359 results match your criteria included lymphoplasmacytic

Demodectic mange in threatened southern sea otters (Enhydra lutris nereis).

Vet Dermatol 2021 Mar 19. Epub 2021 Mar 19.

Marine Wildlife Veterinary Care and Research Center, California Department of Fish and Wildlife, 151 McAllister Way, Santa Cruz, CA, 95060, USA.

Background: Southern sea otters (Enhydra lutris nereis) rely on intact pelage for thermoregulation, and thus clinically significant demodicosis and associated alopecia can cause morbidity and death.

Hypothesis/objectives: This study aimed to describe lesions associated with follicular Demodex sp. infestation, estimate the prevalence and intensity of infestation, describe mite distribution across key anatomical regions, and assess mite presence or absence in relation to lesions and host risk factors. Read More

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New developments in non-Hodgkin lymphoid malignancies.

Pathology 2021 Apr 5;53(3):349-366. Epub 2021 Mar 5.

Department of Laboratory Medicine, University of California San Francisco, CA, USA. Electronic address:

The revised fourth edition of the World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissues (2017) reflects significant advances in understanding the biology, genetic basis and behaviour of haematopoietic neoplasms. This review focuses on some of the major changes in B-cell and T-cell non-Hodgkin lymphomas in the 2017 WHO and includes more recent updates. The 2017 WHO saw a shift towards conservatism in the classification of precursor lesions of small B-cell lymphomas such as monoclonal B-cell lymphocytosis, in situ follicular and in situ mantle cell neoplasms. Read More

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Clinical characteristics and histology of cholecystectomised dogs with nongravity-dependent biliary sludge: 16 cases (2014-2019).

J Small Anim Pract 2021 Feb 24. Epub 2021 Feb 24.

Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK.

Objectives: To report the available histology, biochemistry and clinical progression of dogs without classic overt biliary tract signs that underwent cholecystectomy for nongravity-dependent biliary sludge.

Materials And Methods: Case series of client-owned dogs for which a cholecystectomy was performed for nongravity-dependent biliary sludge. In six dogs, for which nongravity-dependent biliary sludge filled less than half of gall bladder volume, gall bladder ejection fractions were measured. Read More

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February 2021

Histopathological findings in the landscape of IgG4-related pathology in patients with pituitary dysfunction: Review of six cases.

J Neuroendocrinol 2021 Mar 21;33(3):e12942. Epub 2021 Feb 21.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

IgG4-related hypophysitis (IgG4-RH) is increasingly being reported as an isolated entity or, less frequently, as a manifestation of a multiorgan IgG4-related disease (IgG4-RD), in which typical histopathology is a cornerstone for the diagnosis. We aimed to describe the histopathological changes in the surgical specimens from patients with clinical signs of pituitary disease that fulfilled the current diagnostic criteria for IgG4-RH. Histopathological features were correlated with clinical and radiological findings. Read More

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Evaluation and Pathologic Classification of Choledochal Cysts: Clinicopathologic Analysis of 84 Cases From the West.

Am J Surg Pathol 2021 May;45(5):627-637

Departments of Pathology.

Choledochal cyst (CC) is believed to be a mostly Asian disorder. As a clinically defined entity, its pathologic correlates are poorly characterized. Eighty-four resected CCs from the West were reanalyzed. Read More

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Lesions associated with -like bacterium infection in a free-ranging, young-of-the-year raccoon from Prince Edward Island, Canada.

J Vet Diagn Invest 2021 Mar 19;33(2):362-365. Epub 2021 Jan 19.

Southeastern Cooperative Wildlife Disease Study and Warnell School of Forestry and Natural Resources, The University of Georgia, Athens, GA.

A young-of-the year, female raccoon was presented with clinical signs of weakness and tremors. The raccoon was euthanized, and autopsy findings included poor body condition, diffuse lymphadenopathy, and pale, firm kidneys with petechial hemorrhages throughout the renal cortex. Histologic lesions included systemic fibrinoid vascular necrosis and severe renal lesions, including lymphoplasmacytic interstitial nephritis and fibrinosuppurative glomerulonephritis. Read More

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Infectious Bronchitis Virus Prevalence, Characterization and Strain Identification in California Backyard Chickens.

Avian Dis 2021 Jan 5. Epub 2021 Jan 5.

California Animal Health and Food Safety, Davis Lab, UC Davis.

Infectious bronchitis virus (IBV) causes significant losses in the poultry industry throughout the world. Here we characterize the lesions of infectious bronchitis (IB), IBV prevalence and identify the circulating strains in small flocks in California. Backyard chickens (BYCs) submitted to the Davis (Northern California; NorCal) and San Bernardino (Southern California; SoCal) branches of the California Animal Health and Food Safety Laboratory System from January through March 2019 were included in the study. Read More

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January 2021

Distinct clinicopathological features of pulmonary primary angiomatoid fibrous histiocytoma: A report of four new cases and review of the literature.

Thorac Cancer 2021 02 12;12(3):314-323. Epub 2020 Dec 12.

Department of Pathology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Background: The aim of this study was to highlight the clinicopathological features of pulmonary primary angiomatoid fibrous histiocytoma (PPAFH) to assist with a differential diagnosis.

Methods: There were 10 previous reports in the literature and four new PPAFH cases reviewed in this study. Immunohistochemistry (IHC), fluorescence in situ hybridization (FISH) and DNA and RNA-based next-generation sequencing (NGS) was performed in the four new cases reported here. Read More

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February 2021

New Clinicopathologic Scenarios of EBV+ Inflammatory Follicular Dendritic Cell Sarcoma: Report of 9 Extrahepatosplenic Cases.

Am J Surg Pathol 2020 Dec 1. Epub 2020 Dec 1.

Department of Pathology, Fudan University Shanghai Cancer Center.

EBV inflammatory follicular dendritic cell (FDC) sarcoma is an indolent malignant neoplasm of spindled FDCs with a rich lymphoplasmacytic infiltrate and a consistent association with Epstein-Barr virus (EBV). It occurs exclusively in the liver and spleen, with the exception of a few colonic examples. In this study, we report 9 extrahepatosplenic cases, including 4 occurring in previously undescribed sites, but all apparently anatomically related to the aerodigestive tract. Read More

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December 2020

Congenital erythropoietic protoporphyria and protoporphyric hepatopathy in a dog.

J Am Vet Med Assoc 2020 Dec;257(11):1148-1156

Case Description: A 6-month-old sexually intact male Clumber Spaniel was evaluated because of small stature, recurrent dermatitis of the head, and progressive pigmentary hepatopathy.

Clinical Findings: Clinicopathologic findings included nonanemic hypochromic microcytosis, hypocholesterolemia, persistently high serum liver enzyme activities, and anicteric hyperbilirubinemia. Histologic examination of liver biopsy specimens collected when the dog was 6 months and 2 years of age revealed expansion and bridging of portal tracts, occasional centrilobular parenchymal collapse, scattered lymphoplasmacytic infiltrates, and dark red to brown pigment within large aggregates of macrophages, engorged bile canaliculi, and hepatocytes. Read More

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December 2020

Uraemic Encephalopathy in a Persian Cat with Chronic Kidney Disease.

J Comp Pathol 2020 Oct 10;180:100-104. Epub 2020 Oct 10.

Laboratory of Veterinary Pathology, College of Veterinary Medicine, University of Brasília, Brazil. Electronic address:

Uraemic encephalopathy (UE) is rarely associated with acute kidney injury or chronic kidney disease in domestic animals, and we now report the first case in a cat. The animal presented with hypothermia, apathy, lethargy, depression, severe dehydration, uraemic breath, elevated serum urea nitrogen and creatine concentrations, and eventual seizures and coma prior to death. Gross necropsy findings included severe bilateral renal scarring, ulcerative stomatitis and glossitis, and uraemic gastropathy. Read More

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October 2020

Frequency of MYD88 L256P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasm.

Hematol Oncol Stem Cell Ther 2020 Nov 13. Epub 2020 Nov 13.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objective/background: B-cell neoplasms are clonal tumors of B cells at various stages of maturation, including diffuse large B-cell lymphoma (DLBCL), chronic lymphocytic lymphoma (CLL), Burkitt lymphoma (BL), lymphoplasmacytic lymphoma (LPL)/Waldenström's macroglobulinemia (WM), splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), mantle cell lymphoma (MCL), follicular lymphoma (FL), and hairy cell leukemia (HCL). In this study, we analyzed the frequency of MYD88 L265P mutation and its correlation with clinico-hematological profile in mature B-cell neoplasms.

Methods: A total of 110 consecutive cases of B-cell neoplasms showing peripheral blood and/or bone marrow infiltration were included. Read More

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November 2020

Pulmonary nodules in patients with primary Sjögren's syndrome: Causes, clinico-radiologic features, and outcomes.

Respir Med 2020 Nov - Dec;174:106200. Epub 2020 Oct 22.

Division of Pulmonary and Critical Care, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address:

Background: Primary Sjögren's Syndrome (pSS) is characterized by an immune-mediated lymphoplasmacytic infiltration of the salivary and lacrimal glands. Pulmonary nodules are not uncommonly encountered in these patients.

Methods: We conducted a retrospective computer-assisted search for patients with pSS who were encountered at our institution between 1999 and 2018 and had histologically characterized pulmonary nodule(s)/mass (es) (PNs). Read More

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October 2020

Treatment facility volume and patient outcomes in Waldenstrom macroglobulinemia.

Leuk Lymphoma 2021 02 15;62(2):308-315. Epub 2020 Oct 15.

Division of Hematology, Mayo Clinic, Rochester, MN, USA.

Waldenstrom macroglobulinemia (WM) has an annual incidence of 3-3.2 cases per million-person/year. National Cancer Data Base was used to identify newly diagnosed WM cases requiring initiation of therapy and their annual facility volume was used to divide the treatment facilities into four quartiles (Qs). Read More

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February 2021

Naturally Acquired Mouse Kidney Parvovirus Infection Produces a Persistent Interstitial Nephritis in Immunocompetent Laboratory Mice.

Vet Pathol 2020 11 5;57(6):915-925. Epub 2020 Oct 5.

Laboratory Animal Sciences Program, 437329Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.

Mouse kidney parvovirus (MKPV), also known as murine chapparvovirus (MuCPV), is an emerging, highly infectious agent that has been isolated from laboratory and wild mouse populations. In immunocompromised mice, MKPV produces severe chronic interstitial nephropathy and renal failure within 4 to 5 months of infection. However, the course of disease, severity of histologic lesions, and viral shedding are uncertain for immunocompetent mice. Read More

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November 2020

Inflammatory myofibroblastic tumors associated with the placenta: a series of 9 cases.

Hum Pathol 2020 12 21;106:62-73. Epub 2020 Sep 21.

Massachusetts General Hospital, Department of Pathology, Boston, MGH 02114 MA, USA. Electronic address:

Inflammatory myofibroblastic tumors (IMTs) of the uterus are often associated with pregnancy and are delivered with the placenta. We describe the clinical, pathologic, and molecular findings in nine cases of placenta-associated IMT (PaIMT). All the lesions were incidentally discovered at delivery or on placental pathological examination. Read More

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December 2020

Pathologic findings and causes of death in bottlenose dolphins Tursiops truncatus stranded along the Georgia coast, USA (2007-2013).

Dis Aquat Organ 2020 Sep 17;141:25-38. Epub 2020 Sep 17.

Department of Pathology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602, USA.

Between 2007 and 2013, before the 2013 cetacean morbillivirus outbreak, 26 fresh bottlenose dolphin carcasses were necropsied on the coast of Georgia, USA. Here, we present the pathological and microbiological findings associated with their most likely causes of death. The primary cause of death was determined in 25 individuals and included systemic bacterial infection (n = 7), verminous and bacterial bronchopneumonia (n = 5), drowning/entanglement (n = 5), disseminated histoplasmosis (n = 1), intestinal intussusception (n = 1), vegetative endocarditis (n = 1), meningitis (n = 1), necrotizing dermatitis (n = 1), disseminated angiomatosis (n = 1), emaciation (n = 1) and stingray spine trauma (n = 1). Read More

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September 2020

[Primary intraosseous Rosai-Dorfman disease: a clinicopathological analysis of fourteen cases].

Zhonghua Bing Li Xue Za Zhi 2020 Sep;49(9):904-909

Department of Pathology, Beijing Jishuitan Hospital, Beijing 100035, China.

To investigate the clinicopathological characteristics, histogenesis, immunophenotypes and molecular genetic features of primary intraosseous Rosai-Dorfman disease (RDD) for improving diagnostic accuracy and differential diagnosis. This retrospective study included 14 RDD cases diagnosed from January 2009 to January 2019 at Beijing Jishuitan Hospital, China. The immunohistochemical staining for S-100, cyclin D1, CD1a and CD207 expression was analyzed. Read More

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September 2020

Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates.

J Cutan Pathol 2020 Nov 14;47(11):1103-1110. Epub 2020 Sep 14.

Department of Pathology, Oakland University William Beaumont School of Medicine and Beaumont Health Systems, Royal Oak, Michigan, USA.

Background: Atypical cutaneous lymphoid infiltrates are challenging lesions in dermatopathology. We present a summary of the literature regarding kappa and lambda immunohistochemistry (IHC) and in situ hybridization (ISH) in the evaluation of atypical cutaneous or mucosal lymphoid infiltrates.

Methods: Relevant articles from 1967 to 2018 in the English language were identified and summarized. Read More

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November 2020

Histopathological, serological, molecular and electron microscopy detection of Maedi-Visna infection in sheep population in the West of Iran.

Iran J Vet Res 2020 ;21(2):103-108

Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Background: Maedi-Visna (MV) is a progressive lymphoproliferative viral disease that affects multiple organs of small ruminants, including sheep and goats. The disease occurs primarily in the lung tissue and causes interstitial pneumonia.

Aims: The aim of present study was to investigate the prevalence of ovine MV infection in Iranian sheep population through macroscopic, histopathological, serological, and molecular assays, as well as transmission electron microscopy (TEM). Read More

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January 2020

Histochemical and Immunohistochemical Characterizations of Hepatic Trematodiasis in Odontocetes.

Front Vet Sci 2020 30;7:336. Epub 2020 Jun 30.

Laboratory of Veterinary Pathology, Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan.

Hepatic trematodiasis is a common condition in a number of free-ranging cetacean species, which occasionally result in severe hepatic and/or pancreatic lesions. However, even the basic pathological information of this disease is unknown for the majority of affected species. The current study describes and compares the histomorphology and immune reaction induced by hepatic trematodes of the family Brachycladiidae in the liver of the harbor porpoise ( = 8), Dall's porpoise ( = 8), and Hubbs' beaked whale ( = 2). Read More

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J Wildl Dis 2020 10;56(4):873-883

US Geological Survey, National Wildlife Health Center, 6006 Schroeder Road, Madison, Wisconsin 53711, USA.

Before 2001, all serosurveys for morbilliviruses in sea otters (Enhydra lutris) in California, Washington, and Alaska, US, documented a 0% seroprevalence. The first published serologic detections of morbillivirus in sea otters occurred in 2001-02 in live-captured Washington sea otters, with a documented 80% seroprevalence. We conducted a retrospective study of sea otter cases from 1989 to 2010 compiled at the US Geological Survey, National Wildlife Health Center to identify cases of morbilliviral disease in Washington sea otters and to characterize the disease using immunohistochemistry, reverse transcription (RT)-PCR, genetic sequencing, virus isolation, and serology. Read More

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October 2020

Immunomorphological Features of the Placenta in Allogeneic Pregnancy as the Background for the Development of Obstetric Complications.

Pathobiology 2020 20;87(4):232-243. Epub 2020 May 20.

I.M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russian Federation.

Objective: To study the structural and immunohistochemical features of placentas in women after assisted reproductive technology (ART) with allogeneic eggs (oocyte donation and surrogate motherhood).

Study Design: The study involved 89 women whose pregnancy occurred as a result of in vitro fertilization (IVF) with a donor egg in a surrogate motherhood program (IVF-SM, n = 47 patients) or oocyte donation (IVF-DO, n = 42). The comparison group consisted of 21 patients in whom pregnancy occurred as a result of IVF with their own egg (IVF-OE). Read More

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Gastrointestinal manifestations in Satoyoshi syndrome: a systematic review.

Orphanet J Rare Dis 2020 05 19;15(1):115. Epub 2020 May 19.

Department of Internal Medicine, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.

Background: Satoyoshi syndrome (SS) [OMIM 600705; ORFHA 3130] is a multisystemic disease with a probable autoimmune basis, whose main symptoms are muscle spasms, alopecia, diarrhea and skeletal alterations. Chronic diarrhea may be severe and result in malnutrition, anemia, growth retardation, cachexia, disability and even death. However, to date, no review of the digestive symptoms has been carried out. Read More

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Occurrence of lymphoplasmacytic lymphoma in a chronic myeloid leukemia patient following long-term treatment with tyrosine kinase inhibitors: A case report.

Medicine (Baltimore) 2020 May;99(19):e19962

Department of Internal Medicine.

Introduction: After tyrosine kinase inhibitors (TKIs) targeting BCR-ABL1 were introduced for the treatment of chronic myeloid leukemia, clinical outcomes have improved dramatically. However, together with the increase in the survival rate, a more frequent occurrence of secondary malignancies has been observed as well. TKIs have been demonstrated to be a risk factor of malignancies such as non-Hodgkin lymphoma, prostate cancer, and skin cancer. Read More

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Non-necrotizing granulomatous pneumonitis and chronic pleuritis in soldiers deployed to Southwest Asia.

Histopathology 2020 Sep 2;77(3):453-459. Epub 2020 Jul 2.

Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Aims: Reports of respiratory illnesses among soldiers returning from Southwest Asia have been described. During deployment to Southwest Asia, soldiers are exposed to various respiratory hazards, including dust storms, smoke from burn pits and industrial air pollutants. A few studies have reported increased rates of constrictive bronchiolitis and asthma in these patients. Read More

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September 2020

Correlation of Arthroscopic and Histologic Findings in Synovial Membrane Disease of the Temporomandibular Joint.

J Oral Maxillofac Surg 2020 Aug 6;78(8):1297-1303. Epub 2020 Apr 6.

Director of Endoscopic Maxillofacial Surgery Fellowship, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA.

Purpose: The purpose of the present study was to correlate specific arthroscopic findings in temporomandibular joint (TMJ) arthroscopy and histologic results from arthroscopic-guided synovial biopsy.

Patients And Methods: A retrospective cohort study was completed of patients who had undergone arthroscopy and arthroscopic synovial biopsy from January 1, 2011 to March 31, 2016 at the senior author's practice in Miami, Florida. The demographic, arthroscopic, histologic, serologic, and historical variables were recorded by electronic medical record review. Read More

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Clinical guidelines for interstitial cystitis/bladder pain syndrome.

Int J Urol 2020 Jul 14;27(7):578-589. Epub 2020 Apr 14.

Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The clinical guidelines for interstitial cystitis and related symptomatic conditions were revised by updating our previous guidelines. The current guidelines define interstitial cystitis/bladder pain syndrome as a condition with chronic pelvic pain, pressure or discomfort perceived to be related to the urinary bladder accompanied by other urinary symptoms, such as persistent urge to void or urinary frequency in the absence of confusable diseases. The characteristic symptom complex is collectively referred as hypersensitive bladder symptoms. Read More

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Prognostic Factors in Patients with Low-Grade Nonhodgkin Lymphoma.

Indian J Hematol Blood Transfus 2020 Jan 6;36(1):78-83. Epub 2019 Aug 6.

2Department of Hematology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Low-grade Nonhodgkin lymphoma (LG-NHL) is characterized by indolent clinical course, which consist of marginal zone lymphoma (MZL), follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma, lymphoplasmacytic lymphoma, waldenstrom macroglobulinemia (WM) as the most common subtypes. Factors affecting prognosis and treatment need in these patients have long been the subject of research. A retrospective study was conducted with patients diagnosed with LG-NHL in Hematology Departments of two centres between 2010 and 2018. Read More

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January 2020

[Pathomorphological features of the placentas and the placental sites after in vitro fertilization with a donor egg].

Arkh Patol 2020 ;82(1):23-29

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia.

Objective: To identify the structural and immunohistochemical features of the placentas and the placental sites after in vitro fertilization (IVF) with a donor egg (surrogate motherhood).

Subject And Methods: Morphological and immunohistochemical studies were performed on the placental (a placental disk) and placental bed materials obtained after caesarean delivery. The investigation enrolled 26 patients whose pregnancy occurred with IVF with a donor egg according to the surrogacy (IVF-S) program. Read More

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February 2020