2,179 results match your criteria including 667


Assessment of Red Cell Distribution Width, Platelet/lymphocyte Ratio, Systemic Immune-inflammation Index, and Neutrophil/lymphocyte Ratio Values in Patients with Central Retinal Artery Occlusion.

Ocul Immunol Inflamm 2021 Sep 15:1-5. Epub 2021 Sep 15.

Department of Ophthalmology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Purpose: To evaluate complete blood count (CBC)-derived inflammatory indices in central retinal artery occlusion (CRAO).

Methods: A total of 42 patients with CRAO (CRAO group) and 42 age- and sex-matched subjects without CRAO (Control group) were included. CBC parameters including red cell distribution width (RDW) levels were assayed. Read More

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September 2021

Trends and predictors of 30-day readmissions in subjects with eosinophilic esophagitis: results from a national cohort.

Dis Esophagus 2021 Sep 11. Epub 2021 Sep 11.

Department of Gastroenterology, Kansas City VA Medical Center, Kansas City, MO, USA.

Background: Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory condition causing recurrent dysphagia and may predispose patients to repeated hospitalizations. We assessed temporal trends and factors affecting readmissions in patients with EoE.

Methods: Patients with primary diagnosis of EoE and/or a complication (dysphagia, weight loss, and esophageal perforation) from EoE between 2010 and 2017 were identified from the National Readmissions Database using the International Classification of Diseases codes. Read More

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September 2021

Buprenorphine/naloxone associated with a reduced odds of fentanyl exposure among a cohort of people who use drugs in Vancouver, Canada.

Drug Alcohol Depend 2021 Aug 28;228:109006. Epub 2021 Aug 28.

British Columbia Centre on Substance Use, 400-1045 Howe St, Vancouver, British Columbia, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, 667-1081 Burrard St, Vancouver, British Columbia, V6Z 1Y6, Canada. Electronic address:

Background: Little is known about the relationship between opioid agonist therapy (OAT) and fentanyl use, specifically. This study aimed to estimate the association between current use of different forms of OAT, including methadone, buprenorphine/naloxone (BUP/NX), slow release oral morphine (SROM), or injectable opioid agonist treatment (iOAT), and the likelihood of a fentanyl-positive urine drug test (UDT) as compared to no OAT.

Methods: Data were obtained from three community-recruited prospective cohort studies of people who use drugs in Vancouver, Canada from December 2016 through November 2018. Read More

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Clinical Profiles of Neonates Born to COVID-19 Positive Mothers in a Tertiary Care Centre: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Jul 30;59(239):667-671. Epub 2021 Jul 30.

Department of Pediatrics, Patan Academy of Health Sciences, Lalitpur, Nepal.

Introduction: Nepal is one of the countries which has been hit hard by the COVID-19 pandemic and has resulted in high morbidity and mortality across all age groups including neonates. There has been a paucity of studies regarding maternal to neonatal COVID-19 transmission and the published studies also have a poor sample size to reach any definite conclusion. Hence this study was carried out to see the clinical profiles of neonates born to COVID-19 mothers. Read More

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Evaluation of the Medicolegal Process in Neurosurgical Practice with A Scenario.

Turk Neurosurg 2021 ;31(5):667-670

Gazi University, Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey.

The main purpose of medicine is to protect humans from diseases and its complications. Patients may be at risk in the course of diseases or during medical and surgical treatments, which can have undesirable consequences, including death. These risks, which are accepted by all medical authorities and medical literature, are called "complications. Read More

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September 2021

Targeted Therapy for RET Fusion Lung Cancer: Breakthrough and Unresolved Issue.

Front Oncol 2021 23;11:704084. Epub 2021 Aug 23.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

Molecular drugs targeting mutated or rearranged oncogene drivers have become one of the standard recognized treatments in patients with advanced and recurrent non-small cell lung cancer. is located in the long arm of human chromosome 10 and encodes a receptor tyrosine kinase protein, and RET fusion-positive lung adenocarcinoma occurs in 1%-2% of cases. Clinical trials of multikinase inhibitors, including cabozantinib, vandetanib, sorafenib, and lenvatinib, that inhibit RET oncogene activity have shown their antitumor efficacy. Read More

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Nutrient stoichiometry of fishes and invertebrates in coastal marine Caribbean ecosystems.

Authors:
Jacob E Allgeier

Ecology 2021 Sep 8:e03533. Epub 2021 Sep 8.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor.

The importance of animals for mediating ecosystem processes has long been recognized by ecologist. Traditionally, consumer-mediated dynamics have been considered through consumptive pathways such as predation, and herbivory. Yet, consumers also play critical roles in mediating 'bottom-up' pathways associated with nutrient dynamics. Read More

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September 2021

Case Report: A Case of Leukocyte Adhesion Deficiency, Type III Presenting With Impaired Platelet Function, Lymphocytosis and Granulocytosis.

Front Pediatr 2021 16;9:713921. Epub 2021 Aug 16.

Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.

Fermitin family homolog 3 (FERMT3), alternatively kindlin-3 (KIND3), is an integrin binding protein (of 667 residues) encoded by the gene. The molecule is essential for activating integrin αβ (the fibrinogen receptor) on platelets and for the integrin-mediated hematopoietic cell (including platelets, T lymphocytes, B lymphocytes, and granulocytes) adhesion. Its defects are associated with impaired primary hemostasis, described as "Glanzmann's thrombasthenia (MIM#273800)-like bleeding problem. Read More

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Time to resolution of respiratory and systemic COVID-19 symptoms in community setting.

Clin Microbiol Infect 2021 Sep 2. Epub 2021 Sep 2.

Covidom regional telemedicine platform, Assistance Publique-Hôpitaux de Paris, Paris, France; Cardiology department, University Hospital of Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin Bicêtre, France.

Objectives: During the Coronavirus disease 2019 (COVID-19), symptom course among outpatients is not well known. Our aim was to assess the time to resolution of respiratory and systemic symptoms and their associated factors.

Methods: Cohort study including adult outpatients, managed with Covidom, a telesurveillance solution, with RT-PCR confirmed diagnosis, from March 9 2020 until February 23 2021. Read More

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September 2021

Characterization of CD66b and its relationship between immune checkpoints and their synergistic impact in the prognosis of surgically resected lung adenocarcinoma.

Lung Cancer 2021 Aug 28;160:84-91. Epub 2021 Aug 28.

Department of Thoracic and Cardiac Surgery, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. Electronic address:

Objectives: CD66b positive tumor-infiltrating neutrophils (TINs) are key immunity cells in the tumor microenvironment (TME). However, their relationship with clinicopathological features, immune checkpoints (ICs), and prognostic value remains undetermined in lung adenocarcinoma (LUAD). In this study, we aimed to characterize the infiltration by TINs and the prognostic significance in patients with surgically resected LUAD. Read More

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The complete chloroplast genome sequence of (Plantaginaceae).

Mitochondrial DNA B Resour 2021 30;6(9):2777-2778. Epub 2021 Aug 30.

Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, China.

L. is an annual aquatic or marsh plant, wide spread in temperate regions throughout the world. In present study, we sequenced, assembled and annotated the complete chloroplast (cp) genome of . Read More

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Does Prolonged Use of N95 Masks Affect Nasal Mucociliary Clearance? A Single Group Pre-Post Study.

Ann Otol Rhinol Laryngol 2021 Aug 28:34894211041821. Epub 2021 Aug 28.

Department of Otorhinolaryngology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Objective: It has been shown that prolonged use of face masks results in physiological changes in the nasal cavity. The objective of this study was to examine the effect of prolonged use of face masks on nasal mucociliary clearance (NMC).

Methods: A single group pre-post study was conducted to determine the effects of prolonged use of N95 face mask (≥4 hours) on the NMC rates in health care workers. Read More

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Eye injuries from fireworks used during celebrations and associated vision loss: the international globe and adnexal trauma epidemiology study (IGATES).

Graefes Arch Clin Exp Ophthalmol 2021 Aug 28. Epub 2021 Aug 28.

National Healthcare Group Eye Institute at Tan Tock Seng Hospital, Singapore, 308433, Singapore.

Purpose: To report on the factors associated with severe vision loss from fireworks-related ocular trauma during celebrations, including festivals.

Methods: Tertiary eye care hospitals in 5 countries and private ophthalmology practices in the Netherlands. Patients included received treatment for fireworks-related ocular trauma during celebrations. Read More

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Risk of pre-eclampsia after gastric bypass: a matched cohort study.

BJOG 2021 Aug 27. Epub 2021 Aug 27.

Department of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.

Objective: To investigate whether gastric bypass before pregnancy is associated with reduced risk of pre-eclampsia.

Design: Nationwide matched cohort study.

Setting: Swedish national health care. Read More

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Evaluation of Wild Flora Surrounding Blueberry Fields as Viable Hosts of (Matsumura, 1931) (Diptera: Drosophilidae) in Georgia.

Insects 2021 Jul 22;12(8). Epub 2021 Jul 22.

Department of Entomology, University of Georgia 413 Biological Sciences Building, Athens, GA 30602, USA.

, an economically important pest of small and thin-skinned fruits, has caused annual crop losses up to 20% in the state of Georgia's multimillion-dollar blueberry industry. The known host range of is large, yet the breadth of uncultivated and wild plants that can serve as alternative hosts in the southeastern United States is still not fully understood. Establishing comprehensive lists of non-crop hosts in woodlands near blueberry production will assist in the creation of more sustainable integrated pest management (IPM) strategies. Read More

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Predictive Role of Prior Radiotherapy and Immunotherapy-Related Adverse Effects in Advanced NSCLC Patients Receiving Anti-PD-1/L1 Therapy.

J Clin Med 2021 Aug 21;10(16). Epub 2021 Aug 21.

Asan Medical Center, Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea.

The present study evaluated the impact of prior radiotherapy (RT) on patients with advanced non-small cell lung cancer (NSCLC) receiving therapy with immune checkpoint inhibitors (ICIs) and further assessed the prognostic factors in patients receiving both RT and ICI. Patients diagnosed with NSCLC at the Catholic Medical Center and Asan Medical Center between January 2016 and October 2020 and who received immunotherapy were retrospectively reviewed. Among 240 patients, poor Eastern Cooperative Oncology Group (ECOG) score, high PD-L1 expression, and ICI-related adverse events (AE) were significantly associated with progression-free survival (PFS) (HR, 2. Read More

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Development and Validation of a Radiomics Nomogram for Differentiating Mycoplasma Pneumonia and Bacterial Pneumonia.

Diagnostics (Basel) 2021 Jul 24;11(8). Epub 2021 Jul 24.

Department of Radiology, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510000, China.

Objectives: To develop and validate a radiological nomogram combining radiological and clinical characteristics for differentiating mycoplasma pneumonia and bacterial pneumonia with similar CT findings.

Methods: A total of 100 cases of pneumonia patients receiving chest CT scan were retrospectively analyzed, including 60 patients with mycoplasma pneumonia and 40 patients with bacterial pneumonia. The patients were divided into the train set ( = 70) and the test set ( = 30). Read More

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: Pathogenicity and Resistance Mechanisms for Adaptation and Survival.

J Fungi (Basel) 2021 Aug 17;7(8). Epub 2021 Aug 17.

Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), Serdang 43400, Selangor, Malaysia.

is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated species associated with invasive candidiasis (IC) behind . The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. Read More

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Staging Chronic Hepatitis B Related Liver Fibrosis with a Fractional Order Calculus Diffusion Model.

Acad Radiol 2021 Aug 22. Epub 2021 Aug 22.

Central Research Institute, United Imaging Healthcare, Shanghai, China.

Rationale And Objectives: Accurately staging liver fibrosis is of great clinical significance. We aimed to evaluate the clinical potential of the non-Gaussian fractional order calculus (FROC) diffusion model in staging liver fibrosis.

Materials And Methods: A total of 82 patients with chronic hepatitis B (CHB) were included in this prospective study. Read More

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University professors' mental and physical well-being during the COVID-19 pandemic and distance teaching.

Work 2021 ;69(4):1153-1161

Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Jordan.

Background: Strict strategies including lockdowns and working from home were adopted worldwide during the coronavirus (COVID-19) pandemic. University professors suddenly shifted to work from home adopting distance teaching.

Objectives: This study aimed to investigate Health-Related Quality of Life (HRQoL) and its associated occupational and health factors during COVID-19 among university professors. Read More

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A prospective cohort study on the intersectionality of obesity, chronic disease, social factors, and incident risk of COVID-19 in US low-income minority middle-age mothers.

Int J Obes (Lond) 2021 Aug 19. Epub 2021 Aug 19.

Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.

Objective: Coronavirus disease 2019 (COVID-19) has disproportionally affected communities of color. We aimed to determine what factors are associated with COVID-19 testing and test positivity in an underrepresented, understudied, and underreported (U3) population of mothers.

Methods: This study included 2996 middle-aged mothers of the Boston Birth Cohort (a sample of predominantly urban, low-income, Black and Hispanic mothers) who were enrolled shortly after they gave birth and followed onward at the Boston Medical Center. Read More

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[Risk factors analysis for 1-year postoperative survival of patients with benign end-stage lung diseases after lung transplantation].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jul;33(7):832-837

Department of Thoracic Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Corresponding author: Chen Jingyu, Email:

Objective: To investigate the main postoperative complications, causes of death and the risk factors for survival in patient with benign end-stage lung diseases within 1 year after lung transplantation.

Methods: A retrospective analysis was conducted to collect the clinical data of 200 patients with benign end-stage lung disease who underwent lung transplantation admitted to Wuxi People's Hospital Affiliated to Nanjing Medical University from May 2017 to October 2018. The main postoperative complications, survival and causes of death within 1 year after operation were analyzed. Read More

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Reevaluating the Cardiac Risk of Noncardiac Surgery Using the National Surgical Quality Improvement Program.

Am J Med 2021 Aug 16. Epub 2021 Aug 16.

Penn State Heart and Vascular Institute, Penn State College of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.

Background: As surgical techniques evolve and patient outcomes improve over time, a renewed analysis of the cardiac risk of noncardiac surgeries is needed. The goal of this study was to investigate and categorize the cardiac risk of elective noncardiac surgeries.

Methods: This was a cohort study of surgical data and outcomes from the 2018 National Surgical Quality Improvement Program Participant Use Data File. Read More

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Quality Improvement for Outpatient COVID-19 Infection Control.

Cureus 2021 Jul 13;13(7):e16373. Epub 2021 Jul 13.

Family Medicine, Loma Linda University Medical Center, Loma Linda, USA.

Background To stop the spread of COVID-19 in outpatient primary care clinics, infection control strategies were needed including social distancing and masking in Fall 2020. Studies show a significant decrease in COVID-19 transmission when healthcare professionals comply with preventive measures. We tested whether an educational video would improve compliance to infection control behaviors quickly. Read More

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Time to Blood Culture Positivity by Pathogen and Primary Service.

Hosp Pediatr 2021 Sep;11(9):953-961

Department of Pediatric Infectious Diseases, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, Colorado.

Objectives: Initiation and continuation of empirical antimicrobial agents for a 48-72-hour observation period is routine practice in the diagnosis and treatment of infants and children with concern for bacteremia. We examined blood cultures at a freestanding pediatric hospital over a 6-year period to determine the time to positivity.

Methods: Data were extracted for all patients who were hospitalized and had blood cultures drawn between January 2013 and December 2018. Read More

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September 2021

[Clinical characteristics and risk factors of deaths in patients with Wiskott-Aldrich syndrome].

Zhonghua Er Ke Za Zhi 2021 Jul;59(7):576-581

Department of Rheumatology and Immunology, Children's Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Child Infection and Immunity,Chongqing 400014, China.

To explore the clinical characteristics and risk factors of pediatric patients with Wiskott-Aldrich syndrome (WAS). This was a case-control study. Clinical data of 165 cases of pediatric patients with WAS, who visited the Department of Rheumatology, Children's Hospital of Chongqing Medical University between January 2007 and August 2020 were retrospectively analyzed and divided into death group and survival group (control group) according to the prognosis in the follow-up. Read More

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Multisensory Exercise Improves Balance in People with Balance Disorders: A Systematic Review.

Curr Med Sci 2021 Aug 17;41(4):635-648. Epub 2021 Aug 17.

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: To examine the effect of multisensory exercise on balance disorders.

Methods: PubMed, Scopus and Web of Science were searched to identify eligible studies published before January 1, 2020. Eligible studies included randomized control trials (RCTs), non-randomized studies, case-control studies, and cohort studies. Read More

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Effects of Simultaneous Exposure to Smoking and Welding Fume on Pulmonary Function Tests in Spot Welders.

Tanaffos 2021 Jan;20(1):64-70

Center for Research on Occupational Diseases (CROD), Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Background: The respiratory effects of fume exposure during spot welding may aggravate some environmental risk factors such as tobacco smoking. Fume exposure and smoking have negative effects on pulmonary function tests (PFTs). This study assessed the simultaneous effects of smoking and welding fume on spirometry tests in spot welders. Read More

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January 2021

Synergistic inhibitory effects of the oxyresveratrol and dacarbazine combination against melanoma cells.

Oncol Lett 2021 Sep 14;22(3):667. Epub 2021 Jul 14.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea.

Various therapies have been developed to target malignant melanoma, which is associated with a high mortality rate worldwide. Although dacarbazine (DTIC) is employed for treating melanoma, it is associated with several side effects. Hence, patients with melanoma are co-treated with additional drugs to mitigate the side effects of DTIC. Read More

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September 2021

The success of non-invasive mechanical ventilation in lung cancer patients with respiratory failure.

Int J Clin Pract 2021 Aug 12:e14712. Epub 2021 Aug 12.

Atatürk Chest Diseases and Thoracic Surgery Education and Research Hospital, Ankara, Turkey.

Introduction And Aim: Despite the improvement in survival among patients with lung cancer as a result of the development of novel treatment options, acute respiratory failure (ARF), which may occur because of the disease itself, comorbidities or complications in treatment may be life threatening. The most commonly utilised treatment option in cancer patients with ARF is invasive mechanical ventilation (IMV). The prognosis of lung cancer patients admitted to the intensive care unit is poor. Read More

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