33,336 results match your criteria included proportional

Pathologic upstaging in resected pancreatic adenocarcinoma: Risk factors and impact on survival.

J Surg Oncol 2021 Apr 9. Epub 2021 Apr 9.

Section of Surgical Oncology, Division of Surgery, Baptist MD Anderson Cancer Center, Jacksonville, Florida, USA.

Background: Clinical and pathologic staging determine treatment of pancreatic cancer. Clinical stage has been shown to underestimate final pathologic stage in pancreatic cancer, resulting in upstaging.

Methods: National Cancer Database was used to identify clinical stage I pancreatic adenocarcinoma. Read More

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A National Assessment of Optimal Oncologic Surgery for Distal Pancreatic Adenocarcinomas.

Pancreas 2021 Mar;50(3):386-392

From the Division of Surgical Oncology, Department of Surgery, University of Pittsburgh Medical Center Cancer Pavilion, Pittsburgh, PA.

Objectives: The objective of this study was to create a composite measure, optimal oncologic surgery (OOS), for patients undergoing distal pancreatectomy for pancreatic adenocarcinoma and identify factors associated with OOS.

Methods: Adult patients undergoing distal pancreatectomy were identified from the National Cancer Database between 2010 and 2016. Patients were stratified based on receipt of OOS. Read More

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Toxicological Response of Chironomus dilutus in Single Chemical and Binary Mixture Exposure Experiments with Six Perfluoralkyl Substances.

Environ Toxicol Chem 2021 Apr 9. Epub 2021 Apr 9.

Towson University, Towson, Maryland, USA.

Few studies have determined the toxicity of perfluoralkyl substances to aquatic invertebrates. Here, we exposed Chironomus dilutus to six different perfluoroalkyl substances (PFAS) to assess single chemical toxicity and relative or proportional toxicity among substances. A 10 d range finding test was conducted to inform 20 d assays for the following PFAS: (perfluorooctane sulfonate [PFOS], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], perfluorobutanesulfonic acid [PFBS], perfluorohexanesulfonic acid [PFHxS], and perfluoroheptanoic acid [PFHpA]). Read More

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Lu-DOTATATE in older patients with metastatic neuroendocrine tumours: safety, efficacy and health-related quality of life.

Eur J Nucl Med Mol Imaging 2021 Apr 9. Epub 2021 Apr 9.

Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Royal Free Hospital, London, NW3 2QG, UK.

Purpose: The safety and efficacy of Lu-DOTATATE in older patients with advanced neuroendocrine tumours (NET) are not well understood.

Methods: Patients ≥70 years of age and treated with Lu-DOTATATE were included. Toxicity, health-related quality of life (HRQoL), objective response, progression-free survival (PFS) and overall survival (OS) were assessed. Read More

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Differential white blood cell counts in rabbits: a comparison of the Advia 2120 and a manual method.

J Vet Diagn Invest 2021 Apr 9:10406387211007877. Epub 2021 Apr 9.

Easter Bush Pathology, Royal (Dick) School of Veterinary Studies and The Roslin Institute, University of Edinburgh, Roslin, UK.

We evaluated the performance of the Advia 2120 (Siemens) differential leukocyte count (A-Diff) compared to the manual method (M-Diff) in rabbits. EDTA-anticoagulated blood samples collected for diagnostic purposes were analyzed within 6 h of collection. The M-Diff was performed blindly by 2 observers on blood smears by counting 200 cells. Read More

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Nutritional status and its determinants among community-dwelling older adults in Jordan.

Nurs Forum 2021 Apr 8. Epub 2021 Apr 8.

Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: The elderly population of Jordan is growing, due to the low mortality rate, high total fertility rate, and the high rate of forced migration from neighboring countries to Jordan in recent years. However, the prevalence of chronic illnesses associated with other comorbidities among the elderly population in Jordan is high. Maintaining a good nutritional status is essential for maintaining general health and well-being among older people. Read More

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Health literacy and health outcomes in China's floating population: mediating effects of health service.

BMC Public Health 2021 Apr 8;21(1):691. Epub 2021 Apr 8.

Shaoxing College of Arts and Sciences, 508 Huancheng West Road, Shaoxing, China.

Background: The floating population in China consists primarily of internal immigrants and represents a typical health vulnerable group. Poor health literacy has recently become an obstacle in the accessibility and utilization of health services for the vulnerable population, leading to adverse health outcomes. This study aimed to examine whether health literacy affected health outcomes in China's floating population and whether health service utilization had a mediating effect between health literacy and health outcomes. Read More

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Dapagliflozin and Recurrent Heart Failure Hospitalizations in Heart Failure with Reduced Ejection Fraction: An Analysis of DAPA-HF.

Circulation 2021 Apr 9. Epub 2021 Apr 9.

BHF Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom.

Patients with heart failure and reduced ejection fraction (HFrEF) will experience multiple hospitalizations for heart failure during the course of their disease. We assessed the efficacy of dapagliflozin on reducing the rate of total (i.e. Read More

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Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism.

Atherosclerosis 2021 Mar 29;324:84-90. Epub 2021 Mar 29.

Clinical Research Institute of Endocrinology and Metabolism, Kyoto Medical Center, National Hospital Organization, Endocrine Center, Ijinkai Takeda General Hospital, Kyoto, Japan.

Background And Aims: We used a dataset from a Japanese nationwide registry of patients with primary aldosteronism, to determine which of the parameters of hyperaldosteronism and blood pressure before or after treatments for primary aldosteronism (i.e., surgical adrenalectomy or a medication treatment) are important in terms of cardiovascular prognosis. Read More

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Serum 25-hydroxyvitamin D, cardiovascular risk markers, and incident cardiovascular disease in a high risk community population.

Clin Biochem 2021 Apr 5. Epub 2021 Apr 5.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, Health Sciences Centre, Foothills Campus, University of Calgary, 3030 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada; Alberta Precision Laboratories, Diagnostic and Scientific Research Centre, #9 3535 Research Way NW, Calgary, AB, T2L 2K8, Canada; Department of Cardiac Sciences, Cumming School of Medicine, Health Sciences Centre, Foothills Campus, University of Calgary, 3030 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada. Electronic address:

Background: It is unclear whether vitamin D status is related to cardiovascular risk beyond that explained by conventional risk markers. We examined the relationship between serum 25-hydroxy (OH) vitamin D and incident cardiovascular disease (CVD; heart attack/stroke) after adjusting for individual- and community-level covariates from laboratory and administrative data.

Methods: Patients receiving their first 25-OH vitamin D test in Calgary, Alberta from 2009-2013 without a past CVD diagnosis but an electrocardiogram and body mass index (BMI) +/- 3 months from testing were included. Read More

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Mid- to Late- Life Body Mass Index and Dementia Risk: 38 Years of Follow-up of the Framingham Study.

Am J Epidemiol 2021 Apr 8. Epub 2021 Apr 8.

Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.

Growing evidence relates Body Mass index (BMI) to poorer health outcomes; however, results across studies associating BMI and dementia are conflicting. A total of 3632 Framingham Offspring participants aged 20 to 60 years at their second health exam (1979-1982) were included in this study with 190 cases of incident dementia identified by 2017. Cox proportional hazards regression models were performed to investigate the association of BMI at each of their 8 exams as a baseline for dementia risk, and the associations between obesity and dementia across age groups. Read More

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Lead aVR predicts early revascularization but not long-term events in patients referred for stress electrocardiography.

PLoS One 2021 8;16(4):e0249779. Epub 2021 Apr 8.

Division of Cardiovascular Medicine, Department of Medicine, The Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, VA, United States of America.

Background: Exercise stress electrocardiography (ExECG) is recommended as a first-line tool to assess ischemia, but standard ST-analysis has limited diagnostic accuracy. ST elevation in lead aVR has been associated with left main and LAD disease in the population undergoing coronary angiography but has not been studied in the general population undergoing stress testing for the initial evaluation of CAD without coronary angiography. We sought to determine the predictive value of lead aVR elevation for ischemia, early revascularization, and subsequent cardiac events in consecutive patients undergoing ExECG. Read More

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Association of Treatment Intensity and Adherence to Lipid-Lowering Therapy with Major Adverse Cardiovascular Events Among Post-MI Patients in Germany.

Adv Ther 2021 Apr 8. Epub 2021 Apr 8.

Amgen (Europe) GmbH, Rotkreuz, Switzerland.

Introduction: Patients with a history of myocardial infarction (MI) are at very high risk of subsequent cardiovascular events. This study evaluated the association of treatment intensity and adherence to lipid-lowering therapies (LLT) with major adverse cardiovascular events (MACE) among post-MI patients in Germany.

Methods: We carried out a retrospective cohort study using German health claims data (2010-2015). Read More

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Metastatic relapse of stage I-III breast cancer in New Zealand.

Cancer Causes Control 2021 Apr 8. Epub 2021 Apr 8.

Medical Research Centre, The University of Waikato, Private Bag 3105, Hamilton, 3240, New Zealand.

Purpose: This study aims to investigate the factors that influence the risk of metastatic relapse in women presenting with stage I-III breast cancer in New Zealand.

Methods: The study included women diagnosed with stage I-III breast cancer. Cumulative incidence of distant metastatic relapse was examined with the Kaplan-Meier method by cancer stage and subtype. Read More

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Subjective age from childhood to advanced old age: A meta-analysis.

Psychol Aging 2021 Apr 8. Epub 2021 Apr 8.

Department of Psychology, University of Heidelberg.

The present meta-analysis analyzed how the gap between subjective age and chronological age changes across the life-span and whether the size of this gap varies across regions of the globe. In addition, we tested for sources of the national differences. A systematic search in electronic databases (PsycInfo, Medline, Google Scholar, PSYNDEX) and cross-referencing identified 294 studies (with mean age ranging from 8 to 105 years) that were included in random-effects meta-analyses. Read More

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Factors associated with time to first analgesic medication in the emergency department.

J Clin Nurs 2021 Apr 7. Epub 2021 Apr 7.

School of Nursing, Queensland University of Technology, Victoria Park Rd, Kelvin Grove, Brisbane, Qld., Australia.

Aim And Objective: To examine the factors associated with time to first analgesic medication in the emergency department.

Background: Pain is the most common symptom presenting to the emergency department, and the time taken to deliver analgesic medication is a common outcome measure. Factors associated with time to first analgesic medication are likely to be multifaceted, but currently poorly described. Read More

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Effects of aligning prisms on the objective and subjective fixation disparity in far distance.

J Eye Mov Res 2019 Dec 11;12(4). Epub 2019 Dec 11.

Hagen, Germany.

Fixation disparity (FD) refers to a suboptimal condition of binocular vision. The oculomotor aspect of FD refers to a misadjustment in the vergence angle between the two visual axes that is measured in research with eye trackers (objective fixation disparity, oFD). The sensory aspect is psychophysically tested using dichoptic nonius lines (subjective fixation disparity, sFD). Read More

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December 2019

Reproductive factors and lung cancer risk among never-smoking Japanese women with 21 years of follow-up: a cohort study.

Cancer Epidemiol Biomarkers Prev 2021 Apr 7. Epub 2021 Apr 7.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Centre.

Background: Previous studies have reported inconsistent associations between reproductive factors and lung cancer.

Methods: We used data from the Japan Public Health Center-based Prospective Study, which included 400 incident lung cancer cases among 42,615 never-smoking women followed for a median of 21 years, to examine the associations of reproductive and hormonal factors with lung cancer by histological type using Cox proportional hazards models.

Results: Longer fertility span ({greater than or equal to}36 years vs. Read More

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Association of foveal avascular zone area withstructural and functional progression in glaucoma patients.

Br J Ophthalmol 2021 Apr 7. Epub 2021 Apr 7.

Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla, California, USA.

Background: To investigate whether quantitative optical coherence tomography angiography (OCTA) metrics of the superficial/deep macular retina and optic disc are associated with glaucoma progression risk.

Methods: A total of 238 eyes from 119 patients with open angle glaucoma or ocular hypertension, and no history of systemic hypertension or diabetes mellitus were included. All participants underwent OCTA imaging with a swept-source OCT (DRI-OCT 1, Topcon, Japan). Read More

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The Efficacy of Etoposide-Based Therapy in Adult Secondary Hemophagocytic Lymphohistiocytosis.

Acta Haematol 2021 Apr 7:1-9. Epub 2021 Apr 7.

Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, New York, USA.

Data supporting the use of etoposide-based therapy in hemophagocytic lymphohistiocytosis (HLH) arise largely from pediatric studies. There is a lack of comparable data among adult patients with secondary HLH. We conducted a retrospective study to assess the impact of etoposide-based therapy on outcomes in adult secondary HLH. Read More

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The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients.

Blood Purif 2021 Apr 7:1-7. Epub 2021 Apr 7.

Department of Nephrology, Demiroglu Bilim University Faculty of Medicine, Istanbul, Turkey.

Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study.

Methods: A total of 173 prevalent hemodialysis patients were included in this study. Read More

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Outcomes Following a Mandatory Nonmedical Switch From Adalimumab Originator to Adalimumab Biosimilars in Patients With Psoriasis.

JAMA Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.

Importance: The efficacy of adalimumab biosimilars is similar to that of brand-name adalimumab (Humira, hereinafter originator) in clinical trials. However, limited knowledge about real-world data exists for adalimumab biosimilars.

Objective: To assess the outcomes following a mandatory nonmedical switch from adalimumab originator to adalimumab biosimilars in patients with psoriasis. Read More

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Investigation of neonatal disorders in New World camelids and factors associated with death during and after hospitalization of affected crias.

J Am Vet Med Assoc 2021 Apr;258(8):892-898

Objective: To assess signalment, clinical findings, and treatments for New World camelids (NWCs) hospitalized for evaluation and treatment of neonatal disorders and investigate associations between these factors and death during and after hospitalization.

Animals: 267 NWCs ≤ 30 days of age.

Procedures: Medical records of a veterinary teaching hospital were retrospectively reviewed to identify NWCs admitted for evaluation and treatment of neonatal disorders between 2000 and 2010. Read More

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Quantitative Analysis of Adipose Depots by Using Chest CT and Associations with All-Cause Mortality in Chronic Obstructive Pulmonary Disease: Longitudinal Analysis from MESArthritis Ancillary Study.

Radiology 2021 Apr 6:203959. Epub 2021 Apr 6.

From the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N Caroline St, JHOC 3171c, Baltimore, MD 21287 (F.P., S.D.); Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (M.S., T.Q.A.C.S., W.S.P., J.A.C.L.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Lundquist Institute at Harbor-University of California Los Angeles School of Medicine, Torrance, Calif (M.B.); Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY (R.G.B.); and Division of Preventive Medicine, Department of Family Medicine and Public Health, University of Calif San Diego, La Jolla, Calif (M.A.A.).

Background Obesity and sarcopenia are associated with mortality in chronic obstructive pulmonary disease (COPD). Routine chest CT examinations may allow assessment of obesity and sarcopenia by soft-tissue markers for predicting risks of mortality. Purpose To investigate associations between soft-tissue markers subcutaneous adipose tissue (SAT), intermuscular adipose tissue (IMAT), and pectoralis muscle (PM) index from chest CT with mortality in participants with COPD. Read More

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Incorporation of Urinary Neutrophil Gelatinase-Associated Lipocalin and Computed Tomography Quantification to Predict Acute Kidney Injury and In-Hospital Death in COVID-19 Patients.

Kidney Dis (Basel) 2021 Mar 15;7(2):120-130. Epub 2020 Sep 15.

Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: The prevalence of acute kidney injury (AKI) in COVID-19 patients is high, with poor prognosis. Early identification of COVID-19 patients who are at risk for AKI and may develop critical illness and death is of great importance.

Objective: The aim of this study was to develop and validate a prognostic model of AKI and in-hospital death in patients with COVID-19, incorporating the new tubular injury biomarker urinary neutrophil gelatinase-associated lipocalin (u-NGAL) and artificial intelligence (AI)-based chest computed tomography (CT) analysis. Read More

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Clinical prediction tools to identify patients at highest risk of myeloma in primary care: a retrospective open cohort study.

Br J Gen Pract 2021 Apr 6. Epub 2021 Apr 6.

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.

Background: Patients with myeloma experience substantial delays in their diagnosis, which can adversely affect their prognosis.

Aim: To generate a clinical prediction rule to identify primary care patients who are at highest risk of myeloma.

Design And Setting: Retrospective open cohort study using electronic health records data from the UK's Clinical Practice Research Datalink (CPRD) between 1 January 2000 and 1 January 2014. Read More

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Atherosclerotic cardiovascular disease events among statin eligible individuals with and without long-term healthy arterial aging.

Atherosclerosis 2021 Mar 26. Epub 2021 Mar 26.

The Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

Background And Aims: A large proportion of statin eligible candidates have a baseline absence of coronary artery calcium (CAC) and low 10-year atherosclerotic cardiovascular disease (ASCVD) risk. We sought to determine the proportion of statin eligible individuals who had long-term healthy arterial aging (persistent CAC = 0) and their examined 15-year ASCVD outcomes.

Methods: We included 561 statin eligible candidates from the Multi-Ethnic Study of Atherosclerosis who were not on statin therapy with CAC = 0 at Visit 1 (2000-02) and underwent a subsequent CAC scan at Visit 5 (2010-11). Read More

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Falls in ED patients: do elderly patients on direct oral anticoagulants bleed less than those on vitamin K antagonists?

Scand J Trauma Resusc Emerg Med 2021 Apr 6;29(1):56. Epub 2021 Apr 6.

Department of Emergency Medicine, Inselspital, Bern University Hospital, Bern University, Bern, Switzerland.

Background: Falls from standing are common in the elderly and are associated with a significant risk of bleeding. We have compared the proportional incidence of bleeding complications in patients on either direct oral anticoagulants (DOAC) or vitamin K antagonists (VKA).

Methods: Our retrospective cohort study compared elderly patients (≥65 years) on DOAC or VKA oral anticoagulation who presented at the study site - a Swiss university emergency department (ED) - between 01. Read More

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Recurrence of knee flexion contracture after surgical correction in children with cerebral palsy.

Int Orthop 2021 Apr 6. Epub 2021 Apr 6.

Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Purpose: Knee flexion contracture (FC) and crouch gait are challenging to treat in children with cerebral palsy (CCP), and recurrent knee FC after surgery is a severe complication. The aim was to identify factors associated with recurrent knee FC after surgery.

Methods: The records of 62 CCP (age 10. Read More

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Association of oral contraceptives and tubal ligation with risk of early natural menopause.

Hum Reprod 2021 Apr 2. Epub 2021 Apr 2.

Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003, USA.

Study Question: What is the association of oral contraceptives (OCs) and tubal ligation (TL) with early natural menopause?

Summary Answer: We did not observe an association of OC use with risk of early natural menopause; however, TL was associated with a modestly higher risk.

What Is Known Already: OCs manipulate hormone levels, prevent ovulation, and may modify the rate of follicular atresia, while TL may disrupt the blood supply to the ovaries. These mechanisms may be associated with risk of early menopause, a condition associated with increased risk of cardiovascular disease and other adverse health outcomes. Read More

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