82,276 results match your criteria included knowledge


An evaluation of StaySafe, a tablet app to improve health risk decision-making among people under community supervision.

J Subst Abuse Treat 2021 May 14;130:108480. Epub 2021 May 14.

Texas Christian University, Institute of Behavioral Research, TCU Box 298740, Fort Worth, TX 76129, USA. Electronic address:

Background: A self-administered tablet app, StaySafe, helps people under community supervision to make better decisions regarding health risk behaviors, especially those linked to HIV, viral hepatitis, and other sexually transmitted infections. The multi-session StaySafe design uses an interactive, analytical schema called WORKIT that guides users through a series of steps, questions, and exercises aimed at promoting critical thinking about health risks associated with substance use and unprotected sex. Repetition of the WORKIT schema is designed to enhance procedural memory that can be rapidly accessed when individuals are faced with making decisions about risky behaviors. Read More

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Childbirth experiences of immigrant women in Chile: Trading human rights and autonomy for dignity and good care.

Midwifery 2021 May 28;101:103047. Epub 2021 May 28.

Department of Women´s and Newborns Health Promotion, School of Midwifery University of Chile, Santiago, Chile. Electronic address:

Background: Childbirth is a transcendent life experience but may also be a moment of great vulnerability, especially when it occurs outside the mother's country of origin.

Objective: To explore the perceptions and experiences of Spanish-speaking immigrant women regarding the healthcare they received during labour and childbirth in Santiago, Chile.

Methods: This qualitative, transcendental phenomenological research was performed at two maternity hospitals using purposive criterion sampling. Read More

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Prepancreatic common hepatic artery arising from superior mesenteric artery: an exceptional but important finding during pancreaticoduodenectomy.

Surg Radiol Anat 2021 Jun 12. Epub 2021 Jun 12.

HPB Unit, Digestive Surgery Department, Nouvel Hopital Civil, University of Strasbourg, 1 Place de l'Hôpital, 67091, Strasbourg, France.

Purpose: The hepato-mesenteric trunk is an extremely rare condition in which the common hepatic artery (CHA) originates from the superior mesenteric artery (SMA). Usually, CHA passes behind the head of the pancreas. A systematic review was performed to provide guidelines for the perioperative management of patients with this anatomical variation who underwent a pancreaticoduodenectomy (PD). Read More

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Isolation and characterization of two highly insecticidal, endophytic strains of Bacillus thuringiensis.

FEMS Microbiol Ecol 2021 Jun 12. Epub 2021 Jun 12.

Departamento de Biotecnología y Bioquímica, Centro de Investigación y de Estudios Avanzados del IPN, 36500 Irapuato, Gto. Mexico.

Recent discovery of endophytic strains of Bacillus thuringiensis significantly improves the knowledge on its ecology. It also may be a new source for the isolation of insecticidal strains. This report shows the characterization of two endophytic, highly insecticidal strains of B. Read More

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Allele frequencies of single nucleotide polymorphisms of clinically important drug-metabolizing enzymes CYP2C9, CYP2C19, and CYP3A4 in a Thai population.

Sci Rep 2021 Jun 11;11(1):12343. Epub 2021 Jun 11.

Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.

Prior knowledge of allele frequencies of cytochrome P450 polymorphisms in a population is crucial for the revision and optimization of existing medication choices and doses. In the current study, the frequency of the CYP2C9*2, CYP2C9*3, CYP2C19*2, CYP2C19*3, CYP2C19*6, CYP2C19*17, and CYP3A4 (rs4646437) alleles in a Thai population across different regions of Thailand was examined. Tests for polymorphisms of CYP2C9 and CYP3A4 were performed using TaqMan SNP genotyping assay and CYP2C19 was performed using two different methods; TaqMan SNP genotyping assay and Luminex x Tag V3. Read More

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Self-reported knowledge of national guidelines for clinical screening for hip dysplasia: a web-based survey of midwives and general practitioners in Denmark.

BJGP Open 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Medicine, Research Unit for General Practice, Denmark, Aalborg University, Aalborg.

Background: The positive predictive value of clinical hip examinations performed by generalist health professionals in screening for developmental dysplasia of the hip (DDH) is low.

Aim: To assess the self-reported recognition of nationally recommended clinical hip examinations in the screening programme for DDH in Denmark among midwives, general practitioners (GPs), and GPs in training.

Design & Setting: A web based open survey study among Danish midwives, GPs and GPs in training METHOD: Respondents were asked to identify which of six written statements of clinical hip examinations were featured in the national Danish guidelines on DDH screening. Read More

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Sodium-Glucose Cotransporter-2 Inhibitors and Risk of Diabetic Ketoacidosis Among Adults With Type 2 Diabetes: A Systematic Review and Meta-Analysis.

Can J Diabetes 2021 Apr 28. Epub 2021 Apr 28.

Department of Medicine, Sinai Health System and the University of Toronto, Toronto, Ontario, Canada; Department of Medicine, General Internal Medicine, University of Toronto, Toronto, Ontario, Canada.

Objectives: The magnitude and precision regarding the risk of diabetic ketoacidosis (DKA) with sodium-glucose cotransporter-2 (SGLT2) inhibitors is unclear. Thus, we examined the risk of DKA with SGLT2 inhibitors in both observational studies and large clinical trials.

Methods: Searches were performed in PubMed, Embase, CENTRAL and Google Scholar (from inception to April 15, 2019) without language restrictions, including conference proceedings and reference lists. Read More

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American Association of Clinical Endocrinology Clinical Practice Guideline: The Use of Advanced Technology in the Management of Persons With Diabetes Mellitus.

Endocr Pract 2021 Jun;27(6):505-537

Unger Primary Care Concierge Medical Group, Rancho Cucamonga, California.

Objective: To provide evidence-based recommendations regarding the use of advanced technology in the management of persons with diabetes mellitus to clinicians, diabetes-care teams, health care professionals, and other stakeholders.

Methods: The American Association of Clinical Endocrinology (AACE) conducted literature searches for relevant articles published from 2012 to 2021. A task force of medical experts developed evidence-based guideline recommendations based on a review of clinical evidence, expertise, and informal consensus, according to established AACE protocol for guideline development. Read More

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Facilitators, barriers and potential solutions to the integration of depression and non-communicable diseases (NCDs) care in Malawi: a qualitative study with service providers.

Int J Ment Health Syst 2021 Jun 11;15(1):59. Epub 2021 Jun 11.

Malawi Ministry of Health, Lilongwe, Malawi.

Background: Integration of depression services into infectious disease care is feasible, acceptable, and effective in sub-Saharan African settings. However, while the region shifts focus to include chronic diseases, additional information is required to integrate depression services into chronic disease settings. We assessed service providers' views on the concept of integrating depression care into non-communicable diseases' (NCD) clinics in Malawi. Read More

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Metabolic adaptation is associated with less weight and fat mass loss in response to low-energy diets.

Nutr Metab (Lond) 2021 Jun 11;18(1):60. Epub 2021 Jun 11.

Department of Nutrition Sciences, University of Alabama At Birmingham, Birmingham, USA.

Background: The practical relevance of metabolic adaptation remains a controversial issue. To the best of our knowledge, no study has properly evaluated the role of metabolic adaptation in modulating weight loss outcomes. Therefore, the aim of this study was to determine the association between metabolic adaptation, at the level of resting metabolic rate (RMR), and weight and fat mass (FM) loss after low-energy diets (LED), after adjusting for dietary adherence and other confounders. Read More

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Self-reported experiences of siblings of children with life-threatening conditions: A scoping review.

J Child Health Care 2021 Jun 11:13674935211026113. Epub 2021 Jun 11.

Lawrence S. Bloomberg Faculty of Nursing, 7938University of Toronto, Toronto, ON, Canada.

Sibling relationships are one of the most long-lasting and influential relationships in a human's life. Living with a child who has a life-threatening condition changes healthy siblings' experience. This scoping review summarized and mapped research examining healthy siblings' experience of living with a child with a life-threatening condition to identify knowledge gaps and provide direction for future research. Read More

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Thiol/disulfide homeostasis in medication-naive children and adolescents with obsessive-compulsive disorder.

J Psychiatr Res 2021 Jun 2;140:159-164. Epub 2021 Jun 2.

Department of Child and Adolescent Psychiatry, Manisa Celal Bayar University, Faculty of Medicine, Manisa, 45030, Turkey. Electronic address:

Obsessive-compulsive disorder (OCD) causes significant psychic distress and affects children's social and academic functioning. Approximately 80% of OCD cases begin in childhood. Earlier onset is associated with more severe OC symptoms, poorer treatment response, and a more unfavorable clinical course. Read More

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Navigating in the dark: Meta-synthesis of subjective experiences of gender dysphoria amongst transgender and gender non-conforming youth.

Soc Sci Med 2021 Jun 2;281:114094. Epub 2021 Jun 2.

University of Oslo, Department of Psychology, Norway. Electronic address:

Objective: We conducted a meta-synthesis of qualitative research on subjective experiences of gender dysphoria (GD) amongst transgender and gender non-conforming (TGNC) youth in order to improve clinical encounters, complement existing knowledge and potentially influence future research.

Methods: We systematically searched for qualitative studies on GD in English, German, Spanish and Scandinavian languages in seven databases. Starting with 2000 articles, we finally included 12 papers in the meta-synthesis, following Noblit and Hare's (1988) seven steps for qualitative meta-synthesis research. Read More

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The effectiveness of smart home technologies to support the health outcomes of community-dwelling older adults living with dementia: A scoping review.

Int J Med Inform 2021 Jun 4;153:104513. Epub 2021 Jun 4.

Menzies Health Institute Queensland, Griffith University, Brisbane, Australia; Australian Aged Care Technologies Collaborative, Griffith University, Brisbane, Australia. Electronic address:

Objectives: To map the current state-of-knowledge about the effectiveness of smart home technologies to support the health outcomes of community-dwelling older adults living with dementia.

Design: A scoping review following the methodological frameworks described by Arksey and O'Malley (2005) and Levac et al. (2010). Read More

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Changes in kinematics, kinetics, and muscle activity in patients with lumbar spinal stenosis during gait: systematic review.

Spine J 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopaedic Surgery, University of Arkansas for Medical Science, Little Rock, AR; Mechanical and Biomedical Engineering Department, College of Engineering, Boise State University, Boise, ID.

Background Context: Lumbar spinal stenosis (LSS) is one of the most common orthopaedic conditions and affects more than half a million people over the age of 65 in the US. Patients with LSS have gait dysfunction and movement deficits due to pain and symptoms caused by compression of the nerve roots within a narrowed spinal canal.

Purpose: The purpose of the current systematic review was to summarize existing literature reporting biomechanical changes in gait function that occur with LSS, and identify knowledge gaps that merit future investigation in this important patient population. Read More

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Locomotion is impacted differently according to the perinatal brain injury model: Meta-analysis of preclinical studies with implications for cerebral palsy.

J Neurosci Methods 2021 Jun 8;360:109250. Epub 2021 Jun 8.

Posgraduate Program in Neuropsychiatry and Behavior Sciences, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Studies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Postgraduate Program in Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Department of Nursing, CAV, Federal University of Pernambuco, Vitória de Santo Antão, Pernambuco, Brazil. Electronic address:

Background: Different approaches to reproduce cerebral palsy (CP) in animals, contribute to the knowledge of the pathophysiological mechanism of this disease and provide a basis for the development of intervention strategies. Locomotion and coordination are the main cause of disability in CP, however, few studies highlight the quantitative differences of CP models, on locomotion parameters, considering the methodologies to cause brain lesions in the perinatal period.

Methods: Studies with cerebral palsy animal models that assess locomotion parameters were systematically retrieved from Medline/PubMed, SCOPUS, LILACS, and Web of Science. Read More

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Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.

J Obstet Gynecol Neonatal Nurs 2021 Jun 8. Epub 2021 Jun 8.

Objective: To critically review and summarize current knowledge regarding the assessment of newborns with neonatal abstinence syndrome (NAS).

Data Sources: We searched the following databases for articles on the assessment of newborns with NAS that were published in English between January 2014 and June 2020: PubMed, CINAHL, and PsycINFO. Keywords and Medical Subject Heading terms used to identify relevant research articles included neonatal abstinence syndrome; Finnegan Scale; eat, sleep, console; epigenetics; genetics; pharmacokinetics; and measurement. Read More

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Effects of air pollution on health: A mapping review of systematic reviews and meta-analyses.

Environ Res 2021 Jun 8:111487. Epub 2021 Jun 8.

Laboratory of Sport and Exercise Psychology (Lape) - College of Health and Sport Science of the Santa Catarina State University (UDESC), Florianópolis, SC, Brazil. Electronic address:

Background: There has been a notable increase in knowledge production on air pollution and human health.

Objective: To analyze the state of the art on the effects of air pollution on human health through a mapping review of existing systematic reviews and meta-analyses (SRs and MAs).

Methods: The systematic mapping review was based on the recommendations for this type of scientific approach in environmental sciences. Read More

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Experiences with implementation of continuous positive airway pressure for neonates and infants in low-resource settings: A scoping review.

PLoS One 2021 11;16(6):e0252718. Epub 2021 Jun 11.

Vayu Global Health Foundation Boston, Boston, Massachusetts, United States of America.

Background: Continuous positive airway pressure (CPAP) is the gold standard of care in providing non-invasive positive pressure support to neonates in respiratory distress in high-resource settings. While safety has been demonstrated in low-resource settings, there is a lack of knowledge on the barriers and facilitators to proper implementation.

Objective: To identify and describe the barriers, facilitators, and priorities for future implementation of CPAP for neonates and infants in low-resource settings. Read More

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High risk of early sub-therapeutic penicillin concentrations after intramuscular benzathine penicillin G injections in Ethiopian children and adults with rheumatic heart disease.

PLoS Negl Trop Dis 2021 Jun 11;15(6):e0009399. Epub 2021 Jun 11.

Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia.

Introduction: Intramuscular benzathine penicillin G (BPG) injections are a cornerstone of secondary prophylaxis to prevent acute rheumatic fever (ARF) and rheumatic heart disease (RHD). Uncertainties regarding inter-ethnic and preparation variability, and target exposure profiles of BPG injection are key knowledge gaps for RHD control.

Methods: To evaluate BPG pharmacokinetics (PK) in patients receiving 4-weekly doses in Ethiopia, we conducted a prospective cohort study of ARF/RHD patients attending cardiology outpatient clinics. Read More

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Organ failure, aetiology and 7-day all-cause mortality among acute adult patients on arrival to an emergency department: a hospital-based cohort study.

Eur J Emerg Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Emergency Medicine, Odense University Hospital, Odense Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus Department of Public Health, University of Southern Denmark Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense Department of Regional Health Research, University of Southern Denmark Department of Emergency Medicine, Hospital of South West Jutland, Esbjerg Institute of Clinical Research, University of Southern Denmark.

Background: Organ failure is both a frequent and dangerous condition among adult patients on arrival to an emergency department (ED). The risk of an unfavourable outcome could depend on the underlying aetiology. Knowledge of the relation between aetiology and prognosis could improve the risk stratification at arrival. Read More

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A modern network approach to revisiting the Positive and Negative Affective Schedule (PANAS) construct validity.

J Clin Psychol 2021 Jun 11. Epub 2021 Jun 11.

Universidad Siglo 21, Cordoba, Argentina.

Introduction: The factor structure of the Positive and Negative Affective Schedule (PANAS) is still a topic of debate. There are several reasons why using Exploratory Graph Analysis (EGA) for scale validation is advantageous and can help understand and resolve conflicting results in the factor analytic literature.

Objective: The main objective of the present study was to advance the knowledge regarding the factor structure underlying the PANAS scores by utilizing the different functionalities of the EGA method. Read More

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WheatQTLdb: a QTL database for wheat.

Mol Genet Genomics 2021 Jun 11. Epub 2021 Jun 11.

Department of Genetics and Plant Breeding, Chaudhary Charan Singh University, Meerut, Uttar Pradesh, 250004, India.

During the last three decades, QTL analysis in wheat has been conducted for a variety of individual traits, so that thousands of QTL along with the linked markers, their genetic positions and contribution to phenotypic variation (PV) for concerned traits are now known. However, no exhaustive database for wheat QTL is currently available at a single platform. Therefore, the present database was prepared which is an exhaustive information resource for wheat QTL data from the published literature till May, 2020. Read More

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Acupuncture treatment for emotional problems in infertile women: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26306

Department of Korean Medicine Obstetrics and Gynecology, Pusan National University Korean Medicine Hospital.

Background: Infertility causes emotional and psychological problems, including anxiety, depression, low self-efficacy, and chronic mental stress in women. These emotional problems can negatively affect fertility treatment. Numerous studies have reported the clinical therapeutic effects of acupuncture on emotional problems; however, the efficacy and safety of acupuncture treatment for emotional problems in infertile women remain unclear. Read More

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Effects of brain-computer interface training on upper limb function recovery in stroke patients: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26254

The People's Hospital of Mancheng District, Baoding, Hebei Province, China.

Background: In recent years, with the development of medical technology and the increase of inter-disciplinary cooperation technology, new methods in the field of artificial intelligence medicine emerge in an endless stream. Brain-computer interface (BCI), as a frontier technology of multidisciplinary integration, has been widely used in various fields. Studies have shown that BCI-assisted training can improve upper limb function in stroke patients, but its effect is still controversial and lacks evidence-based evidence, which requires further exploration and confirmation. Read More

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Appraisal of awareness on medical emergencies and its management among dentists in Bhubaneswar, India.

Rocz Panstw Zakl Hig 2021 ;72(2):193-201

Department of Public Health Dentistry, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.

Background: Medical emergencies can be distressing for any dental professional, whether in a dental practice, hospital or other sites.

Objectives: To assess the knowledge and awareness of dental practitioners towards medical emergencies and its management in Bhubaneswar.

Material And Methods: In this cross-sectional investigation, a self-administered questionnaire which included demographic details and 19 questions regarding knowledge about medical emergencies, was disseminated to a random sample of 183 dentists working in their private dental clinic set up in Bhubaneswar. Read More

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January 2021

Effect of training programmes on nurses' ability to care for subjects with pressure injuries: A meta-analysis.

Int Wound J 2021 Jun 10. Epub 2021 Jun 10.

Department of General Ward, Shaoxing Central Hospital, Shaoxing, China.

We performed a meta-analysis to evaluate the education effects on nurses' ability to care for subjects with pressure injuries. A systematic literature search up to April 2021 was carried out, and 29 studies included 5704 nurses at the start of the study; 3800 of them were experiment or post-training and 3804 were control or per-training. They were reporting relationships between the education effects on nurses' ability to care for subjects with pressure injuries. Read More

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Systematic review: societal cost of illness of inflammatory bowel disease is increasing due to biologics and varies between continents.

Aliment Pharmacol Ther 2021 Jun 11. Epub 2021 Jun 11.

Department of Gastroenterology & Hepatology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.

Background: Knowledge of the cost of illness of inflammatory bowel disease (IBD) is essential for health policy makers worldwide.

Aim: To assess the cost of illness of IBD from the societal perspective taking into account time trends and geographical differences.

Methods: A systematic review of all population-based studies on cost of illness of IBD published in Embase, Medline, Web of Science and Google Scholar. Read More

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The Ties that Stick: Challenges and future promise in the field of bioadhesives.

Integr Comp Biol 2021 Jun 11. Epub 2021 Jun 11.

University of North Carolina at Charlotte, Charlotte, NC 28223 USA.

Bioadhesives are wet or dry polymeric compounds that rely upon physical and chemical properties to generate characteristic sticky forces. The past decade has seen a rapidly evolving field of research around the functions, genetics, biochemistry, and mimetics of bioadhesives, but challenges unique to this research area continue to arise. We polled the presenters of SICB Symposium #8 to describe the "Ties that Stick:" challenges and exciting prospects that most resonated with their research pursuits. Read More

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Determination of sexual developmental characteristics of adolescents with intellectual disabilities.

J Intellect Disabil 2021 Jun 11:17446295211016180. Epub 2021 Jun 11.

Giresun University, Turkey.

This cross-sectional study was carried out in order to determine the opinions of mothers on sexual development in children with intellectual disabilities. The sampling of this study included mothers of children aged 10-19 years with moderate and severe intellectual disabilities. Of the mothers, 45. Read More

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