Biotechnol Appl Biochem 2021 Sep 23. Epub 2021 Sep 23.
Department of Life Sciences, School of Natural Sciences, Central University of Jharkhand, Ratu, Jharkhand, Ranchi-835205, INDIA.
Human papillomavirus (HPV) infection-dependent cervical cancer is one of the most common gynecological cancers and often becomes aggressive, with rapid proliferation, invasion/migration, and drug resistance. Here, 135 fresh human CSCC tissue specimens, comprising: 21 adjacent normals (AN), 30 cervical-intraepithelial-neoplasia (CIN ), 45 CSCC, and 39 drugs (chemo-radiation)-resistant cervical tumor (DRCT) tissues were included. HPV-positive (HeLa, SiHa), HPV-negative (C33A), and cisplatin-resistant (CisR-HeLa/-SiHa/-C33A) cell lines were used for in vitro studies. Read More