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Open-Label, Single-Arm, Multicenter, Phase II Trial of Lenvatinib for the Treatment of Patients With Anaplastic Thyroid Cancer.

J Clin Oncol 2021 May 7:JCO2003093. Epub 2021 May 7.

The University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Anaplastic thyroid cancer (ATC), an aggressive malignancy, is associated with a poor prognosis and an unmet need for effective treatment, especially for patients without mutations or or fusions. Lenvatinib is US Food and Drug Administration-approved for radioiodine-refractory differentiated thyroid cancer and has previously demonstrated activity in a small study of patients with ATC (n = 17). We aimed to further evaluate lenvatinib in ATC. Read More

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Adequacy of small biopsy and cytology specimens for comprehensive genomic profiling of patients with non-small-cell lung cancer to determine eligibility for immune checkpoint inhibitor and targeted therapy.

J Clin Pathol 2021 May 5. Epub 2021 May 5.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

Aims: In advanced-stage non-small-cell lung cancer (NSCLC), incomplete genotyping for guideline-recommended genomic biomarkers poses a significant challenge to making informed and timely clinical decisions. We report our institution's experience in assessing the adequacy of small specimens for comprehensive genomic profiling for guideline-recommended lung cancer biomarker testing.

Methods: We performed a retrospective evaluation of all image-guided procedures for NSCLC performed in our institution between October 2016 and July 2018, including core needle biopsy (CNB) and fine-needle aspiration (FNA) in patients who had undergone genomic profiling for lung cancer. Read More

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Using Reticulocyte Hemoglobin Equivalent as a Marker for Iron Deficiency and Responsiveness to Iron Therapy.

Mayo Clin Proc 2021 May 2. Epub 2021 May 2.

Department of Laboratory Medicine, Boston Children's Hospital, and Department of Pathology, Harvard Medical School, Boston, MA. Electronic address:

Objective: To assess the accuracy of a simplified approach for the diagnosis of iron deficiency anemia (IDA) based on the complete blood cell count (CBC) and reticulocyte analysis.

Patients And Methods: Five hundred fifty-six consecutive, nonselected patients referred for diagnosis and/or treatment of anemia were included in this diagnostic study to compare the performance of reticulocyte hemoglobin equivalent (RET-He) versus traditional biochemical markers for diagnosis and treatment of IDA. Complete blood count, serum ferritin, iron, and transferrin saturation were performed as clinically indicated. Read More

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RET Protein Expression in Colorectal Cancer; An Immunohistochemical Assessment.

Asian Pac J Cancer Prev 2021 Apr 1;22(4):1019-1023. Epub 2021 Apr 1.

Department of Anatomical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: RET (rearranged during transfection) is a transmembrane receptor tyrosine kinase and a receptor for the GDNF-family ligands. It plays the role of a tumor suppressor in colorectal cancer. Therefore, it is expected that RET gene becomes downregulated in colorectal cancer (CRC). Read More

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Profiling Oncogenic Germline Mutations in Unselected Chinese Lung Cancer Patients.

Front Oncol 2021 7;11:647598. Epub 2021 Apr 7.

Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Introduction: Emerging evidence has suggested that inherited factors are also involved in lung cancer development. However, most studies focused on well-elucidated cancer predisposition genes, the majority of which are tumor suppressor genes. The profile of germline mutations in oncogenic driver genes remains unrevealed, which might also provide potential clinical implications for lung cancer management. Read More

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Assessment of health-related quality of life and patient's knowledge in chronic non-specific low back pain.

BMC Public Health 2021 Apr 23;21(Suppl 1):1479. Epub 2021 Apr 23.

Institute of Physiotherapy and Sports Science, Faculty of Health Sciences, University of Pécs, Vörösmarty u. 3., Pécs, H-7621, Hungary.

Background: Chronic non-specific low back pain syndrome (cnsLBP) is a severe health problem in developed countries, which has an important effect on patients' quality of life and is highly determined by socio-demographic factors and low back pain specific knowledge. We examined patients' health-related quality of life according to the results of the Short Form Health Survey (SF-36), low back pain knowledge (LBPKQ) and the social determinants of the participants.

Methods: We carried out our research in the first half of 2015 in Southern Transdanubia, Hungary. Read More

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Protein Source and Quality for Skeletal Muscle Anabolism in Young and Older Adults: A Systematic Review and Meta-Analysis.

J Nutr 2021 Apr 13. Epub 2021 Apr 13.

School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Background: There is much debate regarding the source/quality of dietary proteins in supporting indices of skeletal muscle anabolism.

Objective: We performed a systematic review and meta-analysis to determine the effect of protein source/quality on acute muscle protein synthesis (MPS) and changes in lean body mass (LBM) and strength, when combined with resistance exercise (RE).

Methods: A systematic search of the literature was conducted to identify studies that compared the effects of ≥2 dose-matched, predominantly isolated protein sources of varying "quality. Read More

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Management and results of thyroidectomies in pediatric patients with men 2 syndrome.

J Pediatr Surg 2021 Mar 3. Epub 2021 Mar 3.

Department of Pediatric Surgery, Gregorio Marañón University Hospital Máiquez Street N 9, 28007 Madrid, Spain.

Aim Of The Study: To evaluate the outcome of prophylactic thyroidectomies (PT) in patients with MEN 2 syndrome in a tertiary center.

Methods: A retrospective study was designed, including all patients with MEN 2 syndrome who underwent PT between 2000 and 2019. Demographics, gene mutation, postoperative complications and histopathological findings were registered. Read More

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Germline Pathogenic Variants Identified by Targeted Next-Generation Sequencing of Susceptibility Genes in Pheochromocytoma and Paraganglioma.

J Kidney Cancer VHL 2021 13;8(1):19-24. Epub 2021 Mar 13.

Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Trakya University, Edirne, Turkey.

The aim of this study was to evaluate germline variant frequencies of pheochromocytoma and paraganglioma targeted susceptibility genes with next-generation sequencing method. Germline DNA from 75 cases were evaluated with targeted next-generation sequencing on an Illumina NextSeq550 instrument. , and genes were included in the study, and Sanger sequencing was used for verifying the variants. Read More

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Genetic and clinical aspects of paediatric pheochromocytomas and paragangliomas.

Clin Endocrinol (Oxf) 2021 Mar 20. Epub 2021 Mar 20.

Unidade de Suprarrenal, Laboratório de Hormônios e Genética Molecular LIM/42, Serviço de Endocrinologia e Metabologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.

Objective: Few and conflicting reports have characterized the genetics of paediatric pheochromocytomas and paragangliomas (PPGLs). This study aimed to investigate the clinical and genetic features of Brazilian children with PPGL.

Patients And Methods: This study included 25 children (52% girls) with PPGL. Read More

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A Series of RET Fusion Spitz Neoplasms With Plaque-Like Silhouette and Dyscohesive Nesting of Epithelioid Melanocytes.

Am J Dermatopathol 2021 Apr;43(4):243-251

Professor of Dermatology and Pathology, Northwestern University, Department of Dermatology, Chicago, IL; and.

Abstract: Two distinct studies have shown that RET fusions are found in 3%-4% of Spitz neoplasms. RET fusions have been well described in papillary thyroid cancer, non-small-cell lung cancer, breast cancer, and soft-tissue mesenchymal tumors as well as some other neoplasms. However, there are no comprehensive descriptions to date of the characteristic morphologic, clinical, or genomic findings in RET fusion Spitz neoplasms. Read More

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Final survival results for the LURET phase II study of vandetanib in previously treated patients with RET-rearranged advanced non-small cell lung cancer.

Lung Cancer 2021 May 10;155:40-45. Epub 2021 Mar 10.

Department of Thoracic Oncology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba 277-8577, Japan.

Objectives: The LURET phase II study evaluated the efficacy and safety of the multikinase inhibitor vandetanib in patients with previously treatedRET-rearranged advanced non-small cell lung cancer (NSCLC). Among the eligible patients included in the primary analysis, the objective response rate met the primary endpoint (53 %, 90 % confidence interval [CI]: 31-74). Here, we report final survival outcomes of the LURET study. Read More

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DLL3 (delta-like protein 3) expression correlates with stromal desmoplasia and lymph node metastases in medullary thyroid carcinomas.

Endocr Connect 2021 Mar;10(3):283-289

Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.

Medullary thyroid carcinomas (MTC) are rare and aggressive neuroendocrine tumors of the thyroid. About 70% of MTC are sporadic; approximately 50% of those harbor somatic RET mutation. DLL3 is widely expressed in many neuroendocrine tumors and has been evaluated as a potential therapeutic target. Read More

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Resonance energy transfer mediated by a chiral molecule.

Authors:
A Salam

J Chem Phys 2021 Feb;154(7):074111

Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, USA.

The problem of resonant energy transfer (RET) between an electric dipole donor, D, and an electric dipole acceptor, A, mediated by a passive, chiral third-body, T, is considered within the framework of molecular quantum electrodynamics theory. To account for the optical activity of the mediator, magnetic dipole and electric quadrupole coupling terms are included in addition to the leading electric dipole interaction term. Fourth-order diagrammatic time-dependent perturbation theory is used to obtain the matrix element. Read More

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February 2021

Morphological and genetic heterogeneity of synchronous multifocal lung adenocarcinoma in a Chinese cohort.

BMC Cancer 2021 Feb 18;21(1):176. Epub 2021 Feb 18.

Department of Pathology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, 215002, China.

Background: Synchronous multifocal lung cancer (SMLC) is diagnosed with increasing frequency in clinical practice globally. Due to innate variation in clinical management and outcome, it is vital to properly distinguish between synchronous multifocal primary lung cancer (SMPLC) and intrapulmonary metastasis (IM). The pathologic features and principal classification criteria of multifocal lung cancer remain unclear. Read More

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February 2021

Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update.

J Clin Oncol 2021 Mar 16;39(9):1040-1091. Epub 2021 Feb 16.

Helen F. Graham Cancer Center and Research Institute, Newark, DE.

Purpose: To provide evidence-based recommendations updating the 2017 ASCO guideline on systemic therapy for patients with stage IV non-small-cell lung cancer (NSCLC) with driver alterations. A guideline update for systemic therapy for patients with stage IV NSCLC without driver alterations was published separately.

Methods: The American Society of Clinical Oncology and Ontario Health (Cancer Care Ontario) NSCLC Expert Panel updated recommendations based on a systematic review of randomized controlled trials (RCTs) from December 2015 to January 2020 and meeting abstracts from ASCO 2020. Read More

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Clinical Presentation and Treatment Outcomes of Children and Adolescents With Pheochromocytoma and Paraganglioma in a Single Center in Korea.

Front Endocrinol (Lausanne) 2020 29;11:610746. Epub 2021 Jan 29.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: Pheochromocytoma (PCC) and paraganglioma (PGL) (PPGL) are rare neuroendocrine tumors, and data on managing these conditions in children and adolescents are lacking. The objective of this study was to demonstrate the clinical presentation and treatment outcomes in children and adolescents with PPGL in a single tertiary care center in Korea.

Methods: This retrospective study included 23 patients diagnosed with PCC ( = 14) and PGL ( = 9) before the age of 21 at Samsung Medical Center (from June 1994 to June 2019). Read More

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January 2021

Anaplastic Thyroid Carcinoma: Current Issues in Genomics and Therapeutics.

Curr Oncol Rep 2021 Feb 13;23(3):31. Epub 2021 Feb 13.

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast Campus, Gold Coast, QLD, 4222, Australia.

Purpose Of Review: Anaplastic thyroid carcinoma is a type of thyroid carcinoma with the most aggressive biological behaviour amongst thyroid cancer. Here, we review the current genomic and the impacts of advances in therapies to improve the management of patients with the cancer.

Recent Findings: Common mutations being identified in anaplastic thyroid carcinoma are p53 and TERT promoter mutations. Read More

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February 2021

Correlation of molecular data with histopathological and clinical features in a series of 66 patients with medullary thyroid carcinoma.

J Endocrinol Invest 2021 Feb 11. Epub 2021 Feb 11.

Unidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil E.P.E., Rua Prof. Lima Basto, 1099-023, Lisboa, Portugal.

Purpose: Medullary thyroid carcinoma (MTC) displays a wide variety of histopathological features, and several histological variants have been described. In follicular cell-derived thyroid carcinomas, there is a good correlation between genotype and phenotype. In this study, we investigated whether such a correlation is also present in MTC. Read More

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February 2021

Differential diagnosis of thalassemia and iron deficiency anemia in pregnant women using new formulas from multidimensional analysis of red blood cells.

Ann Transl Med 2021 Jan;9(2):141

Department of Medical Laboratory, Shenzhen Baoan Women's and Children's Hospital, Shenzhen, China.

Background: Iron deficiency anemia (IDA) and thalassemia trait (TT) are the most common conditions of microcytic hypochromic anemia (MHA) in pregnant women. We used the BC-6800Plus analyzer to study the utility of erythrocyte and reticulocyte parameters for distinguishing TT from IDA in pregnant women.

Methods: A total of 454 anemic pregnant women, including 340 with IDA, 66 with β-thalassemia trait (β-TT) and 48 with α-thalassemia trait (α-TT), were included. Read More

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January 2021

An improved assay for detection of theranostic gene translocations and MET exon 14 skipping in thoracic oncology.

Lab Invest 2021 May 25;101(5):648-660. Epub 2021 Jan 25.

INSERM U1245, Cancer Center Henri Becquerel, Institute of Research and Innovation in Biomedicine (IRIB), University of Normandy, UNIVROUEN, Rouen, France.

Theranostic translocations may be difficult to detect by routine techniques, especially when specimens are exiguous. We recently demonstrated in a series of translocated lung adenocarcinomas that LD-RT-PCR (ligation-dependent reverse transcription polymerase chain reaction) assay could identify ALK, ROS1 and RET rearrangements with 64% sensitivity and 100% specificity. Here, we report an upgraded version of this assay used in a routine prospective cohort of lung carcinomas. Read More

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Supported progressive resistance exercise training to counter the adverse side effects of robot-assisted radical prostatectomy: a randomised controlled trial.

Support Care Cancer 2021 Jan 23. Epub 2021 Jan 23.

Department of Sport, Exercise & Rehabilitation, Faculty of Health & Life Sciences, University of Northumbria at Newcastle, Room 239, Northumberland Building, Newcastle-upon-Tyne, NE1 8ST, UK.

Purpose: To investigate the effects of a supported home-based progressive resistance exercise training (RET) programme on indices of cardiovascular health, muscular strength and health-related quality of life (HR-QoL) in prostate cancer (PCa) patients after treatment with robot-assisted radical prostatectomy (RARP).

Methods: This study was a single-site, two-arm randomised controlled trial, with 40 participants randomised to either the intervention or control group over a 10-month period. In addition to receiving usual care, the intervention group completed three weekly RET sessions using resistance bands for 6 months. Read More

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January 2021

Combined versus Sequential Phacoemulsification and Pars Plana Vitrectomy: A Meta-Analysis.

Ophthalmol Retina 2021 Jan 20. Epub 2021 Jan 20.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Canada; Department of Ophthalmology, St. Michael's Hospital/Unity Health Toronto, Toronto, Canada. Electronic address:

Topic: It is unclear whether differences exist in efficacy and safety between combined versus sequentially performed phacoemulsification and pars plana vitrectomy (phaco-PPV).

Clinical Relevance: This meta-analysis aimed to compare the efficacy and incidence of complications between these surgical methods.

Methods: Ovid MEDLINE, EMBASE, and Cochrane CENTRAL were searched for articles reporting the efficacy and safety of combined versus sequential phaco-PPV for any indication. Read More

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January 2021

Genetic Analysis and Clinical Characteristics of Hereditary Pheochromocytoma and Paraganglioma Syndrome in Korean Population.

Endocrinol Metab (Seoul) 2020 12 23;35(4):858-872. Epub 2020 Dec 23.

Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Background: Pheochromocytoma and paragangliomas (PPGL) are hereditary in approximately 30% to 40% cases. With the advancement of genetic analysis techniques, including next-generation sequencing (NGS), there were attempts to classify PPGL into molecular clusters. With NGS being applied to clinical settings recently, we aimed to review the results of genetic analysis, including NGS, and investigate the association with clinical characteristics in Korean PPGL patients. Read More

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December 2020

Genetic and Clinical Profiles of Pheochromocytoma and Paraganglioma: A Single Center Study.

Front Endocrinol (Lausanne) 2020 11;11:574662. Epub 2020 Dec 11.

Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Pheochromocytoma/paraganglioma (PPGL) has a high genetic heterogeneity with 40% germline variants in known pathogenic genes. Data in Chinese on this aspect are scanty. To detect the genetic and clinical profile of Chinese PPGL patients, we examined the variants of 12 known germline pathogenic genes (, , , , , , , , , , , and ) by next-generation sequencing and Sanger sequencing in 314 Chinese PPGL subjects. Read More

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December 2020

Biomarker testing in non-small cell lung cancer in routine care: Analysis of the first 3,717 patients in the German prospective, observational, nation-wide CRISP Registry (AIO-TRK-0315).

Lung Cancer 2021 02 2;152:174-184. Epub 2020 Nov 2.

Onkologie der Thoraxtumore, Thoraxklinik Heidelberg gGmbH, German Center for Lung Research (DZL), Germany.

Objectives: An increasing number of treatment-determining biomarkers has been identified in non-small cell lung cancer (NSCLC) and molecular testing is recommended to enable optimal individualized treatment. However, data on implementation of these recommendations in the "real-world" setting are scarce. This study presents comprehensive details on the frequency, methodology and results of biomarker testing of advanced NSCLC in Germany. Read More

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February 2021

Head and neck paragangliomas in Norway, importance of genetics, updated diagnostic workup and treatment.

Acta Otolaryngol 2021 Mar 15;141(3):303-308. Epub 2020 Dec 15.

Department of Otorhinolaryngology & Head and Neck Surgery, Oslo University Hospital, Rikshospitalet, Norway.

Background: Head and neck paragangliomas (HNPG) are rare and predominantly benign tumours, originating from the neuroendocrine paraganglionic system. A considerable proportion of HNPGs are hereditary, depending on the population.

Aims/objectives: The purpose of this study was to estimate the rate of hereditary HNPGs in a Scandinavian (Norwegian) population, report long-term experience with HNPGs and offer all patients diagnosed an updated follow-up, with emphasis on identifying hereditary HNPGs through genetic screening and multifocality by 18 F-2-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT). Read More

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Multiple cancer susceptible genes sequencing in BRCA-negative breast cancer with high hereditary risk.

Ann Transl Med 2020 Nov;8(21):1417

Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.

Background: Hereditary factors contributed to breast cancer susceptibility. Low mutation prevalence was demonstrated in previous mutation screening in Chinese breast cancer patients. Multiple-gene sequencing may assist in discovering detrimental germline mutation in. Read More

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November 2020

The Coexistence of Genetic Mutations in Thyroid Carcinoma Predicts Histopathological Factors Associated With a Poor Prognosis: A Systematic Review and Network Meta-Analysis.

Front Oncol 2020 3;10:540238. Epub 2020 Nov 3.

The Department and Key Laboratory of Endocrinology and Metabolism, The First Medical Center of PLA General Hospital, Beijing, China.

Purpose: Genetic mutations may play an important role in the progression and invasion of thyroid carcinoma (TC), and their coexistence may result in mutational synergy. The presence of the mutation, as well as mutations affecting the promoter, , and , may all have an impact on prognosis. The aim of this study was to explore whether synergy between the coexistent mutations predicts histopathological prognostic factors that influence disease outcome. Read More

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November 2020

Implementation of an anaemia walk-in clinic: Feasibility and preliminary data from the Orthopedic University Hospital.

Transfus Med 2020 Dec 25;30(6):467-474. Epub 2020 Nov 25.

Department of Special Orthopedics, Orthopedic University Hospital Friedrichsheim gGmbH, Frankfurt, Germany.

Background: Approximately one in three patients suffers from preoperative anaemia. Even though haemoglobin is measured before surgery, anaemia management is not implemented in every hospital.

Objective: Here, we demonstrate the implementation of an anaemia walk-in clinic at an Orthopedic University Hospital. Read More

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December 2020