2,438,819 results match your criteria includedresults total


Cochlear Implant Failure in the Pediatric Population.

J Audiol Otol 2021 Sep 23. Epub 2021 Sep 23.

Department of Otorhinolaryngology, Head and Neck Surgery, Baskent University Faculty of Medicine, Ankara, Turkey.

Background And Objectives: In cochlear implant (CI) surgery, the results and causes of revision and reimplantation may guide surgeons in establishing surgical protocols for revision surgery with safe audiological outcomes. The aim of this study was to review our experience in terms of etiology, surgical strategy, and hearing outcomes in pediatric patients who underwent CI removal and reimplantation.

Subjects And Methods: All patients received implants of the same brand. Read More

View Article and Full-Text PDF
September 2021

Screening for hypophosphatasia: does biochemistry lead the way?

J Pediatr Endocrinol Metab 2021 Sep 22. Epub 2021 Sep 22.

Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Centre, University of Freiburg, Freiburg, Germany.

Objectives: Patients with childhood hypophosphatasia (HPP) often have unspecific symptoms. It was our aim to identify patients with mild forms of HPP by laboratory data screening for decreased alkaline phosphatase (AP) within a pediatric population.

Methods: We conducted a retrospective hospital-based data screening for AP activity below the following limits: Girls: ≤12 years: <125 U/L; >12 years: <50 U/L Boys: ≤14 years: <125 U/L; >14 years: <70 U/L. Read More

View Article and Full-Text PDF
September 2021

Effects of Light and Water Disturbance on the Growth of Microcystis aeruginosa and the Release of Algal Toxins.

Water Environ Res 2021 Sep 22. Epub 2021 Sep 22.

Beijing Yizhuang Water Company, Beijing, China.

Eutrophication of water constitutes a serious threat to global water quality. Light intensity and water disturbance are important factors affecting the growth of algae and the release of algal toxins. In this study, algal growth indicators, algal enzyme systems and algal toxin release in Microcystis aeruginosa under different light intensities and water disturbances were determined. Read More

View Article and Full-Text PDF
September 2021

Clinical features and related factors of freezing of gait in patients with Parkinson's disease.

Brain Behav 2021 Sep 22:e2359. Epub 2021 Sep 22.

Department of Neurology, General Hospital of Ningxia Medical University, Ningxia Key Laboratory of Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, China.

Background: Freezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients' quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge. The purpose of this study was to explore the clinical characteristics and related factors of FOG in patients with Parkinson's disease (PD). Read More

View Article and Full-Text PDF
September 2021

Calcification of the Aorta-Iliac Trajectory as a Risk Factor for Anastomotic Leakage in Colorectal Surgery: Individual Patient Data Meta-Analysis and Systematic Review.

Surg Technol Int 2021 Sep 20;39. Epub 2021 Sep 20.

Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.

Objective: The purpose of this review is to evaluate the relevance of vascular calcification as a potential risk factor for anastomotic leakage in colorectal surgery.

Method: The Embase, Medline, PubMed, and Cochrane databases and Google Scholar were systematically searched. Studies that assessed calcification of the aorta-iliac trajectory in patients who underwent colorectal surgery were included. Read More

View Article and Full-Text PDF
September 2021

Long-Term Outcomes in Patients with Post-Bulbar Ulcer Bleeding Compared to Bulbar Ulcer Bleeding in the Duodenum.

Digestion 2021 Sep 22:1-7. Epub 2021 Sep 22.

Division of Gastroenterology, Department of Medicine, Jichi Medical University, Shimotsuke, Japan.

Background: Duodenal ulcers are classified into bulbar and post-bulbar ulcers. The aim of this study is to compare the long-term outcomes of patients with post-bulbar ulcer bleeding and those with bulbar ulcer bleeding.

Methods: A total of 272 patients with hemorrhagic duodenal ulcers requiring hospitalization were included. Read More

View Article and Full-Text PDF
September 2021

Epidemiological and Treatment Trends for Acute Ischemic Stroke Preceding and during the COVID-19 Pandemic.

Cerebrovasc Dis 2021 Sep 22:1-4. Epub 2021 Sep 22.

Department of Neurosurgery, Stanford School of Medicine, Stanford, California, USA.

Background: The coronavirus disease 2019 (COVID-19) pandemic heralded a number of indirect perturbations to patient behavior and disease epidemiology, and mounting evidence suggests that the COVID-19 pandemic may have exacerbated underlying health disparities along racial and socioeconomic (SES) groups for acute ischemic stroke (AIS). We used 1 large national insurance database to identify whether patient demographics, disease severity, or mechanical thrombectomy (MT) rates changed for the treatment and management of AIS during COVID-19.

Methods: AIS patient records were queried from the Clinformatics® Data Mart Optum SES Database from the following 2 time periods: March 1, 2019-June 30, 2019 (pre-COVID-19), and March 1, 2020-June 30, 2020 (COVID-19). Read More

View Article and Full-Text PDF
September 2021

Microablative Erbium: YAG Laser Therapy for Vulvodynia - A Report on Efficacy, Safety, and Treatment Satisfaction.

Sex Med 2021 Sep 19;9(6):100432. Epub 2021 Sep 19.

Department of Obstetrics and Gynecology, Medical University of Graz, Austria.

Introduction: Treatment for vulvodynia is challenging and a multidisciplinary approach is recommended.

Aim: To examine the effectiveness, safety and treatment satisfaction of vulvovaginal microablative laser treatment for vulvodynia.

Methods: Case study of women who received laser treatment as part of a multidisciplinary treatment program for vulvodynia. Read More

View Article and Full-Text PDF
September 2021

Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE).

Cancer Genet 2021 Aug 28;258-259:61-68. Epub 2021 Aug 28.

University of California at San Francisco, San Francisco, CA, USA; Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA. Electronic address:

Background: High tumor mutation burden (TMB) and total mutation count (TMC) can be predictive of better response to immune checkpoint blockade (ICB). Nevertheless, TMB and TMC are limited by variation across cancers and inconsistent definitions due to different profiling methods (targeted vs whole genome sequencing). Our objective was to identify genomic alterations (GAs) associated with ICB response and builds a novel genomic signature predictive of ICB response, independent of TMB/TMC. Read More

View Article and Full-Text PDF

Effects of low-crude protein diets supplemented with arginine, glutamine, threonine, and methionine on regulating nutrient absorption, intestinal health, and growth performance of Eimeria-infected chickens.

Poult Sci 2021 Aug 13;100(11):101427. Epub 2021 Aug 13.

Department of Poultry Science, University of Georgia, Athens, GA, USA. Electronic address:

The study was conducted to evaluate the effects of low crude protein diets supplemented with arginine, glutamine, methionine, and/or threonine on apparent ileal digestibility of amino acids, intestinal morphology, intestinal permeability, gene expression of nutrient transporters, and tight junction proteins of broiler chickens challenged with mixed Eimeria spp. A total of five hundred seventy-six, 12-day-old male broiler chickens were allocated into 8 treatments, and 6 replicate cages of 12 chickens per cage. This experiment included a nonchallenged control (NC) fed regular corn-soybean meal-based diet (Regular diet, 19% crude protein), an Eimeria-challenged control (CC) fed Regular diet, an Eimeria challenge group fed low-crude protein diet (LCP, 16% crude protein), 4 Eimeria challenge groups fed low-crude protein diet supplemented with 0. Read More

View Article and Full-Text PDF

Predictors and prognoses of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis.

Seizure 2021 Sep 14;92:189-194. Epub 2021 Sep 14.

Department of Neurology, The Nanjing Brain Hospital Affiliated Nanjing Medical University, 210029 Nanjing, China. Electronic address:

Purpose: This study aimed to investigate the incidence and predictors of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis (AIE). The clinical outcomes of patients with epilepsy after AIE were also explored.

Methods: A total of 111 AIE patients were retrospectively evaluated. Read More

View Article and Full-Text PDF
September 2021

Subvisible Particle Analysis of 17 Monoclonal Antibodies Approved in China Using Flow Imaging and Light Obscuration.

J Pharm Sci 2021 Sep 19. Epub 2021 Sep 19.

Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 31, Huatuo Road, Daxing District, Beijing, 102629, China. Electronic address:

In the study, subvisible particles in 205 samples from 17 commercial mAb drug products approved in China were analyzed using light obscuration (LO) and flow imaging microscopy (FIM) methods. For each method, a total 633 tests (runs) were performed. In the tests, samples in state of lyophilized powder or syringe package had significantly higher particle concentrations. Read More

View Article and Full-Text PDF
September 2021

Cigarette Smoke and Nicotine Effects on Behavior in HIV Transgenic Rats.

Behav Brain Res 2021 Sep 19:113591. Epub 2021 Sep 19.

University of Maryland School Institute of Human Virology; University of Maryland School of Medicine.

HIV-related neurocognitive impairment can be worsened by cigarette smoking and be more severe in women. Therefore, we analyzed the effects of sex on behavioral function in HIV transgenic (Tg) rats that were exposed to either nicotine alone, to smoke from either nicotine-containing or nicotine-free cigarettes, or non-exposed. The animals were then assessed on the open field test for the total distance traveled and for the fraction of the total distance traveled and the total time spent in the center of the field, and the results then compared to WT rats subjected to the same exposures and testing. Read More

View Article and Full-Text PDF
September 2021

A clinical description of chronic pain in a general population using ICD-10 and ICD-11 (The HUNT pain examination study).

J Pain 2021 Sep 19. Epub 2021 Sep 19.

Department of Oncology, Oslo University Hospital, Oslo, Norway; European Palliative Care Research Centre, Department of Oncology, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

The purpose was to present a total description, distribution, and ranking of chronic pain conditions in the general population. This was based on structured clinical examinations of a random sample from a population-based survey (HUNT3) with a calculated oversampling of participants with chronic pain. Supplemented with access to hospital reports, the examination was performed by experienced physicians and psychologists using a consistent definition of chronic pain as well as ICD-10- and the new ICD-11-classification. Read More

View Article and Full-Text PDF
September 2021

Hypomethylating agents and FLT3 inhibitors as maintenance treatment for acute myeloid leukemia and myelodysplastic syndrome following allogeneic hematopoietic stem cell transplant - a systematic review and meta-analysis.

Transplant Cell Ther 2021 Sep 19. Epub 2021 Sep 19.

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medical Oncology, Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA.

Background: Disease relapse remains the major cause of death among patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who receive an allogeneic hematopoietic cell transplant (allo-HCT). Maintenance treatment with FLT3 inhibitors and hypomethylating agents (HMA) has been studied in various clinical trials with mixed results.

Objective: To synthesize the current evidence on the efficacy and safety of FLT3 inhibitors and HMA for maintenance therapy following allo-HCT in AML and MDS. Read More

View Article and Full-Text PDF
September 2021

SMAR1 Suppresses the Cancer Stem Cell Population via hTERT Repression in Colorectal Cancer Cells.

Int J Biochem Cell Biol 2021 Sep 19:106085. Epub 2021 Sep 19.

National Centre for Cell Science, Pune, India; Birla Institute of Technology and Science, Goa, India. Electronic address:

One of the hallmarks of a cancer cell is the ability for indefinite proliferation leading to the immortalization of the cell. Activation of several signaling pathways leads to the immortalization of cancer cells via the reactivation of enzyme telomerase (hTERT). hTERT is active in germ cells, stem cells and also cancer cells. Read More

View Article and Full-Text PDF
September 2021

20% ALA-PDT pre-treated by fire needle in patients with dissecting cellulitis of the scalp: an interim analysis.

Photodiagnosis Photodyn Ther 2021 Sep 19:102544. Epub 2021 Sep 19.

Department of Dermatology, First Medical Center of Chinese PLA General Hospital, Beijing, 100853, China. Electronic address:

Background: Dissecting cellulitis of the scalp (DCS) is a rare but distinctive, chronic suppurative condition, and the treatment is a real therapeutic challenge. Recently, treatment of DCS with 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has been considered as a useful alternative treatment.

Objective: To evaluate the efficacy and safety of 20% ALA-PDT pre-treated by fire needle in the treatment of DCS. Read More

View Article and Full-Text PDF
September 2021

Satisfaction of the Use of Telehealth and Access to Care for Veterans During the COVID-19 Pandemic.

Telemed J E Health 2021 Sep 22. Epub 2021 Sep 22.

Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, California, USA.

While many health care providers have shifted toward telehealth services in response to the COVID-19 pandemic, little is known about the perception and acceptance of such services, particularly among vulnerable populations. Veterans, who are at increased risk of physical and mental health needs, may benefit from the use and availability of telehealth services. Cross sectional survey data related to telehealth use, satisfaction, and access were collected through an online survey. Read More

View Article and Full-Text PDF
September 2021

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.

N Engl J Med 2021 Sep;385(13):1196-1206

From Mount Vernon Cancer Centre, Northwood (P.N.), the Clatterbridge Cancer Centre NHS Foundation Trust, Wirral (J.J.S.), the University of Liverpool, Liverpool (J.J.S.), and Immunocore, Abingdon (S.E.A., C.H., H.G.) - all in the United Kingdom; the Department of Dermatology and the National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg (J.C.H.), the Department of Dermatology and Allergy, University Hospital, Ludwig Maximilian University of Munich, Munich (M.S.), the Department of Hematology and Oncology, Charité-Comprehensive Cancer Center (S.O.), Berlin, and the Department of Dermatology and the Center for Integrated Oncology, University Hospital Cologne, Cologne (C.M.) - all in Germany; Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland (P.R.); Institut Roi Albert II des Cliniques Universitaires Saint-Luc and Université Catholique de Louvain, Brussels (J.-F.B.); Princess Margaret Cancer Centre, Toronto (M.O.B.); Massachusetts General Hospital Cancer Center, Boston (R.J.S.); the Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland (R.D.); Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh (J.M.K.); Sidney Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia (M.O.); Kinghorn Cancer Centre, Saint Vincent's Hospital, Darlinghurst, NSW, Australia (A.M.J.); Memorial Sloan Kettering Cancer Center (A.N.S.) and Irving Medical Center, Columbia University (R.D.C.) - both in New York; Institut d'Investigació Biomèdica de Bellvitge-Centro de Investigación Biomédica en Red de Oncología, Institut Català d'Oncologia, Barcelona (J.M.P.); University of Iowa Hospitals and Clinics, Iowa City (M.M.); Duke University, Durham, NC (A.K.S.S.); Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR (B.C.); N.N. Blokhin Cancer Research Center, Moscow (L.D.); Centre Antoine Lacassagne, Nice (L.G.) and Institut Curie, Paris Sciences and Letters Research University, Paris (S.P.-N.) - both in France; Winship Cancer Institute, Emory University, Atlanta (M.Y.); and the Angeles Clinic and Research Institute, a Cedars-Sinai Affiliate, Los Angeles (O.H.).

Background: Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a 1-year overall survival of approximately 50% in patients with metastatic uveal melanoma. Data showing a proven overall survival benefit with a systemic treatment are lacking. Tebentafusp is a bispecific protein consisting of an affinity-enhanced T-cell receptor fused to an anti-CD3 effector that can redirect T cells to target glycoprotein 100-positive cells. Read More

View Article and Full-Text PDF
September 2021

Evidence of Artemisinin-Resistant Malaria in Africa.

N Engl J Med 2021 Sep;385(13):1163-1171

From the Department of Tropical Medicine and Parasitology, School of Medicine (B.B., N.F., M.I., S.-I.T., M.Y., S.E., T.M.), and the Atopy Research Center, Graduate School of Medicine (B.B.), Juntendo University, Tokyo, the School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki (E.K.), and the Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Osaka University, Osaka (N.M.Q.P., T.H.) - all in Japan; and Mildmay Uganda, Nazibwa Hill, Kampala (O.T.K.), and St. Mary's Hospital Lacor (W.O., M.O.) and the Faculty of Medicine, Gulu University (D.A.A., E.I.O.-A.), Gulu - all in Uganda.

Background: In the six Southeast Asian countries that make up the Greater Mekong Subregion, has developed resistance to derivatives of artemisinin, the main component of first-line treatments for malaria. Clinical resistance to artemisinin monotherapy in other global regions, including Africa, would be problematic.

Methods: In this longitudinal study conducted in Northern Uganda, we treated patients who had infection with intravenous artesunate (a water-soluble artemisinin derivative) and estimated the parasite clearance half-life. Read More

View Article and Full-Text PDF
September 2021

Polygenic Effects of the Lipid Metabolic Pathway Accelerated Pathological Changes and Disrupted Default Mode Network Trajectory Across the Alzheimer's Disease Spectrum.

J Clin Psychiatry 2021 Sep 21;82(6). Epub 2021 Sep 21.

Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.

Dyslipidemia is a controversial risk for Alzheimer's disease (AD) with unknown mechanisms. This study aimed to investigate polygenic effects of the lipid metabolic pathway on cerebrospinal fluid (CSF) core biomarkers, cognition, and default mode network (DMN).

Cross-sectional data on serum lipids, CSF core biomarkers, and functional MRI findings for 113 participants (25 cognitively normal, 20 with subjective cognitive decline, 24 early amnestic, 23 with late mild cognitive impairment, and 21 with AD) from the Alzheimer's Disease Neuroimaging Initiative were included. Read More

View Article and Full-Text PDF
September 2021

PANSS Individual Item and Marder Dimension Analyses From a Pivotal Trial of RBP-7000 (Monthly Extended-Release Risperidone) in Schizophrenia Patients.

J Clin Psychiatry 2021 Sep 21;82(5). Epub 2021 Sep 21.

Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California.

Positive and Negative Syndrome Scale (PANSS) data from a pivotal phase 3 study in participants with schizophrenia of RBP-7000, a recently marketed long-acting subcutaneous injectable risperidone formulation, were examined to determine if dose-response relationships existed for different items of the PANSS.

Changes in the 30 PANSS items were analyzed individually and using the 5 factor-analysis-derived dimensions defined by Marder and colleagues. Subgroups of patients who could benefit from the RBP-7000 120 mg dose were investigated. Read More

View Article and Full-Text PDF
September 2021

New fractionations in breast cancer: a dosimetric study of 3D-CRT versus VMAT.

J Med Radiat Sci 2021 Sep 22. Epub 2021 Sep 22.

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.

Introduction: Adjuvant radiation therapy (RT) following primary surgery in women affected by early breast cancer (EBC) plays a central role in reducing local recurrences and overall mortality. The FAST-FORWARD trial recently demonstrated that 1-week hypofractionated adjuvant RT is not inferior to the standard schedule in terms of local relapse, cosmetic outcomes and toxicity. The aim of this in silico study was to evaluate the dosimetric aspects of a 1-week RT course, administered through volumetric modulated arc therapy (VMAT), compared with traditional three-dimensional conformal radiation therapy (3D-CRT) with tangential fields. Read More

View Article and Full-Text PDF
September 2021

Right ventricular dysfunction and tricuspid regurgitation in functional mitral regurgitation.

ESC Heart Fail 2021 Sep 22. Epub 2021 Sep 22.

The Christ Hospital Health Network, 2139 Auburn Ave, Cincinnati, OH, 45219, USA.

Aim: The objective of this study was to investigate the prognostic importance of right ventricular dysfunction (RVD) and tricuspid regurgitation (TR) in patients with moderate-severe functional mitral regurgitation (FMR) receiving MitraClip procedure. RVD and TR grade are associated with cardiovascular mortality in the general population and other cardiovascular diseases. However, there are limited data from observational studies on the prognostic significance of RVD and TR in FMR receiving MitraClip procedure. Read More

View Article and Full-Text PDF
September 2021

NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models.

J Cell Mol Med 2021 Sep 22. Epub 2021 Sep 22.

Division of Nephrology, Kidney Institute of People's Liberation Army (PLA), Changzheng Hospital, Second Military Medical University, Shanghai, China.

Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by uncontrolled renal cyst formation, and few treatment options are available. There are many parallels between ADPKD and clear-cell renal cell carcinoma (ccRCC); however, few studies have addressed the mechanisms linking them. In this study, we aimed to investigate their convergences and divergences based on bioinformatics and explore the potential of compounds commonly used in cancer research to be repurposed for ADPKD. Read More

View Article and Full-Text PDF
September 2021

Second- or third-generation tyrosine kinase inhibitors in first-line treatment of chronic myeloid leukemia in general population: Is there a real benefit?

Cancer Med 2021 Sep 22. Epub 2021 Sep 22.

Bordeaux Population Health Research Center, Inserm UMR1219-EPICENE, University of Bordeaux, Bordeaux, France.

Introduction: Since 2009, multiple randomized trials have shown faster and deeper responses in CML patients treated with new-generation TKI (NG-TKI) compared to those treated with imatinib (IM). Are the same results observed in the general population?

Materials And Methods: Patients were identified from the three French hematological malignancies population-based registries. All CML patients (ICD-O-3: 9875/3) diagnosed between 2006 and 2016 and resided in registries areas were included. Read More

View Article and Full-Text PDF
September 2021