3,307 results match your criteria including 358


Analysis of vascular involvement in 460 patients with Behçet's syndrome: Clinical characteristics and associated factors.

Joint Bone Spine 2021 Sep 15:105277. Epub 2021 Sep 15.

Ankara University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey.

Objectives: To describe demographic and clinical characteristics of vascular involvement in patients with Behçet's syndrome (BS) and to evaluate associations with such involvement.

Methods: We retrospectively evaluated records of 2118 BS patients. In total, 460 patients diagnosed with superficial thrombophlebitis (ST) and/or major vascular events (venous and/or arterial involvements) were included in current analysis. Read More

View Article and Full-Text PDF
September 2021

Process evaluations of a web-based intervention to increase handwashing during a pandemic: Moving Germ Defence from a randomised controlled trial to public dissemination.

J Med Internet Res 2021 May 30. Epub 2021 May 30.

Center for Clinical and Community Applications of Health Psychology, Department of Psychology, University of Southampton, Building 44 Highfield Campus, Southampton, GB.

Background: Washing hands helps prevent transmission of seasonal and pandemic respiratory viruses. The PRIMIT study developed a fully automated, digital intervention to promote handwashing. In a randomised controlled trial during the Swine Flu outbreak, participants who had access to the intervention reported washing their hands more and experienced less respiratory tract infections than those without access. Read More

View Article and Full-Text PDF

MicroRNAs are potential regulators of the timed artificial insemination effect in gilt endometrium.

Anim Reprod Sci 2021 Sep 3;233:106837. Epub 2021 Sep 3.

Ningbo Sansheng Biotechnology Co., Ltd,Ningbo 315100, China. Electronic address:

To determine effects of timed artificial insemination (TAI) hormonal treatments on reproductive performance of gilts/sows and explore molecular mechanisms, gilts (TAI: 90; Control:149; Total: 239) and sows (TAI: 370; Control: 492) were utilized. Results indicated the estrus/farrowing rate and number of piglets born alive and weaned in the TAI group were greater than in the control group for both gilts and sows. To explore the molecular mechanism for TAI hormonal effects, the small RNA of the gilt endometrium at 16 and 25 of gestation were sampled and sequenced to determine potential functions of microRNA (MiRNA); 358 known and 142 novel MiRNAs were detected. Read More

View Article and Full-Text PDF
September 2021

An Examination of Risk Factors for Tobacco and Cannabis Smoke Exposure in Adolescents Using an Epigenetic Biomarker.

Front Psychiatry 2021 24;12:688384. Epub 2021 Aug 24.

Department of Psychiatry, University of Iowa, Iowa City, IA, United States.

Evolving patterns of nicotine and cannabis use by adolescents require new tools to understand the changing epidemiology of these substances. Here we describe the use of a novel epigenetic biomarker sensitive to both tobacco and cannabis smoke in a longitudinal sample of high-risk adolescents. We examine risk factors for positivity for this epigenetic biomarker in comparison to positivity for conventional serum biomarkers of nicotine and cannabis use. Read More

View Article and Full-Text PDF

Lead (Pb) concentrations and speciation in residential soils from an urban community impacted by multiple legacy sources.

J Hazard Mater 2021 08 15;416:125886. Epub 2021 Apr 15.

Department of Earth and Environmental Sciences, Columbia University, New York, NY, USA; Lamont-Doherty Earth Observatory, Columbia University, Palisades, New York, USA. Electronic address:

In many urban areas, elevated soil lead (Pb) concentrations are indicators of community-level Pb exposure. Here, we examine the spatial distribution and speciation of legacy soil Pb contamination in East Chicago, Ind., an industrial center with a wide range of Pb sources including a former lead smelter. Read More

View Article and Full-Text PDF

Transversus abdominis release (TAR) for ventral hernia repair: open or robotic? Short-term outcomes from a systematic review with meta-analysis.

Hernia 2021 Sep 7. Epub 2021 Sep 7.

Department of General and Specialistic Surgeries, Federico II University Hospital, Naples, Italy.

Purpose: To compare early postoperative outcomes after transversus abdominis release (TAR) for ventral hernia repair with open (oTAR) and robotic (rTAR) approach.

Methods: A systematic search of PubMed/MEDLINE, EMBASE, SCOPUS and Web of Science databases was conducted to identify comparative studies until October 2020. A meta-analysis of postoperative short-term outcomes was performed including complications rate, operative time, length of stay, surgical site infection (SSI), surgical site occurrence (SSO), SSO requiring intervention (SSOPI), systemic complications, readmission, and reoperation rates as measure outcomes. Read More

View Article and Full-Text PDF
September 2021

The profound heterogeneity of substance use disorders: Implications for treatment development.

Curr Dir Psychol Sci 2021 Aug 16;30(4):358-364. Epub 2021 Jul 16.

Yale University School of Medicine.

A single treatment approach will never be sufficient to address the diversity of individuals with substance use disorders (SUDs). SUDs have historically defied definition through simple characterizations or models, and no single characterization has led to the development of broadly effective interventions. The range of dimensions of heterogeneity among individuals with SUDs, including severity, type of substance, and issues that frequently co-occur underscore that highly tailored approaches are needed. Read More

View Article and Full-Text PDF

Development of novel univariate and multivariate validated chemometric methods for the analysis of dasatinib, sorafenib, and vandetanib in pure form, dosage forms and biological fluids.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Aug 28;264:120336. Epub 2021 Aug 28.

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

New precise, responsive and selective univariate and multivariate chemometric spectrophotometric methods were developed and validated for determination of vandetanib (VTB), dasatinib (DTB), and sorafenib (SFB) in pure form, tablets, spiked human (plasma and urine). Determination of these drugs is essential because of their therapeutic benefits. These methods included double divisor ratio spectra derivative univariate method and chemometric multivariate method including partial least-squares (PLS) and principal component regression (PCR). Read More

View Article and Full-Text PDF

Nutrition Status and Renal Function as Predictors in Acute Myocardial Infarction with and without Cancer: A Single Center Retrospective Study.

Nutrients 2021 Jul 30;13(8). Epub 2021 Jul 30.

Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine, Kurume 830-0011, Japan.

Clinical characteristics of nutrition status in acute myocardial infarction (AMI) patients with cancer remains unknown. Therefore, this study aimed to clarify the differences of clinical parameters, including nutrition status, between AMI patients with and without history of cancer. This retrospective cohort study, using the database of AMI between 2014 and 2019 in Kurume University Hospital, enrolled 411 patients; AMI patients without cancer ( = 358, 87. Read More

View Article and Full-Text PDF

Diagnostic performance of an algorithm for automated large vessel occlusion detection on CT angiography.

J Neurointerv Surg 2021 Aug 19. Epub 2021 Aug 19.

Radiology & Nuclear Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Background: Machine learning algorithms hold the potential to contribute to fast and accurate detection of large vessel occlusion (LVO) in patients with suspected acute ischemic stroke. We assessed the diagnostic performance of an automated LVO detection algorithm on CT angiography (CTA).

Methods: Data from the MR CLEAN Registry and PRESTO were used including patients with and without LVO. Read More

View Article and Full-Text PDF

Evidence of changing sexual behaviours and clinical attendance patterns, alongside increasing diagnoses of STIs in MSM and TPSM.

Sex Transm Infect 2021 Aug 19. Epub 2021 Aug 19.

Department of Population Health Sciences, University of Bristol, Bristol, UK.

Background: Due to rising numbers of STI diagnosis and increasing prevalence of antimicrobial resistance, we explored trends in STI testing frequency and diagnoses, alongside sexual decision making and attitudes concerning condom use and HIV pre-exposure prophylaxis (PrEP) at a large urban UK sexual health clinic.

Methods: We examined 66 528 electronic patient records covering 40 321 attendees between 2016 and 2019, 3977 of whom were men who have sex with men or trans persons who have sex with men (MSM/TPSM). We also explored responses from MSM/TPSM attendees sent an electronic questionnaire between November 2018 and 2019 (n=1975) examining behaviours/attitudes towards PrEP. Read More

View Article and Full-Text PDF

Perceptions of a short animated film on adverse childhood experiences: a mixed methods evaluation.

BMJ Open 2021 08 17;11(8):e050398. Epub 2021 Aug 17.

Public Health Collaborating Unit, School of Health Sciences, College of Human Sciences, Bangor University, Wrexham, UK.

Objectives: An evaluation of a short animated film on adverse childhood experiences (ACEs) to explore attitudes and sentiment towards the film including, for a subsample of professionals, associations between attitudes and personal experience of ACEs.

Design: Mixed-method exploratory design.

Setting: Professionals and the general public. Read More

View Article and Full-Text PDF

Insight into the roles of the ER-associated degradation E3 ubiquitin ligase HRD1 in plant cuticular lipid biosynthesis.

Plant Physiol Biochem 2021 Aug 12;167:358-365. Epub 2021 Aug 12.

State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address:

Cuticular lipids consisting of cutin and wax coat aerial plant surfaces providing protection against biotic and abiotic stresses. Although much progress has been made on comprehending the regulation of plant cuticular lipid biosynthesis, their functional relevance in plant protection merits further investigation of potential regulators of their synthesis. HRD1 and DOA10 mediate two major Endoplasmic Reticulum-Associated Degradation (ERAD) pathways in yeast and also regulate common pathways during lipid metabolism. Read More

View Article and Full-Text PDF

Initial outcomes of couple HOPES: A guided online couple intervention for PTSD and relationship enhancement.

Internet Interv 2021 Sep 24;25:100423. Epub 2021 Jun 24.

Department of Psychology, Ryerson University, 350 Victoria St., Toronto, ON M5B 2K3, Canada.

Couple HOPES (Helping Overcome PTSD and Enhance Satisfaction) is a guided, online couple intervention adapted from Cognitive-Behavioral Conjoint Therapy for posttraumatic stress disorder (PTSD). It was created to overcome a range of barriers to accessing evidence-based treatments for PTSD and the intimate relationship problems associated with it. This manuscript describes initial outcomes of the intervention in a series of 10 couples. Read More

View Article and Full-Text PDF
September 2021

Lipid nanoparticles for mRNA delivery.

Nat Rev Mater 2021 Aug 10:1-17. Epub 2021 Aug 10.

Division of Pharmaceutics & Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH USA.

Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow cellular uptake and mRNA release. Lipid nanoparticles have successfully entered the clinic for the delivery of mRNA; in particular, lipid nanoparticle-mRNA vaccines are now in clinical use against coronavirus disease 2019 (COVID-19), which marks a milestone for mRNA therapeutics. Read More

View Article and Full-Text PDF

Neurology podcast utilization during the COVID-19 pandemic.

Neurol Sci 2021 Aug 12. Epub 2021 Aug 12.

Division of Emergency Medicine and Division of Education & Innovation, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Background: As medical education shifted to a virtual environment during the early coronavirus disease 2019 (COVID-19) pandemic, we evaluated how neurology podcasting may have been utilized during this period, and which features of podcasts have been more highly sought by a medical audience.

Methods: We conducted a retrospective analysis of neurology-themed blogs and/or podcasts between April 2019 and May 2020. Programs were eligible if they reported mean monthly downloads > 2000, were affiliated with an academic society, or offered continuing medical education credit. Read More

View Article and Full-Text PDF

Economic burden and health related quality of life of ultra-rare Gaucher disease in China.

Orphanet J Rare Dis 2021 Aug 11;16(1):358. Epub 2021 Aug 11.

Department of Health Policy, Health Management College, Harbin Medical University, No. 157, Baojian 21 Road, Nangang District, Harbin, 150081, Heilongjiang Province, China.

Background: The diagnosis and health care of patients with rare diseases present a tremendous challenge worldwide. This study described the health care service utilization through participants' perspective and estimated the cost of illness (COI), and patients with Gaucher disease (GD)'s/caregivers' health-related quality of life in China.

Method: An online retrospective survey of patients with GD and their caregivers was conducted during May-June 2018. Read More

View Article and Full-Text PDF

The determinant of health insurance ownership among pregnant women in Indonesia.

BMC Public Health 2021 08 11;21(1):1538. Epub 2021 Aug 11.

Faculty of Public Health, Ahmad Dahlan University, Jogjakarta, Indonesia.

Background: Health insurance ownership is one indicator of the readiness of pregnant women for the delivery process. The study aimed to analyze the determinants of health insurance ownership among pregnant women in Indonesia.

Methods: The study population was pregnant women in Indonesia. Read More

View Article and Full-Text PDF

Prognostic nomogram predicting survival of patients with unresectable hepatocellular carcinoma after hepatic arterial infusion chemotherapy.

Eur J Radiol 2021 Sep 4;142:109890. Epub 2021 Aug 4.

Department of Liver Surgery of the Sun Yat-sen University Cancer Center, China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China. Electronic address:

Background And Aim: Hepatic arterial infusion chemotherapy (HAIC) has shown encouraging efficacy in the treatment of hepatocellular carcinoma (HCC). This study aims to establish and validate a novel nomogram to predict individualized survival outcomes for patients with unresectable HCC after HAIC.

Methods: Between January 2016 and December 2018, 463 patients diagnosed with HCC who initially received HAIC were included in this study (training cohort: n = 308; validation cohort: n = 153). Read More

View Article and Full-Text PDF
September 2021

Development of a PCR assay for the effective detection of Enterocytozoon hepatopenaei (EHP) and investigation of EHP prevalence in Shandong Province, China.

J Invertebr Pathol 2021 Sep 8;184:107653. Epub 2021 Aug 8.

School of Agriculture, Ludong University, Yantai, PR China. Electronic address:

Enterocytozoon hepatopenaei (EHP), a recently reported pathogen in the penaeid shrimp, is spreading widely and seriously threatening Penaeus (Litopenaeus) vannamei aquaculture. This study aimed to develop a new and more sensitive polymerase chain reaction (PCR) method for the effective detection of EHP. An EHP PCR assay with a pair of primers specifically amplifying a 358 bp EHP DNA fragment was developed, which was demonstrated to be capable of detecting as low as 2 × 10 copies of EHP and is specific for EHP without cross reaction with DNA samples prepared from five common shrimp pathogens, including white spot syndrome virus (WSSV), infectious hypodermal and haematopoietic virus (IHHNV), hepatopancreatic parvovirus (HPV), infectious myonecrosis virus (IMNV), and yellow head virus (YHV). Read More

View Article and Full-Text PDF
September 2021

Clinical Features and Long-Term Outcomes After Laparoscopic Surgery in Patients Co-existing With Endometriosis and Adenomyosis.

Front Med (Lausanne) 2021 22;8:696374. Epub 2021 Jul 22.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Beijing, China.

To investigate the difference of clinical features and outcomes between EM patients with and without AM after following up for at least 6 years after surgery. We retrospectively analyzed 358 EM patients who had a minimum of 6 years follow-up after laparoscopic cystectomy, which was performed by one single doctor at Peking Union Medical College Hospital from January 2009 to April 2013. All women were divided into AM group and non-AM group and analysis was performed in preoperative characteristics, surgical findings and postoperative outcomes during follow-up. Read More

View Article and Full-Text PDF

A squalene-hopene cyclase in represents a eukaryotic adaptation to sterol-limited anaerobic environments.

Proc Natl Acad Sci U S A 2021 Aug;118(32)

Department of Biotechnology, Delft University of Technology, 2629 HZ Delft, The Netherlands;

Biosynthesis of sterols, which are key constituents of canonical eukaryotic membranes, requires molecular oxygen. Anaerobic protists and deep-branching anaerobic fungi are the only eukaryotes in which a mechanism for sterol-independent growth has been elucidated. In these organisms, tetrahymanol, formed through oxygen-independent cyclization of squalene by a squalene-tetrahymanol cyclase, acts as a sterol surrogate. Read More

View Article and Full-Text PDF

Catestatin in innate immunity and Cateslytin-derived peptides against superbugs.

Sci Rep 2021 Aug 2;11(1):15615. Epub 2021 Aug 2.

BioMaterials and BioEngeneering, Institut National de la Santé et de la Recherche Médicale UMR_S 1121, Federation of Translational Medicine Faculty, of Odontology, University of Strasbourg, Hôpital Civil, Porte de L'Hôpital, 67000, Strasbourg, France.

Chromogranin A (CgA) is the precursor of several antimicrobial peptides, such as Catestatin (Cts, bovine CgA344-364), initially described as a potent inhibitor of catecholamines. This peptide displays direct antimicrobial activities and contributes to immune system regulation. The aim of the present study is to investigate a designed peptide based on Cts to fight infections against superbugs and more particularly Staphylococcus aureus. Read More

View Article and Full-Text PDF

Comprehensive Breast Cancer Risk Assessment for and Pathogenic Variant Carriers Incorporating a Polygenic Risk Score and the Tyrer-Cuzick Model.

JCO Precis Oncol 2021 Jun 24;5. Epub 2021 Jun 24.

Memorial Sloan Kettering Cancer Center, New York City, NY.

Purpose: Breast cancer risks for and pathogenic variant (PV) carriers are modified by an 86-single nucleotide polymorphism polygenic risk score (PRS) and individual clinical factors. Here, we describe comprehensive risk prediction models for women of European ancestry combining PV status, PRS, and individual clinical variables.

Materials And Methods: This study included deidentified clinical records from 358,095 women of European ancestry who received testing with a multigene panel (September 2013 to November 2019). Read More

View Article and Full-Text PDF

Clinical outcomes of drug-coated balloon in coronary lesions: a real-world, all-comers study.

Clin Res Cardiol 2021 Jul 27. Epub 2021 Jul 27.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, Henan, China.

Backgrounds: Although drug-eluting stents are the most common interventional devices for patients with coronary disease, drug-coated balloons (DCBs) represent a novel therapeutic alternative in certain scenarios. This prospective, observational all-comers study explored the clinical outcomes of DCB use in patients with coronary lesions.

Methods And Results: All patients treated with DCBs were enrolled in this study, including patients with in-stent restenosis (ISR) or de novo lesions. Read More

View Article and Full-Text PDF

Is Delinquency Associated With Subsequent Victimization by Community Violence in Adolescents? A Test of the Risky Behavior Model in a Primarily African American Sample.

Psychol Violence 2021 May 22;11(3):234-243. Epub 2020 Oct 22.

Department of Psychology, Virginia Commonwealth University.

Objective: Victimization is common in adolescence and is associated with negative outcomes, including school failure, and poor emotional, behavioral, and physical health. A deeper understanding of the risk of victimization can inform prevention and intervention efforts. This study tests the risky behavior model in adolescents, examining prospective associations between mean levels of and changes in delinquency and risk for victimization over four annual data collections. Read More

View Article and Full-Text PDF

Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms.

J Neuroimmunol 2021 09 10;358:577658. Epub 2021 Jul 10.

Functional Pharmacology Unit, Department of Neuroscience, Uppsala University, Uppsala, Sweden; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia. Electronic address:

Several neurological symptoms and complications have been described in association with COVID-19, such as anosmia, ageusia, encephalitis and Guillain-Barré syndrome. Here, we review the literature describing SARS-CoV-2-induced neurological manifestations and provide a comprehensive discussion of proposed mechanisms underlying the neurological pathophysiology. First, we analyse the neuroinvasiveness potential of the coronavirus family based on previous SARS-CoV-1 studies. Read More

View Article and Full-Text PDF
September 2021

Valorisation of biomass and diaper waste into a sustainable production of the medical mushroom Lingzhi Ganoderma lucidum.

Chemosphere 2021 Jul 10;286(Pt 1):131477. Epub 2021 Jul 10.

Henan Province International Collaboration Lab of Forest Resources Utilization, School of Forestry, Henan Agricultural University, Zhengzhou, 450002, China; Department of Bioscience, Aarhus University, Arctic Research Center (ARC), Frederiksborgvej 399, PO box 358, DK- 4000, Roskilde, Denmark. Electronic address:

Global solid waste is expected to increase by at least 70% annually until year 2050. The mixture of solid waste including food waste from food industry and domestic diaper waste in landfills is causing environmental and human health issues. Nevertheless, food and diaper waste containing high lignocellulose can easily degrade using lignocellulolytic enzymes thereby converted into energy for the development and growth of mushroom. Read More

View Article and Full-Text PDF

Relationship between Prognostic Stage in Breast Cancer and Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

J Clin Med 2021 Jul 19;10(14). Epub 2021 Jul 19.

Department of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.

This retrospective study examined the relationship between the standardized uptake value max (SUVmax) of fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) and the prognostic stage of breast cancer. We examined 358 breast cancers in 334 patients who underwent F-FDG PET/CT for initial staging between January 2016 and December 2019. We extracted data including SUVmax of F-FDG PET and pathological biomarkers, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and nuclear grade. Read More

View Article and Full-Text PDF