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Plasma levels of amino acids and derivatives in retinopathy of prematurity.

Int J Med Sci 2021 27;18(15):3581-3587. Epub 2021 Aug 27.

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Retinopathy of prematurity (ROP) is a retinal disease that causes blindness in premature infants. This study aimed to reveal the changes in amino acids and derivatives in the plasma of ROP patients compared with premature infants without ROP. Metabolomics targeting amino acids and their derivatives was conducted to assess their plasma levels in ROP patients (=58) and premature infants without ROP (=25), and KEGG pathway analysis was used to identify the involved pathways. Read More

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Strengthening retinopathy of prematurity screening and treatment services in Nigeria: a case study of activities, challenges and outcomes 2017-2020.

BMJ Open Ophthalmol 2021 23;6(1):e000645. Epub 2021 Aug 23.

Vitreoretinal Unit, Department of Ophthalmology, University of Benin Teaching Hospital, Benin City, Edo, Nigeria.

Objectives: Retinopathy of prematurity (ROP) will become a major cause of blindness in Nigerian children unless screening and treatment services expand. This article aims to describe the collaborative activities undertaken to improve services for ROP between 2017 and 2020 as well as the outcome of these activities in Nigeria.

Design: Descriptive case study. Read More

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Comparing Nucleated Red Blood Cells in Neonates with and without Retinopathy.

Curr Pediatr Rev 2021 Sep 9. Epub 2021 Sep 9.

Department of Midwifery, Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon. Iran.

Introduction: Retinopathy of prematurity (ROP) is one of the reasons of blindness in children. Numerous predisposing factors have been reported, including prematurity and oxygen therapy. We assessed the number of nucleated red blood cells in neonates with ROP and compared it with the patients that didn t suffer from the situation. Read More

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September 2021

Optimization of retinopathy of prematurity screening in a tertiary neonatal unit in Northern Greece based on 16-year data.

J Perinatol 2021 Sep 1. Epub 2021 Sep 1.

2nd Department of Ophthalmology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital of Thessaloniki, Thessaloniki, Greece.

Objective: The optimal modification of retinopathy of prematurity (ROP) screening policy in our unit, by tightening the applicable screening criteria, without missing treatment-requiring ROP (TR-ROP).

Study Design: Retrospective analysis of screened infants with gestational age (GA) < 32 weeks and/or birth weight (BW) < 1501 g as well as cases beyond these thresholds but with comorbidities (April 2004 to April 2020).

Result: Of 1560 included infants, 18. Read More

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September 2021

Cycled Lighting Versus Continuous Near Darkness in Preterm Infants: A Randomized Controlled Trial.

Klin Padiatr 2021 Sep 1. Epub 2021 Sep 1.

Division of Neonatology, Ankara City Hospital, Ministry of Health, Ankara, Turkey.

Objective: To compare the effectiveness of cycled lighting (CL) or continuous near darkness (CND) on weight in preterm infants.

Study Design: Total 147 infants with a gestational age 25-32 weeks and/or a birth weight 750-1500 g were included in the study. The infants were classified into two groups: CL and CND. Read More

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September 2021

Incidence of retinopathy of prematurity treatment in extremely preterm infants in China.

Paediatr Perinat Epidemiol 2021 Sep 1. Epub 2021 Sep 1.

Children's Hospital of Fudan University, National Children's Medical Centre, Shanghai, China.

Background: Retinopathy of prematurity (ROP) continues to be a major cause of visual impairment and blindness in premature infants and children.

Objectives: To investigate the incidence of severe ROP receiving treatment in extremely preterm (EP) infants in China over time. The risk factors for ROP treatment were also assessed. Read More

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September 2021

Immediate Sequential Bilateral Vitrectomy Surgery for Retinopathy of Prematurity: A Single Surgeon Experience

Turk J Ophthalmol 2021 08;51(4):225-230

Gazi University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey

Objectives: We report the safety and efficacy of simultaneous bilateral vitrectomy for stage 4 and stage 5 retinopathy of prematurity (ROP).

Materials And Methods: Babies who had immediate sequential bilateral vitrectomy surgery for stage 4 or stage 5 ROP were included in this retrospective study. Clinical history, demographic characteristics of the patients, surgical procedure details, perioperative and postoperative ophthalmic and systemic complications, and postoperative anatomical success rates were evaluated. Read More

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Major cardiorespiratory events do not increase after immunizations, eye exams, and other stressors in most very low birth weight infants.

J Neonatal Perinatal Med 2021 Aug 24. Epub 2021 Aug 24.

Department of Pediatrics, Division of Neonatology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Background: Increased cardiorespiratory events with bradycardia and oxygen desaturation have been reported in very low birthweight (VLBW) infants following stressors such as immunizations. These events are difficult to quantify and may be mild. Our group developed an automated algorithm to analyze bedside monitor data from NICU patients for events with bradycardia and prolonged oxygen desaturation (BDs) and used this to compare BDs 24 hours before and after potentially stressful interventions. Read More

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The possible effect of pentoxifylline on development and severity of retinopathy of prematurity.

Cutan Ocul Toxicol 2021 Sep 14:1-6. Epub 2021 Sep 14.

Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, İstanbul, Turkey.

Background And Aim: Retinopathy of prematurity (ROP) is the major ocular problem of preterm infants that occurs with abnormal proliferation of immature retinal vessels. Although pentoxifylline (PTX) was reported to inhibit vasculogenesis and neovascularization in experimental studies, there is no clinical data about the effects of PTX treatment on the development and severity of ROP. This clinical study aimed to investigate the possible effects of PTX on the development of ROP. Read More

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September 2021

[Venous blood flow in ocular vessels of patients with active retinopathy of prematurity].

Vestn Oftalmol 2021 ;137(4):65-71

Kaluga Branch of the S.N. Fedorov National Medical Research Center «MNTK «Eye Microsurgery», Kaluga, Russia.

Purpose: To study the characteristics of venous circulation in the eyes with retinopathy of prematurity (ROP) observed in examination of blood flow in the central retinal vein and superior orbital vein in patients with different forms, stages and state of the disease.

Material And Methods: Color duplex scanning of the central retinal vein and superior orbital vein was performed using color Doppler imaging and pulsed Doppler sonography in 55 premature babies (55 eyes) with active ROP and 8 premature babies (8 eyes) with no signs of ROP. All babies included in the study were born at 25-32 weeks of gestation, their birth weight was 680-1760 g. Read More

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Accuracy of Deep Learning Algorithms for the Diagnosis of Retinopathy of Prematurity by Fundus Images: A Systematic Review and Meta-Analysis.

J Ophthalmol 2021 6;2021:8883946. Epub 2021 Aug 6.

Department of Regenerative and Reconstructive Medicine (Ophthalmology), Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 7008530, Japan.

Background: Retinopathy of prematurity (ROP) occurs in preterm infants and may contribute to blindness. Deep learning (DL) models have been used for ophthalmologic diagnoses. We performed a systematic review and meta-analysis of published evidence to summarize and evaluate the diagnostic accuracy of DL algorithms for ROP by fundus images. Read More

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2-year outcomes of ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW extension study): prospective follow-up of an open label, randomised controlled trial.

Lancet Child Adolesc Health 2021 Aug 12. Epub 2021 Aug 12.

Royal Hospital for Sick Children, University of Edinburgh, Edinburgh, UK.

Background: Intravitreal injection of vascular endothelial growth factor (VEGF) inhibitors is increasingly used to treat retinopathy of prematurity (ROP) in the absence of evidence about long-term efficacy or safety. In this prespecified interim analysis of the RAINBOW extension study, we aimed to prospectively assess outcomes at age 2 years.

Methods: RAINBOW was an open-label, randomised trial that compared intravitreal ranibizumab (at 0·1 mg and 0·2 mg doses) with laser therapy for the treatment of ROP in very low birthweight infants (<1500 g). Read More

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Respiratory problems in preterm infants with pulmonary hemorrhage.

J Matern Fetal Neonatal Med 2021 Aug 12:1-6. Epub 2021 Aug 12.

Biostatistics and Medical Informatics, Kahramanmaras Sutcu Imam University Faculty of Medicine, Kahramanmaras, Turkey.

Aim: Pulmonary hemorrhage is an important cause of morbidity and mortality in premature infants. There are few studies on pulmonary hemorrhage and associated morbidities observed in premature. The aim of this study was to investigate the possible relationship between pulmonary hemorrhage and respiratory problems in premature infants. Read More

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Depth-Resolved Visualization of Perifoveal Retinal Vasculature in Preterm Infants Using Handheld Optical Coherence Tomography Angiography.

Transl Vis Sci Technol 2021 08;10(9):10

Department of Ophthalmology, Duke University, Durham, NC, USA.

Purpose: To establish methods to visualize depth-resolved perifoveal retinal vasculature in preterm infants using handheld optical coherence tomography angiography (OCT-A).

Methods: In this exploratory study, eyes of preterm infants were imaged using an investigational noncontact, handheld swept-source OCT-A device as part of the prospective BabySTEPS infant retinal imaging study. We selected high-quality OCT-A volumes at two developmental stages for analysis. Read More

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Statins and the progression of age-related macular degeneration in the United States.

PLoS One 2021 4;16(8):e0252878. Epub 2021 Aug 4.

Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, United States of America.

Purpose: To study the effect of statin exposure on the progression from non-exudative to exudative age-related macular degeneration (AMD).

Methods: Retrospective cohort study of commercially insured patients diagnosed with non-exudative AMD (n = 231,888) from 2007 to 2015. Time-to-event analysis of the association between exposure to lipid-lowering medications and time from non-exudative AMD to exudative AMD diagnosis was conducted. Read More

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The relationship of retinopathy of prematurity with brain-derivated neurotrophic factor, vascular endotelial growth factor-A, endothelial PAD domain protein 1 and nitric oxide synthase 3 gene polymorphisms.

Ophthalmic Genet 2021 Aug 4:1-7. Epub 2021 Aug 4.

Department of Ophthalmology, Eskişehir Osmangazi University Medical School, Eskişehir, Turkey.

Background: In addition to risk factors such as low birth weight and uncontrolled oxygen therapy, genetic predisposition is also thought to play a role in the development of retinopathy of prematurity (ROP). In our study, we aimed to analyze single-nucleotide polymorphisms (SNPs) in and genes in infants who develop ROP.

Materials And Methods: Seventy-five mild-moderate and 73 severe ROP cases were included in this study. Read More

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Outcomes of very preterm infants with neonatal hyperglycaemia: a systematic review and meta-analysis.

Arch Dis Child Fetal Neonatal Ed 2021 Jul 30. Epub 2021 Jul 30.

Neonatology, King Edward Memorial Hospital for Women, Subiaco, Western Australia, Australia.

Objective: To explore the association between hyperglycaemia and adverse outcomes in very preterm infants.

Design: Systematic review and meta-analysis. Data were pooled separately for adjusted and unadjusted odds ratios (ORs) using random-effects model. Read More

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Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity.

Indian J Ophthalmol 2021 08;69(8):2182-2187

Department of Biostatistics and Medical Informatics, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Purpose: To evaluate the prognostic potential of systemic inflammatory index in the course of retinopathy of prematurity (ROP).

Methods: This is a retrospective case-control study. 303 infants with a gestational age of ≤35 weeks were screened with and without ROP at birth and 1 month after the birth of complete blood counts (CBC) were included in this study. Read More

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Risk of corneal epithelial defects with and without postoperative erythromycin ointment after laser photocoagulation for retinopathy of prematurity.

Indian J Ophthalmol 2021 08;69(8):2178-2181

Department of Ophthalmology, Albany Medical College, Albany, NY, USA.

Purpose: We aim to compare the incidence of corneal epithelial defects after laser for retinopathy of prematurity (ROP) with and without the use of postoperative erythromycin ointment.

Methods: In this retrospective observational cohort study, a total of 100 infants (200 eyes) consecutively treated with laser for ROP between 2012 and 2018. The primary outcome was presence or absence of corneal epithelial defect using fluorescein on bedside examination within the first week following laser for ROP. Read More

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Anti-vascular endothelial growth factor in the management of retinopathy of prematurity: A survey among the members of Indian Retinopathy of Prematurity Society.

Indian J Ophthalmol 2021 08;69(8):2158-2163

Director, MGM Eye Institute, Raipur, Chhattisgarh, India.

Purpose: To report the results of the survey for the role of anti-VEGF in the management of retinopathy of prematurity (ROP) among the members of Indian ROP (iROP) society.

Methods: A questionnaire was designed in English using Google forms and its link was circulated to the members of the iROP society on their mobile numbers. The survey included questions pertaining to demographics, anti-VEGF agents, injection technique, post-injection follow-up, and documentation pertaining to their ROP practice. Read More

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Retinopathy of prematurity screening and retinal hemorrhages - Our experience among Indian babies.

Indian J Ophthalmol 2021 08;69(8):2147-2150

Minto Regional Institute of Ophthalmology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.

Purpose: To evaluate the clinical characteristics of intraocular hemorrhages among babies screened for retinopathy of prematurity (ROP) and thereby their additional risk to the progression of ROP.

Methods: A descriptive study was conducted at a tertiary referral hospital, which included 108 eyes of 60 neonates who were discovered to have retinal hemorrhages on retinal screening of 540 babies at risk for ROP. Maternal, obstetric, and neonatal risk factors were assessed in neonates with retinal hemorrhages. Read More

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Analysis of the parental satisfaction for retinopathy of prematurity screening using binocular indirect ophthalmoscopy versus wide field retinal imaging.

Indian J Ophthalmol 2021 08;69(8):2142-2145

Medical Director, Dhami Eye Care Hospital, Ludhiana, Punjab, India.

Purpose: Analysis of the parental satisfaction for retinopathy of prematurity screening using binocular indirect ophthalmoscopy versus wide field retinal imaging.

Methods: This was an observational, questionnaire survey-based study. The study cohort comprised of parents/legal guardians of consecutive Asian Indian premature infants enrolled for retinopathy of prematurity screening (for infants less than 2000 gms and/or 34-weeks gestational age) using binocular indirect ophthalmoscopy (BIO) with scleral depression and b) wide field retinal imaging using the 3Nethra Neo Camera (Forus Health, India). Read More

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Should parents be present during screening examinations for retinopathy of prematurity?

Indian J Ophthalmol 2021 08;69(8):2134-2140

Department of Ophthalmology, Bilkent City Hospital, Ankara, Turkey.

Purpose: To investigate whether parents should be present during screening examinations for retinopathy of prematurity (ROP) by investigating the anxiety levels of parents using two different approaches.

Methods: This cross-sectional and two-center study was carried out with the parents at the time of the first ROP screening examination of their premature infants. At one center, the parents accompanied the infants during the ROP examination (Group 1), and in the other center, they did not (Group 2). Read More

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Retinopathy of Prematurity: Advances in the Screening and Treatment of Retinopathy of Prematurity Using a Single Center Approach.

Am J Ophthalmol 2021 Jul 20. Epub 2021 Jul 20.

Murray Oncology and Retina, 6705 Red Road, Suite 412, South Miami, FL, 33143.

Purpose: To focus on the longitudinal evaluation of high-risk infants for the development of retinopathy of prematurity (ROP) at a single tertiary neonatal intensive care unit (NICU) and to evaluate evolving demographics of ROP and the transition of treatment-warranted disease.

Methods: Consecutive retrospective review was performed of all infants screened for ROP between 1990 and 2019 at the Jackson Memorial Hospital neonatal intensive care unit. All inborn infants meeting a birth criteria of <32 weeks gestational age (GA) or a birthweight (BW) of 1500 grams were included. Read More

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Risk Factors for Retinopathy of Prematurity in the Netherlands: A Comparison of Two Cohorts.

Neonatology 2021 22;118(4):462-469. Epub 2021 Jul 22.

Wilhelmina Children's Hospital, Utrecht, The Netherlands.

Introduction: Retinopathy of prematurity (ROP) remains an important cause for preventable blindness. Aside from gestational age (GA) and birth weight, risk factor assessment can be important for determination of infants at risk of (severe) ROP.

Methods: Prospective, multivariable risk-analysis study (NEDROP-2) was conducted, including all infants born in 2017 in the Netherlands considered eligible for ROP screening by pediatricians. Read More

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September 2021

The Serum Levels of Asymmetric Dimethylarginine, Vascular Endothelial Growth Factor, and Insulin-Like Growth Factor-1 in Preterms with Retinopathy of Prematurity.

Fetal Pediatr Pathol 2021 Jul 22:1-6. Epub 2021 Jul 22.

Department of Neonatology, University of Health Sciences of Turkey, Dr. Sami Ulus Maternity and Children Training and Research Hospital, Ankara, Turkey.

Objective: To determine the serum levels of asymmetric dimethylarginine (ADMA), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF-1) in preterms with retinopathy of prematurity (ROP). We included 37 preterm infants. The first blood samples were obtained within the first 5 days of life and repeated at the time of the first ophthalmologic examination for ROP. Read More

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Addressing the Third Epidemic of Retinopathy of Prematurity Through Telemedicine and Technology: A Systematic Review.

J Pediatr Ophthalmol Strabismus 2021 Jul-Aug;58(4):261-269. Epub 2021 Jul 1.

The rising prevalence of retinopathy of prematurity (ROP) in low- and middle-income countries has increased the need for screening at-risk infants. The purpose of this article was to review the impact of tele-medicine and technology on ROP screening programs. Adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review was performed using PubMed, Pro-Quest, and Google Scholar bibliographic search engine. Read More

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Cognitive Outcomes Following Intravitreal Bevacizumab for Retinopathy of Prematurity: 4- to 6-Year Outcomes in a Prospective Cohort.

Am J Ophthalmol 2021 Jul 17. Epub 2021 Jul 17.

Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Purpose: To determine the long-term cognitive outcomes in children who underwent intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP).

Design: Prospective cohort study.

Methods: This single-center study enrolled 186 children between 3 and 6 years of age and included 101 children in the final analysis: premature without ROP (group 1), ROP not needing treatment (group 2), IVB monotherapy (group 3), IVB plus laser therapy (group 4), and laser monotherapy (group 5). Read More

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A Good Way to Reduce Screening for Retinopathy of Prematurity: Development of the ROP Model in a China Preterm Population.

Front Pediatr 2021 30;9:697690. Epub 2021 Jun 30.

Neonatal Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Retinopathy of prematurity (ROP) is a preventable cause of blindness in children. Without treatment, more than 45% of eyes may suffer permanent vision loss. Current ROP screening guidelines, which include a range of birth weights (BWs) and gestational ages (GAs), may require screening many low-risk preemies who might develop severe ROP. Read More

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Early Postnatal Oxygen Exposure Predicts Choroidal Thinning in Neonates.

Invest Ophthalmol Vis Sci 2021 Jul;62(9):23

Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California, United States.

Purpose: To evaluate whether choroidal thickness (CT) using arm-mounted optical coherence tomography (OCT) in infants screened for retinopathy of prematurity (ROP) correlates with oxygen exposure in neonates.

Methods: OCT images were obtained in infants screened for ROP in a single level IV neonatal intensive care unit. CT was measured at three different locations: the subfoveal center and 1. Read More

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