24,684 results match your criteria included specimens

A systematic review and meta-analysis of robotic-assisted transabdominal total mesorectal excision and transanal total mesorectal excision: which approach offers optimal short-term outcomes for mid-to-low rectal adenocarcinoma?

Tech Coloproctol 2021 Sep 25. Epub 2021 Sep 25.

Kings College Hospitals, Princess Royal University Hospital, Farnborough Common, London, BR6 8ND, Kent, UK.

Background: Resection of low rectal adenocarcinoma can be challenging in the narrow pelvis of male patients. Transanal total mesorectal excision (TaTME) appears to offer technical advantages for distal rectal tumours, and robotic-assisted transabdominal TME (rTME) was introduced in effort to improve operative precision and ergonomics. However, no study has comprehensively compared these approaches. Read More

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September 2021

A molecular-based identification resource for the arthropods of Finland.

Mol Ecol Resour 2021 Sep 25. Epub 2021 Sep 25.

Pennantie 6 B11, 90230, Oulu, Finland.

To associate specimens identified by molecular characters to other biological knowledge, we need reference sequences annotated by Linnaean taxonomy. In this paper, we 1) report the creation of a comprehensive reference library of DNA barcodes for the arthropods of an entire country (Finland), 2) publish this library, and 3) deliver a new identification tool for insects and spiders, as based on this resource. The reference library contains mtDNA COI barcodes for 11,275 (43%) of 26,437 arthropod species known from Finland, including 10,811 (45%) of 23,956 insect species. Read More

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September 2021

Childhood encephalitis hospitalizations associated with virus agents in medium-endemic states in India.

J Clin Virol 2021 Sep 14;144:104970. Epub 2021 Sep 14.

ICMR - National Institute of Virology, Pune, Maharashtra, India; Kakatiya Medical College, Warangal, Telangana, India; Government Medical College, Nagpur, Maharashtra, India; Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra, India.

Background: Japanese encephalitis (JE) is the leading cause of childhood acute encephalitis syndrome (AES) in India. We enhanced the AES surveillance in sentinel hospitals to determine trends and virus etiologies in central India.

Methods: The neurological hospitalizations among children ≤15 years were tracked by using the AES case definition implemented by the national program. Read More

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September 2021

Using a mobile device for margin assessment of specimen mammography in breast-conserving surgery.

Medicine (Baltimore) 2021 Sep;100(38):e27243

Department of Radiology, Seoul National University Bunding Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Abstract: To compare the performance of margin assessment of specimen mammography (SM) in patients with breast-conserving surgery (BCS) on mobile devices and 5-megapixel (5M) thin film transistor liquid crystal display (TFT-LCD) monitors based on the safety margin for pathologic results.This retrospective study was approved by the institutional review board, and the requirement for informed consent was waived. A total of 105 consecutive breast cancer SM samples from 104 women who underwent BCS were included in the study. Read More

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September 2021

Correlation of clinical symptoms, endoscopic features and density of oesophageal eosinophilia in children with newly-diagnosed eosinophilic esophagitis.

Ann Agric Environ Med 2021 Sep 14;28(3):404-408. Epub 2020 Sep 14.

Department of Paediatric Gastroenterology and Nutrition, Medical University, Warsaw, Poland.

Introduction And Objective: Eosinophilic esophagitis (EoE) is an inflammatory immune-mediated oesophageal disease of growing prevalence. The aim of this study is to characterise the clinical symptoms, endoscopic features and histological findings, as well as their possible correlations, in newly-diagnosed EoE paediatric patients.

Material And Methods: Between 2009-2018, the clinical records of patients diagnosed with EoE at the Paediatric Hospital in Warsaw, Poland, were retrospectively reviewed. Read More

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September 2021

Isolating and Culturing of Precursor Cells from the Adult Human Brain.

Methods Mol Biol 2022 ;2389:95-102

European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff, UK.

Adult neural precursor cells are an integral part of the brain and have been a focus of intense research for half a century. Even though adult neural stem/progenitor cells in the human brain have been identified over 20 years ago, progress in this area has been slow, and the existence of lifelong neurogenesis in humans is still debated. Remarkable species differences exist between humans and rodents in astrocyte development and diversity, suggesting similar differences may exist in neural stem/progenitor cells and underscoring the need for further research in human tissue. Read More

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January 2022

Micro-CT Imaging of Pediatric Thyroglossal Duct Cysts: A Prospective Case Series.

Front Pediatr 2021 7;9:746010. Epub 2021 Sep 7.

Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

To determine the feasibility of micro-CT as a high-resolution 3D imaging tool for thyroglossal duct cysts and to evaluate its role augmenting traditional histopathological examination of resected specimens. A single centre, prospective case series of consecutive children undergoing excision of a thyroglossal duct cyst was performed at a quaternary paediatric referral hospital in the United Kingdom. Consecutive children listed for excision of a thyroglossal duct cyst whose parents agreed to participate were included and there were no exclusion criteria. Read More

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September 2021

Antimicrobial resistance among , , and spp. isolates from clinical specimens from a hospital in Nairobi, Kenya.

PeerJ 2021 1;9:e11958. Epub 2021 Sep 1.

Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, TN, United States of America.

Background: Antimicrobial resistance among pathogens of public health importance is an emerging problem in sub-Saharan Africa. Unfortunately, published information on the burden and patterns of antimicrobial resistance (AMR) in this region is sparse. There is evidence that the burden and patterns of AMR vary by geography and facility. Read More

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September 2021

Antimicrobial resistance of Haemophilus influenzae isolates from pediatric hospitals in Mainland China: Report from the ISPED program, 2017-2019.

Indian J Med Microbiol 2021 Sep 20. Epub 2021 Sep 20.

Department of Infectious Diseases, Kaifeng Children's Hospital, Kaifeng, 475099, PR China.

Purpose: This study set out to determine the antimicrobial resistance trends of Haemophilus influenzae isolates from pediatric hospitals in Mainland China, which would provide basis for clinical treatment.

Methods: The Infectious Disease Surveillance of Pediatrics (ISPED) collaboration group conducted this study. H. Read More

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September 2021

Diagnostic accuracy of core biopsies of renal masses: Experience in a real-life setting from a tertiary center.

Ann Diagn Pathol 2021 Sep 14;55:151830. Epub 2021 Sep 14.

Istanbul University, Istanbul Faculty of Medicine, Department of Pathology, Istanbul, Turkey.

Objective: To document and analyze diagnostic accuracy of renal core biopsy (RCB), its diagnostic correlation with resection specimens, and to question the need for immunohistochemistry (IHC) in the preoperative diagnosis of renal masses.

Material And Method: RCBs performed at a reference center between 2007 and 2017 were included. Pathological, clinical, and radiological data were obtained from medical records. Read More

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September 2021

Glycogen synthase kinase-3β inactivation promotes cervical cancer progression, invasion, and drug resistance.

Biotechnol Appl Biochem 2021 Sep 23. Epub 2021 Sep 23.

Department of Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ratu, Jharkhand, Ranchi-835205, INDIA.

Human papillomavirus (HPV) infection-dependent cervical cancer is one of the most common gynecological cancers and often becomes aggressive, with rapid proliferation, invasion/migration, and drug resistance. Here, 135 fresh human CSCC tissue specimens, comprising: 21 adjacent normals (AN), 30 cervical-intraepithelial-neoplasia (CIN ), 45 CSCC, and 39 drugs (chemo-radiation)-resistant cervical tumor (DRCT) tissues were included. HPV-positive (HeLa, SiHa), HPV-negative (C33A), and cisplatin-resistant (CisR-HeLa/-SiHa/-C33A) cell lines were used for in vitro studies. Read More

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September 2021

Is the appendix a good organ to diagnose total colonic aganglionosis?

Pediatr Surg Int 2021 Sep 23. Epub 2021 Sep 23.

International Center for Colorectal and Urogenital Care, Division of Pediatric Surgery, Children's Hospital Colorado, 13213 E 16th Ave, Anschutz Medical Campus, Box 323, Aurora, CO, 80045, USA.

Purpose: The use of the appendix for diagnosis of Total Colonic Aganglionosis (TCA) remains controversial. This study aimed to categorize the presence of ganglion cells in the appendix and determine its reliability as a histological specimen for the diagnosis of TCA.

Methods: This was a combined retrospective and prospective study. Read More

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September 2021

The effect of estrogen therapy on spermatogenesis in transgender women.

F S Rep 2021 Sep 11;2(3):347-351. Epub 2021 Jun 11.

Department of Obstetrics and Gynecology, Cleveland Clinic Foundation, Cleveland, Ohio.

Objective: To describe the histopathologic parameters of orchiectomy specimens obtained after gender-affirming surgery from transgender women who used gender-affirming hormone therapy (GAHT), which included estrogen and spironolactone. Our hypothesis was that an increasing duration of GAHT affects testicular health.

Design: Retrospective cohort study. Read More

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September 2021

Trochlear Development in Children From 1 Month to 10 Years of Age: A Descriptive Study Utilizing Analysis by Magnetic Resonance Imaging.

Orthop J Sports Med 2021 Sep 16;9(9):23259671211028269. Epub 2021 Sep 16.

Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Understanding the morphology of cartilage/bony maturation in preadolescents may help explain adult trochlear variation.

Purpose: To study trochlear morphology during maturation in children and infants using magnetic resonance imaging (MRI).

Study Design: Descriptive laboratory study. Read More

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September 2021

High Tumor Mutation Burden and DNA Repair Gene Mutations are Associated with Primary Resistance to Crizotinib in -Rearranged Lung Cancer.

Onco Targets Ther 2021 15;14:4809-4817. Epub 2021 Sep 15.

Department of Thoracic Oncology, State Key Laboratory of Respiratory Diseases, National Clinical Research Center of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, People's Republic of China.

Background: About 20% of patients with -rearranged non-small cell lung cancer (NSCLC) develop acquired resistance to tyrosine kinase inhibitor (TKI) during the first 6 months. This study aimed to examine the molecular mechanisms of early TKI resistance and prognosis in -rearranged NSCLC.

Methods: Ten patients with -rearranged NSCLC were included: five who developed rapid resistance to crizotinib (progression-free survival (PFS) ≤3 months) and five who exhibited a good response to crizotinib (PFS ≥36 months). Read More

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September 2021

Antireflux surgery is required after endoscopic treatment for Barrett's esophagus.

Pol Przegl Chir 2021 May;93(5):1-5

Department of Surgery and Proctology and Gastrointestinal Surgery, Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.

<b>Introduction:</b> Barrett's esophagus is an acquired condition that develops as a result of transformation of normal stratified squamous epithelium in the lower part of the esophagus into columnar epithelium. Barrett's esophagus is considered to be a complication of gastroesophageal reflux disease (GERD). Various endoscopic techniques have been shown to be successful in the treatment of this condition. Read More

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The Incidence of Occult Malignant and High-Risk Pathologic Findings in Breast Reduction Specimens.

Plast Reconstr Surg 2021 Oct;148(4):534e-539e

From the Department of Surgery, Division of Plastic and Reconstructive Surgery, and the Department of Pathology and Laboratory Medicine, Emory University School of Medicine.

Background: The goal of this study was to determine the incidence of occult malignancy and high-risk breast pathologic findings in patients who undergo breast reduction procedures.

Methods: Medical records of consecutive patients who underwent reduction mammaplasty performed by the senior authors (A.L. Read More

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October 2021

Magnetic Resonance Imaging Features Associated with Histology of Benign Prostatic Hyperplasia Nodules: Generation of a Predictive Model.

J Endourol 2021 Sep 22. Epub 2021 Sep 22.

UT Southwestern, 12334, Urology, Dallas, Texas, United States;

Background: Histologic phenotypic variation of benign prostatic hyperplasia (BPH) has been hypothesized to underlie response to medical therapy. We evaluate pre-operative magnetic resonance imaging (MRI) of robotic simple prostatectomy (RASP) specimens and determine imaging features associated with histologic phenotype.

Materials And Methods: All patients undergoing RASP from 11/2015 to 11/2019 with a multiparametric MRI ≤ 1 year prior to RASP were included. Read More

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September 2021

Low tumor cell content predicts favorable prognosis in germinoma patients.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab110. Epub 2021 Aug 10.

Department of Neurosurgery, Fujita Health University Hospital, Aichi, Japan.

Background: Germinoma preferentially occurs in pediatric and young adult age groups. Although they are responsive to treatment with chemotherapy and radiation, the treatment may cause long-term sequelae in their later lives. Here, we searched for clinical and histopathological features to predict the prognosis of germinoma and affect treatment response. Read More

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Financial and educational impact of the COVID-19 pandemic in an academic hospital-based tertiary cytopathology practice.

J Am Soc Cytopathol 2021 Sep 2. Epub 2021 Sep 2.

Department of Pathology, State University of New York, Upstate Medical University, Syracuse, New York. Electronic address:

Background: The ongoing COVID-19 pandemic has led to a dramatic shift in volumes and practice patterns for hospitals around the globe. We analyzed its effect on the cytopathology subspecialty practice and resident education at our institution.

Design: Specimen volumes were analyzed for the cytology practice for 2019 and 2020. Read More

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September 2021

A Comparison of Histologic and Intraoperative Visual Assessments of Transverse Carpal Ligament During Revision Carpal Tunnel Release.

J Hand Surg Am 2021 Sep 18. Epub 2021 Sep 18.

Department of Orthopaedic Surgery, Geisinger Commonwealth School of Medicine, Geisinger Musculoskeletal Institute, Danville, PA.

Purpose: We sought to determine surgeon-pathologist agreement with respect to distinguishing between a previously undivided transverse carpal ligament (TCL) and scar during revision carpal tunnel release (CTR). Additionally, we aimed to describe the histologic findings of the TCL and flexor tenosynovium during revision CTR.

Methods: All patients undergoing revision CTR for persistent or recurrent CTS by a single surgeon between 2013 and 2019 were included. Read More

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September 2021

Comparison of microbiota in the upper versus lower respiratory tract in children during health and respiratory disease: protocol for a systematic review.

Syst Rev 2021 Sep 21;10(1):253. Epub 2021 Sep 21.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Background: The upper respiratory tract of children is colonized by various microbial species during the healthy state, whereas the lungs are believed to be sterile. In children with respiratory infections, micro-organisms can be recovered from the upper respiratory sites, as well as the lungs. However, the correlation of microbial yield between the two sites is unclear. Read More

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September 2021

Buccal Bone Remodeling Around Immediate Implants in STZ-Induced Diabetic Dogs: A Histologic and Microcomputed Tomographic Analysis.

Int J Periodontics Restorative Dent 2021 Sep-Oct;41(5):683-690

Buccal bone remodeling around immediate implants placed in animals with streptozotocin (STZ)-induced diabetes has not been investigated. The present histologic and microcomputed tomography (μCT) in vivo experiment assessed the buccal bone remodeling around immediate implants, extraction socket healing, and bone-to-implant contact (BIC) in dogs with and without STZ-induced diabetes. Three male beagle dogs with STZ-induced diabetes and three healthy dogs (controls) were included. Read More

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September 2021

Evaluation of molecular testing for Mycoplasma genitalium for symptomatic women.

Ir J Med Sci 2021 Sep 21. Epub 2021 Sep 21.

Clinical Innovation Unit, Rotunda Hospital, Dublin, Ireland.

Mycoplasma genitalium is an emerging cause of sexually transmitted infections (STI) with a capacity to rapidly develop antibiotic resistance. The aim of this work was to carry out an evaluation and descriptive analysis of routine molecular testing of M. genitalium in symptomatic women at the Rotunda Hospital, Dublin January 2018-December 2019. Read More

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September 2021

Spot specimen testing with GeneXpert MTB/RIF results compared to morning specimen in a programmatic setting in Cotonou, Benin.

BMC Infect Dis 2021 Sep 20;21(1):979. Epub 2021 Sep 20.

National Tuberculosis Program, NTP, Cotonou, Benin.

Background: The diagnosis of tuberculosis (TB) using smear microscopy has been based on testing two specimens: one spot and one early morning sputa. Recently, the World Health Organization (WHO) has recommended to replace, whenever possible, microscopy with GeneXpert® MTB/RIF performed on a single specimen. However, as the bacterial load is higher in early morning specimens than in spot specimens, one could expect lower sensitivity of GeneXpert® MTB/RIF performed only on spot specimens. Read More

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September 2021

Intestinal Metaplasia Influencing the Density of Ghrelin Expressing Cells in Morbid Obese Patients.

Obes Surg 2021 Sep 20. Epub 2021 Sep 20.

University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Department of Gastrointestinal Surgery, 16310, Yildirim, Bursa, Turkey.

Purpose: The aim was to compare the density of ghrelin-expressing cells (GECs) in morbid obese patients with or without intestinal metaplasia (IM).

Materials And Methods: The study included 48 patients out of 244 who underwent laparoscopic sleeve gastrectomy between 2015 and 2019. IM was detected in the sleeve gastrectomy specimens of 24 of these 244 patients. Read More

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September 2021

Lymphocytoma cutis (cutaneous B-cell pseudolymphoma): study of 102 cases with emphasis on the histological characteristics and immunohistochemistry of the miliarial type.

Int J Dermatol 2021 Sep 19. Epub 2021 Sep 19.

División de Investigación Médica, UMAE Hospital de Pediatría CMNO, IMSS, Guadalajara, Jalisco, México.

Background: Lymphocytoma cutis (LC) is a benign reactive lymphoproliferative B-cell process. It has two variants: localized type with solitary lesions and miliarial type with numerous lesions. The objective was to investigate the characteristics of LC with emphasis on the miliarial type. Read More

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September 2021

CD74 Correlated With Malignancies and Immune Microenvironment in Gliomas.

Front Mol Biosci 2021 1;8:706949. Epub 2021 Sep 1.

Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, China.

Cluster of differentiation 74 (CD74) is found to be highly involved in the development of various types of cancers and could affect the activities of infiltrated cells in the tumor microenvironment. However, these studies only focus on a few types of immune cells. Our study aims to comprehensively explore the role of CD74 in glioma prognosis and immune microenvironment. Read More

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September 2021

Validating a nodal regression system for gastric cancer: An ancillary cohort study of the GASTRODOC trial.

Int J Surg 2021 Sep 15;94:106112. Epub 2021 Sep 15.

General and Oncologic Surgery, Department of Surgery, Morgagni-Pierantoni Hospital, Forlì, Italy.

Background: To validate a nodal regression system for gastric cancer and to verify its impact on prognosis.

Methods: This is an ancillary study which included 47 patients of the GASTRODOC trial. The dedicated pathologists of each Institute were invited to revise all the lymph nodes included in the surgical specimens in order to classify the regression according to the grading system proposed by Tsekrekos et al. Read More

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September 2021