the transcriptional level.

Parasitology 2021 May 10:1-9. Epub 2021 May 10.

Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat80160, Thailand.

Cassia angustifolia Vahl. plant is used for many therapeutic purposes, for example, in people with constipation, skin diseases, including helminthic and parasitic infections. In our study, we demonstrated an amoebicidal activity of C. Read More

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Fabrication of label-free and eco-friendly ROS optical sensor with potent antioxidant properties for sensitive hydrogen peroxide detection in human plasma.

Colloids Surf B Biointerfaces 2021 Apr 29;204:111798. Epub 2021 Apr 29.

Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières (UQTR), Trois-Rivières, Québec, G9A, 5H7, Canada. Electronic address:

Herein, biogenic silver nanoparticles, Cafi-AgNPs was produced based on Cassia fistula-phenolic-rich extract (Cafi) only, without any toxic chemical reagent or organic solvent. Cafi bioactives were characterized using UHPLC-ESI-QTOF-MS/MS analysis. The as-synthesized nanoparticles were characterized using physico-chemical techniques including UV-vis, TEM, SEM, EDX, FTIR, DLS, Zeta potential, XRD, TGA and DGA. Read More

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Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of DC. Flowers.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.

Despite being widely used traditionally as a general tonic, especially in South East Asia, scientific research on , remains scarce. In this study, the aim was to evaluate the in vitro activities for acetylcholinesterase (AChE) inhibitory potential, radical scavenging ability, and the anti-inflammatory properties of different extracts of flowers using Ellman's assay, a DPPH assay, and an albumin denaturation assay, respectively. With the exception of the acetylcholinesterase activity, to the best of our knowledge, these activities were reported for the first time for flowers. Read More

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Chemical Constituents of and Their Anti-HIV-1 Activity.

Molecules 2021 Apr 23;26(9). Epub 2021 Apr 23.

Department of Infection and Immunity, Luxembourg Institute of Health, L-4354 Esch-sur-Alzette, Luxembourg.

Three new (-) and 25 known compounds were isolated from the crude extract of . The chemical structures of new compounds were established by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. Cassiabrevone () is the first heterodimer of guibourtinidol and planchol A. Read More

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Metabolomics of Plant Parts (Leaf, Flower, Bud) and Their Antidiabetic Medicinal Potentials.

OMICS 2021 May 27;25(5):294-301. Epub 2021 Apr 27.

Department of Food Science, Gilat Research Center, Agricultural Research Organization M.P. Negev, Israel.

Diabetes is a common chronic disease where therapeutics innovation is much needed. The search for novel antidiabetic molecules can be greatly facilitated by high throughput metabolomic characterization of herbal medicines. is a shrub used in Ayurvedic medicine and native to India and Sri Lanka. Read More

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ANTIMALARIAL ACTIVITY AND TOXICITY STUDIES OF JOHAR () LEAVES FROM THREE DIFFERENT LOCATIONS.

Afr J Infect Dis 2020 31;14(2):23-29. Epub 2020 Jul 31.

Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.

Background: Antimalarial activity of leaves has been proven by the active compound that has been found, i.e. Cassiarin A. Read More

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The effectiveness of a modified Gui Zhi Fu Ling Wan formulation (Gynoclear™) for the treatment of endometriosis: a study protocol for a placebo-controlled, double-blind, randomised controlled trial.

Trials 2021 Apr 21;22(1):299. Epub 2021 Apr 21.

University of New South Wales, Royal Hospital for Women, Randwick, NSW, 2031, Australia.

Background: Endometriosis is the presence of tissue similar to that of the endometrium outside the uterine cavity and is the most common cause of chronic pelvic pain. Current non-surgical treatments such as non-steroidal anti-inflammatories, oral contraceptive pills and hormonal treatments have limited effectiveness, and the side effect profile is bothersome. This study will evaluate the efficacy of Gynoclear™ by change in endometriosis-related pain based on the Endometriosis Pain Daily Diary (EPPD) scores. Read More

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A novel nutritional mixture, MBN, prevents memory impairment via inhibiting NLRP3 inflammasome formation in 5xFAD transgenic mice.

Nutr Neurosci 2021 Apr 20:1-8. Epub 2021 Apr 20.

Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea.

Objectives: Amyloid beta (Aβ)-induced abnormal neuroinflammation is recognized as a major pathological factor of Alzheimer's disease (AD), which results in memory impairment. Inhibition of excessive neuroinflammation mediated by Aβ is considered a promising strategy to ameliorate AD symptoms. To regulate the inflammatory response, nutritional and dietary supplements have been used for centuries. Read More

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Acute toxicity studies and protective effects of bark extract in streptozotocin-induced diabetic rats.

Drug Chem Toxicol 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, India.

The medicinal properties of () bark have been reported for their clinical importance for many diseases including diabetes. However, there is no clear evidence so far regarding dose selection for its hepato- and nephroprotective effect in diabetic condition. Hence, the present study aims at evaluating antioxidant activity, the acute toxicity, and dose fixation of bark for their effective medicinal values in streptozotocin (STZ)-induced rats. Read More

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Anti-inflammatory activity of the Tongmai Yangxin pill in the treatment of coronary heart disease is associated with estrogen receptor and NF-κB signaling pathway.

J Ethnopharmacol 2021 Aug 7;276:114106. Epub 2021 Apr 7.

School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address:

Ethnopharmacological Relevance: The Tongmai Yangxin Pill (TMYX) is a patented traditional Chinese medicine originating from two classic prescriptions, Zhigancao Decoction and Shenmai Yin, which composed of 11 Chinese medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Spatholobus suberectus Dunn, Ophiopogon japonicus (Thunb. Read More

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Microablative radiofrequency versus pelvic floor muscle training for stress urinary incontinence: a randomized controlled trial.

Int Urogynecol J 2021 Apr 10. Epub 2021 Apr 10.

Department of Obstetrics and Gynecology, University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.

Introduction And Hypothesis: The efficacy of radiofrequency (RF) in stress urinary incontinence (SUI) is as yet unknown. The aim was to compare the effect of fractional microablative RF and pelvic floor muscle training (PFMT) against the combination of both therapies (RF + PFMT) in the SUI and on genitourinary syndrome (GSM).

Methods: This was a three-arm randomized clinical trial including 117 climacteric women with SUI. Read More

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The anthelmintic potentials of medicinal plant extracts and an isolated compound (rutin, CHO) from Terminalia catappa L. against Gastrothylax crumenifer.

Vet Parasitol 2021 Mar 14;291:109385. Epub 2021 Feb 14.

Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom, 73170, Thailand. Electronic address:

Paramphistomosis is a pathogenic disease that occurs frequently in tropical and subtropical countries including Thailand. This disease is affected in the parasites causing severe gastrointestinal disorders and death in infected animals. In the present study, we examined the anthelmintic efficacy of albendazole (ABZ) and crude plant extracts from barks of Bombax ceiba L. Read More

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In silico analysis of quranic and prophetic medicinals plants for the treatment of infectious viral diseases including corona virus.

Saudi J Biol Sci 2021 May 23;28(5):3137-3151. Epub 2021 Feb 23.

The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Coronavirus disease (COVID-19) is an infection of the respiratory system caused by single standard RNA viruses named as Severe Acute Respiratory Syndrome 2 (SARS-CoV-2). The disease appeared as a serious problem and the leading cause of death in human beings throughout the world. The main source of different phytochemicals are plants, which helps in the development of new drugs against various ailments. Read More

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The genus Cassia L.: Ethnopharmacological and phytochemical overview.

Phytother Res 2020 Dec 4. Epub 2020 Dec 4.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Nature gifts medicinal plants with the untapped and boundless treasure of active chemical constituents with significant therapeutic potential that makes these plants a beneficial source in the development of phytomedicines. Genus Cassia, with approximately 500 species, is a large group of flowering plants in the family Fabaceae. Cassia species are widely distributed throughout different regions mainly tropical Asia, North America, and East Africa. Read More

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December 2020

Targets and Mechanism Used by Cinnamaldehyde, the Main Active Ingredient in Cinnamon, in the Treatment of Breast Cancer.

Front Pharmacol 2020 9;11:582719. Epub 2020 Dec 9.

Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China.

Breast cancer has become one of the most common malignant tumors in women owing to its increasing incidence each year. Clinical studies have shown that (L.) (cinnamon) has a positive influence on the prevention and treatment of breast cancer. Read More

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December 2020

Therapeutic Potential of Natural Products in Treatment of Cervical Cancer: A Review.

Nutrients 2021 Jan 5;13(1). Epub 2021 Jan 5.

College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

Cervical cancer is the fourth most common cancer among women worldwide. Though several natural products have been reported regarding their efficacies against cervical cancer, there has been no review article that categorized them according to their anti-cancer mechanisms. In this study, anti-cancerous natural products against cervical cancer were collected using Pubmed (including Medline) and google scholar, published within three years. Read More

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January 2021

Protective Effects of Polyphenol Enriched Complex Plants Extract on Metabolic Dysfunctions Associated with Obesity and Related Nonalcoholic Fatty Liver Diseases in High Fat Diet-Induced C57BL/6 Mice.

Molecules 2021 Jan 8;26(2). Epub 2021 Jan 8.

Lee's Biotech Co., Ltd. #416, C Dong, 17 Techno 4-ro, Yuseon-gu, Daejeon 34013, Korea.

Background: Currently, obesity is a global health challenge due to its increasing prevalence and associated health risk. It is associated with various metabolic diseases, including diabetes, hypertension, cardiovascular disease, stroke, certain forms of cancer, and non-alcoholic liver diseases (NAFLD).

Objective: The aim of this study to evaluate the effects of polyphenol enriched herbal complex (/ellagic acid, Bunge/vitexin, chlorogenic acid, /cinnamic acid) on obesity and obesity induced NAFLD in the high-fat diet (HFD)-induced obese mouse model. Read More

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January 2021

Sequencing and phylogenetic analysis of the complete chloroplast genome of Linn.

Mitochondrial DNA B Resour 2019 Nov 13;4(2):4027-4028. Epub 2019 Nov 13.

Department of Resources Science of Traditional Chinese Medicines and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, P. R. China.

Linn. is widely distributed in South-East Asia and South-West Pacific as an important weed. It has many pharmacological activities including anti-allergic, anti-hepatotoxic, and remedy in skin diseases. Read More

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November 2019

Chrysophanol Alleviates Metabolic Syndrome by Activating the SIRT6/AMPK Signaling Pathway in Brown Adipocytes.

Oxid Med Cell Longev 2020 12;2020:7374086. Epub 2020 Nov 12.

The First Clinical Medical College of Guangzhou University of Chinese Medicine, 16 Airport Road, Guangzhou 510405, China.

Chrysophanol, a primary active ingredient of or , has various pharmacological properties, including anticancer, antidiabetic, and anti-inflammatory, as well as blood lipid regulation. However, whether chrysophanol can mitigate obesity, and its underlying mechanisms remains unclear. This study investigated whether chrysophanol effects energy metabolism in high-fat diet- (HFD-) induced obese mice and fat-specific Sirtuin 6- (SIRT6-) knockout (FKO) mice, targeting the SIRT6/AMPK signaling pathway in brown and white fat tissue. Read More

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Exploring natural products-based cancer therapeutics derived from egyptian flora.

J Ethnopharmacol 2021 Apr 25;269:113626. Epub 2020 Nov 25.

Natural Products Laboratory, IBL, Leiden University PO Box 9505, 2300RA, Leiden, the Netherlands.

Ethnopharmacological Relevance: Egyptian plants are a rich source of natural molecules, representing considerable biodiversity due to climate variations between the Northern, Southern, Eastern and Western regions of the country. Sinai is considered a precious nature reserves preserving flora, fauna, marine organisms, and historical habitats with ancient origins. Here, traditional medicinal approaches have been used for hundreds of years. Read More

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The interaction of a thiosemicarbazone derived from R - (+) - limonene with lipid membranes.

Chem Phys Lipids 2021 Jan 21;234:105018. Epub 2020 Nov 21.

IMDEA Nanociencia, Campus Universitario de Cantoblanco, 28049, Madrid, Spain.

As a potential drug, 2-nitrobenzaldehyde-thiosemicarbazone (2-TSC), a thiosemicarbazone derived from the terpene R-(+)-limonene, was studied through calorimetric and spectroscopic techniques. Differential Scanning Calorimetry (DSC) data showed that 2-TSC causes structural changes in a 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DMPC) membrane, strongly decreasing the cooperativity of the bilayer gel-fluid thermal transition. Optical absorption spectroscopy showed that 2-TSC is more soluble in ethanol and lipids than in water medium, and that the drug displays different structures in the different environments. Read More

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January 2021

A Surviving Child from Acute Liver Failure after an Ingestion of Cassia occidentalis Seeds.

J Trop Pediatr 2021 01;67(1)

Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Cassia occidentalis toxicity is thought to be uncommon; however, several cases have been described with acute hepatomyoencephalopathy with a high-mortality rate. We report a previously healthy, 2-year-old girl who developed acute liver failure after fresh seed ingestion. Without a specific antidote, we decided to implement supportive measures and medications including lactulose, sodium benzoate and N-acetylcysteine. Read More

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January 2021

Medicinal plants used to treat "African" diseases by the local communities of Bwambara sub-county in Rukungiri District, Western Uganda.

J Ethnopharmacol 2021 Mar 12;268:113578. Epub 2020 Nov 12.

Department of Chemistry, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.

Ethnopharmacological Relevance: In Africa, traditional medicine encompasses a diverse range of practices, including herbalism and spiritualism, where some diseases are believed to be "African" since they can only be traditionally treated. Indigenous knowledge on the management of "African" diseases using medicinal plants is still handed down orally from generation to generation by tribal societies of tropical Africa, and with the rapid westernization of these societies there is a pressing need to record local knowledge before it is lost forever.

Aim: This study documented medicinal plant species associated with the management of "African" diseases by the local communities of Bwambara sub-county in Rukungiri district, Western Uganda. Read More

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How does traditional knowledge of Cassiae semen shed light on weight management? - A classical and modern literature review.

J Ethnopharmacol 2021 Mar 11;268:113572. Epub 2020 Nov 11.

School of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, Australia. Electronic address:

Ethnopharmacological Relevance: The seed of Senna obtusifolia (L.) H. S. Read More

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Phytoremediation for urban landscaping and air pollution control-a case study in Trivandrum city, Kerala, India.

Environ Sci Pollut Res Int 2021 Feb 7;28(8):9979-9990. Epub 2020 Nov 7.

Postgraduate Department and Research Centre of Botany, University College, University of Kerala, Trivandrum, Kerala, 695 034, India.

Air pollutant concentration of Trivandrum, the capital of Kerala, exceeded the limits of National Ambient Air Quality (NAAQ) standards, according to a study conducted in 2015 by NATPAC. These polluted corridors harbour vegetation on roadsides and traffic islands, planted solely for aesthetic appeal. Analysis of air pollution tolerance levels of existing plants can act as a scientific basis for efficient planning of the urban landscape. Read More

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February 2021

Screening for natural and derived bio-active compounds in preclinical and clinical studies: One of the frontlines of fighting the coronaviruses pandemic.

Phytomedicine 2021 May 29;85:153311. Epub 2020 Aug 29.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91, Stockholm, Sweden; Department of Chemistry, Faculty of Science, Menoufia University, 32512 Shebin El-Kom, Egypt; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China. Electronic address:

Background: Starting December 2019, mankind faced an unprecedented enemy, the COVID-19 virus. The world convened in international efforts, experiences and technologies in order to fight the emerging pandemic. Isolation, hygiene measure, diagnosis, and treatment are the most efficient ways of prevention and intervention nowadays. Read More

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Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review.

Phytother Res 2021 Mar 9;35(3):1298-1312. Epub 2020 Oct 9.

Central Department of Chemistry, Tribhuvan University, Kirtipur, Nepal.

The whole world is entangled by the coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), people are dying in thousands each day, and without an actual medication, it seems not possible for the bringing this global health crisis to a stop. Natural products have been in constant use since ancient times and are proven by time to be effective. Crude extract or pure compounds isolated from medicinal plants and/or herbs such as Artemisia annua, Agastache rugosa, Astragalus membranaceus, Cassia alata, Ecklonia cava, Gymnema sylvestre, Glycyrrhizae uralensis, Houttuynia cordata, Lindera aggregata, Lycoris radiata, Mollugo cerviana, Polygonum multiflorum, Pyrrosia lingua, Saposhnikoviae divaricate, Tinospora cordifolia etc. Read More

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Potential Anti-Acetylcholinesterase Activity of DC.

Molecules 2020 Oct 4;25(19). Epub 2020 Oct 4.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Malaysia.

Seventeen methanol extracts from different plant parts of five different species, including , , , , and were screened against acetylcholinesterase (AChE). extracts were found to exhibit the highest inhibition towards AChE whereby the leaf, stem, and flower methanol extracts showed 94-97% inhibition. As far as we are aware, is one of the least explored spp. Read More

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October 2020

Atelocollagen Application in Human Periodontal Tissue Treatment-A Pilot Study.

Life (Basel) 2020 Jul 16;10(7). Epub 2020 Jul 16.

The Chair and Clinic of Maxillofacial Orthopaedics and Orthodontics, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.

Background: The aim of this study is the clinical observation of gingival tissue condition after atelocollagen injection.

Methods: In 18 patients, 97 gingival class I Miller recessions were divided according to recession height, gingival papillae loss and thickness of gingivae. Atelocollagen (Linerase, 100 mg) was injected into keratinized gingivae twice or thrice, at two-week intervals. Read More

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